Jessica E Malberg

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment
    Jessica E Malberg
    Wyeth Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 28:1562-71. 2003
  2. ncbi request reprint cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response
    Tamar L Gur
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:7860-8. 2007
  3. pmc Implications of adult hippocampal neurogenesis in antidepressant action
    Jessica E Malberg
    Wyeth Research, Princeton, NJ 08543, USA
    J Psychiatry Neurosci 29:196-205. 2004
  4. ncbi request reprint Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs
    Jessica E Malberg
    Neuroscience Discovery, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Curr Pharm Des 11:145-55. 2005
  5. ncbi request reprint Antidepressant action: to the nucleus and beyond
    Jessica E Malberg
    Neuroscience Discovery, Wyeth Research, Princeton, NJ 08543, USA
    Trends Pharmacol Sci 26:631-8. 2005
  6. doi request reprint Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders
    Sarah K Leonard
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 197:601-11. 2008
  7. ncbi request reprint Differentiating antidepressants of the future: efficacy and safety
    Sharon Rosenzweig-Lipson
    Wyeth Discovery Neuroscience, Depression and Anxiety, CN 8000, Princeton, NJ 08543, USA
    Pharmacol Ther 113:134-53. 2007
  8. ncbi request reprint Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects
    Jessica E Malberg
    Wyeth Research, Discovery Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 32:2360-8. 2007
  9. doi request reprint 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats
    Stacey J Sukoff Rizzo
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Int J Neuropsychopharmacol 12:1045-53. 2009
  10. pmc Innovative approaches for the development of antidepressant drugs: current and future strategies
    Lee E Schechter
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    NeuroRx 2:590-611. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment
    Jessica E Malberg
    Wyeth Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 28:1562-71. 2003
    ..These findings demonstrate that exposure to IS, which results in a state of behavioral despair, decreases hippocampal cell proliferation and that this effect can be reversed by fluoxetine treatment...
  2. ncbi request reprint cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response
    Tamar L Gur
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:7860-8. 2007
    ..Together, these data show that increased hippocampal neurogenesis allows for an antidepressant phenotype as well as a rapid onset of behavioral responses to AD treatment...
  3. pmc Implications of adult hippocampal neurogenesis in antidepressant action
    Jessica E Malberg
    Wyeth Research, Princeton, NJ 08543, USA
    J Psychiatry Neurosci 29:196-205. 2004
    ..Research from this emerging field will further our understanding of the effects of stress and depression on the brain and the mechanism of action of antidepressant drugs...
  4. ncbi request reprint Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs
    Jessica E Malberg
    Neuroscience Discovery, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Curr Pharm Des 11:145-55. 2005
    ..In addition, the ability of novel compounds to be tested for the neurogenic potential may become an additional way to evaluate a compound for putative antidepressant effects...
  5. ncbi request reprint Antidepressant action: to the nucleus and beyond
    Jessica E Malberg
    Neuroscience Discovery, Wyeth Research, Princeton, NJ 08543, USA
    Trends Pharmacol Sci 26:631-8. 2005
    ....
  6. doi request reprint Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders
    Sarah K Leonard
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 197:601-11. 2008
    ..Neuropeptide S (NPS) and its receptor (NPSR) comprise a recently deorphaned G protein-coupled receptor system. Recent reports implicate NPS in the mediation of anxiolytic-like activity in rodents...
  7. ncbi request reprint Differentiating antidepressants of the future: efficacy and safety
    Sharon Rosenzweig-Lipson
    Wyeth Discovery Neuroscience, Depression and Anxiety, CN 8000, Princeton, NJ 08543, USA
    Pharmacol Ther 113:134-53. 2007
    ..This review will discuss the many facets of differentiation and potential strategies for the development of novel antidepressants...
  8. ncbi request reprint Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects
    Jessica E Malberg
    Wyeth Research, Discovery Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 32:2360-8. 2007
    ..The present studies demonstrate that an IGFBP inhibitor mimics the behavioral effects of IGF-I and that IGFBP inhibition may represent a novel mechanism by which to increase IGF-I to treat depression and anxiety...
  9. doi request reprint 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats
    Stacey J Sukoff Rizzo
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Int J Neuropsychopharmacol 12:1045-53. 2009
    ..Taken together, these data suggest that 5-HT(1A) antagonist treatment may have utility for the management of SSRI-induced sexual dysfunction...
  10. pmc Innovative approaches for the development of antidepressant drugs: current and future strategies
    Lee E Schechter
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    NeuroRx 2:590-611. 2005
    ..The present review addresses the most exciting approaches and reviews the localization, neurochemical and behavioral data that provide the supporting rationale for each of these targets or target combinations...
  11. ncbi request reprint Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
    Sharon Rosenzweig-Lipson
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 192:159-70. 2007
    ..Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs...
  12. ncbi request reprint Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
    Robert H Ring
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 185:218-25. 2006
    ..Notably, evidence from studies in females has revealed an important role for OT in regulating anxiety behavior...
  13. pmc VGF, a new player in antidepressant action?
    Jessica E Malberg
    PsychoGenics, Inc, Tarrytown, NY 10591, USA
    Sci Signal 1:pe19. 2008
    ..These studies use in vivo approaches to link VGF to the antidepressant-like behavioral effects produced by antidepressant drugs and exercise...
  14. pmc Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments
    Darrick T Balu
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 1211:37-43. 2008
    ....
  15. ncbi request reprint Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
    Brian A Hoshaw
    Department of Psychiatry, University of Pennsylvania, 415 Curie Boulevard, Room 538, Philadelphia, PA 19104, USA
    Brain Res 1037:204-8. 2005
    ..Neither neurotrophic factor had an effect on locomotor activity. The results support a role for neurotrophic factors mediating the behavioral effects of antidepressant drugs...
  16. ncbi request reprint Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
    Shin Nakagawa
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3673-82. 2002
    ..The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis...
  17. ncbi request reprint Ablation of central nervous system progenitor cells in transgenic rats using bacterial nitroreductase system
    Seung P Kwak
    High Q Foundation, New York, NY, USA
    J Neurosci Res 85:1183-93. 2007
    ..These findings shows that targeted expression of NTR under a specific promoter might be of significant value in addressing the function of distinct cell population in vivo...