Beatriz M Carreno

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi request reprint BTLA: a new inhibitory receptor with a B7-like ligand
    Beatriz M Carreno
    Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Trends Immunol 24:524-7. 2003
  2. ncbi request reprint Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
    Laura L Carter
    Wyeth Research, Cambridge, MA 02140, USA
    Immunol Res 28:49-59. 2003
  3. ncbi request reprint PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis
    Laura L Carter
    Inflammation, Wyeth Research, 200 CambridgePark Dr, Cambridge, MA 02140, United States
    J Neuroimmunol 182:124-34. 2007
  4. ncbi request reprint The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses
    Beatriz M Carreno
    Genetics Institute Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Annu Rev Immunol 20:29-53. 2002
  5. ncbi request reprint The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 181:2799-805. 2008
  6. pmc The B7 family of immune-regulatory ligands
    Mary Collins
    Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Genome Biol 6:223. 2005
  7. ncbi request reprint Therapeutic opportunities in the B7/CD28 family of ligands and receptors
    Beatriz M Carreno
    Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:424-30. 2005
  8. ncbi request reprint Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:13447-55. 2007
  9. ncbi request reprint PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
    LauraL Carter
    Wyeth Genetics Institute, Cambridge, MA 02140, USA
    Eur J Immunol 32:634-43. 2002
  10. ncbi request reprint Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss
    Vincent Ling
    Wyeth Research, 200 Cambridge Park Drive, 02140, Cambridge, MA, USA
    Genomics 82:365-77. 2003

Collaborators

Detail Information

Publications19

  1. ncbi request reprint BTLA: a new inhibitory receptor with a B7-like ligand
    Beatriz M Carreno
    Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Trends Immunol 24:524-7. 2003
    ..Thus, cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1) and BTLA comprise an expanding set of inhibitory receptors expressed on lymphocytes...
  2. ncbi request reprint Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
    Laura L Carter
    Wyeth Research, Cambridge, MA 02140, USA
    Immunol Res 28:49-59. 2003
    ..The PD-L/PD-1 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery...
  3. ncbi request reprint PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis
    Laura L Carter
    Inflammation, Wyeth Research, 200 CambridgePark Dr, Cambridge, MA 02140, United States
    J Neuroimmunol 182:124-34. 2007
    ..These results demonstrate that interactions between PD-1/PD-L1, but not PD-1/PDL-2, are crucial in attenuating T cell responses in EAE...
  4. ncbi request reprint The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses
    Beatriz M Carreno
    Genetics Institute Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Annu Rev Immunol 20:29-53. 2002
    ..Understanding these pathways will allow development of new strategies for therapeutic intervention in immune-mediated diseases...
  5. ncbi request reprint The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 181:2799-805. 2008
    ..However, the distinct affinities of the receptor components for IL-17A, IL-17F, and IL-17F/IL-17A heterodimer can be exploited to differentially affect the activity of these cytokines...
  6. pmc The B7 family of immune-regulatory ligands
    Mary Collins
    Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Genome Biol 6:223. 2005
    ..Manipulation of the signals delivered by B7 ligands has shown potential in the treatment of autoimmunity, inflammatory diseases and cancer...
  7. ncbi request reprint Therapeutic opportunities in the B7/CD28 family of ligands and receptors
    Beatriz M Carreno
    Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Pharmacol 5:424-30. 2005
    ..Indeed, recent Phase I clinical studies using agonists and antagonists of the CD28/CTLA-4/B7 pathway have shown promise in inflammatory diseases and cancer...
  8. ncbi request reprint Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
    Jill F Wright
    Department of Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 282:13447-55. 2007
    ..These data suggest that the IL-17F/IL-17A heterodimer may contribute to the T cell-mediated immune responses...
  9. ncbi request reprint PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
    LauraL Carter
    Wyeth Genetics Institute, Cambridge, MA 02140, USA
    Eur J Immunol 32:634-43. 2002
    ..However, CD8(+) T cells may be more sensitive to modulation by the PD-1:PD-L pathway because of their intrinsic inability to produce significant levels of IL-2...
  10. ncbi request reprint Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss
    Vincent Ling
    Wyeth Research, 200 Cambridge Park Drive, 02140, Cambridge, MA, USA
    Genomics 82:365-77. 2003
    ..These results suggest independent, but convergent, paths of B7-H3 active domain duplication followed by divergent histories of exon degeneration in rodents and exon maintenance by humans...
  11. pmc Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation
    Peter J Darlington
    The Biotherapeutics and Transplantation and Immunobiology Groups, The John P Robarts Research Institute, and The Departments of Microbiology and Immunology, and Medicine, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Exp Med 195:1337-47. 2002
    ..These data demonstrate that CTLA-4 within lipid rafts migrates to the IS where it can potentially form lattice structures and inhibit T cell activation...
  12. ncbi request reprint Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A
    Miren L Baroja
    Transplantation and Immunobiology Group, John P Robarts Research Institute, University of Western Ontario, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    J Immunol 168:5070-8. 2002
    ..Our data imply that the lysine-rich motif in CTLA-4 may be used to identify small molecules that block its binding to PP2A and act as agonists for CTLA-4 function...
  13. pmc Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis
    Florencia McAllister
    Lung Immunology and Host Defense Laboratory, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 175:404-12. 2005
    ..aeruginosa. IL-23 and the downstream cytokines IL-17A and IL-17F are critical molecules for proinflammatory gene expression in HBE cells and are likely involved in the proinflammatory cytokine network involved with CF pathogenesis...
  14. ncbi request reprint Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
    Frann Bennett
    Cambridge Antibody Technology, Abington, United Kingdom
    J Immunol 170:711-8. 2003
    ....
  15. ncbi request reprint TCR subunit specificity of CTLA-4-mediated signaling
    Eric Siu
    The FOCIS Centre for Clinical Immunology and Immunotherapeutics, Robarts Research Institute, London, Ontario, Canada N6A 5K8
    J Leukoc Biol 74:1102-7. 2003
    ..Our results suggest that the target specificity of CTLA-4 is determined by its coligation with any given transmembrane receptor rather than by its intracellular mediators...
  16. ncbi request reprint Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand
    Joaquin Madrenas
    Federation of Clinical Immunology Societies Centre for Clinical Immunology and Immunotherapeutics, Robarts Research Institute, and Department of Microbiology, University of Western Ontario, London, Ontario, Canada
    J Immunol 172:5948-56. 2004
    ..Our data demonstrate that the cytoplasmic domain of CTLA-4 has an inherent plasticity for signaling that can be exploited therapeutically with recombinant ligands for this receptor...
  17. ncbi request reprint Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    Bruce R Blazar
    University of Minnesota Cancer Center and Department of Pediatrics, Minneapolis, MN 55455, USA
    J Immunol 171:1272-7. 2003
    ..These data indicate that PD-1 ligation down-regulates GVHD through modulation of IFN-gamma production and suggest a novel therapeutic target for inhibiting GVHD lethality...
  18. ncbi request reprint Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    Geoffrey L Stephens
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:5008-20. 2004
    ..The down-regulation of GITR-L by inflammatory stimuli may enhance the susceptibility of effector T cells to suppressor activity during the course of an infectious insult...
  19. pmc Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides
    Steven M Truscott
    Department of Pathology and Immunology, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:7480-90. 2008
    ..The mechanistic and practical applications of these findings for vaccine development and T cell isolation/enumeration are discussed...