VIKKI ABRAHAMS

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Bacterial modulation of human fetal membrane Toll-like receptor expression
    Vikki M Abrahams
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 69:33-40. 2013
  2. pmc Potential role of macrophages as immunoregulators of pregnancy
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Biol Endocrinol 1:119. 2003
  3. doi request reprint Pattern recognition at the maternal-fetal interface
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Immunol Invest 37:427-47. 2008
  4. ncbi request reprint Toll-like receptors and their role in the trophoblast
    V M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Placenta 26:540-7. 2005
  5. doi request reprint Antagonizing toll-like receptors to prevent preterm labor
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Reprod Sci 15:108-9. 2008
  6. pmc TLR6 modulates first trimester trophoblast responses to peptidoglycan
    Vikki M Abrahams
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:6035-43. 2008
  7. ncbi request reprint Inhibition of human polymorphonuclear cell oxidative burst by 17-beta-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Vikki M Abrahams
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 50:463-72. 2003
  8. doi request reprint Mechanisms of antiphospholipid antibody-associated pregnancy complications
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Thromb Res 124:521-5. 2009
  9. doi request reprint The role of the Nod-like receptor family in trophoblast innate immune responses
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal Fetal Medicine, Yale University School of Medicine, 333 Cedar Street, LSOG 305C, New Haven, CT 06510, USA
    J Reprod Immunol 88:112-7. 2011
  10. ncbi request reprint Macrophages and apoptotic cell clearance during pregnancy
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Reprod Immunol 51:275-82. 2004

