Research Topics
| VIKKI ABRAHAMSSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Bacterial modulation of human fetal membrane Toll-like receptor expressionVikki M Abrahams
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Reprod Immunol 69:33-40. 2013..The objective of this study was to evaluate the expression of TLRs 1-10 in fetal membranes after exposure to pathogens associated with intra-amniotic infection and PTB...- Potential role of macrophages as immunoregulators of pregnancyGil Mor
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
Reprod Biol Endocrinol 1:119. 2003..This review will focus on decidual macrophages and their role on apoptosis and cell clearance during pregnancy... 
Pattern recognition at the maternal-fetal interfaceVikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Immunol Invest 37:427-47. 2008..This review discusses what is currently known about the role of Toll-like receptors and NOD-like receptors in controlling infections at the maternal-fetal interface, and what impact their function may have on pregnancy...
Toll-like receptors and their role in the trophoblastV M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Placenta 26:540-7. 2005....- Antagonizing toll-like receptors to prevent preterm laborVikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Reprod Sci 15:108-9. 2008 - TLR6 modulates first trimester trophoblast responses to peptidoglycanVikki M Abrahams
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 180:6035-43. 2008..Furthermore, the expression of TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation... - Inhibition of human polymorphonuclear cell oxidative burst by 17-beta-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxinVikki M Abrahams
Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Am J Reprod Immunol 50:463-72. 2003..This may have significant consequences on PMN function within the female reproductive tract. This study evaluated the effects of 17-beta-estradiol and TCDD on PMN oxidative burst... - Mechanisms of antiphospholipid antibody-associated pregnancy complicationsVikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Thromb Res 124:521-5. 2009..This review will discuss what is currently known about the mechanisms by which aPL may compromise pregnancy outcome... - The role of the Nod-like receptor family in trophoblast innate immune responsesVikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal Fetal Medicine, Yale University School of Medicine, 333 Cedar Street, LSOG 305C, New Haven, CT 06510, USA
J Reprod Immunol 88:112-7. 2011.... - Macrophages and apoptotic cell clearance during pregnancyVikki M Abrahams
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Reprod Immunol 51:275-82. 2004..This review will discuss the role of decidual macrophages in apoptotic cell clearance during pregnancy... - Divergent trophoblast responses to bacterial products mediated by TLRsVikki M Abrahams
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 173:4286-96. 2004..Our findings provide a novel mechanism of pathogenesis for certain pregnancy complications in which there is engagement of the innate immune system... - Activation of TLR3 in the trophoblast is associated with preterm deliveryKaori Koga
Department of Obstetrics and Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT, USA
Am J Reprod Immunol 61:196-212. 2009..Previously, we described the expression of TLR3 by human trophoblast and their ability to respond to (Poly[I:C]). Here we evaluate the effect of Poly[I:C] on mouse pregnancy and characterize the local and systemic response... - Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine productionEugenia de la Torre
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 182:3735-45. 2009..Such altered trophoblast innate immune responses may have a profound impact on the microenvironment of the maternal-fetal interface and this could influence pregnancy outcome... - Inflammation and pregnancy: the role of the immune system at the implantation siteGil Mor
Department of Obstetrics, Gynecology, and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, Connecticut, USA
Ann N Y Acad Sci 1221:80-7. 2011.... - The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expressionSeth Guller
Department of Obstetrics Gynecology, Yale University School of Medicine, 333 Cedar Street, 339 FMB, P O Box 208063, New Haven, CT 06520 8063, USA
Ann N Y Acad Sci 1127:129-33. 2008.... - Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathwayMelissa J Mulla
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Reprod Immunol 62:96-111. 2009..The objective of this study was to determine the effects of aPL on trophoblast function and the mechanisms involved... - Interaction of the estrogen receptors with the Fas ligand promoter in human monocytesGil Mor
Department of Obstetrics and Gynecology, School of Medicine, Yale University, New Haven, CT 06520, USA
J Immunol 170:114-22. 2003..There is biological relevance to these findings in view of studies showing that accumulation of activated monocytes is involved in the pathogenesis of conditions such as vasculititis, arteriosclerosis, and rheumatoid arthritis... - Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancyGil Mor
Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT 06520, USA
Crit Rev Immunol 25:375-88. 2005.... - TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancerMichael G Kelly
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Cancer Res 66:3859-68. 2006..In addition, we provide new evidence that links TLR-4 signaling, inflammation, and chemoresistance in ovarian cancer cells... - The Fas/Fas ligand system and cancer: immune privilege and apoptosisVikki M Abrahams
Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06520, USA
Mol Biotechnol 25:19-30. 2003..We have also characterized a new form of FasL, different from the classical membranal form, which is secreted by ovarian cancer cells. In this review we describe the main techniques used in these studies... - Regulation of Nod1 and Nod2 in first trimester trophoblast cellsMelissa J Mulla
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Reprod Immunol 61:294-302. 2009..The objectives of this study were to characterize the effects of Nod1 stimulation, and to determine the regulation of Nod1 and Nod2, in the trophoblast... - Viral ssRNA induces first trimester trophoblast apoptosis through an inflammatory mechanismPaulomi B Aldo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USA
Am J Reprod Immunol 64:27-37. 2010..While viruses pose a major threat, little is known about their effect on early pregnancy, or the mechanisms involved. The objective of this study was to characterize the trophoblast response following exposure to viral ssRNA... - Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activityMelissa J Mulla
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Reprod Immunol 63:339-48. 2010..aPL target the placenta by binding to beta(2)-glycoprotein I (beta(2) GPI) expressed by the trophoblast. The objective of this study was to evaluate if and how aPL affect first trimester trophoblast migration... - AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expressionShawn L Straszewski-Chavez
Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Biol Reprod 82:146-52. 2010.... - The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancyShawn L Straszewski-Chavez
Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, 333 Cedar Street FMB 301, New Haven, CT 06520, USA
Endocr Rev 26:877-97. 2005.... - Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)Vikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Hum Reprod 21:2432-9. 2006.... - NOD protein expression and function in first trimester trophoblast cellsMelissa J Costello
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Reprod Immunol 57:67-80. 2007..The aim of this study was to characterize the expression and function of NOD proteins in first trimester trophoblast cells... - Macrophage-trophoblast interactionsGil Mor
Reproductive Immunology Unit, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
Methods Mol Med 122:149-63. 2006..The present chapter will describe some of the approaches used to study the interaction between macrophages and trophoblast cells... - Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharideYuehong Ma
Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520-8063, USA
Am J Reprod Immunol 55:12-8. 2006..This suggests that inflammatory compounds may alter cytokine expression in the syncytium throughout gestation... - Epithelial ovarian cancer cells secrete functional Fas ligandVikki M Abrahams
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven Connecticut 06520, USA
Cancer Res 63:5573-81. 2003.... - A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cellsVikki M Abrahams
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 175:8096-104. 2005..Such altered trophoblast cell responses might contribute to the pathogenesis of certain pregnancy complications... - Influence of stage of the reproductive cycle and estradiol on thymus cell antigen presentationCharles R Wira
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Steroid Biochem Mol Biol 84:79-87. 2003..1 and B7.2. These studies demonstrate that sex hormones play a central role in regulating antigen presentation in the thymus... - Progesterone inhibits basal and TNF-alpha-induced apoptosis in fetal membranes: a novel mechanism to explain progesterone-mediated prevention of preterm birthGuoyang Luo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Reprod Sci 17:532-9. 2010..One third of PTB is associated with preterm premature rupture of membranes (PPROM). We hypothesize that progesterone may block proinflammatory cytokine-induced apoptosis of fetal membrane, thereby preventing PPROM and PTB... - Toll-like receptor-2 and -4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitisYeon Mee Kim
Perinatology Research Branch, National Institute of Child Health and Human Development/NIH/DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 191:1346-55. 2004..These observations have implications for understanding the biologic nature of innate immunity... - Heparin prevents programmed cell death in human trophoblastFrank A Hills
Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, UK
Mol Hum Reprod 12:237-43. 2006..Our results suggest that heparin may be useful in the management of at-risk patients, even in the absence of an identifiable thrombophilic disorder... - Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?Yeon Mee Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 193:921-7. 2005..quot; This study was conducted to determine whether changes in TLR-4 and TLR-2 expressions can be detected in the trophoblasts at the placental bed of women with and without preeclampsia...
Research Grants
- Innate Immune Responses of Trophoblasts in PregnancyVIKKI ABRAHAMS; Fiscal Year: 2007..These studies will provide new insight into how trophoblast cells function in the presence of an infection and will advance our understanding of pathological conditions, such as preeclampsia, IUGR or preterm deliveries. ..
- Innate Immune Responses of Trophoblasts in PregnancyVIKKI ABRAHAMS; Fiscal Year: 2009..These studies will provide new insight into how trophoblast cells function in the presence of an infection and will advance our understanding of pathological conditions, such as preeclampsia, IUGR or preterm deliveries. ..