An T Vu

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives
    An T Vu
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 15:4520-5. 2005
  2. ncbi ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands
    An T Vu
    Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 17:4053-6. 2007
  3. ncbi 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors
    An T Vu
    Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 53:2051-62. 2010
  4. ncbi 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors
    An T Vu
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 19:2464-7. 2009
  5. ncbi Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors
    Paige E Mahaney
    Chemical Sciences, Wyeth Research, Collegeville, PA 19426, United States
    Bioorg Med Chem Lett 19:5807-10. 2009
  6. ncbi Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors
    Casey C McComas
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, S2227A, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 18:4929-31. 2008
  7. ncbi 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors
    Puwen Zhang
    Chemical Sciences, Wyeth Research, S 2250B, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 52:5703-11. 2009
  8. ncbi Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines
    Paige E Mahaney
    Chemical and Screening Sciences, Discovery Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem 14:8455-66. 2006

Detail Information

Publications8

  1. ncbi ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives
    An T Vu
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 15:4520-5. 2005
    ..The best compound, 13b, was profiled as a selective partial agonist for ERbeta at 1 muM in a cell-based transcriptional assay. Uterine weight bioassay of 13b indicated no activation of ERalpha in vivo...
  2. ncbi ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands
    An T Vu
    Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 17:4053-6. 2007
    ..A new class of estrogen receptor beta (ERbeta) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERbeta...
  3. ncbi 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors
    An T Vu
    Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 53:2051-62. 2010
    ....
  4. ncbi 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors
    An T Vu
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 19:2464-7. 2009
    ..A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter...
  5. ncbi Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors
    Paige E Mahaney
    Chemical Sciences, Wyeth Research, Collegeville, PA 19426, United States
    Bioorg Med Chem Lett 19:5807-10. 2009
    ..This study led to the discovery of compound 20 which inhibited the norepinephrine transporter with an IC50 value of 4 nM while exhibiting 86-fold selectivity over the serotonin transporter...
  6. ncbi Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors
    Casey C McComas
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, S2227A, Collegeville, PA 19426, USA
    Bioorg Med Chem Lett 18:4929-31. 2008
    ....
  7. ncbi 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors
    Puwen Zhang
    Chemical Sciences, Wyeth Research, S 2250B, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 52:5703-11. 2009
    ..In addition, compound 20 was also studied in the rat hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain, respectively, and was orally efficacious at doses of 3-10 mg/kg...
  8. ncbi Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines
    Paige E Mahaney
    Chemical and Screening Sciences, Discovery Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem 14:8455-66. 2006
    ....