Feng Liu

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Expression of NALP1 in cerebellar granule neurons stimulates apoptosis
    Feng Liu
    Wyeth Neuroscience Discovery Research, CN 8000, Princeton, NJ 08543, USA
    Cell Signal 16:1013-21. 2004
  2. doi ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey, USA
    J Pharmacol Exp Ther 327:827-39. 2008
  3. ncbi The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey 08852, USA
    J Neurochem 95:1363-72. 2005
  4. doi Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
    Feng Liu
    Wyeth Research, Discovery Neuroscience, 865 Ridge Road, Monmouth Junction, New Jersey 08852, USA
    Nat Neurosci 11:334-43. 2008
  5. ncbi The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices
    Feng Liu
    Wyeth Neuroscience Discovery Research, CN 8000, Princeton, NJ 08543, USA
    Eur J Pharmacol 536:262-8. 2006
  6. doi Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia
    Steven M Grauer
    Wyeth Discovery Neuroscience, Wyeth Research, CN8000, Princeton, New Jersey 08543, USA
    J Pharmacol Exp Ther 331:574-90. 2009
  7. ncbi Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders
    Zoe A Hughes
    Wyeth Research, Discovery Neuroscience, Princeton, New Jersey 08543, USA
    Curr Mol Pharmacol 2:215-36. 2009
  8. doi The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
    Sheree F Logue
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 42:438-47. 2009
  9. doi WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent
    Zoe A Hughes
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 54:1136-42. 2008
  10. ncbi Maternal origins of developmental reproducibility
    Mariela D Petkova
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 24:1283-8. 2014

Detail Information

Publications69

  1. ncbi Expression of NALP1 in cerebellar granule neurons stimulates apoptosis
    Feng Liu
    Wyeth Neuroscience Discovery Research, CN 8000, Princeton, NJ 08543, USA
    Cell Signal 16:1013-21. 2004
    ..Also described here are studies on the mechanism of action studies including deletion analyses and investigations of nucleotide binding, which begin to elucidate a regulatory function for NALP1 in neuronal apoptosis...
  2. doi ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey, USA
    J Pharmacol Exp Ther 327:827-39. 2008
    ..p.) in rats. Taken together, these effects are consistent with the hypothesis that allosteric potentiation of mGlu5 may provide a novel approach for development of antipsychotic and procognitive agents...
  3. ncbi The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey 08852, USA
    J Neurochem 95:1363-72. 2005
    ..Thus, these findings suggest that mGluR5 can modulate the PI3K/Akt/Gsk3beta pathway in the hippocampus, and that modulation of this signaling pathway can reverse beta-amyloid-induced neuronal toxicity...
  4. doi Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
    Feng Liu
    Wyeth Research, Discovery Neuroscience, 865 Ridge Road, Monmouth Junction, New Jersey 08852, USA
    Nat Neurosci 11:334-43. 2008
    ..Our data suggest that activation of ERbeta can regulate hippocampal synaptic plasticity and improve hippocampus-dependent cognition...
  5. ncbi The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices
    Feng Liu
    Wyeth Neuroscience Discovery Research, CN 8000, Princeton, NJ 08543, USA
    Eur J Pharmacol 536:262-8. 2006
    ..These results suggest that allosteric modulators of mGlu5 receptor could have physiologically significant effects by potentiating the actions of glutamate...
  6. doi Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia
    Steven M Grauer
    Wyeth Discovery Neuroscience, Wyeth Research, CN8000, Princeton, New Jersey 08543, USA
    J Pharmacol Exp Ther 331:574-90. 2009
    ..Together, our results suggest that PDE10A inhibitors alleviate both dopaminergic and glutamatergic dysfunction thought to underlie schizophrenia, which may contribute to the broad-spectrum efficacy...
  7. ncbi Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders
    Zoe A Hughes
    Wyeth Research, Discovery Neuroscience, Princeton, New Jersey 08543, USA
    Curr Mol Pharmacol 2:215-36. 2009
    ..In particular we will highlight the molecular mechanisms and signal transduction pathways most likely underlying the effects of estrogen in the CNS...
