Priya S Chockalingam

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes
    Priya S Chockalingam
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Arthritis Rheum 56:4074-83. 2007
  2. ncbi Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1
    Manas K Majumdar
    Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts, USA
    J Cell Physiol 215:68-76. 2008
  3. ncbi Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
    Edward R LaVallie
    Departments of Biological Technologies and Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts 02140 2325, USA
    J Biol Chem 281:24124-37. 2006
  4. ncbi Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype
    Manas K Majumdar
    Wyeth Research, Department of Women s Health and Musculoskeletal Biology, Cambridge, Massachusetts 02140, USA
    J Cell Physiol 209:551-9. 2006
  5. ncbi Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
    Priya S Chockalingam
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 50:2839-48. 2004
  6. pmc Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage
    Lisha Patel
    Tissue Repair, BioTherapeutics Research and Development, Pfizer, Cambridge, MA, USA
    BMC Musculoskelet Disord 12:164. 2011
  7. ncbi Synthesis and SAR of highly selective MMP-13 inhibitors
    Jianchang Li
    Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 15:4961-6. 2005
  8. ncbi Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites
    Carl R Flannery
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 277:42775-80. 2002
  9. ncbi 3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding
    Wei Li
    Department of Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 19:4546-50. 2009
  10. pmc Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp
    Emily L Whitson
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 71:1213-7. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes
    Priya S Chockalingam
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Arthritis Rheum 56:4074-83. 2007
    ....
  2. ncbi Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1
    Manas K Majumdar
    Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts, USA
    J Cell Physiol 215:68-76. 2008
    ..In summary, MM-Sv/HP and MM-Sv/HP-2 show preservation of important characteristics of articular chondrocytes as examined under multiple culture conditions and would provide a useful reagent in the study of chondrocyte biology...
  3. ncbi Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
    Edward R LaVallie
    Departments of Biological Technologies and Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts 02140 2325, USA
    J Biol Chem 281:24124-37. 2006
    ..These data implicate PKCzeta as a necessary component of the IL-1 and TNF signaling pathways in chondrocytes that result in catabolic destruction of extracellular matrix proteins in osteoarthritic cartilage...
  4. ncbi Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype
    Manas K Majumdar
    Wyeth Research, Department of Women s Health and Musculoskeletal Biology, Cambridge, Massachusetts 02140, USA
    J Cell Physiol 209:551-9. 2006
    ....
  5. ncbi Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
    Priya S Chockalingam
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 50:2839-48. 2004
    ....
  6. pmc Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage
    Lisha Patel
    Tissue Repair, BioTherapeutics Research and Development, Pfizer, Cambridge, MA, USA
    BMC Musculoskelet Disord 12:164. 2011
    ..The effect of TN-C on proteoglycan loss from articular cartilage in culture was also assessed...
  7. ncbi Synthesis and SAR of highly selective MMP-13 inhibitors
    Jianchang Li
    Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 15:4961-6. 2005
    ..The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described...
  8. ncbi Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites
    Carl R Flannery
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 277:42775-80. 2002
    ....
  9. ncbi 3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding
    Wei Li
    Department of Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 19:4546-50. 2009
    ..By replacing a backbone benzene with a pyridine and valine with threonine, compounds (e.g., 44) with greatly reduced plasma protein binding were also obtained...
  10. pmc Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp
    Emily L Whitson
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 71:1213-7. 2008
    ..Compounds 1-4 inhibited PKCzeta with IC50 values of 1.59, 0.53, 0.11, and 1.21 microM, respectively. In a cell-based assay, 1-4 also inhibited NF-kappaB activation with EC50 values of 12-64 microM...