Peter V N Bodine

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. doi Wnt signaling control of bone cell apoptosis
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    Cell Res 18:248-53. 2008
  2. ncbi The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 96:1212-30. 2005
  3. ncbi The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 18:1222-37. 2004
  4. ncbi Wnt signaling and osteoblastogenesis
    Peter V N Bodine
    Women s Heath and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Rev Endocr Metab Disord 7:33-9. 2006
  5. doi A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bone 44:1063-8. 2009
  6. ncbi Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Physiol 210:352-7. 2007
  7. ncbi The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation
    Yan Liu
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 21:376-87. 2007
  8. doi A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V)
    Richard J Murrills
    Department of Osteoporosis and Frailty, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 108:1066-75. 2009
  9. doi Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II
    William J Moore
    Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, United States
    Bioorg Med Chem 18:190-201. 2010
  10. ncbi The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells
    Julia Billiard
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 19:90-101. 2005

Collaborators

Detail Information

Publications34

  1. doi Wnt signaling control of bone cell apoptosis
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    Cell Res 18:248-53. 2008
    ..In addition, preclinical studies with pharmacologic compounds such as those that inhibit glycogen synthase kinase-3beta support the importance of the canonical Wnt pathway in modulation of bone formation and osteoblast apoptosis...
  2. ncbi The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 96:1212-30. 2005
    ..Likewise, over-expression of sFRP-1 in HOBs accelerated the rate of cell death threefold. These results establish sFRP-1 as an important negative regulator of human osteoblast and osteocyte survival...
  3. ncbi The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 18:1222-37. 2004
    ..Our findings demonstrate that deletion of sFRP-1 preferentially activates Wnt signaling in osteoblasts, leading to enhanced trabecular bone formation in adults...
  4. ncbi Wnt signaling and osteoblastogenesis
    Peter V N Bodine
    Women s Heath and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Rev Endocr Metab Disord 7:33-9. 2006
    ....
  5. doi A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bone 44:1063-8. 2009
    ..0001 microM. This work demonstrates the feasibility of developing small molecules that inhibit sFRP-1 and stimulate canonical Wnt signaling to increase bone formation...
  6. ncbi Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Physiol 210:352-7. 2007
    ..Moreover, as the effects of sFRP-1 deletion on vBMD increase, the ability of PTH to enhance vBMD declines suggesting that there are overlapping mechanisms of action...
  7. ncbi The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation
    Yan Liu
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 21:376-87. 2007
    ..Finally, using a mouse calvariae ex vivo organ culture model, we demonstrate that these effects of Ror2 result in increased bone formation, suggesting that it may also activate mature osteoblasts...
  8. doi A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V)
    Richard J Murrills
    Department of Osteoporosis and Frailty, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 108:1066-75. 2009
    ....
  9. doi Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II
    William J Moore
    Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, United States
    Bioorg Med Chem 18:190-201. 2010
    ..Details of the structure-activity relationships and biological activity of this structural class of compounds will be discussed...
  10. ncbi The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells
    Julia Billiard
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 19:90-101. 2005
    ....
  11. doi LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4
    Yao Bin Liu
    Tissue Repair, Pfizer, Inc, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 109:794-800. 2010
    ..Consistent with the ability of LPA4 to inhibit osteoblastic differentiation of stem cells, LPA4-deficient mice have increased trabecular bone volume, number, and thickness...
  12. ncbi Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity
    Barry S Komm
    Wyeth Research, Women s Health Research Institute, Collegeville, Pennsylvania 19426, USA
    Endocrinology 146:3999-4008. 2005
    ..Controlled clinical trial data will be needed to confirm these effects...
  13. ncbi Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function
    Ramesh A Bhat
    Women s Health and Musculoskeletal Biology Division, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 102:1519-28. 2007
    ..The structure-function analysis studies of sFRP-1 clearly demonstrate the interaction of several functional domains for its optimal Wnt antagonist function...
  14. ncbi Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation
    Yan Liu
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 21:3050-61. 2007
    ..Our research forms a foundation for several new areas of investigation, including the molecular regulation of 14-3-3 by tyrosine phosphorylation and the role of this scaffold in osteogenesis...
  15. doi Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase
    Yan Liu
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 105:497-502. 2008
    ..Thus we show that Wnt5a activates the classical receptor tyrosine kinase signaling cascade through the Ror2 receptor in cells of osteoblastic origin...
  16. doi Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
    William J Moore
    Chemical and Screening Sciences, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Med Chem 52:105-16. 2009
    ..Details of the structure-activity relationships and biological activity from the first structural class of this scaffold will be discussed...
  17. doi Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens
    Ken C N Chang
    Wyeth Research, Transcriptional Targets, Tissue Repair, Collegeville, PA 19426, USA
    J Steroid Biochem Mol Biol 118:117-24. 2010
    ....