  8. doi The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
    Sheree F Logue
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 42:438-47. 2009
    ..Antipsychotic administration to Gpr88KOs normalized the PPI deficit and blocked AICS. The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders...
  9. doi WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent
    Zoe A Hughes
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 54:1136-42. 2008
    ....
  10. ncbi Maternal origins of developmental reproducibility
    Mariela D Petkova
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 24:1283-8. 2014
    ..Our results indicate that the reproducibility of the morphological structures of embryos originates during oogenesis, which is when the expression of maternally provided patterning factors is precisely controlled. ..
  11. pmc Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network
    Feng Liu
    Joseph Henry Laboratories of Physics and the Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 110:6724-9. 2013
    ....
  12. pmc GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders
    Erik I Charych
    Wyeth Research, Neuroscience Discovery, Princeton NJ 08852, USA
    Neuropharmacology 57:481-95. 2009
    ....
  13. ncbi Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 201:55-70. 2004
    ....
  14. ncbi Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, Indiana 46285, USA
    Transgenic Res 13:385-96. 2004
    ....
  15. doi Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous system
    Abby A Li
    Exponent Health Sciences, San Francisco, CA 94114, USA
    Neurotoxicology 29:504-19. 2008
    ..Dr. Michael Baum and by Dr. Feng Liu presented basic research on the hormonal mechanisms underlying sexual preference and estrogenic effects of ..
  16. ncbi Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites
    Paul Langlais
    Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Biochemistry 44:8890-7. 2005
    ..Taken together, our findings suggest that phosphorylation of the adaptor protein may provide a feedback inhibitory mechanism by which Grb10 regulates insulin signaling...
  17. ncbi PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle
    Lily Q Dong
    Dept of Cellular and Structural Biology, Univ of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 289:E187-96. 2005
    ..Identification and characterization of the bonafide HM kinase(s) will be essential to verify these hypotheses...
  18. doi Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1-14-3-3 dissociation
    Chengwei Yang
    The First Affiliated Hospital of Nanjing Medical University, 300 Guang Zhou Road, Jiangsu 210029, PR China
    Neurosci Lett 441:267-71. 2008
    ..These results indicate that ischemic preconditioning may have a protective affect against ASK1/14-3-3 dissociation-induced spinal cord injuries...
  19. ncbi Fine tuning PDK1 activity by phosphorylation at Ser163
    Ramon A Riojas
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229, USA
    J Biol Chem 281:21588-93. 2006
    ..In support of this, mutation of Tyr149 to Ala is sufficient to reduce PDK1 activity. Taken together, our results suggest that PDK1 phosphorylation of Ser163 may provide a mechanism to fine-tune PDK1 activity and function in cells...
  20. ncbi Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1
    Changhua Wang
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 282:7991-6. 2007
    ..These results indicate that activation of the LKB1/AMPK/TSC1/2 pathway alleviates the p70 S6 kinase-mediated negative regulation of insulin signaling, providing a mechanism by which adiponectin increases insulin sensitivity in cells...
  21. pmc Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo
    Lixin Wang
    Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Mol Cell Biol 27:6497-505. 2007
    ..Taken together, our results provide strong evidence that Grb10 is a negative regulator of insulin signaling and action in vivo...
  22. ncbi Impact of spatially correlated noise on neuronal firing
    Sentao Wang
    National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China
    Phys Rev E Stat Nonlin Soft Matter Phys 69:011909. 2004
    ..The mechanisms underlying these noise-induced effects are also discussed in detail...
  23. ncbi FRAT1 peptide decreases Abeta production in swAPP(751) cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    FEBS Lett 553:347-50. 2003
    ..Thus, we provide evidence that direct regulation of GSK3alpha/beta by FRAT1 peptide significantly decreases Abeta production in swAPP(751) cells...
  24. ncbi Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10
    Paul Langlais
    Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Mol Endocrinol 18:350-8. 2004
    ..In addition, the inhibitory effect of Grb10 on the MAPK pathway is most likely due to a direct block of insulin-stimulated Shc tyrosine phosphorylation...
  25. ncbi Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite
    Ming Hui Zou
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, The University of Tennessee, Knoxville, Tennessee 37920, USA
    J Biol Chem 278:34003-10. 2003
    ....
