MARK HAHN

Summary

Affiliation: Woods Hole Oceanographic Institution
Country: USA

Publications

  1. pmc Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio
    Larissa M Williams
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America Biology Department, Bates College, Lewiston, Maine, United States of America
    PLoS ONE 8:e79574. 2013
  2. pmc Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats
    Adam M Reitzel
    Biology Department, Woods Hole Oceanographic Institution, 45 Water Street, Woods Hole, MA 02568, USA
    BMC Evol Biol 14:6. 2014
  3. pmc Mechanistic research in aquatic toxicology: perspectives and future directions
    Mark E Hahn
    Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, United States
    Aquat Toxicol 105:67-71. 2011
  4. pmc Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site
    Marjorie F Oleksiak
    Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149 USA
    BMC Genomics 12:263. 2011
  5. pmc Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosum
    Kristen E Whalen
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    BMC Ecol 10:24. 2010
  6. ncbi The aryl hydrocarbon receptor: a comparative perspective
    M E Hahn
    Biology Department, Woods Hole Oceanographic Institution, MA 02543 1049, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 121:23-53. 1998
  7. pmc Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator
    Brad R Evans
    Department of Biology, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Mol Pharmacol 73:387-98. 2008
  8. ncbi Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, USA
    J Exp Zool A Comp Exp Biol 305:693-706. 2006
  9. ncbi Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus)
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543 1049, USA
    Pharmacogenetics 14:131-43. 2004
  10. ncbi Aryl hydrocarbon receptors: diversity and evolution
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Redfield 340, MS 32, 45 Water Street, MA 02543 1049, USA
    Chem Biol Interact 141:131-60. 2002

