Surendra Sharma

Summary

Affiliation: Women and Infants' Hospital
Country: USA

Publications

  1. pmc Haplotype-dependent differential activation of the human IL-10 gene promoter in macrophages and trophoblasts: implications for placental IL-10 deficiency and pregnancy complications
    Surendra Sharma
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    Am J Reprod Immunol 64:179-87. 2010
  2. ncbi Genes regulating implantation and fetal development: a focus on mouse knockout models
    Surendra Sharma
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Brown University, Providence, RI 02905, USA
    Front Biosci 11:2123-37. 2006
  3. pmc Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia
    Surendra Sharma
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Reprod Immunol 85:112-6. 2010
  4. pmc Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery
    Shaun P Murphy
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Warren Alpert Medical School of Brown University, Providence, RI, USA
    Am J Obstet Gynecol 200:308.e1-9. 2009
  5. pmc Reduced IL-10 production in fetal type II epithelial cells exposed to mechanical stretch is mediated via activation of IL-6-SOCS3 signaling pathway
    Michael A Hokenson
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 8:e59598. 2013
  6. pmc Differential expression of MMP-2 and -9 and their inhibitors in fetal lung cells exposed to mechanical stretch: regulation by IL-10
    Renda L Hawwa
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA
    Lung 189:341-9. 2011
  7. pmc Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk
    Elisabeth C McGowan
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02915, USA
    Pediatr Res 66:455-60. 2009
  8. pmc TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes
    Jessica E Thaxton
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02905 USA
    J Immunol 183:1144-54. 2009
  9. pmc Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep
    Susan S Cohen
    Department of Pediatrics, The Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905 2499, USA
    Neuroimmunomodulation 20:264-73. 2013
  10. pmc Vascular IL-10: a protective role in preeclampsia
    Satyan Kalkunte
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Reprod Immunol 88:165-9. 2011

