Julian Gomez-Cambronero

Summary

Affiliation: Wright State University
Country: USA

Publications

  1. pmc Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology Wright State University School of Medicine Dayton, OH USA
    Small Gtpases 3:202-8. 2012
  2. pmc Phosphatidic acid, phospholipase D and tumorigenesis
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University School Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA Electronic address
    Adv Biol Regul 54:197-206. 2014
  3. pmc Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression
    Francis J Speranza
    1 Dept of Biochemistry and Molecular Biology, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Leukoc Biol 94:953-62. 2013
  4. pmc Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells
    Ren Hua Na
    Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, Department of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
    BMC Microbiol 13:125. 2013
  5. pmc Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2)
    Julian Gomez-Cambronero
    Wright State University School of Medicine, Department of Biochemistry and Molecular Biology, Dayton, OH, USA
    J Leukoc Biol 92:461-7. 2012
  6. doi request reprint Cloning of PLD2 from baculovirus for studies in inflammatory responses
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH, USA
    Methods Mol Biol 861:201-25. 2012
  7. pmc New concepts in phospholipase D signaling in inflammation and cancer
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, OH, USA
    ScientificWorldJournal 10:1356-69. 2010
  8. ncbi request reprint Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis
    Julian Gomez-Cambronero
    Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Leukoc Biol 82:272-81. 2007
  9. pmc Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD
    Julian Gomez-Cambronero
    Department of Physiology and Biophysics, School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    Leuk Res 28:755-62. 2004
  10. pmc The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF)
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA
    Cell Signal 23:1885-95. 2011

Research Grants

  1. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2007
  2. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    JULIAN GOMEZ CAMBRONERO; Fiscal Year: 2010
  3. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2004
  4. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2005
  5. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2006
  6. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2005
  7. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2009

Collaborators

  • Qing Ye
  • Michael Baumann
  • Michael A Frohman
  • Jeffrey E Segall
  • Haein Park
  • Mary Dinauer
  • LINDA MCPHAIL
  • Dianne Cox
  • Julian Gomez Cambronero
  • Karen M Henkels
  • Madhu Mahankali
  • Mauricio Di Fulvio
  • Hong Juan Peng
  • Kathleen Frondorf
  • JULIAN GOMEZ CAMBRONERO
  • Nicholas Lehman
  • Farnaz Tabatabaian
  • Jason A Lehman
  • Ren Hua Na
  • Francis J Speranza
  • Samuel Kantonen
  • Katie Knapek
  • Stephen Short
  • Jeff Horn
  • Liwang Cui
  • Ji Xuan Luo
  • Xiao Jing Meng
  • Guo Hui Zhu
  • Xiao Guang Chen
  • Gerald Alter
  • DAVID COOL
  • William C Grunwald
  • Andrea L Doseff
  • Christophe Marchal
  • M Elba Gonzalez-Mejia
  • Nathaniel Hatton
  • Terry Farkaly
  • Paula Bubulya
  • Jennalee Post
  • Kevin Dougherty
  • Bill Ledford
  • Nicholas McCray
  • Isabel Campos
  • Mill W Miller
  • Isabel Lopez
  • Victor Calvo