Detail Information

Publications49

  1. pmc Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio
    Larissa M Williams
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America Biology Department, Bates College, Lewiston, Maine, United States of America
    PLoS ONE 8:e79574. 2013
    ..Our results provide a foundation for understanding the role of nrf genes in normal development and in regulating the response to oxidative stress in vertebrate embryos. ..
  2. pmc Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats
    Adam M Reitzel
    Biology Department, Woods Hole Oceanographic Institution, 45 Water Street, Woods Hole, MA 02568, USA
    BMC Evol Biol 14:6. 2014
    ....
  3. pmc Mechanistic research in aquatic toxicology: perspectives and future directions
    Mark E Hahn
    Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, United States
    Aquat Toxicol 105:67-71. 2011
    ....
  4. pmc Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site
    Marjorie F Oleksiak
    Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149 USA
    BMC Genomics 12:263. 2011
    ..heteroclitus populations inhabiting the New Bedford Harbor, Massachusetts (NBH) Superfund site (PCB-resistant) and a reference site, Scorton Creek, Massachusetts (SC; PCB-sensitive)...
  5. pmc Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosum
    Kristen E Whalen
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    BMC Ecol 10:24. 2010
    ....
  6. ncbi The aryl hydrocarbon receptor: a comparative perspective
    M E Hahn
    Biology Department, Woods Hole Oceanographic Institution, MA 02543 1049, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 121:23-53. 1998
    ..Finally, some of the most promising directions for future research on the comparative biochemistry and molecular biology of the AHR and ARNT are discussed...
  7. pmc Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator
    Brad R Evans
    Department of Biology, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Mol Pharmacol 73:387-98. 2008
    ..We propose a mechanism of AHRR action involving "transrepression" of AHR signaling through protein-protein interactions rather than by inhibition of the formation or DNA binding of the AHR-ARNT complex...
  8. ncbi Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, USA
    J Exp Zool A Comp Exp Biol 305:693-706. 2006
    ....
  9. ncbi Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus)
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543 1049, USA
    Pharmacogenetics 14:131-43. 2004
    ..We discuss the possibility of other functional differences in AHR1 variants or their interaction with other killifish loci (AHR2, AHRR) that may contribute to differences in dioxin sensitivity...
  10. ncbi Aryl hydrocarbon receptors: diversity and evolution
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Redfield 340, MS 32, 45 Water Street, MA 02543 1049, USA
    Chem Biol Interact 141:131-60. 2002
    ..Sensitivity to the developmental toxicity of dioxins and related chemicals may have had its origin in the evolution of dioxin-binding capacity of the AHR in the vertebrate lineage...
  11. ncbi Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment
    Mark E Hahn
    Biology Department, Woods Hole Oceanographic Institution, MA 02543 1049, USA
    Sci Total Environ 289:49-69. 2002
    ..Such a battery of mechanism-based, in vitro bioassays could be incorporated into monitoring efforts under recently adopted hazard analysis and critical control point (HACCP) programs...
  12. pmc Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family
    M E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Proc Natl Acad Sci U S A 94:13743-8. 1997
    ....
  13. ncbi Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls
    M E Hahn
    Biology Department, Woods Hole Oceanographic Institution, Massachusetts 02543, USA
    Arch Biochem Biophys 329:163-74. 1996
    ..PLHC-1 cells grown in medium supplemented with ALA may be a useful model System for studying mechanisms of chemical uroporphyria induced by Ah receptor agonists...
  14. ncbi Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fish
    M E Hahn
    Department of Biology, Woods Hole Oceanographic Institution Woods Hole, MA 02543 1049, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:67-75. 1998
    ..Agnathan fish such as hagfish and lamprey may be interesting model species for examining possible ancestral AHR functions not related to CYP1A regulation...
  15. pmc The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome
    J V Goldstone
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Dev Biol 300:366-84. 2006
    ..These results should facilitate future studies on the evolution of chemical defense gene networks and the role of these networks in protecting embryos from chemical stress during development...
  16. ncbi Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes
    S M Bello
    Biology Department, MS32, Woods Hole Oceanographic Institution, 45 Water Street, Woods Hole, Massachusetts 02543, USA
    Toxicol Sci 60:77-91. 2001
    ..The resistance is systemic and pretranslational, and exhibits compound-specific differences in magnitude. These findings suggest an alteration in the AhR signal transduction pathway in NBH fish...
  17. ncbi Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness
    A M Tarrant
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    J Mol Endocrinol 37:105-20. 2006
    ..In addition, regulation of ERRalpha expression in killifish apparently differs from regulation in mammals. Together, these features may facilitate determination of both conserved and specialized ERR gene functions...
  18. ncbi Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian
    S I Karchner
    Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543 1049, USA
    Mar Environ Res 50:51-6. 2000
    ..Future studies include the in vitro expression and functional characterization of AHRs from these and other non-mammalian vertebrates...
  19. ncbi cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas
    B A Jensen
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543
    Toxicol Sci 64:41-56. 2001
    ..Together, these results demonstrate that the use of in vitro-expressed proteins is a promising approach for addressing molecular and biochemical questions concerning PHAH toxicity in endangered or protected species...
  20. ncbi The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant mice
    M E Hahn
    Department of Biology, William Paterson University, Wayne, NJ 07470, USA
    Pharmacol Biochem Behav 67:729-38. 2000
    ..The effects of cocaine, though reliable, were small, explaining only 1-2% of the total sum of squares. The size of the effect is in part due to the differential effect of cocaine on different genotypes...
  21. ncbi Genetic and developmental influences on infant mouse ultrasonic calling. II. Developmental patterns in the calls of mice 2-12 days of age
    M E Hahn
    Department of Biology, William Paterson University, Wayne, New Jersey 07470 2103, USA
    Behav Genet 28:315-25. 1998
    ..Hybrid pups produced more calls of greater length and a lower frequency than inbred pups. These results indicate the presence of cues that could allow adult mice to behave differentially toward pups as a function of their age and sex...
  22. pmc The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor
    Sibel I Karchner
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Proc Natl Acad Sci U S A 103:6252-7. 2006
    ..These studies provide a molecular understanding of species differences in sensitivity to dioxin-like compounds and suggest an approach to using the AHR as a marker of dioxin susceptibility in wildlife...
  23. ncbi Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus
    Rebeka R Merson
    Biology Department, Woods Hole Oceanographic Institution, MA 02543, USA
    Comp Biochem Physiol C Toxicol Pharmacol 142:85-94. 2006
    ..Killifish ARNT2 co-precipitated with AHR1 and AHR2. These sensitive, specific, and versatile antibodies will be valuable to researchers investigating AHR signaling and other physiological processes involving AHR and AHRR proteins...
  24. ncbi Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Maria E Jönsson
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Toxicol Sci 100:180-93. 2007
    ..Moreover, the developmental patterns of expression and induction suggest that CYP1 enzymes could function in normal development and in developmental toxicity of PCB126 in fish embryos...
  25. ncbi Fish models in toxicology
    Michael J Carvan
    Great Lakes Wisconsin Aquaculture Technology and Environmental Research WATER Institute, University of Wisconsin Milwaukee, 600 E Greenfield Avenue, Milwaukee, WI 53204, USA
    Zebrafish 4:9-20. 2007
  26. doi Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States
    Eric W Montie
    Woods Hole Oceanographic Institution WHOI, Woods Hole, MA, United States
    Aquat Toxicol 86:397-412. 2008
    ..The OH-PCBs thus formed have the potential to interfere with thyroid hormone homeostasis...
  27. ncbi Functional characterization and evolutionary history of two aryl hydrocarbon receptor isoforms (AhR1 and AhR2) from avian species
    Tomoko Yasui
    Center for Marine Environmental Studies CMES, Ehime University, Matsuyama 790 8577, Japan
    Toxicol Sci 99:101-17. 2007
    ..The identification and characterization of avian AhR1 and AhR2 provide new insight into the evolution of AhR structure and function in vertebrates...
  28. doi Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum
    Kristen E Whalen
    Biology Department, Woods Hole Oceanographic Institution, MS 32, 45 Water Street, Woods Hole, MA 02543, USA
    Arch Biochem Biophys 478:7-17. 2008
    ..These results provide new insights into metazoan GST diversity and the biochemical mechanisms used by marine organisms to cope with their chemically defended prey...
  29. ncbi Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo
    Brad R Evans
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Arch Biochem Biophys 441:151-67. 2005
    ..Both AHRRs were expressed and induced by TCDD in zebrafish embryos. Thus, zebrafish possess duplicate AHR-regulated AHRR paralogs that act in a negative feedback loop to repress the AHR signaling pathway...
  30. ncbi cDNA cloning of an aryl hydrocarbon receptor from Baikal seals (Phoca sibirica)
    Eun Young Kim
    Environmental Chemistry and Ecotoxicology, Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan
    Mar Environ Res 54:285-9. 2002
    ..This implies that Baikal seal may also be sensitive to dioxin effects...
  31. pmc The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptor
    Eric A Andreasen
    Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA
    Mol Pharmacol 62:234-49. 2002
    ..Finally, using chimeric zfAHR1/zfAHR2 constructs, the lack of TCDD-mediated transcriptional activity was localized to the ligand-binding and C-terminal domains of zfAHR1...
  32. ncbi Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells
    Eli V Hestermann
    Biology Department, Redfield 340, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Aquat Toxicol 58:201-13. 2002
    ..Taken together, the results indicate that PLHC-1 cells are amenable to analysis of AHR-cell cycle interactions, but that heterogeneity of sub-clones may complicate their use for investigating AHR-mediated changes in proliferation...
  33. ncbi Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cells
    Eli V Hestermann
    Biology Department, Redfield 340, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Biochem Pharmacol 63:1405-14. 2002
    ..These results provide a quantitative link between changes in receptor expression and a downstream response, establishing a foundation for future studies of receptor expression and sensitivity to toxic responses in vitro and in vivo...
  34. ncbi Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants
    Wade H Powell
    Biology Department, Kenyon College, Gambier, Ohio 43022, USA
    J Exp Zool 294:17-29. 2002
    ..This study extends the understanding of hypoxia signaling in fish, the evolution and diversity of HIF function, and the evolution of the PAS family of proteins...
  35. ncbi Gonadal feminization and halogenated environmental contaminants in common terns (Sterna hirundo): evidence that ovotestes in male embryos do not persist to the prefledgling stage
    Constance A Hart
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Ecotoxicology 12:125-40. 2003
    ....
  36. ncbi Naturally produced halogenated dimethyl bipyrroles bind to the aryl hydrocarbon receptor and induce cytochrome P4501A and porphyrin accumulation in chicken embryo hepatocytes
    Sheryl A Tittlemier
    Centre for Analytical and Environmental Chemistry, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Environ Toxicol Chem 22:1622-31. 2003
    ..000017. The results of this work illustrate that HDBPs act as agonist ligands for the AhR in the same manner as many anthropogenic organohalogens...
  37. ncbi Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, North Carolina 27708 0328, USA
    Environ Toxicol Chem 22:2337-43. 2003
    ....
  38. ncbi Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2
    Sibel I Karchner
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    J Biol Chem 277:6949-59. 2002
    ..Phylogenetic analysis shows that AHRR, AHR1, and AHR2 are distinct genes, members of an AHR gene family; these three vertebrate AHR-like genes descended from a single invertebrate AHR...
  39. ncbi Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)
    Sonya M Billiard
    Department of Biology, Queen s University, ON, Kingston, Canada
    Comp Biochem Physiol B Biochem Mol Biol 133:55-68. 2002
    ..If PAH toxicity is receptor-mediated and predicted by induction potencies, we will have a powerful mechanistic-based tool for rapidly assessing the risk of toxicity to fish of PAH from any source...
  40. ncbi Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus)
    Wade H Powell
    Marine Biological Laboratory, Woods Hole, MA, USA
    Mar Environ Res 58:119-24. 2004
    ..These studies may ultimately shed light on the importance of P4501A activity in xenobiotic toxicity...
  41. pmc Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics
    Mark J Reimers
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 279:38303-12. 2004
    ..Together these results indicate that class I-like ADH is conserved in zebrafish, albeit with mixed functional properties...
  42. pmc AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes
    Sibel I Karchner
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Biochem J 392:153-61. 2005
    ..We speculate that AHR1B may have a physiological role, such as in embryonic development, whereas AHR2 mediates the response to xenobiotics...
  43. ncbi cDNA cloning and characterization of an aryl hydrocarbon receptor from the harbor seal (Phoca vitulina): a biomarker of dioxin susceptibility?
    Eun Young Kim
    Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Aquat Toxicol 58:57-73. 2002
    ..The characteristics of the AHR potentially can be used as a biomarker of susceptibility to dioxin-like compounds, contributing to the assessment of the risk of these compounds to marine mammals and other protected animals...
  44. ncbi Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics
    Shannon Mala Bard
    Department of Biology, Mail Stop 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Aquat Toxicol 59:237-51. 2002
    ....
  45. ncbi Blubber morphology in wild bottlenose dolphins (Tursiops truncatus) from the Southeastern United States: influence of geographic location, age class, and reproductive state
    Eric W Montie
    Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    J Morphol 269:496-511. 2008
    ..This study demonstrates that ontogeny, geography, and reproductive state may influence morphological parameters such as structural fiber densities and adipocyte numbers and sizes, measured in bottlenose dolphin blubber...
  46. ncbi The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells
    Xinhai Yang
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
    Oncogene 24:7869-81. 2005
    ..These results suggest that the AhR influences the expression of c-Myc, a protein critical to malignant transformation...
  47. pmc A ligand for the aryl hydrocarbon receptor isolated from lung
    Jiasheng Song
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706, USA
    Proc Natl Acad Sci U S A 99:14694-9. 2002
    ....
  48. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    ..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
  49. pmc Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model
    Cole W Matson
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708 0328, United States
    Aquat Toxicol 87:289-95. 2008
    ....

Research Grants12

  1. AH RECEPTOR IN NONMAMMALIAN MODELS
    MARK HAHN; Fiscal Year: 1999
    ..We will determine the diversity and function of AHR genes in fish species commonly used as aquatic models, test the hypothesis that a second AHR-like gene exists in humans, and compare the function of fish and human AHRs. ..
  2. Mechanisms of Embryo Response to Oxidative Stress
    Mark E Hahn; Fiscal Year: 2010
    ....
  3. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2010
    ....
  4. Mechanisms of Embryo Response to Oxidative Stress
    MARK HAHN; Fiscal Year: 2009
    ....
  5. AHR signaling in Mammalian and Non-Mammalian Models
    MARK HAHN; Fiscal Year: 2007
    ..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
  6. AHR signaling in Mammalian and Non-Mammalian Models
    MARK HAHN; Fiscal Year: 2006
    ..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
  7. AHR signaling in Mammalian and Non-Mammalian Models
    MARK HAHN; Fiscal Year: 2005
    ..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
  8. AHR signaling in Mammalian and Non-Mammalian Models
    MARK HAHN; Fiscal Year: 2004
    ..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
  9. AHR signaling in Mammalian and Non-Mammalian Models
    MARK HAHN; Fiscal Year: 2003
    ..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
  10. AH RECEPTOR IN NON-MAMMALIAN MODELS
    MARK HAHN; Fiscal Year: 2001
    ..We will determine the diversity and function of AHR genes in fish species commonly used as aquatic models, test the hypothesis that a second AHR-like gene exists in humans, and compare the function of fish and human AHRs. ..
  11. AH RECEPTOR IN NON-MAMMALIAN MODELS
    MARK HAHN; Fiscal Year: 2000
    ..We will determine the diversity and function of AHR genes in fish species commonly used as aquatic models, test the hypothesis that a second AHR-like gene exists in humans, and compare the function of fish and human AHRs. ..
  12. AHR signaling in Mammalian and Non-Mammalian Models
    Mark E Hahn; Fiscal Year: 2011
    ....