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Bacterial modulation of human fetal membrane Toll-like receptor expression
    Vikki M Abrahams
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 69:33-40. 2013
    ..The objective of this study was to evaluate the expression of TLRs 1-10 in fetal membranes after exposure to pathogens associated with intra-amniotic infection and PTB...
  2. pmc Potential role of macrophages as immunoregulators of pregnancy
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Biol Endocrinol 1:119. 2003
    ..This review will focus on decidual macrophages and their role on apoptosis and cell clearance during pregnancy...
  3. doi request reprint Pattern recognition at the maternal-fetal interface
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Immunol Invest 37:427-47. 2008
    ..This review discusses what is currently known about the role of Toll-like receptors and NOD-like receptors in controlling infections at the maternal-fetal interface, and what impact their function may have on pregnancy...
  4. ncbi request reprint Toll-like receptors and their role in the trophoblast
    V M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Placenta 26:540-7. 2005
    ....
  5. doi request reprint Antagonizing toll-like receptors to prevent preterm labor
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Reprod Sci 15:108-9. 2008
  6. pmc TLR6 modulates first trimester trophoblast responses to peptidoglycan
    Vikki M Abrahams
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:6035-43. 2008
    ..Furthermore, the expression of TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation...
  7. ncbi request reprint Inhibition of human polymorphonuclear cell oxidative burst by 17-beta-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Vikki M Abrahams
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 50:463-72. 2003
    ..This may have significant consequences on PMN function within the female reproductive tract. This study evaluated the effects of 17-beta-estradiol and TCDD on PMN oxidative burst...
  8. doi request reprint Mechanisms of antiphospholipid antibody-associated pregnancy complications
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Thromb Res 124:521-5. 2009
    ..This review will discuss what is currently known about the mechanisms by which aPL may compromise pregnancy outcome...
  9. doi request reprint The role of the Nod-like receptor family in trophoblast innate immune responses
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal Fetal Medicine, Yale University School of Medicine, 333 Cedar Street, LSOG 305C, New Haven, CT 06510, USA
    J Reprod Immunol 88:112-7. 2011
    ....
  10. ncbi request reprint Macrophages and apoptotic cell clearance during pregnancy
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Reprod Immunol 51:275-82. 2004
    ..The quick and effective removal of apoptotic cells by tissue macrophages represents an essential process, which prevents the release of self-antigens, and in the case of pregnancy, paternal alloantigens...
  11. ncbi request reprint Divergent trophoblast responses to bacterial products mediated by TLRs
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 173:4286-96. 2004
    ..Our findings provide a novel mechanism of pathogenesis for certain pregnancy complications in which there is engagement of the innate immune system...
  12. pmc Activation of TLR3 in the trophoblast is associated with preterm delivery
    Kaori Koga
    Department of Obstetrics and Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT, USA
    Am J Reprod Immunol 61:196-212. 2009
    ..Previously, we described the expression of TLR3 by human trophoblast and their ability to respond to (Poly[I:C]). Here we evaluate the effect of Poly[I:C] on mouse pregnancy and characterize the local and systemic response...
  13. pmc Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine production
    Eugenia de la Torre
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 182:3735-45. 2009
    ..Such altered trophoblast innate immune responses may have a profound impact on the microenvironment of the maternal-fetal interface and this could influence pregnancy outcome...
  14. pmc Inflammation and pregnancy: the role of the immune system at the implantation site
    Gil Mor
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1221:80-7. 2011
    ....
  15. pmc The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expression
    Seth Guller
    Department of Obstetrics Gynecology, Yale University School of Medicine, 333 Cedar Street, 339 FMB, P O Box 208063, New Haven, CT 06520 8063, USA
    Ann N Y Acad Sci 1127:129-33. 2008
    ....
  16. pmc Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway
    Melissa J Mulla
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 62:96-111. 2009
    ..The objective of this study was to determine the effects of aPL on trophoblast function and the mechanisms involved...
  17. ncbi request reprint Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes
    Gil Mor
    Department of Obstetrics and Gynecology, School of Medicine, Yale University, New Haven, CT 06520, USA
    J Immunol 170:114-22. 2003
    ..There is biological relevance to these findings in view of studies showing that accumulation of activated monocytes is involved in the pathogenesis of conditions such as vasculititis, arteriosclerosis, and rheumatoid arthritis...
  18. ncbi request reprint Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancy
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT 06520, USA
    Crit Rev Immunol 25:375-88. 2005
    ....
  19. ncbi request reprint TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer
    Michael G Kelly
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Cancer Res 66:3859-68. 2006
    ..In addition, we provide new evidence that links TLR-4 signaling, inflammation, and chemoresistance in ovarian cancer cells...
  20. ncbi request reprint The Fas/Fas ligand system and cancer: immune privilege and apoptosis
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06520, USA
    Mol Biotechnol 25:19-30. 2003
    ..We have also characterized a new form of FasL, different from the classical membranal form, which is secreted by ovarian cancer cells. In this review we describe the main techniques used in these studies...
  21. doi request reprint Regulation of Nod1 and Nod2 in first trimester trophoblast cells
    Melissa J Mulla
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 61:294-302. 2009
    ..The objectives of this study were to characterize the effects of Nod1 stimulation, and to determine the regulation of Nod1 and Nod2, in the trophoblast...
  22. pmc Viral ssRNA induces first trimester trophoblast apoptosis through an inflammatory mechanism
    Paulomi B Aldo
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 64:27-37. 2010
    ..While viruses pose a major threat, little is known about their effect on early pregnancy, or the mechanisms involved. The objective of this study was to characterize the trophoblast response following exposure to viral ssRNA...
  23. doi request reprint Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity
    Melissa J Mulla
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 63:339-48. 2010
    ..aPL target the placenta by binding to beta(2)-glycoprotein I (beta(2) GPI) expressed by the trophoblast. The objective of this study was to evaluate if and how aPL affect first trimester trophoblast migration...
  24. pmc AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression
    Shawn L Straszewski-Chavez
    Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 82:146-52. 2010
    ....
  25. ncbi request reprint The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy
    Shawn L Straszewski-Chavez
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, 333 Cedar Street FMB 301, New Haven, CT 06520, USA
    Endocr Rev 26:877-97. 2005
    ....
  26. ncbi request reprint Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Hum Reprod 21:2432-9. 2006
    ..Recent insight into the immunological capabilities of the trophoblast suggests that the placenta may function as an active barrier by recognizing and responding to pathogens through Toll-like receptors (TLRs)...
  27. ncbi request reprint NOD protein expression and function in first trimester trophoblast cells
    Melissa J Costello
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 57:67-80. 2007
    ..The aim of this study was to characterize the expression and function of NOD proteins in first trimester trophoblast cells...
  28. ncbi request reprint Macrophage-trophoblast interactions
    Gil Mor
    Reproductive Immunology Unit, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Med 122:149-63. 2006
    ..The present chapter will describe some of the approaches used to study the interaction between macrophages and trophoblast cells...
  29. ncbi request reprint Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide
    Yuehong Ma
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Reprod Immunol 55:12-8. 2006
    ..Responsiveness of this cell type to inflammatory compounds remains largely unelucidated...
  30. ncbi request reprint Epithelial ovarian cancer cells secrete functional Fas ligand
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven Connecticut 06520, USA
    Cancer Res 63:5573-81. 2003
    ....
  31. ncbi request reprint A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:8096-104. 2005
    ..Such altered trophoblast cell responses might contribute to the pathogenesis of certain pregnancy complications...
  32. ncbi request reprint Influence of stage of the reproductive cycle and estradiol on thymus cell antigen presentation
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Steroid Biochem Mol Biol 84:79-87. 2003
    ..1 and B7.2. These studies demonstrate that sex hormones play a central role in regulating antigen presentation in the thymus...
  33. doi request reprint Progesterone inhibits basal and TNF-alpha-induced apoptosis in fetal membranes: a novel mechanism to explain progesterone-mediated prevention of preterm birth
    Guoyang Luo
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Reprod Sci 17:532-9. 2010
    ..One third of PTB is associated with preterm premature rupture of membranes (PPROM). We hypothesize that progesterone may block proinflammatory cytokine-induced apoptosis of fetal membrane, thereby preventing PPROM and PTB...
  34. ncbi request reprint Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis
    Yeon Mee Kim
    Perinatology Research Branch, National Institute of Child Health and Human Development NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 191:1346-55. 2004
    ..This study examined Toll-like receptor-2 and -4 expression in fetal membranes in response to labor at term and histologic chorioamnionitis...
  35. ncbi request reprint Heparin prevents programmed cell death in human trophoblast
    Frank A Hills
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, UK
    Mol Hum Reprod 12:237-43. 2006
    ..Our results suggest that heparin may be useful in the management of at-risk patients, even in the absence of an identifiable thrombophilic disorder...
  36. ncbi request reprint Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?
    Yeon Mee Kim
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
    Am J Obstet Gynecol 193:921-7. 2005
    ..quot; This study was conducted to determine whether changes in TLR-4 and TLR-2 expressions can be detected in the trophoblasts at the placental bed of women with and without preeclampsia...

Research Grants5

  1. Innate Immune Responses of Trophoblasts in Pregnancy
    VIKKI ABRAHAMS; Fiscal Year: 2007
    ..These studies will provide new insight into how trophoblast cells function in the presence of an infection and will advance our understanding of pathological conditions, such as preeclampsia, IUGR or preterm deliveries. ..
  2. Innate Immune Responses of Trophoblasts in Pregnancy
    VIKKI ABRAHAMS; Fiscal Year: 2009
    ..These studies will provide new insight into how trophoblast cells function in the presence of an infection and will advance our understanding of pathological conditions, such as preeclampsia, IUGR or preterm deliveries. ..