Research Topics
| MARK HAHNSummaryAffiliation: Woods Hole Oceanographic Institution Country: USA Publications
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Publications
Mechanistic research in aquatic toxicology: perspectives and future directionsMark E Hahn
Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, United States
Aquat Toxicol 105:67-71. 2011....- Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund siteMarjorie F Oleksiak
Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149 USA
BMC Genomics 12:263. 2011..heteroclitus populations inhabiting the New Bedford Harbor, Massachusetts (NBH) Superfund site (PCB-resistant) and a reference site, Scorton Creek, Massachusetts (SC; PCB-sensitive)... - Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosumKristen E Whalen
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
BMC Ecol 10:24. 2010.... 
Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenylsM E Hahn
Biology Department, Woods Hole Oceanographic Institution, Massachusetts 02543, USA
Arch Biochem Biophys 329:163-74. 1996..PLHC-1 cells grown in medium supplemented with ALA may be a useful model System for studying mechanisms of chemical uroporphyria induced by Ah receptor agonists...- Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus)Mark E Hahn
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543 1049, USA
Pharmacogenetics 14:131-43. 2004..We discuss the possibility of other functional differences in AHR1 variants or their interaction with other killifish loci (AHR2, AHRR) that may contribute to differences in dioxin sensitivity... - Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomicsMark E Hahn
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, USA
J Exp Zool A Comp Exp Biol 305:693-706. 2006.... - Aryl hydrocarbon receptors: diversity and evolutionMark E Hahn
Biology Department, Woods Hole Oceanographic Institution, Redfield 340, MS 32, 45 Water Street, MA 02543 1049, USA
Chem Biol Interact 141:131-60. 2002..Sensitivity to the developmental toxicity of dioxins and related chemicals may have had its origin in the evolution of dioxin-binding capacity of the AHR in the vertebrate lineage... - Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocatorBrad R Evans
Department of Biology, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Mol Pharmacol 73:387-98. 2008..We propose a mechanism of AHRR action involving "transrepression" of AHR signaling through protein-protein interactions rather than by inhibition of the formation or DNA binding of the AHR-ARNT complex... - Biomarkers and bioassays for detecting dioxin-like compounds in the marine environmentMark E Hahn
Biology Department, Woods Hole Oceanographic Institution, MA 02543 1049, USA
Sci Total Environ 289:49-69. 2002..Such a battery of mechanism-based, in vitro bioassays could be incorporated into monitoring efforts under recently adopted hazard analysis and critical control point (HACCP) programs... - Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS familyM E Hahn
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Proc Natl Acad Sci U S A 94:13743-8. 1997.... - The aryl hydrocarbon receptor: a comparative perspectiveM E Hahn
Biology Department, Woods Hole Oceanographic Institution, MA 02543 1049, USA
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 121:23-53. 1998..Finally, some of the most promising directions for future research on the comparative biochemistry and molecular biology of the AHR and ARNT are discussed... - Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fishM E Hahn
Department of Biology, Woods Hole Oceanographic Institution Woods Hole, MA 02543 1049, USA
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:67-75. 1998..Agnathan fish such as hagfish and lamprey may be interesting model species for examining possible ancestral AHR functions not related to CYP1A regulation... - Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsivenessA M Tarrant
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
J Mol Endocrinol 37:105-20. 2006..In addition, regulation of ERRalpha expression in killifish apparently differs from regulation in mammals. Together, these features may facilitate determination of both conserved and specialized ERR gene functions... - Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymesS M Bello
Biology Department, MS32, Woods Hole Oceanographic Institution, 45 Water Street, Woods Hole, Massachusetts 02543, USA
Toxicol Sci 60:77-91. 2001..The resistance is systemic and pretranslational, and exhibits compound-specific differences in magnitude. These findings suggest an alteration in the AhR signal transduction pathway in NBH fish... - The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genomeJ V Goldstone
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Dev Biol 300:366-84. 2006..These results should facilitate future studies on the evolution of chemical defense gene networks and the role of these networks in protecting embryos from chemical stress during development... - Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibianS I Karchner
Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543 1049, USA
Mar Environ Res 50:51-6. 2000..Future studies include the in vitro expression and functional characterization of AHRs from these and other non-mammalian vertebrates... - cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucasB A Jensen
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543
Toxicol Sci 64:41-56. 2001..Together, these results demonstrate that the use of in vitro-expressed proteins is a promising approach for addressing molecular and biochemical questions concerning PHAH toxicity in endangered or protected species... - The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant miceM E Hahn
Department of Biology, William Paterson University, Wayne, NJ 07470, USA
Pharmacol Biochem Behav 67:729-38. 2000..The effects of cocaine, though reliable, were small, explaining only 1-2% of the total sum of squares. The size of the effect is in part due to the differential effect of cocaine on different genotypes... - Genetic and developmental influences on infant mouse ultrasonic calling. II. Developmental patterns in the calls of mice 2-12 days of ageM E Hahn
Department of Biology, William Paterson University, Wayne, New Jersey 07470 2103, USA
Behav Genet 28:315-25. 1998..Hybrid pups produced more calls of greater length and a lower frequency than inbred pups. These results indicate the presence of cues that could allow adult mice to behave differentially toward pups as a function of their age and sex... - The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptorSibel I Karchner
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Proc Natl Acad Sci U S A 103:6252-7. 2006..These studies provide a molecular understanding of species differences in sensitivity to dioxin-like compounds and suggest an approach to using the AHR as a marker of dioxin susceptibility in wildlife... - Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitusRebeka R Merson
Biology Department, Woods Hole Oceanographic Institution, MA 02543, USA
Comp Biochem Physiol C Toxicol Pharmacol 142:85-94. 2006..Killifish ARNT2 co-precipitated with AHR1 and AHR2. These sensitive, specific, and versatile antibodies will be valuable to researchers investigating AHR signaling and other physiological processes involving AHR and AHRR proteins... - Functional characterization and evolutionary history of two aryl hydrocarbon receptor isoforms (AhR1 and AhR2) from avian speciesTomoko Yasui
Center for Marine Environmental Studies CMES, Ehime University, Matsuyama 790 8577, Japan
Toxicol Sci 99:101-17. 2007..The identification and characterization of avian AhR1 and AhR2 provide new insight into the evolution of AhR structure and function in vertebrates... - Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxinMaria E Jönsson
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
Toxicol Sci 100:180-93. 2007..Moreover, the developmental patterns of expression and induction suggest that CYP1 enzymes could function in normal development and in developmental toxicity of PCB126 in fish embryos... - Fish models in toxicologyMichael J Carvan
Great Lakes Wisconsin Aquaculture Technology and Environmental Research (WATER) Institute, University of Wisconsin-Milwaukee, 600 E. Greenfield Avenue, Milwaukee, WI 53204, USA
Zebrafish 4:9-20. 2007 
Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United StatesEric W Montie
Woods Hole Oceanographic Institution WHOI, Woods Hole, MA, United States
Aquat Toxicol 86:397-412. 2008..The OH-PCBs thus formed have the potential to interfere with thyroid hormone homeostasis...- Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosumKristen E Whalen
Biology Department, Woods Hole Oceanographic Institution, MS 32, 45 Water Street, Woods Hole, MA 02543, USA
Arch Biochem Biophys 478:7-17. 2008..These results provide new insights into metazoan GST diversity and the biochemical mechanisms used by marine organisms to cope with their chemically defended prey... - Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivoBrad R Evans
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Arch Biochem Biophys 441:151-67. 2005..Both AHRRs were expressed and induced by TCDD in zebrafish embryos. Thus, zebrafish possess duplicate AHR-regulated AHRR paralogs that act in a negative feedback loop to repress the AHR signaling pathway... - AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genesSibel I Karchner
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Biochem J 392:153-61. 2005..We speculate that AHR1B may have a physiological role, such as in embryonic development, whereas AHR2 mediates the response to xenobiotics... - Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2Sibel I Karchner
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
J Biol Chem 277:6949-59. 2002..Phylogenetic analysis shows that AHRR, AHR1, and AHR2 are distinct genes, members of an AHR gene family; these three vertebrate AHR-like genes descended from a single invertebrate AHR... - Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variantsWade H Powell
Biology Department, Kenyon College, Gambier, Ohio 43022, USA
J Exp Zool 294:17-29. 2002..This study extends the understanding of hypoxia signaling in fish, the evolution and diversity of HIF function, and the evolution of the PAS family of proteins... - Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cellsEli V Hestermann
Biology Department, Redfield 340, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Biochem Pharmacol 63:1405-14. 2002..These results provide a quantitative link between changes in receptor expression and a downstream response, establishing a foundation for future studies of receptor expression and sensitivity to toxic responses in vitro and in vivo... - Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cellsEli V Hestermann
