Frank E Koehn

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi The evolving role of natural products in drug discovery
    Frank E Koehn
    Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Nat Rev Drug Discov 4:206-20. 2005
  2. ncbi High impact technologies for natural products screening
    Frank E Koehn
    Natural Products Discovery Research Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Prog Drug Res 65:175, 177-210. 2008
  3. ncbi Therapeutic potential of natural product signal transduction agents
    Frank E Koehn
    Natural Products Discovery, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    Curr Opin Biotechnol 17:631-7. 2006
  4. doi New strategies and methods in the discovery of natural product anti-infective agents: the mannopeptimycins
    Frank E Koehn
    Natural Products Discovery, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA
    J Med Chem 51:2613-7. 2008
  5. doi A cell wall-active lipopeptide from the fungus Pochonia bulbillosa
    Frank E Koehn
    Natural Products Discovery and Discovery Analytical Chemistry, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA
    J Nat Prod 71:2045-8. 2008
  6. ncbi Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria
    Russell G Dushin
    Wyeth Research, Chemical and Screening Sciences, Medicinal Chemistry, Pearl River, NY 10965, USA
    J Med Chem 47:3487-90. 2004
  7. ncbi Reassessing the structure of pyranonigrin
    Gerhard Schlingmann
    Department of Natural Products, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Nat Prod 70:1180-7. 2007
  8. doi Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry
    Xidong Feng
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem 17:2154-61. 2009
  9. ncbi Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:279-82. 2004
  10. ncbi Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy
    Mark J Milton
    Wyeth Research, Chemical and Screening Sciences, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 16:4279-82. 2006

Collaborators

Detail Information

Publications16

  1. ncbi The evolving role of natural products in drug discovery
    Frank E Koehn
    Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Nat Rev Drug Discov 4:206-20. 2005
    ....
  2. ncbi High impact technologies for natural products screening
    Frank E Koehn
    Natural Products Discovery Research Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Prog Drug Res 65:175, 177-210. 2008
    ..As we apply these technologies and develop them even further, we can look forward to increased impact of natural products in the HTS based drug discovery...
  3. ncbi Therapeutic potential of natural product signal transduction agents
    Frank E Koehn
    Natural Products Discovery, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    Curr Opin Biotechnol 17:631-7. 2006
    ..Given these examples, together with the diversity of as yet undiscovered agents, natural product signal transduction agents offer great potential for future drug discovery efforts...
  4. doi New strategies and methods in the discovery of natural product anti-infective agents: the mannopeptimycins
    Frank E Koehn
    Natural Products Discovery, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA
    J Med Chem 51:2613-7. 2008
  5. doi A cell wall-active lipopeptide from the fungus Pochonia bulbillosa
    Frank E Koehn
    Natural Products Discovery and Discovery Analytical Chemistry, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA
    J Nat Prod 71:2045-8. 2008
    ..The potent cell wall activity and synthetically accessible structure of 1 make it a potential lead for further investigation...
  6. ncbi Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria
    Russell G Dushin
    Wyeth Research, Chemical and Screening Sciences, Medicinal Chemistry, Pearl River, NY 10965, USA
    J Med Chem 47:3487-90. 2004
    ..The preferentially formed monofunctionalized 4,6-acetals and -ketals display potent antibacterial activities against Gram-positive microorganisms, including MRSA, PRSP, and VRE pathogens...
  7. ncbi Reassessing the structure of pyranonigrin
    Gerhard Schlingmann
    Department of Natural Products, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Nat Prod 70:1180-7. 2007
    ....
  8. doi Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry
    Xidong Feng
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem 17:2154-61. 2009
    ....
  9. ncbi Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:279-82. 2004
    ..The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity...
  10. ncbi Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy
    Mark J Milton
    Wyeth Research, Chemical and Screening Sciences, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 16:4279-82. 2006
    ..The conformation of HTI-286 (I) in complex with the protein was determined from TRNOESY/ROESY experiments and is similar to the X-ray crystal structure conformation observed for hemiasterlin methyl ester in the absence of protein...
  11. ncbi Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics
    Phaik Eng Sum
    Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2805-8. 2003
    ..These compounds were synthesized via electrophilic aromatic substitution. Many of the new ether derivatives exhibited potent antibacterial activity against Gram-positive resistant strains including VRE, MRSA, and PRSP...
  12. pmc Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
    Benfang Ruan
    Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    Proc Natl Acad Sci U S A 105:33-8. 2008
    ..We propose that these immunophilin ligands can protect neurons from Ca(2+)-induced cell death by modulating Ca(2+) channels and promote neurite outgrowth via FKBP52 binding...
  13. doi The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics
    Hans Peter Gerber
    Pfizer Worldwide Research and Development, Oncology Research Unit, 401 Middletown Road, Pearl River, NY, USA
    Nat Prod Rep 30:625-39. 2013
    ....
  14. ncbi New silyl ether reagents for the absolute stereochemical determination of secondary alcohols
    R Thomas Williamson
    Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Org Lett 5:1745-8. 2003
    ..These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol...
  15. ncbi Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers
    Adam M Gilbert
    Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965 1299, and Bone Metabolism and Osteoporosis Research, Wyeth Research, 145 King of Prussia Road, Radnor, Pennsylvania 19087 4588
    J Med Chem 45:2342-5. 2002
    ..These two series are notable examples of small molecules that act as CT-inducers, a method to potentially treat bone loss diseases...
  16. ncbi Absolute configurational assignments of secondary amines by CD-sensitive dimeric zinc porphyrin host
    Xuefei Huang
    Department of Chemistry, Columbia University, New York, New York 10027, USA
    J Am Chem Soc 124:10320-35. 2002
    ..This chiroptical protocol in combination with molecular modeling represents a general method for configurational assignments of secondary amines...