Genomes and Genes
Neil M Wolfman
Affiliation: Wyeth Research
- Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinasesNeil M Wolfman
Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Proc Natl Acad Sci U S A 100:15842-6. 2003....
- The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complexJill F Wright
Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
J Immunol 181:2799-805. 2008..However, the distinct affinities of the receptor components for IL-17A, IL-17F, and IL-17F/IL-17A heterodimer can be exploited to differentially affect the activity of these cytokines...
- Inhibition of myostatin in adult mice increases skeletal muscle mass and strengthLisa Anne Whittemore
Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 300:965-71. 2003..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
- Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domainsJennifer J Hill
Department of Protein Chemistry and Proteomics, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
Mol Endocrinol 17:1144-54. 2003..Surprisingly, recombinant GASP-1 binds directly not only to mature myostatin, but also to the myostatin propeptide. Thus, GASP-1 represents a novel class of inhibitory TGFbeta binding proteins...
- Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cellsJill F Wright
Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
J Biol Chem 282:13447-55. 2007..These data suggest that the IL-17F/IL-17A heterodimer may contribute to the T cell-mediated immune responses...
- A fluorescent assay suitable for inhibitor screening and vanin tissue quantificationBenfang H Ruan
Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
Anal Biochem 399:284-92. 2010..Preliminary screening of a library of 1280 pharmaceutically active compounds identified inhibitors with novel chemical scaffolds. This assay will be a powerful tool for target validation and drug lead identification and characterization...
- IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22Paul W Wu
Wyeth Research Inflammation, Cambridge, MA 02140, USA
J Mol Biol 382:1168-83. 2008..Our results also provide a model for how IL-19, IL-20, IL-24, and IL-26 which are other IL-10-like cytokines, interact with their respective cell surface receptors...
- Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2Jing Li
Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
Int Immunopharmacol 4:693-708. 2004..We propose, based on this data, a temporal model for the development of a functional IL-22 cytokine-receptor complex...
- The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serumJennifer J Hill
Department of Protein Chemistry and Proteomics, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
J Biol Chem 277:40735-41. 2002..Functional studies show that FLRG inhibits myostatin activity in a reporter gene assay. These experiments suggest that the myostatin propeptide and FLRG are major negative regulators of myostatin in vivo...
- Regulation of muscle growth by multiple ligands signaling through activin type II receptorsSe Jin Lee
Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:18117-22. 2005..Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo...
- Induction of cachexia in mice by systemically administered myostatinTeresa A Zimmers
Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Science 296:1486-8. 2002..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...