Mei Chu Lo

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
    Mei Chu Lo
    Biophysics Enzymology Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Anal Biochem 332:153-9. 2004
  2. doi request reprint A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase
    Mei Chu Lo
    Chemistry Research and Discovery, Amgen, South San Francisco, CA 94080, USA
    Anal Biochem 376:122-30. 2008
  3. ncbi request reprint Probing the interaction of HTI-286 with tubulin using a stilbene analogue
    Mei Chu Lo
    Biophysics Enzymology Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Am Chem Soc 126:9898-9. 2004
  4. ncbi request reprint Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules
    Girija Krishnamurthy
    Biophysics Enzymology, Screening Sciences, Oncology Research, and Chemical Sciences, Wyeth Research, Pearl River, New York 10965, USA
    Biochemistry 42:13484-95. 2003
  5. doi request reprint Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors
    Pawel Nowak
    Chemical Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, United States
    Bioorg Med Chem Lett 20:632-5. 2010
  6. ncbi request reprint Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase
    Andrea M Olland
    Wyeth Ayerst Research, Department of Biological Chemistry, Cambridge, Massachusetts 02140, USA
    J Biol Chem 277:3698-707. 2002

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
    Mei Chu Lo
    Biophysics Enzymology Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Anal Biochem 332:153-9. 2004
    ..The potential pitfalls in the data analysis of thermal shift assays are also discussed...
  2. doi request reprint A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase
    Mei Chu Lo
    Chemistry Research and Discovery, Amgen, South San Francisco, CA 94080, USA
    Anal Biochem 376:122-30. 2008
    ..This assay is also amenable to automation for high-throughput screening and yields excellent assay statistics (Z' > 0.8). In addition, it can be applied to the screening for inhibitors of any other enzymes that generate acetyl-CoA...
  3. ncbi request reprint Probing the interaction of HTI-286 with tubulin using a stilbene analogue
    Mei Chu Lo
    Biophysics Enzymology Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Am Chem Soc 126:9898-9. 2004
    ..The stable complex between the inhibitor and tubulin monomer was not detected under our experimental conditions. The binding site of the stilbene analogue does not overlap with the classic tubulin-binding agent, colchicine...
  4. ncbi request reprint Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules
    Girija Krishnamurthy
    Biophysics Enzymology, Screening Sciences, Oncology Research, and Chemical Sciences, Wyeth Research, Pearl River, New York 10965, USA
    Biochemistry 42:13484-95. 2003
    ..In contrast to the microtubule-stabilizing effects of paclitaxel, both HTI-286 and hemiasterlin depolymerize preassembled microtubules at micromolar concentrations...
  5. doi request reprint Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors
    Pawel Nowak
    Chemical Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, United States
    Bioorg Med Chem Lett 20:632-5. 2010
    ..Lead optimization using structure-based focused libraries led to the identification of low nanomolar BACE1 inhibitors such as 20b with substituents which extend from the S(1) to the S(3) pocket...
  6. ncbi request reprint Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase
    Andrea M Olland
    Wyeth Ayerst Research, Department of Biological Chemistry, Cambridge, Massachusetts 02140, USA
    J Biol Chem 277:3698-707. 2002
    ..Interactions of the nicotinic acid with backbone atoms indicate the structural basis for specificity...