Dalin Tang

Summary

Affiliation: Worcester Polytechnic Institute
Country: USA

Publications

  1. ncbi request reprint Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an IVUS-based fluid-structure interaction multi-patient study
    Rui Fan
    School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 13:32. 2014
  2. ncbi request reprint Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: data, modeling, validation, uncertainty and predictions
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China Worcester Polytechnic Institute, Worcester, MA 01609, USA Electronic address
    J Biomech 47:834-46. 2014
  3. pmc Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 12:105. 2013
  4. pmc Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study
    Biyue Liu
    Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA
    Biomed Eng Online 11:43. 2012
  5. pmc Image-based modeling and precision medicine: patient-specific carotid and coronary plaque assessment and predictions
    Dalin Tang
    Southeast University, Nanjing 210018, China
    IEEE Trans Biomed Eng 60:643-51. 2013
  6. pmc Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress
    Chun Yang
    School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
    Biomed Eng Online 10:61. 2011
  7. pmc Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3D fluid-structure interaction study
    Xueying Huang
    School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, PR China
    Biomed Eng Online 9:86. 2010
  8. pmc Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study
    Dalin Tang
    Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
    Biomed Eng Online 8:15. 2009
  9. pmc Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Stroke 40:3258-63. 2009
  10. pmc 3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis
    Dalin Tang
    Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 131:061010. 2009

