Deborah A Young

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    Deborah Herber
    Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Immunol 178:3822-30. 2007
  2. ncbi request reprint Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    Deborah A Young
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 56:1152-63. 2007
  3. ncbi request reprint mTOR--beyond transplantation
    Deborah A Young
    Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:418-23. 2005
  4. ncbi request reprint IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma
    Hak Ling Ma
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 171:608-15. 2003
  5. doi request reprint Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells
    Hak Ling Ma
    Wyeth Research, Cambridge, MA, USA
    Arthritis Rheum 62:430-40. 2010
  6. pmc IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
    Hak Ling Ma
    Inflammation and Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Clin Invest 118:597-607. 2008
  7. doi request reprint Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis
    Yijun Carrier
    Inflammation and Immunology, BioTherapeutic Research, Pfizer, Cambridge, Massachusetts 02140, USA
    J Invest Dermatol 131:2428-37. 2011
  8. ncbi request reprint IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity
    Mary Collins
    Inflammation, Wyeth Research, Cambridge, MA, USA
    Immunol Res 28:131-40. 2003
  9. ncbi request reprint IL-21 induces the apoptosis of resting and activated primary B cells
    Devangi S Mehta
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 170:4111-8. 2003
  10. ncbi request reprint IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    Marion T Kasaian
    Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    Immunity 16:559-69. 2002

Collaborators

Detail Information

Publications17

  1. ncbi request reprint IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    Deborah Herber
    Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Immunol 178:3822-30. 2007
    ..From a clinical standpoint, these results suggest that blocking IL-21 in systemic lupus erythematosus patients may represent a promising novel therapeutic approach...
  2. ncbi request reprint Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    Deborah A Young
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 56:1152-63. 2007
    ..In this study, the effects of blocking IL-21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL-21 contributes to their pathologic processes...
  3. ncbi request reprint mTOR--beyond transplantation
    Deborah A Young
    Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:418-23. 2005
    ..Selective inhibition of cell activation in the appropriate setting might prove to be beneficial for several autoimmune or inflammatory diseases...
  4. ncbi request reprint IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma
    Hak Ling Ma
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 171:608-15. 2003
    ..We conclude that IL-21 immunotherapy warrants clinical evaluation as a potential treatment for cancer...
  5. doi request reprint Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells
    Hak Ling Ma
    Wyeth Research, Cambridge, MA, USA
    Arthritis Rheum 62:430-40. 2010
    ..This study was undertaken to explore the mechanisms underlying TNFalpha blockade-induced exacerbation of skin inflammation in murine psoriasis-like skin disease...
  6. pmc IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
    Hak Ling Ma
    Inflammation and Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Clin Invest 118:597-607. 2008
    ..We propose that IL-22 antagonism might be a promising therapy for the treatment of human psoriasis...
  7. doi request reprint Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis
    Yijun Carrier
    Inflammation and Immunology, BioTherapeutic Research, Pfizer, Cambridge, Massachusetts 02140, USA
    J Invest Dermatol 131:2428-37. 2011
    ..We propose that a feedback loop between the IL-36 and Th17 cytokines is involved in driving cytokine expression in psoriatic tissues...
  8. ncbi request reprint IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity
    Mary Collins
    Inflammation, Wyeth Research, Cambridge, MA, USA
    Immunol Res 28:131-40. 2003
    ..Here we summarize our current knowledge of this new cytokine pathway, and its role in innate and adaptive immunity...
  9. ncbi request reprint IL-21 induces the apoptosis of resting and activated primary B cells
    Devangi S Mehta
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 170:4111-8. 2003
    ..These studies reveal a novel pathway that mediates B cell apoptosis via the IL-21R and suggest that IL-21 may play a role in regulating B cell homeostasis...
  10. ncbi request reprint IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    Marion T Kasaian
    Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    Immunity 16:559-69. 2002
    ..These observations suggest that IL-21 promotes the transition between innate and adaptive immunity...
  11. doi request reprint IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis
    Ruolan Liu
    Department of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Exp Neurol 211:14-24. 2008
    ..These results suggest that a temporal influence of IL-21 on the activity of immunoregulatory circuits can be important in the modulation of the course of the autoimmune disease...
  12. ncbi request reprint DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections
    Anthony R French
    Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:4981-90. 2006
    ..The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate...
  13. pmc The IL-21 receptor augments Th2 effector function and alternative macrophage activation
    John Pesce
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 116:2044-55. 2006
    ..Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases...
  14. ncbi request reprint Autoreactive T cells mediate NK cell degeneration in autoimmune disease
    Ruolan Liu
    Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    J Immunol 176:5247-54. 2006
    ..Thus, NK cell degeneration may serve as a means evolved by the immune system to control excessive autoimmunity...
  15. ncbi request reprint CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  16. ncbi request reprint Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    Geoffrey L Stephens
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:5008-20. 2004
    ..The down-regulation of GITR-L by inflammatory stimuli may enhance the susceptibility of effector T cells to suppressor activity during the course of an infectious insult...
  17. pmc Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells
    Andrea L Wurster
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 196:969-77. 2002
    ..These results suggest that Th2 cell-derived IL-21 regulates the development of IFN-gamma-producing Th1 cells which could serve to amplify a Th2 response...