Anthony Kreft

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Brain and plasma exposure profiling in early drug discovery using cassette administration and fast liquid chromatography-tandem mass spectrometry
    Mei Yi Zhang
    Chemical and Screening Sciences, Wyeth Research, CN8000, Princeton, NJ 08543 8000, USA
    J Pharm Biomed Anal 34:359-68. 2004
  2. ncbi Discovery of a novel series of Notch-sparing gamma-secretase inhibitors
    Anthony Kreft
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem Lett 18:4232-6. 2008
  3. ncbi Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
    Robert L Martone
    Wyeth Research, Departments of Discovery Neuroscience, Princeton, New Jersey 08543, USA
    J Pharmacol Exp Ther 331:598-608. 2009
  4. ncbi Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors
    Eric Gundersen
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem Lett 15:1891-4. 2005

Collaborators

Detail Information

Publications4

  1. ncbi Brain and plasma exposure profiling in early drug discovery using cassette administration and fast liquid chromatography-tandem mass spectrometry
    Mei Yi Zhang
    Chemical and Screening Sciences, Wyeth Research, CN8000, Princeton, NJ 08543 8000, USA
    J Pharm Biomed Anal 34:359-68. 2004
    ..The method described here has been used for providing early brain penetration information in several CNS exploratory and discovery programs...
  2. ncbi Discovery of a novel series of Notch-sparing gamma-secretase inhibitors
    Anthony Kreft
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem Lett 18:4232-6. 2008
    ..Lead optimization studies led to the discovery of analog 8e with improved gamma-secretase inhibitory potency and Notch-sparing selectivity...
  3. ncbi Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
    Robert L Martone
    Wyeth Research, Departments of Discovery Neuroscience, Princeton, New Jersey 08543, USA
    J Pharmacol Exp Ther 331:598-608. 2009
    ..In healthy human volunteers, oral administration of a single dose of GSI-953 produces dose-dependent changes in plasma Abeta levels, confirming pharmacodynamic activity of GSI-953 in humans...
  4. ncbi Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors
    Eric Gundersen
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem Lett 15:1891-4. 2005
    ..Described below is a series of gamma-secretase inhibitors designed from a scaffold identified by a ROCS [J. Comput. Chem.1996, 17, 1653] search of the corporate database...