Collaborators

Detail Information

Publications36

  1. pmc Haplotype-dependent differential activation of the human IL-10 gene promoter in macrophages and trophoblasts: implications for placental IL-10 deficiency and pregnancy complications
    Surendra Sharma
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    Am J Reprod Immunol 64:179-87. 2010
    ..We hypothesized that because of these genotypic changes, the IL-10 promoter might be expressed in a cell type-specific manner and may respond differentially to inflammatory triggers...
  2. ncbi Genes regulating implantation and fetal development: a focus on mouse knockout models
    Surendra Sharma
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Brown University, Providence, RI 02905, USA
    Front Biosci 11:2123-37. 2006
    ..The critical genetic loci involved in blastocyst implantation and fetal growth will be discussed with a focus on those genes with available mouse knockout models...
  3. pmc Beyond the threshold: an etiological bridge between hypoxia and immunity in preeclampsia
    Surendra Sharma
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Reprod Immunol 85:112-6. 2010
    ....
  4. pmc Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery
    Shaun P Murphy
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Warren Alpert Medical School of Brown University, Providence, RI, USA
    Am J Obstet Gynecol 200:308.e1-9. 2009
    ..The purpose of this study was to determine in a mouse model whether uterine natural killer (uNK) cell cytotoxic activation induces infection/inflammation-associated preterm labor and delivery...
  5. pmc Reduced IL-10 production in fetal type II epithelial cells exposed to mechanical stretch is mediated via activation of IL-6-SOCS3 signaling pathway
    Michael A Hokenson
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 8:e59598. 2013
    ..SOCS3 could be a therapeutic target to increase IL-10 production in lung cells exposed to mechanical injury...
  6. pmc Differential expression of MMP-2 and -9 and their inhibitors in fetal lung cells exposed to mechanical stretch: regulation by IL-10
    Renda L Hawwa
    Department of Pediatrics, Women and Infants Hospital of Rhode Island and Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA
    Lung 189:341-9. 2011
    ..The objective of these studies was to investigate in vitro the release of MMP-2 and -9 and their respective inhibitors TIMP-2 and -1, and to explore potential regulation by IL-10...
  7. pmc Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk
    Elisabeth C McGowan
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02915, USA
    Pediatr Res 66:455-60. 2009
    ..01-0.70, p = 0.02). These results suggest that a placental balance between inflammatory and anti-inflammatory cytokines is crucial to normal lung organogenesis. Importantly, IL-10 seems to be protective against the development of BPD...
  8. pmc TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes
    Jessica E Thaxton
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02905 USA
    J Immunol 183:1144-54. 2009
    ..Depletion of F4/80(+) macrophages or neutralization of TNF-alpha rescued pregnancy to term. Our results have important implications for IL-10-mediated "uterine tolerance" against CpG-driven innate immune activation...
  9. pmc Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep
    Susan S Cohen
    Department of Pediatrics, The Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905 2499, USA
    Neuroimmunomodulation 20:264-73. 2013
    ..We hypothesized that interleukin-6 (IL-6) downregulates key protein constituents of endothelial tight junctions (e.g. occludin and claudin-5)...
  10. pmc Vascular IL-10: a protective role in preeclampsia
    Satyan Kalkunte
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Reprod Immunol 88:165-9. 2011
    ..In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation...
  11. pmc Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface
    Satyan S Kalkunte
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Immunol 182:4085-92. 2009
    ..Overall, these results demonstrate that empowerment of uNK cells with angiogenic factors keeps them noncytotoxic. This phenotype is critical to their pregnancy-compatible immunovascular role during placentation and fetal development...
  12. pmc The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies
    Neetu Tewari
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    J Biol Chem 284:15224-32. 2009
    ..Importantly, recombinant IL-10 reversed PCB-induced in vivo and in vitro effects. These data demonstrate for the first time that the IL-10-AQP1 axis is a novel regulator of PCB-induced in utero effects...
  13. pmc Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model
    Satyan S Kalkunte
    Departments of Pediatrics and Pathology, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, Rhode Island
    Am J Pathol 183:1425-36. 2013
    ..Our findings suggest that a focus on transthyretin structure and function is a novel strategy to understand and combat preeclampsia...
  14. pmc NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice
    Jessica E Thaxton
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    J Immunol 190:3639-47. 2013
    ..Thus, we demonstrate that pregnancy-disrupting inflammatory events mimicked by poly(I:C) are regulated by IL-10 and depend on the effector function of uterine NKG2D(+) NK cells in WT mice and NKG2D(-) T cells in IL-10 null mice...
  15. pmc Novel approaches for mechanistic understanding and predicting preeclampsia
    Satyan Kalkunte
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Reprod Immunol 83:134-8. 2009
    ..This review attempts to address some of these issues and discuss the signature biochemical serum factors and propose new and better ways to predict PE...
  16. pmc Interleukin-10: a multi-faceted agent of pregnancy
    Jessica E Thaxton
    Department of Pediatrics, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
    Am J Reprod Immunol 63:482-91. 2010
    ..Importantly, we discuss investigations on adverse pregnancy conditions to further elucidate the multifarious role of IL-10 at the maternal-fetal interface...
  17. pmc IL-10 inhibits inflammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch
    Renda L Hawwa
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley Street, Providence, Rhode Island 02905, USA
    Pediatr Pulmonol 46:640-9. 2011
    ..Mechanical ventilation plays an important role in the pathogenesis of bronchopulmonary dysplasia. However, the molecular mechanisms by which excessive stretch induces lung inflammation are not well characterized...
  18. pmc A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice
    Zhongbin Lai
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Hypertension 57:505-14. 2011
    ..Collectively, we conclude that severe preeclampsia pathology could be triggered under certain threshold oxygen levels coupled with intrinsic IL-10 deficiency, which lead to excessive activation of antiangiogenic and apoptotic pathways...
  19. pmc Schistosoma japonicum soluble egg antigens attenuate invasion in a first trimester human placental trophoblast model
    Emily A McDonald
    Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, United States of America
    PLoS Negl Trop Dis 7:e2253. 2013
    ..We therefore sought to determine the impact of schistosome antigens on key characteristics of first trimester trophoblast cells, including migration and invasion...
  20. pmc Schistosome egg antigens elicit a proinflammatory response by trophoblast cells of the human placenta
    Emily A McDonald
    Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA
    Infect Immun 81:704-12. 2013
    ..Our data indicate that schistosome antigens can activate proinflammatory responses in trophoblasts, which might compromise maternal-fetal health in pregnancies complicated by schistosomiasis...
  21. pmc Sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay
    Satyan Kalkunte
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School, Lifespan Center for International Health Research, Brown University, 101 Dudley St, Providence, RI 02905, USA
    Am J Pathol 177:2387-98. 2010
    ..These results indicate that preeclampsia patient sera can be used to understand the pregnancy-specific disease pathology in mice and can predict the disorder...
  22. pmc Evolution of non-cytotoxic uterine natural killer cells
    Satyan Kalkunte
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Am J Reprod Immunol 59:425-32. 2008
    ..This article discusses the factors and pathways that bridge the angiogenic and non-cytotoxic response machineries at the maternal-fetal interface...
  23. pmc A bioinformatics approach to preterm birth
    Alper Uzun
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, USA
    Am J Reprod Immunol 67:273-7. 2012
    ..The curated articles and collected genetic information are available in a web-based tool, the database for preterm birth (dbPTB) that forms a unique resource for investigators interested in preterm birth...
  24. pmc Uterine Regulatory T cells, IL-10 and hypertension
    TANIA NEVERS
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI, USA
    Am J Reprod Immunol 66:88-92. 2011
    ..In addition to the anti-inflammatory properties, IL-10 has emerged as an important vascular cytokine choreographing endovascular interactions and angiogenesis and regulates hypertension...
  25. ncbi Hyperoxia-induced apoptosis and Fas/FasL expression in lung epithelial cells
    Monique E De Paepe
    Dept of Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Am J Physiol Lung Cell Mol Physiol 289:L647-59. 2005
    ..Elucidation of regulation of hyperoxia-induced lung apoptosis may lead to alternative therapeutic strategies for perinatal or adult pulmonary diseases characterized by dysregulated type II cell apoptosis...
  26. pmc dbPTB: a database for preterm birth
    Alper Uzun
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
    Database (Oxford) 2012:bar069. 2012
    ..The Database for Preterm Birth exemplifies an approach that is generalizable to other disorders for which there is evidence of significant genetic contributions...
  27. ncbi Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice
    Shaun P Murphy
    Departments of Pediatrics and Pathology, Women and Infants Hospital, Rhode Island Hospital Brown University, Providence, RI 02905, USA
    J Immunol 175:4084-90. 2005
    ..Our results identify an immune mechanism of fetal demise involving IL-10 deficiency, NK cells, and inflammation. These results may provide insight into adverse pregnancy outcomes in humans...
  28. pmc Inter-alpha inhibitor protein administration improves survival from neonatal sepsis in mice
    Kultar Singh
    Department of Pediatrics, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Pediatr Res 68:242-7. 2010
    ..IaIp may offer significant benefits as a therapeutic..
  29. pmc Ontogeny and the effects of in utero brain ischemia on interleukin-1β and interleukin-6 protein expression in ovine cerebral cortex and white matter
    Grazyna B Sadowska
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA
    Int J Dev Neurosci 30:457-63. 2012
    ....
  30. ncbi Interleukin-10 protects cultured fetal rat type II epithelial cells from injury induced by mechanical stretch
    Hyeon Soo Lee
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905, USA
    Am J Physiol Lung Cell Mol Physiol 294:L225-32. 2008
    ..Collectively, our studies suggest that IL-10 may play an important role in protection of fetal type II epithelial cells from injury secondary to stretch...
  31. ncbi IFN-gamma-mediated inhibition of COX-2 expression in the placenta from term and preterm labor pregnancies
    Nazeeh Hanna
    Division of Neonatology, Department of Pediatrics, UMDNJ Robert Wood, Johnson Medical School, New Brunswick, NJ 08903, USA
    Am J Reprod Immunol 51:311-8. 2004
    ..The aim of this study was to evaluate the effects of interferon (IFN)-gamma on the expression of Cyclooxygenase (COX)-2 and production of prostaglandin E(2) (PGE(2)) in the human placenta from term and preterm labor deliveries...
  32. ncbi The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:529-47. 2008
    ..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI)...
  33. pmc TLR6 modulates first trimester trophoblast responses to peptidoglycan
    Vikki M Abrahams
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:6035-43. 2008
    ..Furthermore, the expression of TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation...
  34. pmc Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype
    Charlotte Gustafsson
    Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    PLoS ONE 3:e2078. 2008
    ..Although uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known...
  35. ncbi Systemic Th1/Th2 cytokine responses to paternal and vaccination antigens in preeclampsia: no differences compared with normal pregnancy
    Yvonne Jonsson
    Autoimmunity and Immune Regulation, Department of Clinical and Molecular Medicine, Division of Clinical Immunology, University Hospital, Linkoping, Sweden
    Am J Reprod Immunol 51:302-10. 2004
    ..This study was designed to compare Th1/Th2 related cytokine secretion in blood between women with preeclampsia (n = 15) and normal pregnancies (n = 15), using a high-sensitivity technique for cytokine detection...