Jeffrey E Janso

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Penicillium dravuni, a new marine-derived species from an alga in Fiji
    Jeffrey E Janso
    Wyeth Research, Natural Products Microbiology, 401 North Middletown Road, Pearl River, New York 10965, USA
    Mycologia 97:444-53. 2005
  2. doi request reprint Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues
    Anokha S Ratnayake
    Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Nat Prod 72:496-9. 2009
  3. ncbi request reprint Septocylindrins A and B: peptaibols produced by the terrestrial fungus Septocylindrium sp. LL-Z1518
    Mia Y Summers
    Department of Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    J Nat Prod 70:391-6. 2007
  4. ncbi request reprint Cytosporacin, a highly unsaturated polyketide: application of the ACCORD-ADEQUATE experiment to the structural determination of natural products
    Haiyin He
    Natural Products Research, Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Org Chem 68:6079-82. 2003
  5. doi request reprint Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry
    Xidong Feng
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem 17:2154-61. 2009
  6. ncbi request reprint Novel alpha-pyrones produced by a marine Pseudomonas sp. F92S91: taxonomy and biological activities
    Maya P Singh
    Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    J Antibiot (Tokyo) 56:1033-44. 2003
  7. ncbi request reprint Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252
    Haiyin He
    Wyeth Research, Pearl River, New York 10965, USA
    J Nat Prod 69:736-41. 2006
  8. ncbi request reprint Isolation, structure determination and biological activity of 15-deoxo-7,32-O-didesmethylrapamycin from the soil actinomycete LL-D45042
    Edmund I Graziani
    Department of Chemical and Screening Sciences, Oncology, Wyeth Research, 401 North Middletown Road, Pearl River, New York, 10965, USA
    J Antibiot (Tokyo) 57:462-4. 2004
  9. pmc Cytoskyrins and cytosporones produced by Cytospora sp. CR200: taxonomy, fermentation and biological activities
    Maya P Singh
    Natural Products Research, Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Mar Drugs 5:71-84. 2007
  10. ncbi request reprint Oxasetin, a new antibacterial polyketide produced by fungus Vaginatispora aquatica, HK1821
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Infectious Disease Research, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    J Antibiot (Tokyo) 55:821-5. 2002

Detail Information

Publications13

  1. ncbi request reprint Penicillium dravuni, a new marine-derived species from an alga in Fiji
    Jeffrey E Janso
    Wyeth Research, Natural Products Microbiology, 401 North Middletown Road, Pearl River, New York 10965, USA
    Mycologia 97:444-53. 2005
    ..However this new species shares only a distant ancestor with this clade because it branches by itself early in the lineage. P. dravuni also is known to produce the secondary metabolites dictyosphaeric acids A and B and carviolin...
  2. doi request reprint Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues
    Anokha S Ratnayake
    Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Nat Prod 72:496-9. 2009
    ..Both derivatives showed modest antibacterial activity against the Gram-positive coccus Staphylococcus aureus with MIC values in the range 8-32 microg/mL...
  3. ncbi request reprint Septocylindrins A and B: peptaibols produced by the terrestrial fungus Septocylindrium sp. LL-Z1518
    Mia Y Summers
    Department of Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    J Nat Prod 70:391-6. 2007
    ..The absolute configurations of amino acids present in 1 were determined using Marfey's methodology. Both compounds were isolated through bioassay-guided fractionation and exhibited significant antibacterial and antifungal activity...
  4. ncbi request reprint Cytosporacin, a highly unsaturated polyketide: application of the ACCORD-ADEQUATE experiment to the structural determination of natural products
    Haiyin He
    Natural Products Research, Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    J Org Chem 68:6079-82. 2003
    ..NOE studies established the relative configuration and revealed the presence of two rotamers. A biosynthetic (13)C-labeling experiment indicated that cytosporacin was derived from acetate origin...
  5. doi request reprint Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry
    Xidong Feng
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    Bioorg Med Chem 17:2154-61. 2009
    ....
  6. ncbi request reprint Novel alpha-pyrones produced by a marine Pseudomonas sp. F92S91: taxonomy and biological activities
    Maya P Singh
    Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    J Antibiot (Tokyo) 56:1033-44. 2003
    ..These data suggest that pyrone-I, unlike triclosan, selectively affects bacterial membrane function...
  7. ncbi request reprint Culicinin D, an antitumor peptaibol produced by the fungus Culicinomyces clavisporus, strain LL-12I252
    Haiyin He
    Wyeth Research, Pearl River, New York 10965, USA
    J Nat Prod 69:736-41. 2006
    ..Studies on the 3D structure of 4 using NOE data and computer modeling revealed a dominant conformation of the right-handed helix...
  8. ncbi request reprint Isolation, structure determination and biological activity of 15-deoxo-7,32-O-didesmethylrapamycin from the soil actinomycete LL-D45042
    Edmund I Graziani
    Department of Chemical and Screening Sciences, Oncology, Wyeth Research, 401 North Middletown Road, Pearl River, New York, 10965, USA
    J Antibiot (Tokyo) 57:462-4. 2004
  9. pmc Cytoskyrins and cytosporones produced by Cytospora sp. CR200: taxonomy, fermentation and biological activities
    Maya P Singh
    Natural Products Research, Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Mar Drugs 5:71-84. 2007
    ..Micro- and macroscopic morphological observations of the conidia and conidiomata, respectively, also suggested this fungus to be a Cytospora sp...
  10. ncbi request reprint Oxasetin, a new antibacterial polyketide produced by fungus Vaginatispora aquatica, HK1821
    Haiyin He
    Department of Natural Products Chemistry, Chemical Sciences, Infectious Disease Research, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, USA
    J Antibiot (Tokyo) 55:821-5. 2002
  11. ncbi request reprint Erratum
    Maya P Singh
    Natural Products Research, Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Mar Drugs 7:95-6. 2009
    ..This corrects the article on p. 71 in vol. 5, PMID: 18463719.]...
  12. ncbi request reprint Dictyosphaeric acids A and B: new decalactones from an undescribed Penicillium sp. obtained from the alga Dictyosphaeria versluyii
    Tim S Bugni
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 67:1396-9. 2004
    ..The relative stereochemistry of dictyosphaeric acids A and B was determined using the J-based configuration analysis method in conjunction with ROE and NOE correlations...
  13. ncbi request reprint Brocaenols A-C: novel polyketides from a marine derived Penicillium brocae
    Tim S Bugni
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Org Chem 68:2014-7. 2003
    ..The absolute stereochemistry of brocaenol A was established by using a modified Mosher method. The taxonomy of the producing fungus was elucidated by using both morphological and rDNA sequence analysis...