  26. ncbi Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Exp Cell Res 287:387-96. 2003
    ....
  27. ncbi Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
    Yan Zhou
    Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Science 302:1215-7. 2003
    ..Thus, the Rho-Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Abeta42 through inhibition of Rho activity...
  28. pmc Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors
    Feng Liu
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 277:45393-9. 2002
    ..Together, these studies suggest that DHPG activates CK1(epsilon) via Ca(2+)-dependent stimulation of calcineurin and subsequent dephosphorylation of inhibitory C-terminal autophosphorylation sites...
  29. pmc Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling
    Akinori Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 100:1322-7. 2003
    ..The results demonstrate that mGlu5 receptors potentiate adenosine A(2A)DARPP-32 signaling by stimulating the adenosine A(2A) receptor-mediated formation of cAMP in an extracellular signal-regulated kinase-dependent manner...
  30. ncbi Neurotensin negatively modulates Akt activity in neurotensin receptor-1-transfected AV12 cells
    Feng Liu
    Lilly Research Laboratories, Indianapolis, Indiana 46225, USA
    J Cell Biochem 92:603-11. 2004
    ..Our results provide insight into the role of NT in the modulation of Akt signaling and the potential physiological significance of Akt regulation by NT...
  31. pmc DARPP-32 mediates serotonergic neurotransmission in the forebrain
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3188-93. 2002
    ..Our data indicate that DARPP-32 is essential not only for dopaminergic but also for serotonergic neurotransmission...
  32. ncbi Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells
    Michael J Wick
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 277:16632-8. 2002
    ..Taken together, our results suggest that mPDK-1 undergoes autophosphorylation at multiple sites and that this phosphorylation may be essential for PDK-1 to interact with and phosphorylate its downstream substrates in vivo...
  33. ncbi Simulation of Brugada syndrome using cellular and three-dimensional whole-heart modeling approaches
    Ling Xia
    Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People s Republic of China
    Physiol Meas 27:1125-42. 2006
    ..The model can reproduce a variety of electrophysiological behaviors and provides a good basis for understanding the genesis of abnormal ECG under the condition of BS disease...
  34. ncbi Gastrodin interaction with human fibrinogen: anticoagulant effects and binding studies
    Yang Liu
    College of Chemistry and Molecular Engineering Peking University Beijing, 100871, China
    Chemistry 12:7807-15. 2006
    ..The study has also shown the potential usefulness of QCM biosensor technology for the rapid screening of drug-protein interactions...
  35. ncbi Characterization of a partially protective B-cell epitope within the 62 kDa antigen of Schistosoma japonicum
    Lei Zhang
    Department of Pathogen Biology and Immunology, Jiangsu Province Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 39:770-8. 2007
    ..japonicum. These results indicated that the epitope B3 from S. japonicum 62-kDa antigen might act as a candidate immunogen for future epitope vaccine investigation...
  36. ncbi The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF-7 and its adriamycin resistant cells
    Feng Liu
    The Key Laboratory of Chemical Biology, Guangdong Province, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
    Biol Pharm Bull 30:2279-83. 2007
    ..Our results suggest that survivin might play a key role in MDR in the presence of Pgp, and this might represent a novel strategy for modulating MDR in cancer cells...
  37. ncbi Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 547:193-6. 2003
    ..These results confirm the involvement of Cdk5 in APP processing, and suggest that p35- and p25-mediated Cdk5 activities lead to discrete APP phosphorylation...
  38. doi T cell epitope-based peptide-DNA dual vaccine induces protective immunity against Schistosoma japonicum infection in C57BL/6J mice
    Lei Zhang
    Department of Pathogen Biology and Immunology, Jiangsu Province Laboratory of Pathogen Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, PR China
    Microbes Infect 10:251-9. 2008
    ..Together, these results suggest that P5 could be used as a vaccine immunogen for both worm killing and disease prevention against S. japonicum...
  39. ncbi Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta
    Lily Q Dong
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 294:136-44. 2002
    ..The specific expression of mPDK-1 beta in mouse testis and brains of aged mice also suggests potential involvement of this kinase in regulating animal spermatogenesis and aging...
  40. ncbi Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta
    Feng Liu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 16:950-62. 2002
    ....
  41. pmc Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylethanolamine Bilayers
    Feng Liu
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biophys J 87:2470-82. 2004
    ....
  42. ncbi Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
    ..Our results identify a novel mechanism underlying a non-syndromic form of progressive hearing loss in mice...
  43. ncbi A structural model for the osmosensor, transporter, and osmoregulator ProP of Escherichia coli
    Janet M Wood
    Department of Molecular and Cellular Biology and Guelph Waterloo Centre for Graduate Work in Chemistry and Biochemistry, University of Guelph, Guelph N1G 2W1, Ontario, Canada
    Biochemistry 44:5634-46. 2005
    ....
  44. pmc Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem J 373:547-58. 2003
    ..More importantly, fractalkine increased cell-cell adhesion and aortic SMC proliferation, indicating a role in initiation and progression of atherosclerotic vascular disease...
  45. doi Truncated total least squares: a new regularization method for the solution of ECG inverse problems
    Guofa Shou
    Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
    IEEE Trans Biomed Eng 55:1327-35. 2008
    ..This investigation suggests that TTLS is able to robustly reconstruct EPs from BSPs and is a promising alternative method for the solution of ECG inverse problems...
  46. ncbi Mechanism of naked DNA clearance after intravenous injection
    Feng Liu
    Division of Molecular Pharmaceutics, University of North Carolina School of Pharmacy, Chapel Hill, NC 27599, USA
    J Gene Med 9:613-9. 2007
    ..Naked DNA after intravenous (i.v.) injection will be taken up by the liver and depredated by serum nucleases...
  47. ncbi A novel recently evolved gene C19orf24 encodes a non-classical secreted protein
    Xin rong Wang
    School of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, China
    Cell Mol Biol Lett 11:161-70. 2006
    ....
  48. ncbi Caldesmon is a cytoskeletal target for PKC in endothelium
    Natalia V Bogatcheva
    Department of Medicine, Section of Pulmonary and Critical Care, The University of Chicago Center for Integrative Science, 929 E 57th Street, Chicago, IL 60637, USA
    J Cell Biochem 99:1593-605. 2006
    ..Our results suggest that PKC-dependent phosphorylation of caldesmon is involved in PMA-mediated complex cytoskeletal changes leading to the EC barrier compromise...
  49. ncbi Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation
    Bin Wang
    Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, China
    Gene 379:132-40. 2006
    ..And the NYGGF4 expression 3T3-L1 cells had a greater number of cells in S-phase. Our data suggest that NYGGF4 might be a signaling molecule and could play a role in cell growth and adipogenesis process...
  50. ncbi Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase
    Roy J Vaz
    Aventis Pharmaceuticals, 1041 Route 202 206 N, Bridgewater, NJ 088707, USA
    Bioorg Med Chem Lett 14:6053-6. 2004
    ..This approach is demonstrated by the syntheses and evaluation of pseudo-bivalent ligands as potent inhibitors of human beta-tryptase...
  51. ncbi Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells
    Mei Ann Lim
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Oncogene 23:9348-58. 2004
    ..Our findings suggest that PDK-1/Akt signaling pathway plays a major role in regulating cell migration induced by PTEN deficiency...
  52. ncbi Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 287:L86-93. 2004
    ....
  53. ncbi p38 MAP kinase-dependent regulation of endothelial cell permeability
    Talaibek Borbiev
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 287:L911-8. 2004
    ..These results suggest the involvement of p38 MAP kinase activities and caldesmon phosphorylation in the MLCK-independent regulation of thrombin-induced endothelial cell permeability...
  54. ncbi Optimal synchrony state for maximal information transmission
    Yuguo Yu
    Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Neuroreport 15:1605-10. 2004
    ..Our results indicate that it is not the weaker or stronger but an appropriate synchronous state may be of more functional significance in sensory encoding...
  55. ncbi Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
    Suzanne Stratford
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Biol Chem 279:36608-15. 2004
    ..Moreover the results obtained provide a unifying theory to account for the numerous dissenting reports investigating the actions of ceramide toward Akt/PKB...
  56. ncbi Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
    ..Moreover, lithium treatment abolished GSK3beta-mediated Abeta increase in the brains of GSK3beta transgenics and reduced plaque burden in the brains of the PDAPP (APP(V717F)) transgenic mice...
  57. ncbi Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
    Milla Koistinaho
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nat Med 10:719-26. 2004
    ..Thus, Apoe seems to be important in the degradation and clearance of deposited Abeta species by astrocytes, a process that may be impaired in Alzheimer disease...
  58. ncbi MAP kinases in lung endothelial permeability induced by microtubule disassembly
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, MFL Center Tower, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 289:L75-84. 2005
    ..These data suggest a direct link between p38 MAPK activation, remodeling of MT network, and EC barrier regulation...
  59. ncbi Gene transcription profile in mice vaccinated with ultraviolet-attenuated cercariae of Schistosoma japonicum reveals molecules contributing to elevated IFN-gamma levels
    Xiang Zhu
    Department of Pathogenic Biology, Nanjing Medical University, Nanjing 210029, China
    Acta Biochim Biophys Sin (Shanghai) 37:254-64. 2005
    ..A comprehensive understanding of the immune mechanisms of attenuated cercariae-induced protection may contribute to developing efficient vaccination strategies against S. japonicum, especially during the early stage of infection...
  60. ncbi Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction
    Talaibek Borbiev
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 285:L43-54. 2003
    ..These results strongly suggest the involvement of CaM kinase II and ERK activities in thrombin-mediated caldesmon phosphorylation and both contractile and barrier regulation...
  61. ncbi [Bacteriologic examination in experimental maxillary sinusitis of rabbits]
    Feng Liu
    Department of Otolaryngology, Changhai Hospital, Second Military Medical University, Shanghai 200433
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 17:291-3. 2003
    ..To investigate how to induce experimental maxillary sinusitis so as to explore its bacteriologic changes...
  62. ncbi APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
    Xuming Mao
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Nat Cell Biol 8:516-23. 2006
    ..These results demonstrate a key function for APPL1 in adiponectin signalling and provide a molecular mechanism for the insulin sensitizing function of adiponectin...
  63. ncbi Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop
    Michael J Wick
    Departments of Pharmacology, Biochemistry, and Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 278:42913-9. 2003
    ....
  64. pmc CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression
    Feng Liu
    Department of Biological Chemistry, 839 Medical Science Court, 124 Sprague Hall, University of California, Irvine, CA 92697, USA
    Mol Cell Biol 26:3124-34. 2006
    ..Taken together, these results suggest that, contrary to the postulated universal corepressor role, CtIP activates a subset of E2F-responsive promoters by releasing RB-imposed repression and therefore promotes G(1)/S progression...
  65. ncbi Propagation of firing rate in a feed-forward neuronal network
    Sentao Wang
    National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China
    Phys Rev Lett 96:018103. 2006
    ..These abilities in information processing due to synchrony can be modulated by noise and the operating mode of neurons, and our results are relevant to experimental findings...
  66. ncbi Mitochondria-regulated death pathway mediates (DIPP-L-Leu)2-L-LysOCH3-induced K562 cells apoptosis
    Jie Yang
    The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055 P R China
    Protein Pept Lett 13:129-34. 2006
    ..These results suggest that the mitochondria-regulated death pathway mediates (DIPP-L-Leu)2-L-LysOCH3-induced K562 cells apoptosis...
  67. ncbi A novel kind of nitrogen heterocycle compound induces apoptosis of human chronic myelogenous leukemia K562 cells
    Guoyu Ding
    Key Laboratory of Chemical Biology, Guangdong Province, Graduate School of Shenzhen, Tsinghua University, Shenzhen 518057, PR China
    Bioorg Med Chem 14:3766-74. 2006
    ..Moreover, it might also provide a background mechanism for the introduction of this new type of promising therapeutic agent...
  68. ncbi Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation
    Fresnida J Ramos
    Dept of Pharmacology, UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 290:E1262-6. 2006
    ..Together, our results suggest that, in addition to inhibiting IR kinase activity by directly binding to the IR, Grb10 also negatively regulates insulin signaling by mediating insulin-stimulated degradation of the receptor...
  69. pmc Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
    James P McClung
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:8852-7. 2004
    ....