Clara Abraham

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Inducing intestinal growth
    Clara Abraham
    Department of Medicine, University of Chicago, Chicago, USA
    N Engl J Med 353:2297-9. 2005
  2. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
  3. pmc Pathway analysis comparison using Crohn's disease genome wide association studies
    David Ballard
    Robert S Boas Center for Human Genetics and Genomics, Feinstein Institute for Medical Research, Manhasset, New York, USA
    BMC Med Genomics 3:25. 2010
  4. ncbi request reprint IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease
    Clara Abraham
    Section of Digestive Diseases, Departments of 1Medicine, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Med 60:97-110. 2009
  5. doi request reprint Interleukin-23/Th17 pathways and inflammatory bowel disease
    Clara Abraham
    Department of Medicine, Digestive Diseases, Yale University, New Haven, Connecticut 06520, USA
    Inflamm Bowel Dis 15:1090-100. 2009
  6. doi request reprint A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis
    Clara Abraham
    Yale University School of Medicine, Department of Internal Medicine, Section of Digestive Diseases, 333 Cedar St 1080 LMP, PO Box 208019, New Haven, CT 06520 8019, USA
    Nat Clin Pract Gastroenterol Hepatol 5:172-6. 2008
  7. ncbi request reprint Interactions between the host innate immune system and microbes in inflammatory bowel disease
    Clara Abraham
    Department of Medicine, Yale University, New Haven, Connecticut, USA
    Gastroenterology 140:1729-37. 2011
  8. ncbi request reprint Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele
    Matija Hedl
    Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06510, USA
    Immunity 40:734-46. 2014
  9. ncbi request reprint NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury
    Xingxin Wu
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520
    J Immunol 192:3409-18. 2014
  10. pmc NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 304:G583-96. 2013

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Inducing intestinal growth
    Clara Abraham
    Department of Medicine, University of Chicago, Chicago, USA
    N Engl J Med 353:2297-9. 2005
  2. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...
  3. pmc Pathway analysis comparison using Crohn's disease genome wide association studies
    David Ballard
    Robert S Boas Center for Human Genetics and Genomics, Feinstein Institute for Medical Research, Manhasset, New York, USA
    BMC Med Genomics 3:25. 2010
    ....
  4. ncbi request reprint IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease
    Clara Abraham
    Section of Digestive Diseases, Departments of 1Medicine, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Med 60:97-110. 2009
    ..The identification of IL-23 pathway and Th17 expressed genes in IBD pathogenesis highlights the importance of the proper regulation of the IL-23/Th17 pathway in maintaining intestinal immune homeostasis...
  5. doi request reprint Interleukin-23/Th17 pathways and inflammatory bowel disease
    Clara Abraham
    Department of Medicine, Digestive Diseases, Yale University, New Haven, Connecticut 06520, USA
    Inflamm Bowel Dis 15:1090-100. 2009
    ..As such, the IL-23/Th17 pathway contributes to immune responses that play a role in defenses to microbial infection, as well as in the intestinal inflammation observed in both animal models of colitis and human IBD...
  6. doi request reprint A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis
    Clara Abraham
    Yale University School of Medicine, Department of Internal Medicine, Section of Digestive Diseases, 333 Cedar St 1080 LMP, PO Box 208019, New Haven, CT 06520 8019, USA
    Nat Clin Pract Gastroenterol Hepatol 5:172-6. 2008
    ..Ten days after beginning treatment she developed jaundice and ascites. All medications were discontinued, but her symptoms continued to worsen...
  7. ncbi request reprint Interactions between the host innate immune system and microbes in inflammatory bowel disease
    Clara Abraham
    Department of Medicine, Yale University, New Haven, Connecticut, USA
    Gastroenterology 140:1729-37. 2011
    ..We review the cell populations and mechanisms that mediate interactions between host defense and tolerance and how the dysregulation of host-microbe interactions leads to intestinal inflammation and IBD...
  8. ncbi request reprint Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele
    Matija Hedl
    Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06510, USA
    Immunity 40:734-46. 2014
    ..Taken together, ICOSL amplifies PRR-initiated outcomes, which might contribute to immune homeostasis...
  9. ncbi request reprint NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury
    Xingxin Wu
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520
    J Immunol 192:3409-18. 2014
    ....
  10. pmc NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 304:G583-96. 2013
    ..Therefore, we identify mechanisms mediating the distinct inflammatory and microbicidal outcomes upon chronic stimulation of the CD-associated protein Nod2...
  11. ncbi request reprint CD18 is required for intestinal T cell responses at multiple immune checkpoints
    Marissa Marski
    Section of Gastroenterology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 178:2104-12. 2007
    ..This argues for a complex role for CD18 in the early priming checkpoints and ultimately in the trafficking of T cells to the intestinal tissues during an intestinal immune response...
  12. pmc IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, CT 06510, USA
    J Immunol 188:5348-56. 2012
    ....
  13. pmc Chronic stimulation of Nod2 mediates tolerance to bacterial products
    Matija Hedl
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:19440-5. 2007
    ..Significantly, intestinal macrophages exhibit tolerance to MDP per production of inflammatory cytokines. These results illustrate a role for chronic stimulation of Nod2 in mediating tolerance to bacterial products...
  14. pmc CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells
    Ritu Sarin
    Department of Medicine, Yale University, 333 Cedar St, 1080 LMP, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 303:G851-60. 2012
    ..Overall, these data argue for an essential and broad role for CD18 in lymphopenia-induced proliferation...
  15. pmc IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    Samuel Huber
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 491:259-63. 2012
    ..Thus, the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon...
  16. pmc NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms
    Shasha Zheng
    Department of Medicine, Yale University, New Haven, Connecticut, USA
    Mol Cell Biol 33:4857-71. 2013
    ..Therefore, we identify NF-κB1 and ATF3 as critical mechanisms through which NOD2 downregulates cytokines and contributes to intestinal immune homeostasis. ..
  17. pmc Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines
    Matija Hedl
    Department of Medicine, Yale University, New Haven, Connecticut, USA
    Gastroenterology 143:1530-43. 2012
    ..Activation of MAPK by PRR has varied effects on inflammatory cytokine secretion. We investigated whether different levels of autocrine IL-1 mediate these varied effects...
  18. pmc Unraveling the genetics of autoimmunity
    Lauren A Zenewicz
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Cell 140:791-7. 2010
    ..New genomic technologies applied to classic genetic studies involving twins, early onset cases, and phenotypic extremes may provide key insights into developmental and gene-environment interactions in autoimmunity...
  19. pmc The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
    Laurence Menard
    Department of Immunobiology, Yale University School of Medicine, 300 George Street, New Haven, Connecticut 06511, USA
    J Clin Invest 121:3635-44. 2011
    ..These data demonstrate that early B cell tolerance defects in autoimmunity can result from specific polymorphisms and precede the onset of disease...
  20. pmc Secretory mediators regulate Nod2-induced tolerance in human macrophages
    Matija Hedl
    Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, USA
    Gastroenterology 140:231-41. 2011
    ..Therefore, an emerging hypothesis is that Nod2-mediated cytokine down-regulation is required for intestinal homeostasis, but the mechanisms mediating this down-regulation are incompletely understood...
  21. ncbi request reprint The influence of depression on quality of life in patients with inflammatory bowel disease
    Clarence K Zhang
    Keck Biotechnology Laboratory, Yale University School of Medicine, New Haven, Connecticut, USA
    Inflamm Bowel Dis 19:1732-9. 2013
    ..In this cross-sectional study, we examined the role of depression and disease activity as independent factors in predicting patient's HR-QOL...
  22. pmc Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses
    Ritu Sarin
    Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:9560-5. 2011
    ..Our results show that the R381Q IL23R variant leads to selective, potentially desirable, loss of function alterations in primary human CD4+ and CD8+ T cells, resulting in highly significant protection against autoimmunity...
