Annmarie L Sabb
Affiliation: Wyeth Research
- Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptorAnnmarie L Sabb
Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
Bioorg Med Chem Lett 14:2603-7. 2004..In addition, WAY-629 was active in vivo in a rat model of feeding behavior. An SAR study based on WAY-629 led to compound 11 (K(i) 13 nM, E(max) 102%)...
- WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activityKaren L Marquis
Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
J Pharmacol Exp Ther 320:486-96. 2007..p.). Thus, the profile of the 5-HT2C selective receptor agonist WAY-163909 is similar to that of an atypical antipsychotic and additionally may have rapid onset properties...
- WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activityJohn Dunlop
Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
J Pharmacol Exp Ther 313:862-9. 2005..4 and 5.19 mg/kg i.p., respectively, consistent with the potential utility of 5-HT(2C) receptor agonists as anti-obesity agents...
- The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonistsWayne E Childers
Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543 8000, USA
J Med Chem 53:4066-84. 2010....