Jill F Wright

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:13447-55. 2007
  2. ncbi An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
    Spencer C Liang
    Inflammation Technologies, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 179:7791-9. 2007
  3. ncbi The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 181:2799-805. 2008
  4. doi Th17 cytokines and their emerging roles in inflammation and autoimmunity
    Lynette A Fouser
    Wyeth Research Inflammation, Cambridge, MA 02140, USA
    Immunol Rev 226:87-102. 2008
  5. pmc Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases
    Neil M Wolfman
    Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Proc Natl Acad Sci U S A 100:15842-6. 2003
  6. doi Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner
    Benfang Helen Ruan
    Inflammation and Immunology, Pfizer BioTherapeutics Research and Development, Cambridge, MA 02140, USA
    J Immunol 185:4213-22. 2010
  7. ncbi Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
    Jing Li
    Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Int Immunopharmacol 4:693-708. 2004
  8. doi A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
    Benfang H Ruan
    Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
    Anal Biochem 399:284-92. 2010
  9. ncbi Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003
  10. pmc Regulation of muscle growth by multiple ligands signaling through activin type II receptors
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:18117-22. 2005

Detail Information

Publications10

  1. ncbi Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:13447-55. 2007
    ..These data suggest that the IL-17F/IL-17A heterodimer may contribute to the T cell-mediated immune responses...
  2. ncbi An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
    Spencer C Liang
    Inflammation Technologies, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 179:7791-9. 2007
    ..Taken together, our data elucidate the regulation of IL-17F/A heterodimer expression by Th17 cells and demonstrate an in vivo function for this cytokine in airway neutrophilia...
  3. ncbi The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 181:2799-805. 2008
    ..However, the distinct affinities of the receptor components for IL-17A, IL-17F, and IL-17F/IL-17A heterodimer can be exploited to differentially affect the activity of these cytokines...
  4. doi Th17 cytokines and their emerging roles in inflammation and autoimmunity
    Lynette A Fouser
    Wyeth Research Inflammation, Cambridge, MA 02140, USA
    Immunol Rev 226:87-102. 2008
    ..Future clinical studies will allow us to evaluate the role of each cytokine independently in contributing to human diseases with immune-mediated pathologies and to design optimal cytokine-targeted therapies for these diseases...
  5. pmc Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases
    Neil M Wolfman
    Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Proc Natl Acad Sci U S A 100:15842-6. 2003
    ....
  6. doi Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner
    Benfang Helen Ruan
    Inflammation and Immunology, Pfizer BioTherapeutics Research and Development, Cambridge, MA 02140, USA
    J Immunol 185:4213-22. 2010
    ..These findings indicate a potential role of RAGE in autoimmune diseases that show accumulation of immunostimulatory DNA and C3a...
  7. ncbi Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
    Jing Li
    Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Int Immunopharmacol 4:693-708. 2004
    ..We propose, based on this data, a temporal model for the development of a functional IL-22 cytokine-receptor complex...
  8. doi A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
    Benfang H Ruan
    Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
    Anal Biochem 399:284-92. 2010
    ..Preliminary screening of a library of 1280 pharmaceutically active compounds identified inhibitors with novel chemical scaffolds. This assay will be a powerful tool for target validation and drug lead identification and characterization...
  9. ncbi Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003
    ..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
  10. pmc Regulation of muscle growth by multiple ligands signaling through activin type II receptors
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:18117-22. 2005
    ..Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo...