Y Yang

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. pmc Biochemical characterization of novel tetrahydrofuranyl 1beta-methylcarbapenems: stability to hydrolysis by renal dehydropeptidases and bacterial beta-lactamases, binding to penicillin binding proteins, and permeability properties
    Y Yang
    Infectious Disease Research Section, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 43:2904-9. 1999
  2. ncbi request reprint Mechanism of inhibition of the class A beta -lactamases PC1 and TEM-1 by tazobactam. Observation of reaction products by electrospray ionization mass spectrometry
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    J Biol Chem 275:26674-82. 2000
  3. pmc Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1671-6. 1998
  4. pmc CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1980-4. 1998
  5. ncbi request reprint Kinetic properties and metal content of the metallo-beta-lactamase CcrA harboring selective amino acid substitutions
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    J Biol Chem 274:15706-11. 1999
  6. ncbi request reprint Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors
    V P Sandanayaka
    Chemical Sciences and Infectious Diseases, Wyeth Ayerst Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 11:997-1000. 2001
  7. ncbi request reprint Dipolar cycloaddition of novel 6-(nitrileoxidomethyl) penam sulfone: an efficient route to a new class of beta-lactamase inhibitors
    V P Sandanayaka
    Chemical Sciences and Infectious Diseases, Wyeth Ayerst Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Org Lett 2:3087-90. 2000
  8. ncbi request reprint Reduction of ENU-induced transversion mutations by the isoflavone genistein in Escherichia coli
    Y Yang
    Department of Microbiology, Southern Illinois University, Carbondale, IL 62901-6508, USA
    Mutat Res 479:63-70. 2001
  9. ncbi request reprint Carriage of antibiotic-resistant pneumococci among Asian children: a multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP)
    N Y Lee
    Samsung Medical Center, Sungkyunkwan University, Seoul, Korea
    Clin Infect Dis 32:1463-9. 2001
  10. ncbi request reprint [High expression of rabbit sperm membrane protein rSP10 in Escherichia coli and preparation of its specific antisera]
    J X Liu
    National Laboratories for Agrobiotechnology, China Agricultural University, Beijing 100094, China
    Sheng Wu Gong Cheng Xue Bao 17:314-7. 2001

