Research Topics
Species | Frank E KoehnSummaryAffiliation: Wyeth Research Country: USA Publications
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Detail Information
Publications
The evolving role of natural products in drug discoveryFrank E Koehn
Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
Nat Rev Drug Discov 4:206-20. 2005....- High impact technologies for natural products screeningFrank E Koehn
Natural Products Discovery Research Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
Prog Drug Res 65:175, 177-210. 2008..As we apply these technologies and develop them even further, we can look forward to increased impact of natural products in the HTS based drug discovery... 
A cell wall-active lipopeptide from the fungus Pochonia bulbillosaFrank E Koehn
Natural Products Discovery and Discovery Analytical Chemistry, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA
J Nat Prod 71:2045-8. 2008..The potent cell wall activity and synthetically accessible structure of 1 make it a potential lead for further investigation...- New strategies and methods in the discovery of natural product anti-infective agents: the mannopeptimycinsFrank E Koehn
Natural Products Discovery, Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA
J Med Chem 51:2613-7. 2008 - Therapeutic potential of natural product signal transduction agentsFrank E Koehn
Natural Products Discovery, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
Curr Opin Biotechnol 17:631-7. 2006..Given these examples, together with the diversity of as yet undiscovered agents, natural product signal transduction agents offer great potential for future drug discovery efforts... - Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteriaRussell G Dushin
Wyeth Research, Chemical and Screening Sciences, Medicinal Chemistry, Pearl River, NY 10965, USA
J Med Chem 47:3487-90. 2004..The preferentially formed monofunctionalized 4,6-acetals and -ketals display potent antibacterial activities against Gram-positive microorganisms, including MRSA, PRSP, and VRE pathogens... - Reassessing the structure of pyranonigrinGerhard Schlingmann
Department of Natural Products, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
J Nat Prod 70:1180-7. 2007.... - Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometryXidong Feng
Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
Bioorg Med Chem 17:2154-61. 2009.... - Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopyMark J Milton
Wyeth Research, Chemical and Screening Sciences, Pearl River, NY 10965, USA
Bioorg Med Chem Lett 16:4279-82. 2006..The conformation of HTI-286 (I) in complex with the protein was determined from TRNOESY/ROESY experiments and is similar to the X-ray crystal structure conformation observed for hemiasterlin methyl ester in the absence of protein... - Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteriaHaiyin He
Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA
Bioorg Med Chem Lett 14:279-82. 2004..The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity... - Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibioticsPhaik Eng Sum
Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA
Bioorg Med Chem Lett 13:2805-8. 2003..These compounds were synthesized via electrophilic aromatic substitution. Many of the new ether derivatives exhibited potent antibacterial activity against Gram-positive resistant strains including VRE, MRSA, and PRSP... 
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activitiesBenfang Ruan
Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
Proc Natl Acad Sci U S A 105:33-8. 2008..We propose that these immunophilin ligands can protect neurons from Ca(2+)-induced cell death by modulating Ca(2+) channels and promote neurite outgrowth via FKBP52 binding...- New silyl ether reagents for the absolute stereochemical determination of secondary alcoholsR Thomas Williamson
Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
Org Lett 5:1745-8. 2003..These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol... - Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducersAdam M Gilbert
Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965-1299, and Bone Metabolism and Osteoporosis Research, Wyeth Research, 145 King of Prussia Road, Radnor, Pennsylvania 19087-4588
J Med Chem 45:2342-5. 2002..These two series are notable examples of small molecules that act as CT-inducers, a method to potentially treat bone loss diseases... - Absolute configurational assignments of secondary amines by CD-sensitive dimeric zinc porphyrin hostXuefei Huang
Department of Chemistry, Columbia University, New York, New York 10027, USA
J Am Chem Soc 124:10320-35. 2002..This chiroptical protocol in combination with molecular modeling represents a general method for configurational assignments of secondary amines...