Mark Day

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Ovariectomy-induced disruption of long-term synaptic depression in the hippocampal CA1 region in vivo is attenuated with chronic estrogen replacement
    Mark Day
    School of Psychology, Cardiff University, Park Place, Cardiff CF10 3YG, UK
    Neurobiol Learn Mem 83:13-21. 2005
  2. ncbi Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning
    Mark Day
    Wyeth Research, Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA
    Behav Brain Res 164:128-31. 2005
  3. ncbi Post-training N-methyl-D-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze
    M Day
    Laboratory for Cognitive Neuroscience, Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Neuroscience 137:19-28. 2006
  4. doi Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
    Feng Liu
    Wyeth Research, Discovery Neuroscience, 865 Ridge Road, Monmouth Junction, New Jersey 08852, USA
    Nat Neurosci 11:334-43. 2008
  5. doi The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists
    Wayne E Childers
    Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543 8000, USA
    J Med Chem 53:4066-84. 2010
  6. doi WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent
    Zoe A Hughes
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 54:1136-42. 2008
  7. doi ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey, USA
    J Pharmacol Exp Ther 327:827-39. 2008
  8. ncbi Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke
    Giora Z Feuerstein
    Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cereb Blood Flow Metab 28:217-9. 2008
  9. doi Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405)
    Warren D Hirst
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 325:134-45. 2008
  10. ncbi Glutamate-receptor-mediated encoding and retrieval of paired-associate learning
    M Day
    Laboratory for Cognitive Neuroscience, Division and Centre for Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    Nature 424:205-9. 2003

Detail Information

Publications16

  1. ncbi Ovariectomy-induced disruption of long-term synaptic depression in the hippocampal CA1 region in vivo is attenuated with chronic estrogen replacement
    Mark Day
    School of Psychology, Cardiff University, Park Place, Cardiff CF10 3YG, UK
    Neurobiol Learn Mem 83:13-21. 2005
    ....
  2. ncbi Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning
    Mark Day
    Wyeth Research, Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA
    Behav Brain Res 164:128-31. 2005
    ..This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse...
  3. ncbi Post-training N-methyl-D-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze
    M Day
    Laboratory for Cognitive Neuroscience, Centre for Neuroscience Research, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Neuroscience 137:19-28. 2006
    ..Those data suggest that specific post-training N-methyl-D-aspartate receptor blockade does not impair memory consolidation and it may also offer a memory trace mild protection from retrograde interference...
  4. doi Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
    Feng Liu
    Wyeth Research, Discovery Neuroscience, 865 Ridge Road, Monmouth Junction, New Jersey 08852, USA
    Nat Neurosci 11:334-43. 2008
    ..Our data suggest that activation of ERbeta can regulate hippocampal synaptic plasticity and improve hippocampus-dependent cognition...
  5. doi The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists
    Wayne E Childers
    Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543 8000, USA
    J Med Chem 53:4066-84. 2010
    ....
  6. doi WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent
    Zoe A Hughes
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 54:1136-42. 2008
    ....
  7. doi ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey, USA
    J Pharmacol Exp Ther 327:827-39. 2008
    ..p.) in rats. Taken together, these effects are consistent with the hypothesis that allosteric potentiation of mGlu5 may provide a novel approach for development of antipsychotic and procognitive agents...
  8. ncbi Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke
    Giora Z Feuerstein
    Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cereb Blood Flow Metab 28:217-9. 2008
    ..Finally, rational patient selection and new outcome scales tailored in an adaptive design model must be evaluated...
  9. doi Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405)
    Warren D Hirst
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 325:134-45. 2008
    ..These results further support the rationale for use of this compound class in the treatment of cognitive dysfunction associated with psychiatric and neurological conditions...
  10. ncbi Glutamate-receptor-mediated encoding and retrieval of paired-associate learning
    M Day
    Laboratory for Cognitive Neuroscience, Division and Centre for Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK
    Nature 424:205-9. 2003
    ..Thus we conclude that unique what-where paired associates depend on encoding and retrieval within a hippocampal memory space, with consolidation of the memory traces representing repeated paired associates in circuits elsewhere...
  11. ncbi Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test
    Rachel Navarra
    Discovery Neuroscience, Wyeth Research, 500 Arcola Road, PA 19426 USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:34-41. 2008
    ..Those data suggest that the 5CSRT test can be used to differentiate stimulant and non-stimulant pharmacotherapies on measures of impulsivity...
  12. ncbi Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test
    Mark Day
    Discovery Translational Medicine, Wyeth Research, 500 Arcola Road, PA 19426, USA
    Biochem Pharmacol 73:1123-34. 2007
    ..We also expanded on previous positive findings by others with ciproxifan on attention and both Wyeth and Abbott demonstrate for the first time decreased impulsivity with this mechanism...
  13. doi Translational medicine--a paradigm shift in modern drug discovery and development: the role of biomarkers
    Mark Day
    Wyeth Research, 500 Arcola Road, COL S2307, Collegeville, Pennsylvania 19426, USA
    Adv Exp Med Biol 655:1-12. 2009
    ..Successful deployment of biomarkers research, validation and implementation is adopted and embraced as key strategy to improved the drug discovery and development towards new medical entities...
  14. doi The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test
    Rachel Navarra
    Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA
    Behav Brain Res 188:412-5. 2008
    ..WAY-163909 treatment selectively and dose-dependently decreased impulsivity suggesting that agonism of the 5-HT(2C) receptor may be useful for modulating impulsivity in disease states where impulsivity is a pathological feature...
  15. doi Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous system
    Abby A Li
    Exponent Health Sciences, San Francisco, CA 94114, USA
    Neurotoxicology 29:504-19. 2008
    ..Understanding of the hormonal mechanisms of these behaviors, and of relevance to humans, is needed to develop biologically plausible hypotheses regarding the potential effects of hormonally active chemicals in humans...
  16. ncbi Cognitive endpoints as disease biomarkers: optimizing the congruency of preclinical models to the clinic
    Mark Day
    PsychoGenics Inc, Cognitive Neurosciences, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Curr Opin Investig Drugs 9:696-706. 2008
    ....