Research Topics
Genomes and Genes | J V GoldstoneSummaryAffiliation: Woods Hole Oceanographic Institution Country: USA Publications
Research Grants
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Detail Information
Publications
The genome of the sea urchin Strongylocentrotus purpuratusErica Sodergren
Science 314:941-52. 2006..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
Methodological approaches to cytochrome P450 profiling in embryosJared V Goldstone
Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
Methods Mol Biol 889:265-75. 2012..Here, we present methods to examine CYP expression during early development in zebrafish, with an emphasis on developmental microarrays...- Identification and developmental expression of the full complement of Cytochrome P450 genes in ZebrafishJared V Goldstone
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
BMC Genomics 11:643. 2010..Here we identify and annotate the full suite of CYP genes in zebrafish, compare these to the human CYP gene complement, and determine the expression of CYP genes during normal development... - Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosumKristen E Whalen
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
BMC Ecol 10:24. 2010.... - The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genomeJ V Goldstone
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Dev Biol 300:366-84. 2006..These results should facilitate future studies on the evolution of chemical defense gene networks and the role of these networks in protecting embryos from chemical stress during development... - Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensisJ V Goldstone
Biology Department MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Cell Biol Toxicol 24:483-502. 2008..New genomic resources should stimulate the study of chemical stress sensing and response mechanisms in cnidaria and allow us to further illuminate the evolution of chemical defense gene networks... 
Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene familyJared V Goldstone
Department of Biology, Woods Hole Oceanographic Institution, Woods Hole
Mol Biol Evol 24:2619-31. 2007..The CYP1 family has undergone multiple rounds of gene duplication followed by functional divergence, with at least one gene lost in mammals. This study provides new insight into the origin and evolution of CYP1 genes...- Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDDJ V Goldstone
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
Arch Biochem Biophys 482:7-16. 2009..CYP1D1 in zebrafish is a CYP1A-like gene that could have metabolic functions targeting endogenous compounds... - The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysisCeline A J Godard
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Biochem Biophys Res Commun 331:1016-24. 2005..RT-PCR results indicate that CYP1C1 and CYP1C2 are variously expressed in several scup organs... - Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafishMaria E Jönsson
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Toxicol Appl Pharmacol 221:29-41. 2007..While CYP1A may have a protective role against AHR agonists in liver and gut, CYP1B1, CYP1C1, and CYP1C2 may also play endogenous roles in eye and heart and possibly other organs, as well as during development... - Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosumKristen E Whalen
Biology Department, Woods Hole Oceanographic Institution, MS 32, 45 Water Street, Woods Hole, MA 02543, USA
Arch Biochem Biophys 478:7-17. 2008..These results provide new insights into metazoan GST diversity and the biochemical mechanisms used by marine organisms to cope with their chemically defended prey... - Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp.): a CYP3 line in early deuterostomes?Tim Verslycke
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Mol Phylogenet Evol 40:760-71. 2006..Comparing these genes with other members of the CYP clan 3, show that the Ciona sequences bear remarkable similarity to vertebrate CYP3A genes, and may be an early deuterostome CYP3 line... - New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126Juliano Zanette
Biology Department, MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Aquat Toxicol 93:234-43. 2009..Determining basal and induced levels of protein and the substrate specificity for all five CYP1s will be necessary to better understand their roles in chemical effects and physiology... - Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes)Jared V Goldstone
Biology Department, Redfield 3 42 MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Mar Environ Res 66:19-20. 2008..There also were differing numbers of putative xenobiotic response elements in the CYP1D1 of the various species. Whether the stickleback or medaka genes are inducible by aryl hydrocarbon receptor (AHR) agonists is yet to be determined... - Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiationLars Behrendt
Biology Department, Redfield 352 MS 32, Woods Hole Oceanographic Institution, 45 Water Street, Woods Hole, MA 02543, USA
Aquat Toxicol 98:74-82. 2010..The results show that UVB can induce expression of CYP1 genes as well stress response genes in developing zebrafish, and that UVB intensity and duration influence the responses... - Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congenersJennifer J Schlezinger
Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
Aquat Toxicol 77:422-32. 2006..The uncoupling and release of ROS further suggest a participation of CYP1A in the oxidative stress associated with some planar halogenated aryl hydrocarbon receptor agonists... - Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologsJahnavi C Prasad
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
Biochemistry 46:2640-54. 2007..The results demonstrate the utility of this ensemble modeling method, which can account for uncertainty inherent in homology modeling and docking by producing statistical distributions of ligand positions... - Cloning a new cytochrome P450 isoform (CYP356A1) from oyster Crassostrea gigasGuilherme de Toledo-Silva
Laboratório de Biomarcadores de Contaminação Aquática, Departamento de Bioquimica, CCB, UFSC, Florianopolis, SC, Brazil
Mar Environ Res 66:15-8. 2008..Results showed slightly higher CYP356A1 expression in digestive gland and mantle, than the other tissues, indicating a possible role of the CYP356A1 in xenobiotic biotransformation and/or steroid metabolism... - Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognitaPierre Abad
INRA, UMR 1301, 400 Route des Chappes, F 06903 Sophia Antipolis, France
Nat Biotechnol 26:909-15. 2008..Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies...
Research Grants
- Mechanism of cytochrome P450 uncoupling and inactivationJARED GOLDSTONE; Fiscal Year: 2005..Recently identified AhR-agonistic persistent pollutants, such as polybrominated diphenyl ethers will also be investigated. ..