Collaborators

Detail Information

Publications22

  1. pmc Biochemical characterization of novel tetrahydrofuranyl 1beta-methylcarbapenems: stability to hydrolysis by renal dehydropeptidases and bacterial beta-lactamases, binding to penicillin binding proteins, and permeability properties
    Y Yang
    Infectious Disease Research Section, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 43:2904-9. 1999
    ..coli and S. aureus, and penetrated gram-negative enteric bacteria at rates comparable to those for meropenem and biapenem...
  2. ncbi request reprint Mechanism of inhibition of the class A beta -lactamases PC1 and TEM-1 by tazobactam. Observation of reaction products by electrospray ionization mass spectrometry
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    J Biol Chem 275:26674-82. 2000
    ....
  3. pmc Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1671-6. 1998
    ..Sulbactam was less effective than the other inhibitors. The Thr182 mutation previously reported in an inhibitor-resistant beta-lactamase did not cause the TEM-43 enzyme to become resistant to any of the inhibitors...
  4. pmc CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1980-4. 1998
    ..These results indicated the presence of a novel extended-spectrum beta-lactamase, designated CTX-M-5, that specifically confers resistance to cefotaxime...
  5. ncbi request reprint Kinetic properties and metal content of the metallo-beta-lactamase CcrA harboring selective amino acid substitutions
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    J Biol Chem 274:15706-11. 1999
    ..Two enzymes with substitutions of Cys104 or Cys104 and Cys155 were also composed of mixed enzyme populations...
  6. ncbi request reprint Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors
    V P Sandanayaka
    Chemical Sciences and Infectious Diseases, Wyeth Ayerst Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 11:997-1000. 2001
    ..A new method was developed to prepare propargyl penam sulfone. The majority of the triazoles prepared by this route exhibited good activity against all three representative enzymes used for the inhibition assay...
  7. ncbi request reprint Dipolar cycloaddition of novel 6-(nitrileoxidomethyl) penam sulfone: an efficient route to a new class of beta-lactamase inhibitors
    V P Sandanayaka
    Chemical Sciences and Infectious Diseases, Wyeth Ayerst Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Org Lett 2:3087-90. 2000
    ..By this new method, several potent beta-lactamase inhibitors were synthesized. The regio- and stereoselectivity outcomes of the cycloaddition process are also discussed...
  8. ncbi request reprint Reduction of ENU-induced transversion mutations by the isoflavone genistein in Escherichia coli
    Y Yang
    Department of Microbiology, Southern Illinois University, Carbondale, IL 62901-6508, USA
    Mutat Res 479:63-70. 2001
    ..These results suggest that genistein may interfere with expression of the SOS response, including the UmuC-mediated lesion bypass mechanism that is necessary for UV-mutagenesis and the generation of transversions by ENU in E. coli...
  9. ncbi request reprint Carriage of antibiotic-resistant pneumococci among Asian children: a multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP)
    N Y Lee
    Samsung Medical Center, Sungkyunkwan University, Seoul, Korea
    Clin Infect Dis 32:1463-9. 2001
    ....
  10. ncbi request reprint [High expression of rabbit sperm membrane protein rSP10 in Escherichia coli and preparation of its specific antisera]
    J X Liu
    National Laboratories for Agrobiotechnology, China Agricultural University, Beijing 100094, China
    Sheng Wu Gong Cheng Xue Bao 17:314-7. 2001
    ..Specific antisera against re-rSP10 was induced using purified re-rSP10 as an antigen. The motility of capacitated sperms were affected but no aggregation was observed...
  11. ncbi request reprint Expression of penicillin G acylase from the cloned pac gene of Escherichia coli ATCC11105. Effects of pacR and temperature
    M Dai
    Department of Microbiology, Institute of Plant Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China
    Eur J Biochem 268:1298-303. 2001
    ..Our investigations confirmed the hypothesis of pacR-mediated PAA induction for PGA expression and clarified the inhibitory effect of high temperature upon the post-translational processing of the PGA precursor polypeptide...
  12. ncbi request reprint [The clinical investigation of bacteriology of chronic suppurative otitis media]
    Y Yang
    Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:550-2. 2001
    ..CONCLUSION: Pseudomonas aeruginosa, aureus staphylococcus and bacillus proteus are the main pathogens of chronic suppurative otitis media, and their sensitive rates for ciprofloxacin are high...
  13. pmc Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli
    Y Yang
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Rutgers Robert Wood Johnson Medical School, Piscataway 08854
    Proc Natl Acad Sci U S A 88:11057-61. 1991
    ....
  14. pmc DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences
    Y Yang
    Department of Biochemistry, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 85:8850-4. 1988
    ..In addition, we speculate that these interactions may be of a structural nature, such as involvement in the higher-order structure of the bacterial chromosome...
  15. ncbi request reprint The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
    T Durfee
    Center for Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio 78245
    Genes Dev 7:555-69. 1993
    ..Cell cycle synchrony experiments revealed that this association occurs from mitosis to early G1. The implications of these findings on the regulation of both proteins are discussed...
  16. pmc Crystal structure of thioltransferase at 2.2 A resolution
    S K Katti
    Bayer Corporation, Pharmaceutical Division, West Haven, Connecticut 06516, USA
    Protein Sci 4:1998-2005. 1995
    ..Pro 70, which is in close proximity to the disulfide bridge, assumes a conserved cis-peptide configuration. Mutational data available on the protein are in agreement with the three-dimensional structure...
  17. ncbi request reprint Identification of the pdxK gene that encodes pyridoxine (vitamin B6) kinase in Escherichia coli K-12
    Y Yang
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School 77030 1501, USA
    FEMS Microbiol Lett 141:89-95. 1996
    ....
  18. pmc Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12
    Y Yang
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, 77030 1501, USA
    J Bacteriol 180:1814-21. 1998
    ..pdxY is completely cotranscribed with tyrS, but about 92% of tyrS transcripts terminate at a putative Rho-factor-dependent attenuator located in the tyrS-pdxY intercistronic region...
  19. pmc Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12
    Y Yang
    Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas 77030 1501, USA
    J Bacteriol 180:4294-9. 1998
    ..These results implicate the GapA and Epd dehydrogenases in de novo PLP and PMP coenzyme biosynthesis...
  20. ncbi request reprint Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin
    Y Yang
    Department of Oncology and Experimental Pathology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
    Blood 92:3912-23. 1998
    ..Immunohistochemical staining suggested that endothelial cells were the major sources of eotaxin expression...
  21. ncbi request reprint Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity
    Y Yang
    Structural Biology Program, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Biochemistry 37:17145-56. 1998
    ..Comparison of the human thioltransferase with other thiol-disulfide oxidoreductases reveals structural and functional differences...
  22. ncbi request reprint Antimicrobial resistance and serotypes of nasopharyngeal strains of Streptococcus pneumoniae in Chinese children with acute respiratory infections
    K Yao
    Department of Respiratory Diseases and Laboratory of Microbiology and Immunology, Beijing Children s Hospital Affiliated to Capital University of Medical Sciences, Beijing, China
    J Int Med Res 35:253-67. 2007
    ..In particular, these features will allow for documentation of serotype replacement after the introduction of widespread vaccination...