Scott C Mayer

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Stability studies of C-4',6' acetal benzylmaltosides synthesized as inhibitors of smooth muscle cell proliferation
    Scott C Mayer
    Chemical and Screening Sciences Department, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem Lett 14:2829-33. 2004
  2. doi request reprint Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
    Scott C Mayer
    Wyeth Research, Chemical and Screening Sciences, 865 Ridge Road, Monmouth Junction, Princeton, NJ 08852, USA
    Bioorg Med Chem Lett 18:3641-5. 2008
  3. doi request reprint Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease
    Scott C Mayer
    Chemical and Screening Sciences, and Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 51:7348-51. 2008
  4. doi request reprint Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
    Robert L Martone
    Wyeth Research, Departments of Discovery Neuroscience, Princeton, New Jersey 08543, USA
    J Pharmacol Exp Ther 331:598-608. 2009
  5. doi request reprint Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
    Lori M Miller
    Wyeth Research, Chemical and Screening Sciences, Princeton, NJ, USA
    Bioorg Med Chem Lett 19:62-6. 2009
  6. ncbi request reprint Direct inhibition of Ih by analgesic loperamide in rat DRG neurons
    Dmitry V Vasilyev
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    J Neurophysiol 97:3713-21. 2007
  7. ncbi request reprint Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains
    Minsheng Zhang
    Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 17:2401-3. 2007
  8. doi request reprint Ion channel screening plates: design, construction, and maintenance
    Scott C Mayer
    Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543, USA
    Assay Drug Dev Technol 8:504-11. 2010
  9. doi request reprint A novel high-throughput screening assay for HCN channel blocker using membrane potential-sensitive dye and FLIPR
    Dmitry V Vasilyev
    Discovery Neuroscience, Wyeth Research, Princeton, New Jersey 08543 8000, USA
    J Biomol Screen 14:1119-28. 2009

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Stability studies of C-4',6' acetal benzylmaltosides synthesized as inhibitors of smooth muscle cell proliferation
    Scott C Mayer
    Chemical and Screening Sciences Department, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem Lett 14:2829-33. 2004
    ..Several novel variants with increased acid stability and comparable in vitro activity were prepared...
  2. doi request reprint Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
    Scott C Mayer
    Wyeth Research, Chemical and Screening Sciences, 865 Ridge Road, Monmouth Junction, Princeton, NJ 08852, USA
    Bioorg Med Chem Lett 18:3641-5. 2008
    ..The strategies, synthesis, and SAR behind this interesting kinase scaffold will be described...
  3. doi request reprint Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease
    Scott C Mayer
    Chemical and Screening Sciences, and Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 51:7348-51. 2008
    ..Further side chain modification afforded the potent Notch-1-sparing GSI begacestat (5), which was selected for development for the treatment of Alzheimer's disease...
  4. doi request reprint Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
    Robert L Martone
    Wyeth Research, Departments of Discovery Neuroscience, Princeton, New Jersey 08543, USA
    J Pharmacol Exp Ther 331:598-608. 2009
    ..In healthy human volunteers, oral administration of a single dose of GSI-953 produces dose-dependent changes in plasma Abeta levels, confirming pharmacodynamic activity of GSI-953 in humans...
  5. doi request reprint Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
    Lori M Miller
    Wyeth Research, Chemical and Screening Sciences, Princeton, NJ, USA
    Bioorg Med Chem Lett 19:62-6. 2009
    ..Now we have identified a series of 3-cyanoquinoline compounds that are low nanomolar inhibitors of IGF-1R. The strategies, synthesis, and SAR behind the cyanoquinoline scaffold will be discussed...
  6. ncbi request reprint Direct inhibition of Ih by analgesic loperamide in rat DRG neurons
    Dmitry V Vasilyev
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    J Neurophysiol 97:3713-21. 2007
    ..Because I(h) channels are involved in pain processing, loperamide-induced inhibition of I(h) channels could provide an additional molecular mechanism for its analgesic action...
  7. ncbi request reprint Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains
    Minsheng Zhang
    Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 17:2401-3. 2007
    ....
  8. doi request reprint Ion channel screening plates: design, construction, and maintenance
    Scott C Mayer
    Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543, USA
    Assay Drug Dev Technol 8:504-11. 2010
    ....
  9. doi request reprint A novel high-throughput screening assay for HCN channel blocker using membrane potential-sensitive dye and FLIPR
    Dmitry V Vasilyev
    Discovery Neuroscience, Wyeth Research, Princeton, New Jersey 08543 8000, USA
    J Biomol Screen 14:1119-28. 2009
    ..The reported HTS-compatible HCN channel blocker assay can serve as a tool in drug discovery in the pursuit of HCN channel isoform-selective small molecules that could be used in the development of clinically relevant compounds...