  23. ncbi request reprint Bugging of the intestinal mucosa
    Clara Abraham
    Department of Medicine, University of Chicago, Chicago, USA
    N Engl J Med 357:708-10. 2007
  24. pmc Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Biol Chem 286:26440-9. 2011
    ..Our findings clarify mechanisms of IL-1β contributions to Nod2 responses and elucidate the dominant role of IL-1β in MDP-initiated MAPK and cytokine secretion...
  25. ncbi request reprint The IL18RAP Region Disease Polymorphism Decreases IL-18RAP/IL-18R1/IL-1R1 Expression and Signaling through Innate Receptor-Initiated Pathways
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, CT 06510
    J Immunol 192:5924-32. 2014
    ....
  26. ncbi request reprint Functional consequences of NOD2 (CARD15) mutations
    Clara Abraham
    Department of Medicine, Section of Gastroenterology, University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 12:641-50. 2006
    ..Improved understanding of NOD2-mediated pathways may lead to identification of other molecules that can also contribute to the development of Crohn's disease in humans...
  27. pmc Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells
    Hui Shen
    Department of Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e57746. 2013
    ..Variable expression of CD161, IL-23R and RORC affects IL-23 responsiveness and contributes to the inter-individual susceptibility to IL-23-mediated defenses and inflammatory processes...
  28. ncbi request reprint A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
    ..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
  29. ncbi request reprint Inflammatory bowel disease genetics: Nod2
    Judy H Cho
    Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Annu Rev Med 58:401-16. 2007
    ..Here we review general aspects of IBD genetics with particular focus on the role of Nod2 in CD...
  30. ncbi request reprint CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells
    Marissa Marski
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 175:7889-97. 2005
    ..Therefore, we define a crucial role for CD18 in optimal CD4+CD25+ Treg development and function...
  31. ncbi request reprint LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo
    Sravanthi Kandula
    Department of Medicine, Section of Gastroenterology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 173:4443-51. 2004
    ..Taken together, these results demonstrate that LFA-1 is required for optimal CD4(+) T cell priming in vivo...
  32. ncbi request reprint Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations
    Jing Li
    The Martin Boyer Laboratories, Gastroenterology Section, Department of Medicine, The University of Chicago, IL 60637, USA
    Hum Mol Genet 13:1715-25. 2004
    ..Taken together, these studies suggest that a signaling defect of innate immunity to MDP may be an essential underlying defect in the pathogenesis of some CD patients...
  33. pmc Effector CD4+ T cell expression signatures and immune-mediated disease associated genes
    Wei Zhang
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 7:e38510. 2012
    ..The comprehensive integration of differential gene expression between cell subsets with disease-association signals, and functional pathways provides insight into disease pathogenesis...
  34. pmc CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells
    Luciana L Molinero
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 182:6736-43. 2009
    ..These data suggest a modified model of nTreg development in which TCR-CBM-dependent signals are essential to commit immature thymocytes to the nTreg lineage...

Research Grants4

  1. Mechanisms of Chronic Nod2-mediated Effects in Human Macrophages
    Clara Abraham; Fiscal Year: 2010
    ..We will then extend these findings directly into human intestinal macrophages and determine if individuals harboring Crohn's disease associated NOD2 mutations are defective in these mechanisms. ..
  2. Mechanisms of Chronic Nod2-mediated Effects in Human Macrophages
    Clara Abraham; Fiscal Year: 2009
    ..We will then extend these findings directly into human intestinal macrophages and determine if individuals harboring Crohn's disease associated NOD2 mutations are defective in these mechanisms. ..
  3. Mechanisms of Chronic Nod2-mediated Effects in Human Macrophages
    Clara Abraham; Fiscal Year: 2009
    ..We will then extend these findings directly into human intestinal macrophages and determine if individuals harboring Crohn's disease associated NOD2 mutations are defective in these mechanisms. ..