Neil M Wolfman

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. pmc Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases
    Neil M Wolfman
    Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Proc Natl Acad Sci U S A 100:15842-6. 2003
  2. ncbi request reprint The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 181:2799-805. 2008
  3. ncbi request reprint Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003
  4. ncbi request reprint Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Mol Endocrinol 17:1144-54. 2003
  5. ncbi request reprint Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:13447-55. 2007
  6. doi request reprint A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
    Benfang H Ruan
    Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
    Anal Biochem 399:284-92. 2010
  7. doi request reprint IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22
    Paul W Wu
    Wyeth Research Inflammation, Cambridge, MA 02140, USA
    J Mol Biol 382:1168-83. 2008
  8. ncbi request reprint Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
    Jing Li
    Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Int Immunopharmacol 4:693-708. 2004
  9. ncbi request reprint The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Biol Chem 277:40735-41. 2002
  10. pmc Regulation of muscle growth by multiple ligands signaling through activin type II receptors
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:18117-22. 2005

Collaborators

Detail Information

Publications11

  1. pmc Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases
    Neil M Wolfman
    Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Proc Natl Acad Sci U S A 100:15842-6. 2003
    ....
  2. ncbi request reprint The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 181:2799-805. 2008
    ..However, the distinct affinities of the receptor components for IL-17A, IL-17F, and IL-17F/IL-17A heterodimer can be exploited to differentially affect the activity of these cytokines...
  3. ncbi request reprint Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003
    ..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
  4. ncbi request reprint Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Mol Endocrinol 17:1144-54. 2003
    ..Surprisingly, recombinant GASP-1 binds directly not only to mature myostatin, but also to the myostatin propeptide. Thus, GASP-1 represents a novel class of inhibitory TGFbeta binding proteins...
  5. ncbi request reprint Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:13447-55. 2007
    ..These data suggest that the IL-17F/IL-17A heterodimer may contribute to the T cell-mediated immune responses...
  6. doi request reprint A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
    Benfang H Ruan
    Inflammation and Immunology, Pfizer Biotherapeutics R and D, Cambridge, MA 02140, USA
    Anal Biochem 399:284-92. 2010
    ..Preliminary screening of a library of 1280 pharmaceutically active compounds identified inhibitors with novel chemical scaffolds. This assay will be a powerful tool for target validation and drug lead identification and characterization...
  7. doi request reprint IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22
    Paul W Wu
    Wyeth Research Inflammation, Cambridge, MA 02140, USA
    J Mol Biol 382:1168-83. 2008
    ..Our results also provide a model for how IL-19, IL-20, IL-24, and IL-26 which are other IL-10-like cytokines, interact with their respective cell surface receptors...
  8. ncbi request reprint Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
    Jing Li
    Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Int Immunopharmacol 4:693-708. 2004
    ..We propose, based on this data, a temporal model for the development of a functional IL-22 cytokine-receptor complex...
  9. ncbi request reprint The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Biol Chem 277:40735-41. 2002
    ..Functional studies show that FLRG inhibits myostatin activity in a reporter gene assay. These experiments suggest that the myostatin propeptide and FLRG are major negative regulators of myostatin in vivo...
  10. pmc Regulation of muscle growth by multiple ligands signaling through activin type II receptors
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:18117-22. 2005
    ..Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo...
  11. ncbi request reprint Induction of cachexia in mice by systemically administered myostatin
    Teresa A Zimmers
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 296:1486-8. 2002
    ..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...