Debra D Donaldson

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. pmc Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2
    Nancy Wood
    Department of Respiratory Disease, Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 197:703-9. 2003
  2. ncbi IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13
    Susan C Fish
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 174:7716-24. 2005
  3. ncbi IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
    Andrea Bree
    Wyeth Research, Cambridge, MA 02140, USA
    J Allergy Clin Immunol 119:1251-7. 2007
  4. ncbi IL-21 effects on human IgE production in response to IL-4 or IL-13
    Nancy Wood
    Wyeth Research, Cambridge, MA, USA
    Cell Immunol 231:133-45. 2004
  5. ncbi IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    Marion T Kasaian
    Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    Immunity 16:559-69. 2002
  6. ncbi Efficacy of IL-13 neutralization in a sheep model of experimental asthma
    Marion T Kasaian
    Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Am J Respir Cell Mol Biol 36:368-76. 2007
  7. ncbi Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?
    Richard Leigh
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Am J Respir Crit Care Med 170:851-6. 2004
  8. ncbi IL-13 regulates the immune response to inhaled antigens
    Jocelyn Padilla
    James P Mara Center for Lung Diseases, St Luke s Roosevelt Hospital and Department of Pathology, Columbia University, New York, NY 10019, USA
    J Immunol 174:8097-105. 2005
  9. ncbi Effects of IL-13 on airway responses in the guinea pig
    Brian Morse
    Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L44-9. 2002
  10. pmc Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis
    Henry W Murray
    Department of Medicine, Weill Medical College of Cornell University, Box 136, 1300 York Ave, New York, New York 10021, USA
    Infect Immun 73:3903-11. 2005

Collaborators

Detail Information

Publications23

  1. pmc Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2
    Nancy Wood
    Department of Respiratory Disease, Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 197:703-9. 2003
    ..These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Ralpha2 in regulating immune responses in wild-type mice...
  2. ncbi IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13
    Susan C Fish
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 174:7716-24. 2005
    ..These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13...
  3. ncbi IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
    Andrea Bree
    Wyeth Research, Cambridge, MA 02140, USA
    J Allergy Clin Immunol 119:1251-7. 2007
    ..IL-13 is a key inducer of airway inflammation in rodent models of respiratory disease, but a role for IL-13 has not been demonstrated in primates...
  4. ncbi IL-21 effects on human IgE production in response to IL-4 or IL-13
    Nancy Wood
    Wyeth Research, Cambridge, MA, USA
    Cell Immunol 231:133-45. 2004
    ..In contrast, IL-21-stimulated secretion of IgG4 from PBMC. Our findings indicate that IL-21 may influence the production of both human IgE and IgG4, and thus contribute to the regulation of atopic reactions...
  5. ncbi IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    Marion T Kasaian
    Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    Immunity 16:559-69. 2002
    ..These observations suggest that IL-21 promotes the transition between innate and adaptive immunity...
  6. ncbi Efficacy of IL-13 neutralization in a sheep model of experimental asthma
    Marion T Kasaian
    Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Am J Respir Cell Mol Biol 36:368-76. 2007
    ..These findings suggest that IL-13 contributes to allergen-induced airway responses in this sheep model of asthma, and that neutralization of IL-13 is an effective strategy for blocking these A. suum-induced effects...
  7. ncbi Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?
    Richard Leigh
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Am J Respir Crit Care Med 170:851-6. 2004
    ....
  8. ncbi IL-13 regulates the immune response to inhaled antigens
    Jocelyn Padilla
    James P Mara Center for Lung Diseases, St Luke s Roosevelt Hospital and Department of Pathology, Columbia University, New York, NY 10019, USA
    J Immunol 174:8097-105. 2005
    ..These data indicate that blockade of IL-13 may have therapeutic potential for controlling the immune response to inhaled Ags...
  9. ncbi Effects of IL-13 on airway responses in the guinea pig
    Brian Morse
    Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L44-9. 2002
    ....
  10. pmc Antagonizing deactivating cytokines to enhance host defense and chemotherapy in experimental visceral leishmaniasis
    Henry W Murray
    Department of Medicine, Weill Medical College of Cornell University, Box 136, 1300 York Ave, New York, New York 10021, USA
    Infect Immun 73:3903-11. 2005
    ..donovani infection...
  11. ncbi Intraepithelial NK cell-derived IL-13 induces intestinal pathology associated with nematode infection
    Jacqueline R McDermott
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 175:3207-13. 2005
    ..These data provide the first evidence that intestinal tissue restructuring during helminth infection is an innate event dependent on IL-13 production by NK cells resident in the epithelium of the intestine...
  12. ncbi Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:6398-406. 2004
    ..These results show that FcepsilonRI is important for the development of AHR after an aerosolized allergen sensitization protocol and that this effect is mediated through FcepsilonRI on mast cells and production of IL-13 in the lung...
  13. pmc IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis
    Margaret M Mentink-Kane
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:586-90. 2004
    ..Here, we show that the IL-13 receptor alpha 2 (IL-13R alpha 2) is a critical mediator of immune down-modulation, identifying the receptor as a life-sustaining off signal for chronic and pernicious inflammation in schistosomiasis...
  14. ncbi The role of IL-13 in established allergic airway disease
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:6482-9. 2002
    ....
  15. pmc Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
    Monica G Chiaramonte
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:687-701. 2003
    ..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response...
  16. ncbi Natural immunosurveillance against spontaneous, autochthonous breast cancers revealed and enhanced by blockade of IL-13-mediated negative regulation
    Jong Myun Park
    Vaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10 Room 6B 12, 9000 Rockville Pk, Bethesda, MD 20892 1578, USA
    Cancer Immunol Immunother 57:907-12. 2008
    ..However, it was unknown whether natural immunosurveillance inhibits growth of completely spontaneous autochthonous tumors, and whether it can be improved by inhibition of negative regulation...
  17. ncbi Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity
    Dianne C Webb
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Eur J Immunol 33:3377-85. 2003
    ..Collectively, these results demonstrate that IL-13-dependent processes regulating the development of AHR and T helper bias persist in the in the lungs of allergic IL-4Ralpha(-/-) mice...
  18. pmc Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence
    Masaki Terabe
    Molecular Immunogenetics and Vaccine Research Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1741-52. 2003
    ....
  19. ncbi Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen
    Jung Won Park
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:1078-87. 2003
    ..The combination of allergen exposure and RSV infection is known to increase AHR and lung inflammation, but whether IL-13 regulates this increase is similarly not known...
  20. ncbi Unmasking immunosurveillance against a syngeneic colon cancer by elimination of CD4+ NKT regulatory cells and IL-13
    Jong Myun Park
    Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 114:80-7. 2005
    ..Thus, even for a nonregressor tumor, immunosurveillance exists but is negatively regulated via CD4+ NKT cells possibly mediated by IL-13, and can be unmasked by removal of these negative regulatory components...
  21. pmc A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40L
    Jeffrey D Ahlers
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:13020-5. 2002
    ..These results argue for a push-pull approach to maximize vaccine efficacy, especially for HIV and cancer...
  22. ncbi Roles of interleukin-13 and interferon-gamma in lung inflammation
    Gabriele Grunig
    Department of Pathology, Columbia University, New York, NY, USA
    Chest 121:88S. 2002
  23. pmc Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation
    Frank Blaeser
    Deparment of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 198:1189-200. 2003
    ..These results define an important role for the I4R motif in regulating allergic inflammation...