Howard Seeherman

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis
    Gang Li
    The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
    J Orthop Res 20:779-88. 2002
  2. doi rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model
    Howard J Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 90:2206-19. 2008
  3. ncbi rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations
    Howard Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 88:144-60. 2006
  4. ncbi A review of preclinical program development for evaluating injectable carriers for osteogenic factors
    Howard Seeherman
    Wyeth Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 85:96-108. 2003
  5. doi rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model
    Howard J Seeherman
    Musculoskeletal Therapies, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 92:411-26. 2010
  6. ncbi Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model
    Howard J Seeherman
    Women s Health and Bone, Wyeth Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 86:1961-72. 2004
  7. ncbi Delivery of bone morphogenetic proteins for orthopedic tissue regeneration
    Howard Seeherman
    Women s Health and Bone, Wyeth Discovery Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Cytokine Growth Factor Rev 16:329-45. 2005
  8. ncbi rhBMP-2 delivered in a calcium phosphate cement accelerates bridging of critical-sized defects in rabbit radii
    Howard J Seeherman
    Department of Surgery, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    J Bone Joint Surg Am 88:1553-65. 2006
  9. ncbi Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model
    John Louis-Ugbo
    Department of Orthopaedic Surgery, School of Medicine, Emory University, Altanta, GA 30322, USA
    J Orthop Res 20:1050-9. 2002
  10. doi Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair
    Scott A Jelinsky
    Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    J Orthop Res 29:1604-12. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis
    Gang Li
    The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
    J Orthop Res 20:779-88. 2002
    ..In Summary, both injection of rhBMP-2/buffer and implantation of rhBMP-2/ACS enhanced the consolidation stage of distraction osteogenesis in this rabbit model...
  2. doi rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model
    Howard J Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 90:2206-19. 2008
    ..This study was performed to evaluate the ability of recombinant human bone morphogenetic protein-12 (rhBMP-12), administered in several carriers, to accelerate healing in a sheep model of rotator cuff repair...
  3. ncbi rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations
    Howard Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 88:144-60. 2006
    ....
  4. ncbi A review of preclinical program development for evaluating injectable carriers for osteogenic factors
    Howard Seeherman
    Wyeth Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 85:96-108. 2003
  5. doi rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model
    Howard J Seeherman
    Musculoskeletal Therapies, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 92:411-26. 2010
    ..This study characterizes treatment with rhBMP-2/ACS in metaphyseal bone with use of a nonhuman primate core-defect model...
  6. ncbi Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model
    Howard J Seeherman
    Women s Health and Bone, Wyeth Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 86:1961-72. 2004
    ..In this study, we used a nonhuman primate fibular osteotomy model to evaluate injectable rhBMP-2/carrier formulations that can be administered in closed fractures...
  7. ncbi Delivery of bone morphogenetic proteins for orthopedic tissue regeneration
    Howard Seeherman
    Women s Health and Bone, Wyeth Discovery Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Cytokine Growth Factor Rev 16:329-45. 2005
    ..Alternative BMP delivery systems include viral vectors, genetically altered cells, conjugated factors and small molecules...
  8. ncbi rhBMP-2 delivered in a calcium phosphate cement accelerates bridging of critical-sized defects in rabbit radii
    Howard J Seeherman
    Department of Surgery, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    J Bone Joint Surg Am 88:1553-65. 2006
    ....
  9. ncbi Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model
    John Louis-Ugbo
    Department of Orthopaedic Surgery, School of Medicine, Emory University, Altanta, GA 30322, USA
    J Orthop Res 20:1050-9. 2002
    ..Systemic catabolism and elimination of the rhBMP-2 was extensive and systemic presence of the protein was negligible...
  10. doi Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair
    Scott A Jelinsky
    Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    J Orthop Res 29:1604-12. 2011
    ....
  11. pmc Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy
    Peter Bialek
    Tissue Repair, Pfizer Research, Cambridge, Massachusetts 02140, USA
    Physiol Genomics 43:1075-86. 2011
    ..These data suggest that there are multiple mechanisms leading to muscle atrophy and that specific therapeutic agents may be necessary to combat atrophy resulting from different conditions...
  12. ncbi Bone morphogenetic protein delivery systems
    Howard Seeherman
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Spine (Phila Pa 1976) 27:S16-23. 2002
    ..A review was conducted...
  13. doi Tendon-selective genes identified from rat and human musculoskeletal tissues
    Scott A Jelinsky
    Tissue Repair, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    J Orthop Res 28:289-97. 2010
    ..Identification of tendon-selective genes provides potential molecular tools to facilitate a better understanding of tendon development and tendon repair...
  14. ncbi Clinical application of recombinant human bone morphogenetic protein-2 in 4 dogs
    Milan Milovancev
    Department of Surgical Sciences, College of Veterinary Medicine, University of Wisconsin, Madison, WI 53706 1102, USA
    Vet Surg 36:132-40. 2007
    ..To describe outcome in dogs with insufficient bone healing treated with recombinant human bone morphogenetic protein-2 (rhBMP-2)...
  15. ncbi Protein-based tissue engineering in bone and cartilage repair
    John M Wozney
    Wyeth Research, 87 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Biotechnol 15:392-8. 2004
    ..Although a similar rationale exists for the regeneration of articular cartilage with bioactive factors, advancement in this area has not been as substantial...
  16. ncbi Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomy
    Ryland B Edwards
    Comparative Orthopaedic Research Laboratory, Departments of Surgical Sciences and Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706 1102, USA
    J Bone Joint Surg Am 86:1425-38. 2004
    ..We hypothesized that the osteotomy sites would heal faster after percutaneous delivery of rhBMP-2/alpha-BSM than they would after injection of alpha-BSM alone or after no treatment...