Wayne E Childers

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan
    Wayne E Childers
    Chemical and Screening Sciences and Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Med Chem 48:3467-70. 2005
  2. ncbi N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief
    Wayne E Childers
    Department of Chemical and Screening Sciences, Wyeth Research, Inc, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Med Chem 50:2557-62. 2007
  3. doi The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists
    Wayne E Childers
    Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543 8000, USA
    J Med Chem 53:4066-84. 2010
  4. doi Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405)
    Warren D Hirst
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 325:134-45. 2008
  5. doi Prodrugs of perzinfotel with improved oral bioavailability
    Reinhardt B Baudy
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 52:771-8. 2009
  6. doi 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3
    Lisa M Havran
    Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem 17:7755-68. 2009
  7. ncbi Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue
    Zhi Hao Zhang
    Department of Women s Health and Bone, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Biol Chem 279:29226-30. 2004

Collaborators

Detail Information

Publications7

  1. ncbi Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan
    Wayne E Childers
    Chemical and Screening Sciences and Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Med Chem 48:3467-70. 2005
    ..Compound 11c (Lecozotan) was selected for further development and is currently in clinical trials...
  2. ncbi N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief
    Wayne E Childers
    Department of Chemical and Screening Sciences, Wyeth Research, Inc, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Med Chem 50:2557-62. 2007
  3. doi The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists
    Wayne E Childers
    Chemical Sciences, Pfizer Global Research and Development, Princeton, New Jersey 08543 8000, USA
    J Med Chem 53:4066-84. 2010
    ....
  4. doi Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405)
    Warren D Hirst
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 325:134-45. 2008
    ..These results further support the rationale for use of this compound class in the treatment of cognitive dysfunction associated with psychiatric and neurological conditions...
  5. doi Prodrugs of perzinfotel with improved oral bioavailability
    Reinhardt B Baudy
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 52:771-8. 2009
    ..Taken together, these results demonstrate that an oxymethylene-spaced prodrug approach increased the bioavailability of 1...
  6. doi 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3
    Lisa M Havran
    Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Bioorg Med Chem 17:7755-68. 2009
    ..The synthesis, biological evaluation and structure-activity relationships of the pyrimidoindolones are described...
  7. ncbi Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue
    Zhi Hao Zhang
    Department of Women s Health and Bone, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Biol Chem 279:29226-30. 2004
    ....