Jennifer J Hill

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Mol Endocrinol 17:1144-54. 2003
  2. ncbi request reprint The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Biol Chem 277:40735-41. 2002
  3. doi request reprint Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators
    Tatyana A Souza
    Department of Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02149, USA
    Mol Endocrinol 22:2689-702. 2008
  4. ncbi request reprint Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Mol Endocrinol 17:1144-54. 2003
    ..Surprisingly, recombinant GASP-1 binds directly not only to mature myostatin, but also to the myostatin propeptide. Thus, GASP-1 represents a novel class of inhibitory TGFbeta binding proteins...
  2. ncbi request reprint The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum
    Jennifer J Hill
    Department of Protein Chemistry and Proteomics, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Biol Chem 277:40735-41. 2002
    ..Functional studies show that FLRG inhibits myostatin activity in a reporter gene assay. These experiments suggest that the myostatin propeptide and FLRG are major negative regulators of myostatin in vivo...
  3. doi request reprint Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators
    Tatyana A Souza
    Department of Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02149, USA
    Mol Endocrinol 22:2689-702. 2008
    ....
  4. ncbi request reprint Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003
    ..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...