Brian Bates

Summary

Affiliation: Wyeth Research
Country: USA

Publications

  1. ncbi Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene
    Brian Bates
    Wyeth Research, Functional Genomics, 35 Cambridge Park Drive, Cambridge, MA 02140, USA
    Brain Res Mol Brain Res 109:18-33. 2002
  2. ncbi Characterization of Gpr101 expression and G-protein coupling selectivity
    Brian Bates
    Wyeth Research, Biological Technologies, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Brain Res 1087:1-14. 2006
  3. ncbi Cloning and expression of MRG receptors in macaque, mouse, and human
    Lin Zhang
    Wyeth Research, Functional Genomics Department, 87 Cambridge Park Drive, Cambridge, MA 02140, United States
    Brain Res Mol Brain Res 133:187-97. 2005
  4. ncbi Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78
    Philip G Jones
    Neuroscience Discovery Research, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Biochim Biophys Acta 1770:890-901. 2007
  5. ncbi Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae
    Mark H Pausch
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Biochem Biophys Res Commun 324:171-7. 2004
  6. doi The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
    Sheree F Logue
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 42:438-47. 2009
  7. doi An approach to quantifying N-linked glycoproteins by enzyme-catalyzed 18O3-labeling of solid-phase enriched glycopeptides
    Quazi Shakey
    Global Biotherapeutics Technologies, Pfizer, Cambridge, Massachusetts 02140, USA
    Anal Chem 82:7722-8. 2010
  8. pmc Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain
    David von Schack
    Biological Technologies, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17670. 2011
  9. pmc SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1
    Ulrich Y Schaff
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Eur J Immunol 38:550-64. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene
    Brian Bates
    Wyeth Research, Functional Genomics, 35 Cambridge Park Drive, Cambridge, MA 02140, USA
    Brain Res Mol Brain Res 109:18-33. 2002
    ..The ability of mGluR5R to associate with mGluR1alpha and mGluR5 suggests that it may be a modulator of class I metabotropic glutamate receptor function...
  2. ncbi Characterization of Gpr101 expression and G-protein coupling selectivity
    Brian Bates
    Wyeth Research, Biological Technologies, 87 Cambridge Park Drive, Cambridge, MA 02140, USA
    Brain Res 1087:1-14. 2006
    ..These results indicate that GPR101 participates in a potentially wide range of activities in the CNS via modulation of cAMP levels...
  3. ncbi Cloning and expression of MRG receptors in macaque, mouse, and human
    Lin Zhang
    Wyeth Research, Functional Genomics Department, 87 Cambridge Park Drive, Cambridge, MA 02140, United States
    Brain Res Mol Brain Res 133:187-97. 2005
    ..Although expression in DRG neurons was the prominent feature of this family, we also found that MrgE was expressed in numerous brain regions of macaque, mouse, and human...
  4. ncbi Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78
    Philip G Jones
    Neuroscience Discovery Research, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Biochim Biophys Acta 1770:890-901. 2007
    ..50) in the so-called DRY box. Site-directed mutants R3.50 in GPR26 were constructed and retained their constitutive activity suggesting that these 2 receptors activate G proteins in a manner that is distinct from other group 1 GPCRs...
  5. ncbi Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae
    Mark H Pausch
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Biochem Biophys Res Commun 324:171-7. 2004
    ..Murine P2Y12 mRNA was expressed at high levels in the brain and at lower levels in a variety of peripheral tissues. In situ hybridization analysis indicated glia-specific expression within the brain...
  6. doi The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
    Sheree F Logue
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Mol Cell Neurosci 42:438-47. 2009
    ..Antipsychotic administration to Gpr88KOs normalized the PPI deficit and blocked AICS. The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders...
  7. doi An approach to quantifying N-linked glycoproteins by enzyme-catalyzed 18O3-labeling of solid-phase enriched glycopeptides
    Quazi Shakey
    Global Biotherapeutics Technologies, Pfizer, Cambridge, Massachusetts 02140, USA
    Anal Chem 82:7722-8. 2010
    ..The strategy can be easily adapted to the analysis of glycoproteins in tissues, cell lines, and other sample origins...
  8. pmc Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain
    David von Schack
    Biological Technologies, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17670. 2011
    ..Our results suggest the potential for miRNAs to play a direct role in neuropathic pain...
  9. pmc SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1
    Ulrich Y Schaff
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Eur J Immunol 38:550-64. 2008
    ..We conclude that SLIC-1 serves as a sorting molecule that cycles PSGL-1 into endosomes with no impact on leukocyte recruitment...