Priya S Chockalingam

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes
    Priya S Chockalingam
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Arthritis Rheum 56:4074-83. 2007
  2. ncbi request reprint Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1
    Manas K Majumdar
    Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts, USA
    J Cell Physiol 215:68-76. 2008
  3. ncbi request reprint Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
    Edward R LaVallie
    Departments of Biological Technologies and Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts 02140 2325, USA
    J Biol Chem 281:24124-37. 2006
  4. ncbi request reprint Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype
    Manas K Majumdar
    Wyeth Research, Department of Women s Health and Musculoskeletal Biology, Cambridge, Massachusetts 02140, USA
    J Cell Physiol 209:551-9. 2006
  5. ncbi request reprint Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
    Priya S Chockalingam
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 50:2839-48. 2004
  6. pmc Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage
    Lisha Patel
    Tissue Repair, BioTherapeutics Research and Development, Pfizer, Cambridge, MA, USA
    BMC Musculoskelet Disord 12:164. 2011
  7. ncbi request reprint Synthesis and SAR of highly selective MMP-13 inhibitors
    Jianchang Li
    Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 15:4961-6. 2005
  8. ncbi request reprint Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites
    Carl R Flannery
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 277:42775-80. 2002
  9. doi request reprint 3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding
    Wei Li
    Department of Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 19:4546-50. 2009
  10. pmc Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp
    Emily L Whitson
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 71:1213-7. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes
    Priya S Chockalingam
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Arthritis Rheum 56:4074-83. 2007
    ....
  2. ncbi request reprint Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1
    Manas K Majumdar
    Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts, USA
    J Cell Physiol 215:68-76. 2008
    ..In summary, MM-Sv/HP and MM-Sv/HP-2 show preservation of important characteristics of articular chondrocytes as examined under multiple culture conditions and would provide a useful reagent in the study of chondrocyte biology...
  3. ncbi request reprint Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
    Edward R LaVallie
    Departments of Biological Technologies and Women s Health and Musculoskeletal Biology, Wyeth Research, Cambridge, Massachusetts 02140 2325, USA
    J Biol Chem 281:24124-37. 2006
    ..These data implicate PKCzeta as a necessary component of the IL-1 and TNF signaling pathways in chondrocytes that result in catabolic destruction of extracellular matrix proteins in osteoarthritic cartilage...
  4. ncbi request reprint Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype
    Manas K Majumdar
    Wyeth Research, Department of Women s Health and Musculoskeletal Biology, Cambridge, Massachusetts 02140, USA
    J Cell Physiol 209:551-9. 2006
    ....
  5. ncbi request reprint Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
    Priya S Chockalingam
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 50:2839-48. 2004
    ....
  6. pmc Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage
    Lisha Patel
    Tissue Repair, BioTherapeutics Research and Development, Pfizer, Cambridge, MA, USA
    BMC Musculoskelet Disord 12:164. 2011
    ..The effect of TN-C on proteoglycan loss from articular cartilage in culture was also assessed...
  7. ncbi request reprint Synthesis and SAR of highly selective MMP-13 inhibitors
    Jianchang Li
    Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 15:4961-6. 2005
    ..The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described...
  8. ncbi request reprint Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites
    Carl R Flannery
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 277:42775-80. 2002
    ....
  9. doi request reprint 3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding
    Wei Li
    Department of Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem Lett 19:4546-50. 2009
    ..By replacing a backbone benzene with a pyridine and valine with threonine, compounds (e.g., 44) with greatly reduced plasma protein binding were also obtained...
  10. pmc Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp
    Emily L Whitson
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 71:1213-7. 2008
    ..Compounds 1-4 inhibited PKCzeta with IC50 values of 1.59, 0.53, 0.11, and 1.21 microM, respectively. In a cell-based assay, 1-4 also inhibited NF-kappaB activation with EC50 values of 12-64 microM...