  18. doi Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse
    Richard J Murrills
    Department of Osteoporosis and Frailty, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania, USA
    J Pharmacol Exp Ther 340:676-87. 2012
    ..We conclude that the Src inhibitor compound I is osteogenic, presumably because of its potent stimulation of osteoblast differentiation and activation, possibly mediated by β-CGRP...
  19. ncbi High bone mass in mice expressing a mutant LRP5 gene
    Philip Babij
    Genomics, Wyeth Research, Andover, Massachusetts, USA
    J Bone Miner Res 18:960-74. 2003
    ..Together, these findings establish the importance of this novel and unexpected role of a lipoprotein receptor in regulating bone mass and afford a new model to explore LRP5 and its recent association with Wnt signaling in bone biology...
  20. doi The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention
    Yogendra Kharode
    Wyeth Research, Women s Health and Musculoskeletal Biology, Collegeville, Pennsylvania 19426, USA
    Endocrinology 149:6084-91. 2008
    ..These preclinical findings showed that the appropriate dose combination of bazedoxifene/CE exhibits positive vasomotor, lipid, and skeletal responses with minimal uterine stimulation...
  21. doi Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling
    Ramesh A Bhat
    Department of Osteoporosis and Frailty, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA
    J Cell Biochem 109:876-84. 2010
    ..In addition, this methodology can be utilized to identify inhibitors of either Wnt, Fz or interactors of the canonical pathway, which may have potential therapeutic value in the treatment of cancers and other diseases...
  22. ncbi Regulated expression of sFRP-1 protein by the GeneSwitch system
    Ramesh A Bhat
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Protein Expr Purif 37:327-35. 2004
    ..The regulated expression of sFRP-1 utilizing adenovirus vectors provides an opportunity to address the contribution of sFRP-1 in the regulation of stem cell differentiation, maturation, and their function by modulating the Wnt signaling...
  23. doi (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate
    Jeffrey C Pelletier
    Chemical Sciences, Drug Safety and Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 52:6962-5. 2009
    ..Compound 5 has excellent pharmacokinetic properties and showed a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration...
  24. doi Utility of the ovariectomized rat as a model for human osteoporosis in drug discovery
    Yogendra P Kharode
    Osteoporosis Research, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA, USA
    Methods Mol Biol 455:111-24. 2008
    ..This chapter describes the procedure for performing ovariectomy on the rat and the utility of the ovx rat model we have utilized over the last two decades in our laboratory...
  25. doi Parathyroid hormone synergizes with non-cyclic AMP pathways to activate the cyclic AMP response element
    Richard J Murrills
    Department of Osteoporosis and Frailty, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 106:887-95. 2009
    ..We conclude that non-cAMP pathways (EGF pathway, calcium pathway, PKC pathway) converge on, and have synergistic effects on, the response of a CRE reporter to PTH...
  26. ncbi Tissue culture models for studies of hormone and vitamin action in bone cells
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Ayerst Research, Collegeville, Pennsylvania 19426, USA
    Vitam Horm 64:101-51. 2002
    ..These models should accelerate our understanding of bone physiology and pathophysiology as well as our ability to develop important new therapies to prevent and treat skeletal diseases...
  27. ncbi Estrogenic effects of 7alpha-methyl-17alpha-ethynylestradiol: a newly discovered tibolone metabolite
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Steroids 67:681-6. 2002
    ..This steroid appears to be the most potent estrogenic metabolite of tibolone identified to date, and additional studies are, therefore, warranted regarding the role of this metabolite in the biological actions of the drug...
  28. ncbi Signal transduction pathways involved in macrophage migration induced by peritoneal fluid chemotactic factors in stages I and II endometriosis
    Maria Claudia Perez
    Endocrinology Department, Women s Health Research Institute, Wyeth Pharmaceuticals, Collegeville, Pennsylvania 19426, USA
    Fertil Steril 77:1261-8. 2002
    ..To explore the role of G-protein coupled signaling pathways in activation of macrophage migration in endometriosis stages I and II...
  29. ncbi PTH-dependent adenylyl cyclase activation in SaOS-2 cells: passage dependent effects on G protein interactions
    Hong Gao
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Cell Physiol 193:10-8. 2002
    ..The results suggest that the coupling between the components of the complex may be pivotally important in the differential responsiveness of early and late passage SaOS-2 cells to PTH...
  30. ncbi Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice
    Gadi Turgeman
    Molecular Pathology Laboratory, Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    J Cell Biochem 86:461-74. 2002
    ..In summary, our study shows that AMSCs are a good target for systemically active anabolic compounds like rhBMP-2...
  31. ncbi Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells
    Shuanhu Zhou
    Skeletal Biotechnology Laboratory, Hebrew University Hadassah Medical Center, Jerusalem 91120, Israel
    Mol Endocrinol 17:56-66. 2003
    ..Estrogenic compounds may enhance bone formation by increasing the transcription of the BMP-2 gene...
  32. doi Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development
    Brune Trevant
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 217:113-26. 2008
    ....
  33. ncbi Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression
    Tripti Gaur
    Department of Cell Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Biol Chem 280:33132-40. 2005
    ..We propose that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-beta signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development...
  34. ncbi Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 208:87-96. 2006
    ..Microarray gene profiling provided additional novel insights into the regulatory factors for appropriate Wnt signaling necessary for the control of chondrocyte maturation...