Afshin Ghavami

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Selective phosphodiesterase (PDE)-4 inhibitors: a novel approach to treating memory deficit?
    Afshin Ghavami
    Neuroscience Discovery Research, Wyeth Research, Monmouth Junction, New Jersey 08852 2718, USA
    Drugs R D 7:63-71. 2006
  2. ncbi Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo
    Chad E Beyer
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1022:214-20. 2004
  3. ncbi Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast
    Julia N Heinrich
    Neuroscience Discovery Research, Wyeth Research, 865 Ridge Road, Monmouth Junction, New Jersey 08852 2718, USA
    Cell Signal 18:795-806. 2006
  4. doi Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors
    Andrew F Donnell
    Worldwide Medicinal Chemistry, Pfizer Global Research and Development, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 20:2163-7. 2010
  5. ncbi Differential effects of regulator of G protein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2 receptor-mediated signaling and adenylyl cyclase activity
    Afshin Ghavami
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Cell Signal 16:711-21. 2004

Detail Information

Publications5

  1. ncbi Selective phosphodiesterase (PDE)-4 inhibitors: a novel approach to treating memory deficit?
    Afshin Ghavami
    Neuroscience Discovery Research, Wyeth Research, Monmouth Junction, New Jersey 08852 2718, USA
    Drugs R D 7:63-71. 2006
    ....
  2. ncbi Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo
    Chad E Beyer
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1022:214-20. 2004
    ....
  3. ncbi Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast
    Julia N Heinrich
    Neuroscience Discovery Research, Wyeth Research, 865 Ridge Road, Monmouth Junction, New Jersey 08852 2718, USA
    Cell Signal 18:795-806. 2006
    ..Phosphorylation at Y304 could not be substituted by an acidic amino acid. The RRS provides a genetic system to probe Shc proteins and potentially identify member specific protein partners and pharmacological reagents...
  4. doi Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors
    Andrew F Donnell
    Worldwide Medicinal Chemistry, Pfizer Global Research and Development, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 20:2163-7. 2010
    ..We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B and high selectivity over the PDE4D subtype...
  5. ncbi Differential effects of regulator of G protein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2 receptor-mediated signaling and adenylyl cyclase activity
    Afshin Ghavami
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Cell Signal 16:711-21. 2004
    ..Our results suggest specificity and selectivity of RGS proteins on G-protein-dependent and -independent signaling in mammalian cells...