P A Bradford

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Characterization of expanded-spectrum cephalosporin resistance in E. coli isolates associated with bovine calf diarrhoeal disease
    P A Bradford
    Wyeth Ayerst Research, 401 N Middletown Rd, Pearl River, NY 10965 USA
    J Antimicrob Chemother 44:607-10. 1999
  2. ncbi Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Clin Microbiol Rev 14:933-51, table of contents. 2001
  3. ncbi Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 41:563-9. 1997
  4. ncbi Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes
    P A Bradford
    Infectious Disease Discovery Research, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 43:2960-3. 1999
  5. ncbi CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1980-4. 1998
  6. ncbi Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1671-6. 1998
  7. ncbi SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients
    P A Bradford
    Lederle Laboratories, Pearl River, New York, USA
    Antimicrob Agents Chemother 39:899-905. 1995
  8. ncbi TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases
    P A Bradford
    Wyeth Ayerst Research, Lederle Laboratories, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 40:260-2. 1996
  9. ncbi Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: antibacterial and mechanistic activities
    M P Singh
    Natural Products Microbiology Antibacterial Research, Infectious Disease Section, Wyeth Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 47:62-9. 2003
  10. ncbi Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis
    P M Dunman
    Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA
    J Clin Microbiol 42:4275-83. 2004

Collaborators

Detail Information

Publications13

  1. ncbi Characterization of expanded-spectrum cephalosporin resistance in E. coli isolates associated with bovine calf diarrhoeal disease
    P A Bradford
    Wyeth Ayerst Research, 401 N Middletown Rd, Pearl River, NY 10965 USA
    J Antimicrob Chemother 44:607-10. 1999
    ..These results suggest that the use of antibiotics in animals could lead to a reservoir of antibiotic-resistant bacteria that could potentially infect humans...
  2. ncbi Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Clin Microbiol Rev 14:933-51, table of contents. 2001
    ..They have also been found in other Enterobacteriaceae strains and Pseudomonas aeruginosa. Strains expressing these beta-lactamases will present a host of therapeutic challenges as we head into the 21st century...
  3. ncbi Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 41:563-9. 1997
    ..pneumoniae when a high level of the ACT-1 beta-lactamase is produced in combination with the loss of a major outer membrane protein...
  4. ncbi Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes
    P A Bradford
    Infectious Disease Discovery Research, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 43:2960-3. 1999
    ..The automated thermal cycling method was clearly superior and consistently resulted in the correct sequences for these genes...
  5. ncbi CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1980-4. 1998
    ..These results indicated the presence of a novel extended-spectrum beta-lactamase, designated CTX-M-5, that specifically confers resistance to cefotaxime...
  6. ncbi Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1671-6. 1998
    ..Sulbactam was less effective than the other inhibitors. The Thr182 mutation previously reported in an inhibitor-resistant beta-lactamase did not cause the TEM-43 enzyme to become resistant to any of the inhibitors...
  7. ncbi SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients
    P A Bradford
    Lederle Laboratories, Pearl River, New York, USA
    Antimicrob Agents Chemother 39:899-905. 1995
    ..This novel SHV-type extended-spectrum beta-lactamase is designated SHV-7...
  8. ncbi TEM-28 from an Escherichia coli clinical isolate is a member of the His-164 family of TEM-1 extended-spectrum beta-lactamases
    P A Bradford
    Wyeth Ayerst Research, Lederle Laboratories, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 40:260-2. 1996
    ..1, and 5.6, respectively, relative to that for benzylpenicillin (100). The nucleotide sequence of blaTEM-28 differed from that of blaTEM-1 by two base changes, resulting in amino acid substitutions of Arg-164 to His and Glu-240 to Lys...
  9. ncbi Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: antibacterial and mechanistic activities
    M P Singh
    Natural Products Microbiology Antibacterial Research, Infectious Disease Section, Wyeth Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 47:62-9. 2003
    ..coli imp, suggesting a lack of membrane damage to prokaryotic or eukaryotic cells...
  10. ncbi Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis
    P M Dunman
    Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA
    J Clin Microbiol 42:4275-83. 2004
    ..aureus strains and may play a major role in epidemiological studies in the future where correlating genes with particular disease phenotypes is critical...
  11. ncbi In vitro activity of tigecycline and occurrence of tetracycline resistance determinants in isolates from patients enrolled in phase 3 clinical trials for community-acquired pneumonia
    P A Bradford
    Infectious Diseases Discovery Research, Wyeth Research, Pearl River, NY 10965, USA
    Clin Microbiol Infect 14:882-6. 2008
    ..The excellent in vitro activity of tigecycline against these clinical isolates confirmed its potential utility against pathogens associated with community-acquired pneumonia...
  12. ncbi Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002
    S K Bouchillon
    Laboratories International for Microbiology Studies, 2122 Palmer Road, Schaumburg, IL 60173 3817, USA
    Int J Antimicrob Agents 24:119-24. 2004
    ..4% (294/908) and 8.7% (83/949), respectively. PEARLS provides baseline data against which prospective changes in resistant determinants and outcomes can be measured in this ongoing study...
  13. ncbi Penicillin-binding proteins and induction of AmpC beta-lactamase
    C C Sanders
    Center for Research in Anti Infectives and Biotechnology, Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Antimicrob Agents Chemother 41:2013-5. 1997
    ..Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs...