Kevin J Curran

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. doi Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent
    Kevin J Curran
    Chemical Sciences, Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 20:1440-4. 2010
  2. ncbi Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV
    Jonathan D Bloom
    Chemical and Screening Sciences and Infectious Disease Research, Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:3401-6. 2004
  3. ncbi Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus
    Martin J Di Grandi
    Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:4157-60. 2004
  4. doi Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase
    Pawel Nowak
    Chemical Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 52:7081-9. 2009
  5. ncbi Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site
    Ariamala Gopalsamy
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 49:3052-5. 2006
  6. ncbi Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV
    Jonathan D Bloom
    Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2929-32. 2003

Collaborators

Detail Information

Publications6

  1. doi Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent
    Kevin J Curran
    Chemical Sciences, Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 20:1440-4. 2010
    ....
  2. ncbi Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV
    Jonathan D Bloom
    Chemical and Screening Sciences and Infectious Disease Research, Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:3401-6. 2004
    ..A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM...
  3. ncbi Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus
    Martin J Di Grandi
    Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 14:4157-60. 2004
    ..Several analogs demonstrated IC50s<0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus...
  4. doi Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase
    Pawel Nowak
    Chemical Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 52:7081-9. 2009
    ..These pyrazolopyrimidines represent an exciting new series of mTOR-selective inhibitors with potential for development for cancer therapy...
  5. ncbi Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site
    Ariamala Gopalsamy
    Chemical and Screening Sciences, Wyeth Research, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 49:3052-5. 2006
    ..The crystal structure of 6 and NS5b polymerase complex confirmed the binding near the active site region. The optimization approach and SAR are discussed in detail...
  6. ncbi Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV
    Jonathan D Bloom
    Wyeth Research, Pearl River, NY 10965, USA
    Bioorg Med Chem Lett 13:2929-32. 2003
    ..Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate...