Research Topics
| Dalin TangSummaryAffiliation: Worcester Polytechnic Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stressChun Yang
School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
Biomed Eng Online 10:61. 2011..It has been well-accepted that atherosclerosis initiation and early progression correlate negatively with flow wall shear stresses (FSS). However, mechanisms governing advanced plaque progression are not well understood...- Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3D fluid-structure interaction studyXueying Huang
School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, PR China
Biomed Eng Online 9:86. 2010.... - Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient studyDalin Tang
Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
Biomed Eng Online 8:15. 2009..However, large-scale studies based on in vivo patient data combining mechanical stress analysis, plaque morphology and composition for carotid plaque vulnerability assessment are lacking in the current literature... - Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction studyDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Stroke 40:3258-63. 2009..To test that hypothesis, 3D fluid-structure interaction models were constructed based on in vivo MRI data of human atherosclerotic carotid plaques to assess structural stress behaviors of plaques with and without rupture... - Patient-specific MRI-based 3D FSI RV/LV/patch models for pulmonary valve replacement surgery and patch optimizationDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
J Biomech Eng 130:041010. 2008..More patient studies are needed to validate our findings... 
Two-layer passive/active anisotropic FSI models with fiber orientation: MRI-based patient-specific modeling of right ventricular response to pulmonary valve insertion surgeryDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Mol Cell Biomech 4:159-76. 2007..Maximum Stress-P1 value from the active anisotropic model was 121.2% higher than that from the passive isotropic model. Computational RV volume predictions agreed well with CMR-measured volume data (error < 2%)...- A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress: in vivo MRI-based 2D/3D FSI modelsDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
J Biomech 41:727-36. 2008..637). These pilot studies suggest that both lower PWS and lower FSS may contribute to continued plaque progression and should be taken into consideration in future investigations of diseases related to atherosclerosis... - Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI modelsDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
J Biomech Eng 127:1185-94. 2005..Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. Methods to assess plaque vulnerability noninvasively and predict possible plaque rupture are urgently needed... - Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessmentDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Ann Biomed Eng 33:1789-801. 2005..Large-scale and long-term patient studies are needed to further validate our findings for more accurate quantitative plaque vulnerability assessment... - Effect of stenosis asymmetry on blood flow and artery compression: a three-dimensional fluid-structure interaction modelDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Ann Biomed Eng 31:1182-93. 2003..Stenosis asymmetry leads to higher artery compression, higher shear stress and a larger flow separation region. Computational results are verified by available experimental data... - 3D MRI-based multicomponent FSI models for atherosclerotic plaquesDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Ann Biomed Eng 32:947-60. 2004..Large-scale patient studies are needed to validate the computational findings for possible plaque vulnerability assessment and rupture predictions... - Effect of a lipid pool on stress/strain distributions in stenotic arteries: 3-D fluid-structure interactions (FSI) modelsDalin Tang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
J Biomech Eng 126:363-70. 2004.... - 3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysisDalin Tang
Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA
J Biomech Eng 131:061010. 2009.... - Patient-specific artery shrinkage and 3D zero-stress state in multi-component 3D FSI models for carotid atherosclerotic plaques based on in vivo MRI dataXueying Huang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Mol Cell Biomech 6:121-34. 2009..Our results indicated that accurate knowledge of artery shrinkages and the shrink-stretch process will considerably improve the accuracy of computational predictions made based on results from those in vivo MRI-based FSI models... - 3D critical plaque wall stress is a better predictor of carotid plaque rupture sites than flow shear stress: An in vivo MRI-based 3D FSI studyZhongzhao Teng
Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA
J Biomech Eng 132:031007. 2010..Critical wall stress values may become indicators of high risk sites of rupture. Future work with a larger population will establish a possible CPWS-based plaque vulnerability classification... - IVUS-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessmentHaofei Liu
Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA
Mol Cell Biomech 9:77-93. 2012..Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated... - Using in vivo Cine and 3D multi-contrast MRI to determine human atherosclerotic carotid artery material properties and circumferential shrinkage rate and their impact on stress/strain predictionsHaofei Liu
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
J Biomech Eng 134:011008. 2012..Accurate patient-specific material properties and circumferential shrinkage could considerably improve the accuracy of in vivo MRI-based computational stress/strain predictions... - An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directionsZhongzhao Teng
Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
J Biomech 42:2535-9. 2009..50+/-0.22). These measurements of the material strength limits for human atherosclerotic carotid arteries could be useful in improving computational models that assess plaque vulnerability... - Planar biaxial characterization of diseased human coronary and carotid arteries for computational modelingMehmet H Kural
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, United States
J Biomech 45:790-8. 2012.... 
Quantifying effect of intraplaque hemorrhage on critical plaque wall stress in human atherosclerotic plaques using three-dimensional fluid-structure interaction modelsXueying Huang
School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, P R C Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609
J Biomech Eng 134:121004. 2012..Large-scale studies are needed to further validate our findings...- In vivo serial MRI-based models and statistical methods to quantify sensitivity and specificity of mechanical predictors for carotid plaque rupture: location and beyondZheyang Wu
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
J Biomech Eng 133:064503. 2011..With large-scale patient studies, this predictive modeling process may provide more solid ground for rupture predictor selection strategies and methods for image-based plaque vulnerability assessment... - Using contracting band to improve right ventricle ejection fraction for patients with repaired tetralogy of Fallot: a modeling study using patient-specific CMR-based 2-layer anisotropic models of human right and left ventriclesChun Yang
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, Mass 01609, USA
J Thorac Cardiovasc Surg 145:285-93, 293.e1-2. 2013..A new surgical option of placing an elastic band in the right ventricle is proposed to improve right ventricular cardiac function as measured by the ejection fraction... - Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivoJie Zheng
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Magn Reson Med 54:1360-8. 2005..Noninvasive quantification of the MR contrast and mechanical properties of plaque may provide a comprehensive biomarker for the assessment of vulnerability of atherosclerotic plaques... - Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: mediation by gradient of cell densityShu Q Liu
Biomedical Engineering Department, E334, Technology Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
Am J Physiol Heart Circ Physiol 285:H1072-80. 2003..These observations suggest that nonuniform shear stress may regulate the pattern formation of SMCs, possibly via mediating the gradient of cell density in the neointima of vascular polymer implants... - Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and SrcShu Q Liu
Biomedical Engineering Department, E334, Technology Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
Am J Physiol Heart Circ Physiol 285:H1081-90. 2003..These observations suggest that PDGF-beta receptor and Src possibly serve as mediating factors in nonuniform shear-induced formation of cell density gradients and alignment of SMCs in the neointima of vascular polymer implants...
Research Grants
- CRCNS: Modeling for Carotid Plaque Rupture and StrokeDalin Tang; Fiscal Year: 2007..abstract_text> ..
- In Vivo IVUS Image-Based Modeling for Human Coronary Plaque AssessmentJie Zheng; Fiscal Year: 2010..Commercialization of the research results is possible with the automation of model construction and data analysis procedures. ..
- In Vivo IVUS Image-Based Modeling for Human Coronary Plaque AssessmentDALIN contact TANG; Fiscal Year: 2011..Commercialization of the research results is possible with the automation of model construction and data analysis procedures. ..