Biology Department, Redfield 340, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Aquat Toxicol 58:201-13. 2002..Taken together, the results indicate that PLHC-1 cells are amenable to analysis of AHR-cell cycle interactions, but that heterogeneity of sub-clones may complicate their use for investigating AHR-mediated changes in proliferation... - cDNA cloning and characterization of an aryl hydrocarbon receptor from the harbor seal (Phoca vitulina): a biomarker of dioxin susceptibility?Eun Young Kim
Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Aquat Toxicol 58:57-73. 2002..The characteristics of the AHR potentially can be used as a biomarker of susceptibility to dioxin-like compounds, contributing to the assessment of the risk of these compounds to marine mammals and other protected animals... - The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptorEric A Andreasen
Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA
Mol Pharmacol 62:234-49. 2002..Finally, using chimeric zfAHR1/zfAHR2 constructs, the lack of TCDD-mediated transcriptional activity was localized to the ligand-binding and C-terminal domains of zfAHR1... - Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)Sonya M Billiard
Department of Biology, Queen s University, ON, Kingston, Canada
Comp Biochem Physiol B Biochem Mol Biol 133:55-68. 2002..If PAH toxicity is receptor-mediated and predicted by induction potencies, we will have a powerful mechanistic-based tool for rapidly assessing the risk of toxicity to fish of PAH from any source... - cDNA cloning of an aryl hydrocarbon receptor from Baikal seals (Phoca sibirica)Eun Young Kim
Environmental Chemistry and Ecotoxicology, Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan
Mar Environ Res 54:285-9. 2002..This implies that Baikal seal may also be sensitive to dioxin effects... - Naturally produced halogenated dimethyl bipyrroles bind to the aryl hydrocarbon receptor and induce cytochrome P4501A and porphyrin accumulation in chicken embryo hepatocytesSheryl A Tittlemier
Centre for Analytical and Environmental Chemistry, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Environ Toxicol Chem 22:1622-31. 2003..000017. The results of this work illustrate that HDBPs act as agonist ligands for the AhR in the same manner as many anthropogenic organohalogens... - Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristicsMark J Reimers
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
J Biol Chem 279:38303-12. 2004..Together these results indicate that class I-like ADH is conserved in zebrafish, albeit with mixed functional properties... - Gonadal feminization and halogenated environmental contaminants in common terns (Sterna hirundo): evidence that ovotestes in male embryos do not persist to the prefledgling stageConstance A Hart
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Ecotoxicology 12:125-40. 2003.... - Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus)Wade H Powell
Marine Biological Laboratory, Woods Hole, MA, USA
Mar Environ Res 58:119-24. 2004..These studies may ultimately shed light on the importance of P4501A activity in xenobiotic toxicity... - Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure historiesJoel N Meyer
Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, North Carolina 27708-0328, USA
Environ Toxicol Chem 22:2337-43. 2003.... - Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental modelCole W Matson
Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708 0328, United States
Aquat Toxicol 87:289-95. 2008.... - A ligand for the aryl hydrocarbon receptor isolated from lungJiasheng Song
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706, USA
Proc Natl Acad Sci U S A 99:14694-9. 2002.... - Blubber morphology in wild bottlenose dolphins (Tursiops truncatus) from the Southeastern United States: influence of geographic location, age class, and reproductive stateEric W Montie
Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
J Morphol 269:496-511. 2008..This study demonstrates that ontogeny, geography, and reproductive state may influence morphological parameters such as structural fiber densities and adipocyte numbers and sizes, measured in bottlenose dolphin blubber... - Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobioticsShannon Mala Bard
Department of Biology, Mail Stop 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Aquat Toxicol 59:237-51. 2002.... - The genome of the sea urchin Strongylocentrotus purpuratusErica Sodergren
Science 314:941-52. 2006..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes... - The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cellsXinhai Yang
Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
Oncogene 24:7869-81. 2005..These results suggest that the AhR influences the expression of c-Myc, a protein critical to malignant transformation...
Research Grants
- Mechanisms of Embryo Response to Oxidative StressMark E Hahn; Fiscal Year: 2010....
- AHR signaling in Mammalian and Non-Mammalian ModelsMark E Hahn; Fiscal Year: 2010....
- AHR signaling in Mammalian and Non-Mammalian ModelsMARK HAHN; Fiscal Year: 2007..These studies will provide a better understanding of the possible role of human AHRR in modulating dioxin effects. ..
- AH RECEPTOR IN NON-MAMMALIAN MODELSMARK HAHN; Fiscal Year: 2001..We will determine the diversity and function of AHR genes in fish species commonly used as aquatic models, test the hypothesis that a second AHR-like gene exists in humans, and compare the function of fish and human AHRs. ..
- AHR signaling in Mammalian and Non-Mammalian ModelsMark E Hahn; Fiscal Year: 2011....