Thomas M Smith

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases
    Thomas M Smith
    Department of Inflammation Biology, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Arch Biochem Biophys 406:105-15. 2002
  2. ncbi The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes
    Thomas M Smith
    Department of Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, Massachusetts, 02140, USA
    Purinergic Signal 2:327-33. 2006
  3. ncbi Structure and protein design of a human platelet function inhibitor
    Jiayin Dai
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 116:649-59. 2004
  4. ncbi Characterization of an alternative splice variant of human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): a possible modulator of nucleotidase activity and purinergic signaling
    Patrick A Crawford
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0575, USA
    Arch Biochem Biophys 457:7-15. 2007
  5. ncbi A phylogenetic Gibbs sampler that yields centroid solutions for cis-regulatory site prediction
    Lee A Newberg
    The Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Bioinformatics 23:1718-27. 2007

Collaborators

Detail Information

Publications5

  1. ncbi Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases
    Thomas M Smith
    Department of Inflammation Biology, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Arch Biochem Biophys 406:105-15. 2002
    ..No traditional apyrase-conserved regions or nucleotide-binding domains were identified in this human enzyme, indicating membership in a new family of extracellular nucleotidases...
  2. ncbi The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes
    Thomas M Smith
    Department of Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, Massachusetts, 02140, USA
    Purinergic Signal 2:327-33. 2006
    ..The potential therapeutic value of these proteins is also discussed...
  3. ncbi Structure and protein design of a human platelet function inhibitor
    Jiayin Dai
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 116:649-59. 2004
    ..The engineered enzyme is a potent inhibitor of platelet aggregation and may serve as the basis for the development of a new class of antithrombotic agents...
  4. ncbi Characterization of an alternative splice variant of human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): a possible modulator of nucleotidase activity and purinergic signaling
    Patrick A Crawford
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267 0575, USA
    Arch Biochem Biophys 457:7-15. 2007
    ..This suggests a role for the NTPDase3beta variant in the regulation of NTPDase3 nucleotidase activity, and therefore the control of purinergic signaling, in those cells and tissues expressing both NTPDase3alpha and NTPDase3beta...
  5. ncbi A phylogenetic Gibbs sampler that yields centroid solutions for cis-regulatory site prediction
    Lee A Newberg
    The Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    Bioinformatics 23:1718-27. 2007
    ..Comparative-genomics studies must be able to address the phylogenetic correlation in the data and efficiently explore the alignment space, in order to make specific and biologically relevant predictions...