Julian Gomez-Cambronero


Affiliation: Wright State University
Country: USA


  1. Gomez Cambronero J, Ganesan R. Targeting Phospholipase D Genetically and Pharmacologically for Studying Leukocyte Function. Methods Mol Biol. 2018;1835:297-314 pubmed publisher
    ..By using the three-step thorough approach, we could understand the molecular underpinning of PLD in the pathological conditions indicated above, IRI-neutrophilia and atherosclerosis. ..
  2. Gomez Cambronero J. Lack of effective translational regulation of PLD expression and exosome biogenesis in triple-negative breast cancer cells. Cancer Metastasis Rev. 2018;37:491-507 pubmed publisher
    ..A new signaling miR•PARN•PLD node could serve as new biomarkers for TNBC abnormal signaling and metastatic disease staging, potentially before metastases are able to be visualized using conventional imaging. ..
  3. Gomez Cambronero J. New concepts in phospholipase D signaling in inflammation and cancer. ScientificWorldJournal. 2010;10:1356-69 pubmed publisher
    ..In summary, the involvement of PLD2 in cell signaling continues to expand geometrically. It involves gene transcription, mitogenic and cell migration effects as seen in normal growth, tumor development, and inflammation. ..
  4. Mahankali M, Alter G, Gomez Cambronero J. Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model. Cell Signal. 2015;27:69-81 pubmed publisher
    ..Since tumor-aggravating properties have been found in mice overexpressing PLD2 enzyme, the 3D model of PLD2 will be also useful, to a large extent, in developing pharmaceuticals to modulate its in vivo activity. ..
  5. Ganesan R, Mahankali M, Alter G, Gomez Cambronero J. Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket. Biochim Biophys Acta. 2015;1851:261-72 pubmed publisher
  6. Hatton N, Lintz E, Mahankali M, Henkels K, Gomez Cambronero J. Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor. Mol Cell Biol. 2015;35:3131-44 pubmed publisher
    ..Thus, PLD2-mediated production of PA contributed to the control of EGFR exposure to ligand through a multipronged transcriptional and posttranscriptional program during the out-of-control accumulation of EGFR signaling in cancer cells. ..
  7. Gomez Cambronero J. The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal. 2011;23:1885-95 pubmed publisher
    ..This provides only the latest level of PLD2 regulation in a field that promises newer and exciting advances in the next few years. ..
  8. Fite K, Elkhadragy L, Gomez Cambronero J. A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells. Mol Cell Biol. 2016;36:1078-89 pubmed publisher
    ..It can further prevent inhibition of apoptosis and allow cells to survive nutrient deprivation, which normal cells cannot do. ..
  9. Ganesan R, Mallets E, Gomez Cambronero J. The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion. Mol Oncol. 2016;10:663-76 pubmed publisher
    ..The newly uncovered feedback loops in highly invasive cancer cells have important implications in the process of EMT. ..

More Information


  1. Miller T, Gomez Cambronero J. A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells. Biol Open. 2017;6:176-186 pubmed publisher
    ..In summary, we report for the first time the involvement of a phospholipase (PLD2) and PA in mediating PARN-induced eukaryotic mRNA decay and the crosstalk between the two enzymes that is deregulated in breast cancer cells. ..
  2. Gomez Cambronero J, Morris A, Henkels K. PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. Methods Enzymol. 2017;583:327-357 pubmed publisher
    ..Detection of PA in mammalian cells with a new biosensor showed colocalization in and around the nucleus. We also described methods for quantitation of PA in biological materials by HPLC electrospray ionization tandem mass spectrometry. ..
  3. Gomez Cambronero J, Carman G. Thematic minireview series on phospholipase D and cancer. J Biol Chem. 2014;289:22554-6 pubmed publisher
    ..PLD represents a potential target for the rational development of therapeutics against cancer and other diseases. ..
  4. Speranza F, Mahankali M, Henkels K, Gomez Cambronero J. The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D. J Biol Chem. 2014;289:28885-97 pubmed publisher
    ..A prolonged adhesion could effectively counteract the reversible intrinsic nature of this cellular process and constitute a key player in chronic inflammation. ..
  5. Gomez Cambronero J. Phosphatidic acid, phospholipase D and tumorigenesis. Adv Biol Regul. 2014;54:197-206 pubmed publisher
  6. Henkels K, Mallets E, Dennis P, Gomez Cambronero J. S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding. FASEB J. 2015;29:1299-313 pubmed publisher
    ..This new signaling set, PA-S6K-FLNA-actin, sheds light for the first time into the morphogenic pathway of cytoskeletal structures that are crucial for adhesion and cell locomotion during inflammation and metastasis. ..
  7. request reprint
    Gomez Cambronero J, Horn J, Paul C, Baumann M. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 2003;171:6846-55 pubmed
    ..These data indicate that GM-CSF exhibits chemotactic functionality and suggest new avenues for the investigation of the molecular basis of chemotaxis as it relates to inflammation and tissue injury. ..
  8. Speranza F, Mahankali M, Gomez Cambronero J. Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over ?-catenin-induced PLD expression. J Leukoc Biol. 2013;94:953-62 pubmed publisher
    ..If this immobilization is prolonged enough, it could lead to chronic inflammation. ..
  9. Fite K, Gomez Cambronero J. Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion. J Biol Chem. 2016;291:719-30 pubmed publisher
  10. Gomez Cambronero J, Fite K, Miller T. How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD. Adv Biol Regul. 2018;68:107-119 pubmed publisher
  11. Gomez Cambronero J, Frye T, Baumann M. Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD. Leuk Res. 2004;28:755-62 pubmed