Affiliation: Yale University
Mulla M, Pasternak M, Salmon J, Chamley L, Abrahams V. Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation. J Autoimmun. 2018;: pubmed publisher
..These findings suggest that a bacterial infection at the maternal-fetal interface may exacerbate the impact aPL have on trophoblast inflammation and, thus, on pregnancy outcome. ..
Potter J, Garg M, Girard S, Abrahams V. Viral single stranded RNA induces a trophoblast pro-inflammatory and antiviral response in a TLR8-dependent and -independent manner. Biol Reprod. 2015;92:17 pubmed publisher
..Thus, ssRNA viral infections may compromise pregnancy by altering placental trophoblast survival and function through both TLR8 and non-TLR8 signaling pathways, leading to immune changes at the maternal-fetal interface. ..
Gysler S, Mulla M, Guerra M, Brosens J, Salmon J, Chamley L, et al
. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Mol Hum Reprod. 2016;22:465-74 pubmed publisher
..Finzi Memorial Student Summer Fellowship from the Lupus Foundation of America (to S.M.G.), and the Yale University School of Medicine Medical Student Fellowship (to S.M.G.). The authors declare no competing financial interests. N/A. ..
Abrahams V, Aldo P, Murphy S, Visintin I, Koga K, Wilson G, et al
. TLR6 modulates first trimester trophoblast responses to peptidoglycan. J Immunol. 2008;180:6035-43 pubmed
..Furthermore, the expression of TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation. ..
Cross S, Potter J, Aldo P, Kwon J, Pitruzzello M, Tong M, et al
. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. J Immunol. 2017;199:2885-2895 pubmed publisher
..These findings indicate a novel mechanism by which viruses alter normal FM immune responses to bacteria, potentially giving rise to adverse pregnancy outcomes. ..