Lisa Anne Whittemore
Affiliation: Wyeth Research
- Inhibition of myostatin in adult mice increases skeletal muscle mass and strengthLisa Anne Whittemore
Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 300:965-71. 2003..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
- Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscleStefan Girgenrath
Wyeth Department of Cardiovascular and Metabolic Diseases, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
Muscle Nerve 31:34-40. 2005..Our findings suggest that myostatin has a critical role in regulating the formation, proliferation, or differentiation of fetal myoblasts and postnatal fibers...
- Functional improvement of dystrophic muscle by myostatin blockadeSasha Bogdanovich
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Richards A 601, Philadelphia, Pennsylvania 19104 6085, USA
Nature 420:418-21. 2002....
- Myostatin propeptide-mediated amelioration of dystrophic pathophysiologySasha Bogdanovich
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
FASEB J 19:543-9. 2005....