Donna K Slonim

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma
    Natalie C Twine
    Discovery Medicine, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cancer Res 63:6069-75. 2003
  2. ncbi request reprint From patterns to pathways: gene expression data analysis comes of age
    Donna K Slonim
    Department of Genomics, Wyeth Research, 35 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Nat Genet 32:502-8. 2002
  3. pmc Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression
    Itai Yanai
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Syst Biol 4:163. 2008
  4. ncbi request reprint Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma
    Michael E Burczynski
    Molecular Profiling and Biomarker Discovery, Wyeth Research, 1 Burtt Road, Andover, MA 01810, USA
    Clin Cancer Res 11:1181-9. 2005
  5. pmc Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions
    L Ryan Baugh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Genome Biol 6:R45. 2005
  6. ncbi request reprint The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo
    L Ryan Baugh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:1843-54. 2005
  7. ncbi request reprint Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells
    Margot O'Toole
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Arch Neurol 62:1531-6. 2005
  8. ncbi request reprint Composition and dynamics of the Caenorhabditis elegans early embryonic transcriptome
    L Ryan Baugh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 130:889-900. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma
    Natalie C Twine
    Discovery Medicine, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cancer Res 63:6069-75. 2003
    ..The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies...
  2. ncbi request reprint From patterns to pathways: gene expression data analysis comes of age
    Donna K Slonim
    Department of Genomics, Wyeth Research, 35 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Nat Genet 32:502-8. 2002
    ..Several approaches to each problem, and their relative merits, are discussed and key areas for additional research highlighted...
  3. pmc Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression
    Itai Yanai
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Syst Biol 4:163. 2008
    ..The coupling of asynchronous and topologically distinct modules may be a general principle of module assembly that functions to potentiate genetic switches...
  4. ncbi request reprint Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma
    Michael E Burczynski
    Molecular Profiling and Biomarker Discovery, Wyeth Research, 1 Burtt Road, Andover, MA 01810, USA
    Clin Cancer Res 11:1181-9. 2005
    ....
  5. pmc Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions
    L Ryan Baugh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Genome Biol 6:R45. 2005
    ..Genetic interactions within a homologous set of genes involved in vertebrate myogenesis indicate broad conservation of the muscle module and suggest that other genetic modules identified in C. elegans will be conserved...
  6. ncbi request reprint The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo
    L Ryan Baugh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:1843-54. 2005
    ..Transcription of targets is initiated in four temporal phases, which together with their spatial expression patterns leads to a model of the regulatory network specified by PAL-1...
  7. ncbi request reprint Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells
    Margot O'Toole
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Arch Neurol 62:1531-6. 2005
    ..Six immunizations were planned but were halted when meningoencephalitis was recognized as an adverse event in 6% of immunized patients...
  8. ncbi request reprint Composition and dynamics of the Caenorhabditis elegans early embryonic transcriptome
    L Ryan Baugh
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 130:889-900. 2003
    ..Finally, a versatile analytical platform based on cluster analysis and developmental classification of genes is provided...