Julian Gomez-Cambronero

Summary

Affiliation: Wright State University
Country: USA

Publications

  1. Fite K, Elkhadragy L, Gomez Cambronero J. A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells. Mol Cell Biol. 2016;36:1078-89 pubmed publisher
    ..It can further prevent inhibition of apoptosis and allow cells to survive nutrient deprivation, which normal cells cannot do. ..
  2. Ganesan R, Mallets E, Gomez Cambronero J. The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion. Mol Oncol. 2016;10:663-76 pubmed publisher
    ..The newly uncovered feedback loops in highly invasive cancer cells have important implications in the process of EMT. ..
  3. Miller T, Gomez Cambronero J. A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells. Biol Open. 2017;6:176-186 pubmed publisher
    ..In summary, we report for the first time the involvement of a phospholipase (PLD2) and PA in mediating PARN-induced eukaryotic mRNA decay and the crosstalk between the two enzymes that is deregulated in breast cancer cells. ..
  4. Gomez Cambronero J, Morris A, Henkels K. PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. Methods Enzymol. 2017;583:327-357 pubmed publisher
    ..Detection of PA in mammalian cells with a new biosensor showed colocalization in and around the nucleus. We also described methods for quantitation of PA in biological materials by HPLC electrospray ionization tandem mass spectrometry. ..
  5. request reprint
    Gomez Cambronero J, Horn J, Paul C, Baumann M. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 2003;171:6846-55 pubmed
    ..These data indicate that GM-CSF exhibits chemotactic functionality and suggest new avenues for the investigation of the molecular basis of chemotaxis as it relates to inflammation and tissue injury. ..
  6. Gomez Cambronero J, Frye T, Baumann M. Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD. Leuk Res. 2004;28:755-62 pubmed
    ....
  7. Speranza F, Mahankali M, Gomez Cambronero J. Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over ?-catenin-induced PLD expression. J Leukoc Biol. 2013;94:953-62 pubmed publisher
    ..If this immobilization is prolonged enough, it could lead to chronic inflammation. ..
  8. Gomez Cambronero J. Phosphatidic acid, phospholipase D and tumorigenesis. Adv Biol Regul. 2014;54:197-206 pubmed publisher
    ....
  9. Gomez Cambronero J, Carman G. Thematic minireview series on phospholipase D and cancer. J Biol Chem. 2014;289:22554-6 pubmed publisher
    ..PLD represents a potential target for the rational development of therapeutics against cancer and other diseases. ..
  10. Speranza F, Mahankali M, Henkels K, Gomez Cambronero J. The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D. J Biol Chem. 2014;289:28885-97 pubmed publisher
    ..A prolonged adhesion could effectively counteract the reversible intrinsic nature of this cellular process and constitute a key player in chronic inflammation. ..

Locale

Collaborators

Detail Information

Publications13

  1. Fite K, Elkhadragy L, Gomez Cambronero J. A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells. Mol Cell Biol. 2016;36:1078-89 pubmed publisher
    ..It can further prevent inhibition of apoptosis and allow cells to survive nutrient deprivation, which normal cells cannot do. ..
  2. Ganesan R, Mallets E, Gomez Cambronero J. The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion. Mol Oncol. 2016;10:663-76 pubmed publisher
    ..The newly uncovered feedback loops in highly invasive cancer cells have important implications in the process of EMT. ..
  3. Miller T, Gomez Cambronero J. A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells. Biol Open. 2017;6:176-186 pubmed publisher
    ..In summary, we report for the first time the involvement of a phospholipase (PLD2) and PA in mediating PARN-induced eukaryotic mRNA decay and the crosstalk between the two enzymes that is deregulated in breast cancer cells. ..
  4. Gomez Cambronero J, Morris A, Henkels K. PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA. Methods Enzymol. 2017;583:327-357 pubmed publisher
    ..Detection of PA in mammalian cells with a new biosensor showed colocalization in and around the nucleus. We also described methods for quantitation of PA in biological materials by HPLC electrospray ionization tandem mass spectrometry. ..
  5. request reprint
    Gomez Cambronero J, Horn J, Paul C, Baumann M. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 2003;171:6846-55 pubmed
    ..These data indicate that GM-CSF exhibits chemotactic functionality and suggest new avenues for the investigation of the molecular basis of chemotaxis as it relates to inflammation and tissue injury. ..
  6. Gomez Cambronero J, Frye T, Baumann M. Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD. Leuk Res. 2004;28:755-62 pubmed
    ....
  7. Speranza F, Mahankali M, Gomez Cambronero J. Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over ?-catenin-induced PLD expression. J Leukoc Biol. 2013;94:953-62 pubmed publisher
    ..If this immobilization is prolonged enough, it could lead to chronic inflammation. ..
  8. Gomez Cambronero J. Phosphatidic acid, phospholipase D and tumorigenesis. Adv Biol Regul. 2014;54:197-206 pubmed publisher
    ....
  9. Gomez Cambronero J, Carman G. Thematic minireview series on phospholipase D and cancer. J Biol Chem. 2014;289:22554-6 pubmed publisher
    ..PLD represents a potential target for the rational development of therapeutics against cancer and other diseases. ..
  10. Speranza F, Mahankali M, Henkels K, Gomez Cambronero J. The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D. J Biol Chem. 2014;289:28885-97 pubmed publisher
    ..A prolonged adhesion could effectively counteract the reversible intrinsic nature of this cellular process and constitute a key player in chronic inflammation. ..
  11. Henkels K, Mallets E, Dennis P, Gomez Cambronero J. S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding. FASEB J. 2015;29:1299-313 pubmed publisher
    ..This new signaling set, PA-S6K-FLNA-actin, sheds light for the first time into the morphogenic pathway of cytoskeletal structures that are crucial for adhesion and cell locomotion during inflammation and metastasis. ..
  12. Fite K, Gomez Cambronero J. Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion. J Biol Chem. 2016;291:719-30 pubmed publisher
    ....
  13. Gomez Cambronero J, Fite K, Miller T. How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD. Adv Biol Regul. 2017;: pubmed publisher
    ....