Laura L Carter

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
    Laura L Carter
    Wyeth Research, Cambridge, MA 02140, USA
    Immunol Res 28:49-59. 2003
  2. ncbi request reprint PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis
    Laura L Carter
    Inflammation, Wyeth Research, 200 CambridgePark Dr, Cambridge, MA 02140, United States
    J Neuroimmunol 182:124-34. 2007
  3. ncbi request reprint Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis
    Patricia W Bedard
    Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Pharmacol Exp Ther 324:497-506. 2008
  4. ncbi request reprint PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    Kelly Ann Sheppard
    Inflammation Department, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    FEBS Lett 574:37-41. 2004
  5. ncbi request reprint Therapeutic opportunities in the B7/CD28 family of ligands and receptors
    Beatriz M Carreno
    Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:424-30. 2005
  6. ncbi request reprint IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    Marion T Kasaian
    Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    Immunity 16:559-69. 2002

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
    Laura L Carter
    Wyeth Research, Cambridge, MA 02140, USA
    Immunol Res 28:49-59. 2003
    ..The PD-L/PD-1 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery...
  2. ncbi request reprint PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis
    Laura L Carter
    Inflammation, Wyeth Research, 200 CambridgePark Dr, Cambridge, MA 02140, United States
    J Neuroimmunol 182:124-34. 2007
    ..These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE...
  3. ncbi request reprint Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis
    Patricia W Bedard
    Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Pharmacol Exp Ther 324:497-506. 2008
    ....
  4. ncbi request reprint PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    Kelly Ann Sheppard
    Inflammation Department, Wyeth Research, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    FEBS Lett 574:37-41. 2004
    ....
  5. ncbi request reprint Therapeutic opportunities in the B7/CD28 family of ligands and receptors
    Beatriz M Carreno
    Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:424-30. 2005
    ..Indeed, recent Phase I clinical studies using agonists and antagonists of the CD28/CTLA-4/B7 pathway have shown promise in inflammatory diseases and cancer...
  6. ncbi request reprint IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    Marion T Kasaian
    Genetics Institute, Wyeth Research, Cambridge, MA 02140, USA
    Immunity 16:559-69. 2002
    ..These observations suggest that IL-21 promotes the transition between innate and adaptive immunity...