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an IVUS-based fluid-structure interaction multi-patient study
    Rui Fan
    School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 13:32. 2014
    ....
  2. ncbi request reprint Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: data, modeling, validation, uncertainty and predictions
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China Worcester Polytechnic Institute, Worcester, MA 01609, USA Electronic address
    J Biomech 47:834-46. 2014
    ....
  3. pmc Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 12:105. 2013
    ..Long-term patient follow up was used to gather data and investigate if the correlations identified above were reproducible...
  4. pmc Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study
    Biyue Liu
    Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA
    Biomed Eng Online 11:43. 2012
    ..The role of flow wall shear stress in atherosclerosis progression has been under intensive investigation, while the impact of blood pressure on plaque progression has been under-studied...
  5. pmc Image-based modeling and precision medicine: patient-specific carotid and coronary plaque assessment and predictions
    Dalin Tang
    Southeast University, Nanjing 210018, China
    IEEE Trans Biomed Eng 60:643-51. 2013
    ..The key steps and factors in image-based models for human carotid and coronary plaques were illustrated, as well as grand challenges facing the researchers in the field to develop more accurate screening tools...
  6. pmc Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress
    Chun Yang
    School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
    Biomed Eng Online 10:61. 2011
    ..It has been well-accepted that atherosclerosis initiation and early progression correlate negatively with flow wall shear stresses (FSS). However, mechanisms governing advanced plaque progression are not well understood...
  7. pmc Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3D fluid-structure interaction study
    Xueying Huang
    School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, PR China
    Biomed Eng Online 9:86. 2010
    ....
  8. pmc Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study
    Dalin Tang
    Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
    Biomed Eng Online 8:15. 2009
    ..However, large-scale studies based on in vivo patient data combining mechanical stress analysis, plaque morphology and composition for carotid plaque vulnerability assessment are lacking in the current literature...
  9. pmc Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Stroke 40:3258-63. 2009
    ..To test that hypothesis, 3D fluid-structure interaction models were constructed based on in vivo MRI data of human atherosclerotic carotid plaques to assess structural stress behaviors of plaques with and without rupture...
  10. pmc 3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis
    Dalin Tang
    Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 131:061010. 2009
    ....
  11. pmc Patient-specific MRI-based 3D FSI RV/LV/patch models for pulmonary valve replacement surgery and patch optimization
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 130:041010. 2008
    ..More patient studies are needed to validate our findings...
  12. ncbi request reprint Effect of a lipid pool on stress/strain distributions in stenotic arteries: 3-D fluid-structure interactions (FSI) models
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 126:363-70. 2004
    ....
  13. ncbi request reprint Two-layer passive/active anisotropic FSI models with fiber orientation: MRI-based patient-specific modeling of right ventricular response to pulmonary valve insertion surgery
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Mol Cell Biomech 4:159-76. 2007
    ..Maximum Stress-P1 value from the active anisotropic model was 121.2% higher than that from the passive isotropic model. Computational RV volume predictions agreed well with CMR-measured volume data (error < 2%)...
  14. pmc A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress: in vivo MRI-based 2D/3D FSI models
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 41:727-36. 2008
    ..637). These pilot studies suggest that both lower PWS and lower FSS may contribute to continued plaque progression and should be taken into consideration in future investigations of diseases related to atherosclerosis...
  15. pmc Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 127:1185-94. 2005
    ..Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. Methods to assess plaque vulnerability noninvasively and predict possible plaque rupture are urgently needed...
  16. pmc Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 33:1789-801. 2005
    ..Large-scale and long-term patient studies are needed to further validate our findings for more accurate quantitative plaque vulnerability assessment...
  17. ncbi request reprint Effect of stenosis asymmetry on blood flow and artery compression: a three-dimensional fluid-structure interaction model
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 31:1182-93. 2003
    ..Stenosis asymmetry leads to higher artery compression, higher shear stress and a larger flow separation region. Computational results are verified by available experimental data...
  18. ncbi request reprint 3D MRI-based multicomponent FSI models for atherosclerotic plaques
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 32:947-60. 2004
    ..Large-scale patient studies are needed to validate the computational findings for possible plaque vulnerability assessment and rupture predictions...
  19. pmc Patient-specific artery shrinkage and 3D zero-stress state in multi-component 3D FSI models for carotid atherosclerotic plaques based on in vivo MRI data
    Xueying Huang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Mol Cell Biomech 6:121-34. 2009
    ..Our results indicated that accurate knowledge of artery shrinkages and the shrink-stretch process will considerably improve the accuracy of computational predictions made based on results from those in vivo MRI-based FSI models...
  20. pmc 3D critical plaque wall stress is a better predictor of carotid plaque rupture sites than flow shear stress: An in vivo MRI-based 3D FSI study
    Zhongzhao Teng
    Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA
    J Biomech Eng 132:031007. 2010
    ..Critical wall stress values may become indicators of high risk sites of rupture. Future work with a larger population will establish a possible CPWS-based plaque vulnerability classification...
  21. pmc IVUS-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessment
    Haofei Liu
    Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Mol Cell Biomech 9:77-93. 2012
    ..Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated...
  22. pmc Using contracting band to improve right ventricle ejection fraction for patients with repaired tetralogy of Fallot: a modeling study using patient-specific CMR-based 2-layer anisotropic models of human right and left ventricles
    Chun Yang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, Mass 01609, USA
    J Thorac Cardiovasc Surg 145:285-93, 293.e1-2. 2013
    ..A new surgical option of placing an elastic band in the right ventricle is proposed to improve right ventricular cardiac function as measured by the ejection fraction...
  23. pmc Using in vivo Cine and 3D multi-contrast MRI to determine human atherosclerotic carotid artery material properties and circumferential shrinkage rate and their impact on stress/strain predictions
    Haofei Liu
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 134:011008. 2012
    ..Accurate patient-specific material properties and circumferential shrinkage could considerably improve the accuracy of in vivo MRI-based computational stress/strain predictions...
  24. pmc Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling
    Mehmet H Kural
    Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, United States
    J Biomech 45:790-8. 2012
    ....
  25. pmc An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directions
    Zhongzhao Teng
    Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 42:2535-9. 2009
    ..50+/-0.22). These measurements of the material strength limits for human atherosclerotic carotid arteries could be useful in improving computational models that assess plaque vulnerability...
  26. doi request reprint Higher critical plaque wall stress in patients who died of coronary artery disease compared with those who died of other causes: a 3D FSI study based on ex vivo MRI of coronary plaques
    Xueying Huang
    School of Mathematical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA Electronic address
    J Biomech 47:432-7. 2014
    ..With further validation, analysis of CPWS may prove to be an important component in assessment of plaque vulnerability...
  27. pmc In vivo serial MRI-based models and statistical methods to quantify sensitivity and specificity of mechanical predictors for carotid plaque rupture: location and beyond
    Zheyang Wu
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    J Biomech Eng 133:064503. 2011
    ..With large-scale patient studies, this predictive modeling process may provide more solid ground for rupture predictor selection strategies and methods for image-based plaque vulnerability assessment...
  28. doi request reprint Quantifying effect of intraplaque hemorrhage on critical plaque wall stress in human atherosclerotic plaques using three-dimensional fluid-structure interaction models
    Xueying Huang
    School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, PRC
    J Biomech Eng 134:121004. 2012
    ..Large-scale studies are needed to further validate our findings...
  29. pmc Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo
    Jie Zheng
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 54:1360-8. 2005
    ..Noninvasive quantification of the MR contrast and mechanical properties of plaque may provide a comprehensive biomarker for the assessment of vulnerability of atherosclerotic plaques...
  30. ncbi request reprint Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: mediation by gradient of cell density
    Shu Q Liu
    Biomedical Engineering Department, E334, Technology Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
    Am J Physiol Heart Circ Physiol 285:H1072-80. 2003
    ..These observations suggest that nonuniform shear stress may regulate the pattern formation of SMCs, possibly via mediating the gradient of cell density in the neointima of vascular polymer implants...
  31. ncbi request reprint Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src
    Shu Q Liu
    Biomedical Engineering Department, E334, Technology Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
    Am J Physiol Heart Circ Physiol 285:H1081-90. 2003
    ..These observations suggest that PDGF-beta receptor and Src possibly serve as mediating factors in nonuniform shear-induced formation of cell density gradients and alignment of SMCs in the neointima of vascular polymer implants...

Research Grants6

  1. CRCNS: Modeling for Carotid Plaque Rupture and Stroke
    Dalin Tang; Fiscal Year: 2004
    ..abstract_text> ..
  2. CRCNS: Modeling for Carotid Plaque Rupture and Stroke
    Dalin Tang; Fiscal Year: 2005
    ..abstract_text> ..
  3. CRCNS: Modeling for Carotid Plaque Rupture and Stroke
    Dalin Tang; Fiscal Year: 2006
    ..abstract_text> ..
  4. CRCNS: Modeling for Carotid Plaque Rupture and Stroke
    Dalin Tang; Fiscal Year: 2007
    ..abstract_text> ..
  5. In Vivo IVUS Image-Based Modeling for Human Coronary Plaque Assessment
    Jie Zheng; Fiscal Year: 2010
    ..Commercialization of the research results is possible with the automation of model construction and data analysis procedures. ..
  6. In Vivo IVUS Image-Based Modeling for Human Coronary Plaque Assessment
    DALIN contact TANG; Fiscal Year: 2011
    ..Commercialization of the research results is possible with the automation of model construction and data analysis procedures. ..