P Shughrue

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 372:395-414. 1996
  2. pmc Responses in the brain of estrogen receptor alpha-disrupted mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Proc Natl Acad Sci U S A 94:11008-12. 1997
  3. ncbi request reprint Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 388:507-25. 1997
  4. ncbi request reprint Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 138:5476-84. 1997
  5. ncbi request reprint The distribution of estrogen receptor-beta mRNA in forebrain regions of the estrogen receptor-alpha knockout mouse
    P Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 138:5649-52. 1997
  6. ncbi request reprint Estrogen action in the estrogen receptor alpha-knockout mouse: is this due to ER-beta?
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Mol Psychiatry 3:299-302. 1998
  7. ncbi request reprint Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 139:5267-70. 1998
  8. ncbi request reprint Evidence for novel estrogen binding sites in the rat hippocampus
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, 145 King of Prussia Road, Radnor, PA 19087, USA
    Neuroscience 99:605-12. 2000
  9. ncbi request reprint Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
  10. ncbi request reprint Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    I Merchenthaler
    Womens Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 403:261-80. 1999

Collaborators

Detail Information

Publications14

  1. ncbi request reprint In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 372:395-414. 1996
    ....
  2. pmc Responses in the brain of estrogen receptor alpha-disrupted mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Proc Natl Acad Sci U S A 94:11008-12. 1997
    ..The results demonstrate that estrogen binds in the ERalphaKO brain and is capable of modulating PR gene expression, thus supporting the presence and functionality of a nonclassical estrogen receptor...
  3. ncbi request reprint Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 388:507-25. 1997
    ..In addition, this comparative study provides evidence that the region-specific expression of ER-alpha, ER-beta, or both may be important in determining the physiological responses of neuronal populations to estrogen action...
  4. ncbi request reprint Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 138:5476-84. 1997
    ..Together, the results of these studies provide important information about the central activity of estrogens and provide evidence for their tissue-specifc actions in the rat...
  5. ncbi request reprint The distribution of estrogen receptor-beta mRNA in forebrain regions of the estrogen receptor-alpha knockout mouse
    P Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 138:5649-52. 1997
    ..In addition, these morphological data provides evidence that estrogen may exert its actions in the ER alphaKO mouse brain via ER beta and thereby maintain organizational and activational effects...
  6. ncbi request reprint Estrogen action in the estrogen receptor alpha-knockout mouse: is this due to ER-beta?
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Mol Psychiatry 3:299-302. 1998
    ..Moreover, the localization of ER-beta mRNA in many new brain regions, including those associated with learning and memory, may provide new insight about the anatomical substrate for estrogen action in the brain...
  7. ncbi request reprint Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 139:5267-70. 1998
    ....
  8. ncbi request reprint Evidence for novel estrogen binding sites in the rat hippocampus
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, 145 King of Prussia Road, Radnor, PA 19087, USA
    Neuroscience 99:605-12. 2000
    ..These observations challenge our current thinking about steroid hormones and their mechanism(s) of action in a region associated with learning and memory and affected by the neurodegenerative conditions of aging...
  9. ncbi request reprint Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
    ..These data provide the first evidence that ER beta mRNA is translated into a biologically active protein in the rodent brain...
  10. ncbi request reprint Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    I Merchenthaler
    Womens Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 403:261-80. 1999
    ....
  11. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
    ..Our discovery that ER alpha mediates protection of the brain carries far-reaching implications for the selective targeting of ERs in the treatment and prevention of neural dysfunction associated with normal aging or brain injury...
  12. ncbi request reprint Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain
    E Hrabovszky
    Department of Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083 Hungary
    Endocrinology 142:3261-4. 2001
    ..The gene targets and molecular mechanisms of this regulation remain unknown...
  13. ncbi request reprint Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury
    P J Shughrue
    The Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Neuroscience 116:851-61. 2003
    ....
  14. ncbi request reprint Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development
    C P Austin
    Department of Neuroscience, Merck Research Laboratories, WP26A 3000, PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, USA
    Neuroscience 124:3-10. 2004
    ..These results demonstrate that Disc1 marks the hippocampus from its earliest stages, and suggest that developmental Disc1 dysfunction may lead to defects in hippocampal function that are associated with schizophrenia...