Detail Information

Publications41

  1. pmc Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology Wright State University School of Medicine Dayton, OH USA
    Small Gtpases 3:202-8. 2012
    ..Future experiments will ascertain how the newly described PLD2's GEF is regulated in the context of cell activation...
  2. pmc Phosphatidic acid, phospholipase D and tumorigenesis
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University School Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA Electronic address
    Adv Biol Regul 54:197-206. 2014
    ....
  3. pmc Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression
    Francis J Speranza
    1 Dept of Biochemistry and Molecular Biology, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Leukoc Biol 94:953-62. 2013
    ..If this immobilization is prolonged enough, it could lead to chronic inflammation...
  4. pmc Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells
    Ren Hua Na
    Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, Department of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
    BMC Microbiol 13:125. 2013
    ....
  5. pmc Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2)
    Julian Gomez-Cambronero
    Wright State University School of Medicine, Department of Biochemistry and Molecular Biology, Dayton, OH, USA
    J Leukoc Biol 92:461-7. 2012
    ..This new concept will help our understanding of leukocyte crucial functions, such as cell migration and adhesion, and how their deregulation impacts chronic inflammation...
  6. doi request reprint Cloning of PLD2 from baculovirus for studies in inflammatory responses
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH, USA
    Methods Mol Biol 861:201-25. 2012
    ....
  7. pmc New concepts in phospholipase D signaling in inflammation and cancer
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, OH, USA
    ScientificWorldJournal 10:1356-69. 2010
    ..In summary, the involvement of PLD2 in cell signaling continues to expand geometrically. It involves gene transcription, mitogenic and cell migration effects as seen in normal growth, tumor development, and inflammation...
  8. ncbi request reprint Understanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis
    Julian Gomez-Cambronero
    Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Leukoc Biol 82:272-81. 2007
    ..There are reasons to expect that leukocytes and their leukemic cell line counterparts will continue yielding invaluable information to cell biologists to resolve standing molecular and functional issues concerning PLD...
  9. pmc Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD
    Julian Gomez-Cambronero
    Department of Physiology and Biophysics, School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    Leuk Res 28:755-62. 2004
    ....
  10. pmc The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF)
    Julian Gomez-Cambronero
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA
    Cell Signal 23:1885-95. 2011
    ..This provides only the latest level of PLD2 regulation in a field that promises newer and exciting advances in the next few years...
  11. ncbi request reprint Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway
    Julian Gomez-Cambronero
    Department of Physiology and Biophysics, Wright State University, Dayton, OH 45435, USA
    J Immunol 171:6846-55. 2003
    ..These data indicate that GM-CSF exhibits chemotactic functionality and suggest new avenues for the investigation of the molecular basis of chemotaxis as it relates to inflammation and tissue injury...
  12. pmc Rapamycin inhibits GM-CSF-induced neutrophil migration
    Julian Gomez-Cambronero
    Department of Physiology and Biophysics, 064 Medical Science Building, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    FEBS Lett 550:94-100. 2003
    ..This serves to underscore the relevance of the mTOR/S6K pathway in neutrophil migration...
  13. pmc Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function
    Farnaz Tabatabaian
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    J Biol Chem 285:18991-9001. 2010
    ..We propose that IL-8 reverses an mTOR/S6K-led down-regulation of PLD2 expression and enables PLD2 to fully function as a facilitator for cell migration...
  14. pmc Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity
    Madhu Mahankali
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    J Biol Chem 287:41417-31. 2012
    ..Thus, this study reveals for the first time the catalytic site that forms the basis for the mechanism behind the GEF activity of PLD2...
  15. pmc Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2
    Madhu Mahankali
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA
    Proc Natl Acad Sci U S A 108:19617-22. 2011
    ..The benefit to the cell is that PLD2 brings spatially separated molecules together in a membrane environment, ready for fast intracellular signaling and cell function...
  16. pmc A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism
    Samuel Kantonen
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    Mol Cell Biol 31:4524-37. 2011
    ..The heterotrimer PLD2-Grb2-WASp then enables actin nucleation at the phagocytic cup and phagocytosis, which are at the center of the innate immune system function...
  17. pmc A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells
    Qing Ye
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    J Biol Chem 288:9881-91. 2013
    ..Modulating this new JAK3-Fes-PLD2 pathway could be important to control the highly invasive phenotype of breast cancer cells...
  18. pmc Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling
    Kathleen Frondorf
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    J Biol Chem 285:15837-47. 2010
    ..In summary, we report the discovery of PA as a leukocyte chemoattractant via cell entry and activation of S6K to mediate the cytoskeletal actin polymerization and leukocyte chemotaxis required for the immune function of these cells...
  19. ncbi request reprint Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase
    Jason A Lehman
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, Ohio 45435, USA
    J Biol Chem 278:28130-8. 2003
    ....
  20. pmc The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF
    Mauricio Di Fulvio
    Cell Biology and Physiology, Wright State University, School of Medicine, Dayton, OH 45435, USA
    J Mol Biol 367:814-24. 2007
    ..These results demonstrate for the first time that the presence of Grb2 and its interaction with localized intracellular structures is essential for PLD2 activity and signaling in vivo...
  21. pmc Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action
    Mauricio Di Fulvio
    Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, OH 45435, USA
    J Biol Chem 287:393-407. 2012
    ..Differentiation shortening could have a clinical impact on reducing the time of return to normalcy of the white cell counts after chemotherapy in patients with acute promyelocytic leukemia...
  22. pmc Molecular crosstalk between p70S6k and MAPK cell signaling pathways
    Jason A Lehman
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, OH 45435, USA
    Biochem Biophys Res Commun 293:463-9. 2002
    ..Thus, a connection between these two kinases extends from the molecular level to cell migration, a key functionality in non-proliferative, mature phagocytes such as neutrophils...
  23. pmc The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis
    Hong Juan Peng
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    Mol Cell Biol 31:2227-40. 2011
    ..This work supports the importance of functional interactions between PLD and Rac in the biological response of cell migration...
  24. pmc Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras
    Karen M Henkels
    Wright State University School of Medicine, Department of Biochemistry and Molecular Biology, OH 45435, USA
    Cell Signal 25:198-205. 2013
    ..This can be crucial to cancer biology in that not only Ras mutations explain abnormal growth, but the existence of a new GEF for Ras: a GEF molecule that happens to be a phospholipase...
  25. pmc Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion
    Qing Ye
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA
    J Mol Biol 425:755-66. 2013
    ..This is especially important in the absence of growth factors in serum, coincidental with migration of these cells to new locations...
  26. pmc The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts
    Katie Knapek
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA
    Mol Cell Biol 30:4492-506. 2010
    ....
  27. pmc Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2
    Nicholas Lehman
    Department of Cell Biology and Physiology, Wright State University School of Medicine, Dayton, OH 45435, USA
    Blood 108:3564-72. 2006
    ..These data represent the first demonstration of the involvement of PLD and its enzymatic activity toward chemokines in the key physiologic process of leukocyte migration...
  28. ncbi request reprint Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR
    Nicholas Lehman
    Cell Biology and Physiology, Wright State University, School of Medicine, 3640 Colonel Glenn Hwy, Dayton, Ohio 45435, USA
    FASEB J 21:1075-87. 2007
    ..These results show for the first time a direct (mTOR-independent) participation of PLD in the p70S6K pathway and implicate PA as a nexus that brings together cell phospholipases and kinases...
  29. pmc A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration
    Madhu Mahankali
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, OH 45435, USA
    J Cell Sci 126:1416-28. 2013
    ..This is the first report of a temporal inter-regulation of two enzymatic activities that reside in the same molecule with profound biological consequences in leukocyte cell migration...
  30. pmc A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation
    Karen M Henkels
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    Mol Cell Biol 30:2251-63. 2010
    ..Thus, phosphorylation of PLD2-Y(296) could be the signal for lowering the level of PLD2 activity in transformed cells with low invasive capabilities...
  31. pmc Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3)
    Karen M Henkels
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Mol Biol 408:850-62. 2011
    ....
  32. pmc Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2
    Hong Juan Peng
    Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, Ohio 45435, USA
    J Biol Chem 286:16308-20. 2011
    ..We propose that in activated cells PLD2 affects Rac2 in an initial positive feedback, but as Rac2-GTP accumulates in the cell, this constitutes a "termination signal" leading to PLD2 inactivation...
  33. pmc Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis
    Mauricio Di Fulvio
    Cell Biology and Physiology, Wright State University, School of Medicine, Dayton, OH 45435, USA
    Biochem Biophys Res Commun 357:737-42. 2007
    ..Thus, a viable knock-down and rescue protocol has demonstrated that Grb2 is crucial for cell proliferation...
  34. pmc Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner
    Mauricio Di Fulvio
    Cell Biology and Physiology, Wright State University, School of Medicine, Dayton, OH 45435, USA
    Cell Signal 20:176-85. 2008
    ..This might be critical for the maintenance of the PLD2-regulated proliferative status...
  35. pmc PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation
    Karen M Henkels
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH 45435, USA
    Biochem Biophys Res Commun 389:224-8. 2009
    ....
  36. pmc The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association
    Madhu Mahankali
    Dept Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, OH 45435, USA
    Cell Signal 23:1291-8. 2011
    ..Since membrane ruffling precedes cell migration, the results herein provide a novel mechanism for control of membrane dynamics, crucial for the physiology of leukocytes...
  37. pmc Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF
    Michael Baumann
    Research Service, Department of Veterans Affairs, Medicine 111W, VAMC, 4100 W Third Street, Dayton, OH 45428, USA
    Leuk Res 29:73-8. 2005
    ..This information may prove useful for the understanding of conditions in which neutrophil proliferative/differentiative balancing is dysregulated, such as myeloid leukemia and myelodysplastic disorders...
  38. pmc IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)
    Karen M Henkels
    Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, OH 45435, USA
    FEBS Lett 585:159-66. 2011
    ..These new findings lay the basis for understanding the molecular mechanism of cell migration as it relates to neutrophil-mediated chronic inflammatory processes...
  39. pmc The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2
    Jeff Horn
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, OH 45435, USA
    Biochem Biophys Res Commun 332:58-67. 2005
    ....
  40. ncbi request reprint Phospholipase D (PLD) gene expression in human neutrophils and HL-60 differentiation
    Mauricio Di Fulvio
    Department of Physiology and Biophysics, Wright State University, Dayton, OH 45435, USA
    J Leukoc Biol 77:999-1007. 2005
    ..These results demonstrate for the first time that human neutrophils express five PLD transcripts and that the PLD genes undergo qualitative changes in transcription regulation during granulocytic differentiation...
  41. pmc Measurements of phospholipases A2, C, and D (PLA2, PLC, and PLD). In vitro microassays, analysis of enzyme isoforms, and intact-cell assays
    Julian Gomez-Cambronero
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, OH, USA
    Methods Mol Biol 218:155-76. 2003
    ..Finally, the intact-cell assays allow for the accurate measurement of receptor-mediated activation in vivo...

Research Grants8

  1. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2007
    ..Inhibitors can then be designed to prevent leukocyte-mediated tissue injury that occurs during ischemia/reperfusion and in similar host-damaging inflammation pathologies. ..
  2. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    JULIAN GOMEZ CAMBRONERO; Fiscal Year: 2010
    ..This proposal seeks to elucidate the molecular mechanism chemotaxis and its interplay with fundamental molecules of the cytoskeletal cellular machinery, as necessary for the key life function of immune defense. ..
  3. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2004
    ..Inhibitors can then be designed to prevent leukocyte-mediated tissue injury that occurs during ischemia/reperfusion and in similar host-damaging inflammation pathologies. ..
  4. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2005
    ..Inhibitors can then be designed to prevent leukocyte-mediated tissue injury that occurs during ischemia/reperfusion and in similar host-damaging inflammation pathologies. ..
  5. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2006
    ..Inhibitors can then be designed to prevent leukocyte-mediated tissue injury that occurs during ischemia/reperfusion and in similar host-damaging inflammation pathologies. ..
  6. Molecular Basis of GM-CSF-induced Neutrophil Chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2005
    ..Inhibitors can then be designed to prevent leukocyte-mediated tissue injury that occurs during ischemia/reperfusion and in similar host-damaging inflammation pathologies. ..
  7. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2009
    ..This proposal seeks to elucidate the molecular mechanism chemotaxis and its interplay with fundamental molecules of the cytoskeletal cellular machinery, as necessary for the key life function of immune defense. ..