Research Topics
Genomes and Genes | Debra D DonaldsonSummaryAffiliation: Wyeth Research Country: USA Publications
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Detail Information
Publications
Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2Nancy Wood
Department of Respiratory Disease, Wyeth Research, Cambridge, MA 02140, USA
J Exp Med 197:703-9. 2003..These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Ralpha2 in regulating immune responses in wild-type mice...
IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13Susan C Fish
Wyeth Research, Cambridge, MA 02140, USA
J Immunol 174:7716-24. 2005..These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13...- IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeysAndrea Bree
Wyeth Research, Cambridge, MA 02140, USA
J Allergy Clin Immunol 119:1251-7. 2007..IL-13 is a key inducer of airway inflammation in rodent models of respiratory disease, but a role for IL-13 has not been demonstrated in primates... - IL-21 effects on human IgE production in response to IL-4 or IL-13Nancy Wood
Wyeth Research, Cambridge, MA, USA
Cell Immunol 231:133-45. 2004..In contrast, IL-21-stimulated secretion of IgG4 from PBMC. Our findings indicate that IL-21 may influence the production of both human IgE and IgG4, and thus contribute to the regulation of atopic reactions... - IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunityMarion T Kasaian
Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
Immunity 16:559-69. 2002..These observations suggest that IL-21 promotes the transition between innate and adaptive immunity... - Efficacy of IL-13 neutralization in a sheep model of experimental asthmaMarion T Kasaian
Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Am J Respir Cell Mol Biol 36:368-76. 2007..These findings suggest that IL-13 contributes to allergen-induced airway responses in this sheep model of asthma, and that neutralization of IL-13 is an effective strategy for blocking these A. suum-induced effects... - Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?Richard Leigh
Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
Am J Respir Crit Care Med 170:851-6. 2004.... - IL-13 regulates the immune response to inhaled antigensJocelyn Padilla
James P Mara Center for Lung Diseases, St Luke s Roosevelt Hospital and Department of Pathology, Columbia University, New York, NY 10019, USA
J Immunol 174:8097-105. 2005..These data indicate that blockade of IL-13 may have therapeutic potential for controlling the immune response to inhaled Ags... - Effects of IL-13 on airway responses in the guinea pigBrian Morse
Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 282:L44-9. 2002.... 
Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasisHenry W Murray
Department of Medicine, Weill Medical College of Cornell University, Box 136, 1300 York Ave, New York, New York 10021, USA
Infect Immun 73:3903-11. 2005..donovani infection...- Intraepithelial NK cell-derived IL-13 induces intestinal pathology associated with nematode infectionJacqueline R McDermott
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
J Immunol 175:3207-13. 2005..These data provide the first evidence that intestinal tissue restructuring during helminth infection is an innate event dependent on IL-13 production by NK cells resident in the epithelium of the intestine... - Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvantChristian Taube
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 172:6398-406. 2004..These results show that FcepsilonRI is important for the development of AHR after an aerosolized allergen sensitization protocol and that this effect is mediated through FcepsilonRI on mast cells and production of IL-13 in the lung... - IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasisMargaret M Mentink-Kane
Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:586-90. 2004..Here, we show that the IL-13 receptor alpha 2 (IL-13R alpha 2) is a critical mediator of immune down-modulation, identifying the receptor as a life-sustaining off signal for chronic and pernicious inflammation in schistosomiasis... - The role of IL-13 in established allergic airway diseaseChristian Taube
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 169:6482-9. 2002.... - Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune responseMonica G Chiaramonte
Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 197:687-701. 2003..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response... - Natural immunosurveillance against spontaneous, autochthonous breast cancers revealed and enhanced by blockade of IL-13-mediated negative regulationJong Myun Park
Vaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10 Room 6B 12, 9000 Rockville Pk, Bethesda, MD 20892 1578, USA
Cancer Immunol Immunother 57:907-12. 2008..However, it was unknown whether natural immunosurveillance inhibits growth of completely spontaneous autochthonous tumors, and whether it can be improved by inhibition of negative regulation... - Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivityDianne C Webb
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
Eur J Immunol 33:3377-85. 2003..Collectively, these results demonstrate that IL-13-dependent processes regulating the development of AHR and T helper bias persist in the in the lungs of allergic IL-4Ralpha(-/-) mice... - Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrenceMasaki Terabe
Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 198:1741-52. 2003.... - Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergenJung Won Park
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 112:1078-87. 2003.... - Unmasking immunosurveillance against a syngeneic colon cancer by elimination of CD4+ NKT regulatory cells and IL-13Jong Myun Park
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 114:80-7. 2005..Thus, even for a nonregressor tumor, immunosurveillance exists but is negatively regulated via CD4+ NKT cells possibly mediated by IL-13, and can be unmasked by removal of these negative regulatory components... - A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40LJeffrey D Ahlers
Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:13020-5. 2002..These results argue for a push-pull approach to maximize vaccine efficacy, especially for HIV and cancer... - Roles of interleukin-13 and interferon-gamma in lung inflammationGabriele Grunig
Department of Pathology, Columbia University, New York, NY, USA
Chest 121:88S. 2002 - Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammationFrank Blaeser
Deparment of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
J Exp Med 198:1189-200. 2003..These results define an important role for the I4R motif in regulating allergic inflammation...