Seongeun Cho

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Temporal assessment of caspase activation in experimental models of focal and global ischemia
    Seongeun Cho
    Neuroscience Division, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 982:146-55. 2003
  2. ncbi Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures
    Seongeun Cho
    Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Neurochem Int 45:117-27. 2004
  3. ncbi Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival
    Seongeun Cho
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Exp Neurol 203:274-8. 2007
  4. ncbi Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury
    Michael Finley
    Neuroscience Division, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1001:125-32. 2004
  5. ncbi Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities
    Ming D Qian
    Antibody Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Neurosci 26:9394-403. 2006
  6. pmc Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay
    Peter H Reinhart
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
    Neurobiol Dis 43:248-56. 2011
  7. ncbi Cyclic-AMP response element-based signaling assays for characterization of Trk family tyrosine kinases modulators
    Jie Zhang
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543 8000, USA
    Neurosignals 15:26-39. 2006

Collaborators

  • Jie Zhang
  • Ping Li
  • Linda S Kaltenbach
  • Andrew Wood
  • Peter H Reinhart
  • Ming D Qian
  • Michael Finley
  • Donald C Lo
  • C Todd DeMarco
  • Gregory J Turmel
  • Denise E Dunn
  • Joshua A Eudailey
  • Christian Essrich
  • Jennifer C Whaley
  • Davinder Gill
  • Xiang Yang Tan
  • Danni Liu
  • Denise Fairman

Detail Information

Publications7

  1. ncbi Temporal assessment of caspase activation in experimental models of focal and global ischemia
    Seongeun Cho
    Neuroscience Division, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 982:146-55. 2003
    ..Caspase-3 activation may be responsible for the loss of these cells, thereby hindering the endogenous recovery process...
  2. ncbi Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures
    Seongeun Cho
    Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Neurochem Int 45:117-27. 2004
    ..Inhibition of a Ca(2+)-dependent cysteine protease, calpain, by MDL28170 also elicited partial neuroprotective effects...
  3. ncbi Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival
    Seongeun Cho
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Exp Neurol 203:274-8. 2007
    ..These and previous data collectively suggest that the 5-HT4 receptor may be an effective therapeutic target for AD, providing both symptomatic improvements and neuroprotection...
  4. ncbi Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury
    Michael Finley
    Neuroscience Division, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1001:125-32. 2004
    ....
  5. ncbi Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities
    Ming D Qian
    Antibody Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Neurosci 26:9394-403. 2006
    ..Therefore, they could represent novel reagents to explore the pathophysiological roles of TrkB and its potential therapeutic utility in treating CNS disorders...
  6. pmc Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay
    Peter H Reinhart
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
    Neurobiol Dis 43:248-56. 2011
    ..The nature of these targets provide further support for non-cell autonomous mechanisms mediating significant aspects of neuropathogenesis induced by mutant HTT fragment proteins...
  7. ncbi Cyclic-AMP response element-based signaling assays for characterization of Trk family tyrosine kinases modulators
    Jie Zhang
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543 8000, USA
    Neurosignals 15:26-39. 2006
    ....