I Merchenthaler

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint The effect of estrogens and antiestrogens in a rat model for hot flush
    I Merchenthaler
    Functional Morphology Division, Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Maturitas 30:307-16. 1998
  2. ncbi request reprint In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 372:395-414. 1996
  3. ncbi request reprint Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 138:5476-84. 1997
  4. ncbi request reprint Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain
    E Hrabovszky
    Department of Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083 Hungary
    Endocrinology 142:3261-4. 2001
  5. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
  6. ncbi request reprint Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor alpha-dependent manner
    E S Shen
    Peptide Pharmacology Section, Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 140:2628-31. 1999
  7. ncbi request reprint Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
  8. pmc Responses in the brain of estrogen receptor alpha-disrupted mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Proc Natl Acad Sci U S A 94:11008-12. 1997
  9. ncbi request reprint Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury
    P J Shughrue
    The Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Neuroscience 116:851-61. 2003
  10. ncbi request reprint Estrogen stimulates galanin expression within luteinizing hormone-releasing hormone-immunoreactive (LHRH-i) neurons via estrogen receptor-beta (ERbeta) in the female rat brain
    I Merchenthaler
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, 10 S Pine Str MSTF Rm 9 00F Baltimore, MD 21201, USA
    Neuropeptides 39:341-3. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The effect of estrogens and antiestrogens in a rat model for hot flush
    I Merchenthaler
    Functional Morphology Division, Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Maturitas 30:307-16. 1998
    ..0 mg/kg dose. Our results demonstrate the potential utility of this model to evaluate and discriminate among classes of compounds with varying degrees of estrogen agonist and antagonist activity...
  2. ncbi request reprint In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 372:395-414. 1996
    ....
  3. ncbi request reprint Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 138:5476-84. 1997
    ..Together, the results of these studies provide important information about the central activity of estrogens and provide evidence for their tissue-specifc actions in the rat...
  4. ncbi request reprint Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain
    E Hrabovszky
    Department of Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083 Hungary
    Endocrinology 142:3261-4. 2001
    ..The gene targets and molecular mechanisms of this regulation remain unknown...
  5. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
    ..Our discovery that ER alpha mediates protection of the brain carries far-reaching implications for the selective targeting of ERs in the treatment and prevention of neural dysfunction associated with normal aging or brain injury...
  6. ncbi request reprint Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor alpha-dependent manner
    E S Shen
    Peptide Pharmacology Section, Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Endocrinology 140:2628-31. 1999
    ....
  7. ncbi request reprint Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    Endocrinology 140:2613-20. 1999
    ..These data provide the first evidence that ER beta mRNA is translated into a biologically active protein in the rodent brain...
  8. pmc Responses in the brain of estrogen receptor alpha-disrupted mice
    P J Shughrue
    Women s Health Research Institute, Wyeth Ayerst Research, Radnor, PA 19087, USA
    Proc Natl Acad Sci U S A 94:11008-12. 1997
    ..The results demonstrate that estrogen binds in the ERalphaKO brain and is capable of modulating PR gene expression, thus supporting the presence and functionality of a nonclassical estrogen receptor...
  9. ncbi request reprint Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury
    P J Shughrue
    The Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Neuroscience 116:851-61. 2003
    ....
  10. ncbi request reprint Estrogen stimulates galanin expression within luteinizing hormone-releasing hormone-immunoreactive (LHRH-i) neurons via estrogen receptor-beta (ERbeta) in the female rat brain
    I Merchenthaler
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, 10 S Pine Str MSTF Rm 9 00F Baltimore, MD 21201, USA
    Neuropeptides 39:341-3. 2005
    ..Moreover, ERbeta may mediate, at least in part, the positive feedback effect of estrogens during the preovulatory LHRH and subsequent LH surges...
  11. ncbi request reprint Gonadotropin-releasing hormone neurons express estrogen receptor-beta
    E Hrabovszky
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083 Hungary
    J Clin Endocrinol Metab 92:2827-30. 2007
    ....