Genomes and Genes
Jill F Wright
Affiliation: Wyeth Research
- Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cellsJill F Wright
Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
J Biol Chem 282:13447-55. 2007..These data suggest that the IL-17F/IL-17A heterodimer may contribute to the T cell-mediated immune responses...
- An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitmentSpencer C Liang
Inflammation Technologies, Wyeth Research, Cambridge, MA 02140, USA
J Immunol 179:7791-9. 2007..Taken together, our data elucidate the regulation of IL-17F/A heterodimer expression by Th17 cells and demonstrate an in vivo function for this cytokine in airway neutrophilia...
- The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complexJill F Wright
Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
J Immunol 181:2799-805. 2008..However, the distinct affinities of the receptor components for IL-17A, IL-17F, and IL-17F/IL-17A heterodimer can be exploited to differentially affect the activity of these cytokines...
- Th17 cytokines and their emerging roles in inflammation and autoimmunityLynette A Fouser
Wyeth Research Inflammation, Cambridge, MA 02140, USA
Immunol Rev 226:87-102. 2008..Future clinical studies will allow us to evaluate the role of each cytokine independently in contributing to human diseases with immune-mediated pathologies and to design optimal cytokine-targeted therapies for these diseases...
- Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinasesNeil M Wolfman
Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Proc Natl Acad Sci U S A 100:15842-6. 2003....
- Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent mannerBenfang Helen Ruan
Inflammation and Immunology, Pfizer BioTherapeutics Research and Development, Cambridge, MA 02140, USA
J Immunol 185:4213-22. 2010..These findings indicate a potential role of RAGE in autoimmune diseases that show accumulation of immunostimulatory DNA and C3a...
- Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2Jing Li
Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
Int Immunopharmacol 4:693-708. 2004..We propose, based on this data, a temporal model for the development of a functional IL-22 cytokine-receptor complex...
- A fluorescent assay suitable for inhibitor screening and vanin tissue quantificationBenfang H Ruan
Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
Anal Biochem 399:284-92. 2010..Preliminary screening of a library of 1280 pharmaceutically active compounds identified inhibitors with novel chemical scaffolds. This assay will be a powerful tool for target validation and drug lead identification and characterization...
- Inhibition of myostatin in adult mice increases skeletal muscle mass and strengthLisa Anne Whittemore
Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 300:965-71. 2003..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
- Regulation of muscle growth by multiple ligands signaling through activin type II receptorsSe Jin Lee
Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:18117-22. 2005..Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo...