Padma L Channavajhala

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling
    Padma L Channavajhala
    Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Biol Chem 278:47089-97. 2003
  2. doi request reprint Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway
    Lin Liu
    Department of Biological Technologies, Wyeth, Cambridge, MA 02140, USA
    Biochim Biophys Acta 1794:1485-95. 2009
  3. ncbi request reprint Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity
    Brenda S Luciano
    Department of Molecular Inflammation, Inflammation Signaling, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 279:52117-23. 2004
  4. ncbi request reprint hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation
    Padma L Channavajhala
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 334:1214-8. 2005

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling
    Padma L Channavajhala
    Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Biol Chem 278:47089-97. 2003
    ..Taken together, these results indicate that hKSR-2, a new member of the KSR family, negatively regulates Cot-mediated MAP kinase and NF-kappaB pathway signaling...
  2. doi request reprint Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway
    Lin Liu
    Department of Biological Technologies, Wyeth, Cambridge, MA 02140, USA
    Biochim Biophys Acta 1794:1485-95. 2009
    ..While interactions with these molecules are not known for KSR-1, it's reasonable to hypothesize that KSR-1 may also play a similar role in mediating these downstream signaling pathways...
  3. ncbi request reprint Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity
    Brenda S Luciano
    Department of Molecular Inflammation, Inflammation Signaling, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 279:52117-23. 2004
    ..Together these results showed that phosphorylation of Cot at Thr-290 is necessary but not sufficient for full kinase activity in the MEK/ERK pathway...
  4. ncbi request reprint hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation
    Padma L Channavajhala
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 334:1214-8. 2005
    ..We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective...