Alan H Katz

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Structure-based design approaches to cell wall biosynthesis inhibitors
    Alan H Katz
    Wyeth Ayerst Research, Princeton, NJ 08540, USA
    Curr Pharm Des 9:857-66. 2003
  2. ncbi request reprint 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis
    Kristina M K Kutterer
    Wyeth Research, Chemical and Screening Sciences, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 15:2527-31. 2005
  3. ncbi request reprint Identification and characterization of small molecule modulators of KChIP/Kv4 function
    Mark R Bowlby
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem 13:6112-9. 2005
  4. ncbi request reprint Use of a murine cell line for identification of human nitric oxide synthase inhibitors
    Saule Naureckiene
    Neuroscience Discovery Research, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    J Pharmacol Toxicol Methods 55:303-13. 2007
  5. ncbi request reprint Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase
    Adam M Gilbert
    Chemical and Screening Sciences and Infectious Diseases Research, Wyeth, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 49:6027-36. 2006
  6. ncbi request reprint Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1
    Robert H Scannevin
    Neuroscience Discovery Research, Wyeth Research CN 8000, Princeton, NJ 08543, USA
    Neuron 41:587-98. 2004
  7. doi request reprint Modeling G protein-coupled receptors for structure-based drug discovery using low-frequency normal modes for refinement of homology models: application to H3 antagonists
    Brajesh K Rai
    Wyeth Research, CN8000, Princeton, New Jersey 08543 8000, USA
    Proteins 78:457-73. 2010
  8. ncbi request reprint Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis
    Gerardo D Francisco
    Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:235-8. 2004

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Structure-based design approaches to cell wall biosynthesis inhibitors
    Alan H Katz
    Wyeth Ayerst Research, Princeton, NJ 08540, USA
    Curr Pharm Des 9:857-66. 2003
    ..For example, mutations within the d-Ala-d-Ala ligases lead to the inability of Vancomycin antibiotics to bind...
  2. ncbi request reprint 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis
    Kristina M K Kutterer
    Wyeth Research, Chemical and Screening Sciences, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 15:2527-31. 2005
    ..Derivative 7l demonstrated antibacterial activity against both gram-positive and gram-negative bacteria. Derivatives 7f and 10a also demonstrated potent nanomolar Kd values in their binding to MurB...
  3. ncbi request reprint Identification and characterization of small molecule modulators of KChIP/Kv4 function
    Mark R Bowlby
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Bioorg Med Chem 13:6112-9. 2005
    ..Molecular modeling using the KChIP1 crystal structure indicates that compound binding may occur in a small tryptophan-containing binding pocket located on the hydrophilic side of the protein...
  4. ncbi request reprint Use of a murine cell line for identification of human nitric oxide synthase inhibitors
    Saule Naureckiene
    Neuroscience Discovery Research, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    J Pharmacol Toxicol Methods 55:303-13. 2007
    ..This upregulation is due in part to the induction of inducible nitric oxide synthase (iNOS) by proinflammatory cytokines in several different cell types, including macrophages and their CNS derivative, microglia...
  5. ncbi request reprint Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase
    Adam M Gilbert
    Chemical and Screening Sciences and Infectious Diseases Research, Wyeth, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 49:6027-36. 2006
    ..Docking studies using FLO and PharmDock produced several binding orientations for these molecules in the MurB active site...
  6. ncbi request reprint Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1
    Robert H Scannevin
    Neuroscience Discovery Research, Wyeth Research CN 8000, Princeton, NJ 08543, USA
    Neuron 41:587-98. 2004
    ....
  7. doi request reprint Modeling G protein-coupled receptors for structure-based drug discovery using low-frequency normal modes for refinement of homology models: application to H3 antagonists
    Brajesh K Rai
    Wyeth Research, CN8000, Princeton, New Jersey 08543 8000, USA
    Proteins 78:457-73. 2010
    ....
  8. ncbi request reprint Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis
    Gerardo D Francisco
    Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:235-8. 2004
    ..3,4-Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria...