Monique E De Paepe

Summary

Affiliation: Women and Infants' Hospital
Country: USA

Publications

  1. ncbi Postmortem RNA and protein stability in perinatal human lungs
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA
    Diagn Mol Pathol 11:170-6. 2002
  2. doi What-and why-the pathologist should know about twin-to-twin transfusion syndrome
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI, USA
    Pediatr Dev Pathol 16:237-51. 2013
  3. ncbi Long-term outcome of human cord blood-derived hematopoietic progenitor cells in murine lungs
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Exp Lung Res 39:59-69. 2013
  4. pmc The human fetal lung xenograft: validation as model of microvascular remodeling in the postglandular lung
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Brown University, Providence, RI, USA
    Pediatr Pulmonol 47:1192-203. 2012
  5. doi Correlation between cord insertion type and superficial choriovasculature in diamniotic-monochorionic twin placentas
    M E De Paepe
    Department of Pathology, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI 02905, USA
    Placenta 32:901-5. 2011
  6. pmc Resilience of the human fetal lung following stillbirth: potential relevance for pulmonary regenerative medicine
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, and Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    Exp Lung Res 38:43-54. 2012
  7. pmc Growth of pulmonary microvasculature in ventilated preterm infants
    Monique E De Paepe
    Women and Infants Hospital, Department of Pathology, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Crit Care Med 173:204-11. 2006
  8. pmc Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Am J Pathol 178:1329-39. 2011
  9. pmc Endoglin (CD105) up-regulation in pulmonary microvasculature of ventilated preterm infants
    Monique E De Paepe
    Women and Infants Hospital, Department of Pathology, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Crit Care Med 178:180-7. 2008
  10. doi Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Fertil Steril 95:1119.e15-7. 2011

Collaborators

Detail Information

Publications41

  1. ncbi Postmortem RNA and protein stability in perinatal human lungs
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA
    Diagn Mol Pathol 11:170-6. 2002
    ..RNA is equivalent, if not superior, to LN for preservation of postmortem RNA and protein in developing human lungs...
  2. doi What-and why-the pathologist should know about twin-to-twin transfusion syndrome
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI, USA
    Pediatr Dev Pathol 16:237-51. 2013
    ..It is our expectation that overviews such as this may serve as a template to generate consensus guidelines for standardized and evidence-based pathologic evaluation of monochorionic twin placentas...
  3. ncbi Long-term outcome of human cord blood-derived hematopoietic progenitor cells in murine lungs
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Exp Lung Res 39:59-69. 2013
    ..Cord blood-CD34+ cell administration appears to have growth-promoting effects in injured newborn lungs, without affecting alveolar development in this model...
  4. pmc The human fetal lung xenograft: validation as model of microvascular remodeling in the postglandular lung
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Brown University, Providence, RI, USA
    Pediatr Pulmonol 47:1192-203. 2012
    ..Coordinated remodeling of epithelium and vasculature is essential for normal postglandular lung development. The value of the human-to-rodent lung xenograft as model of fetal microvascular development remains poorly defined...
  5. doi Correlation between cord insertion type and superficial choriovasculature in diamniotic-monochorionic twin placentas
    M E De Paepe
    Department of Pathology, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI 02905, USA
    Placenta 32:901-5. 2011
    ..The choriovascular correlates of peripheral cord insertion in diamniotic-monochorionic twin placentas remain undetermined...
  6. pmc Resilience of the human fetal lung following stillbirth: potential relevance for pulmonary regenerative medicine
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, and Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    Exp Lung Res 38:43-54. 2012
    ..In conclusion, fetal lung tissues from second trimester stillbirths can regain their inherent high regenerative potential following short-term culture, even if harvested more than 36 hours after delivery...
  7. pmc Growth of pulmonary microvasculature in ventilated preterm infants
    Monique E De Paepe
    Women and Infants Hospital, Department of Pathology, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Crit Care Med 173:204-11. 2006
    ....
  8. pmc Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Am J Pathol 178:1329-39. 2011
    ..Graft proliferation and alveolar epithelial differentiation are promoted by lung injury...
  9. pmc Endoglin (CD105) up-regulation in pulmonary microvasculature of ventilated preterm infants
    Monique E De Paepe
    Women and Infants Hospital, Department of Pathology, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Crit Care Med 178:180-7. 2008
    ..The molecular regulation of this BPD-associated dysangiogenesis remains undetermined...
  10. doi Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Fertil Steril 95:1119.e15-7. 2011
    ..To report a case of antenatally diagnosed congenital mesoblastic nephroma in an assisted reproductive technology (ART) conception...
  11. doi Angiogenesis-related gene expression profiling in ventilated preterm human lungs
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Exp Lung Res 36:399-410. 2010
    ..This angiogenic shift may be implicated in the regulation of dysmorphic angiogenesis and, consequently, deficient alveolarization characteristic of infants with BPD...
  12. doi Pulmonary dendritic cells in lungs of preterm infants: neglected participants in bronchopulmonary dysplasia?
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI, USA
    Pediatr Dev Pathol 14:20-7. 2011
    ..Elucidation of the role of this immunovascular axis may lead to novel therapeutic approaches to BPD...
  13. doi Placental markers of twin-to-twin transfusion syndrome in diamniotic-monochorionic twins: A morphometric analysis of deep artery-to-vein anastomoses
    M E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA
    Placenta 31:269-76. 2010
    ..Elucidation of the role of the various placental determinants in diamniotic-monochorionic twin gestations may lead to further refinement of therapeutic strategies...
  14. doi Placental characteristics of selective birth weight discordance in diamniotic-monochorionic twin gestations
    M E De Paepe
    Department of Pathology, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
    Placenta 31:380-6. 2010
    ..Elucidation of the mechanisms whereby velamentous cord insertion affects fetal growth may lead to more focused and effective therapeutic strategies for twin and singleton pregnancies complicated by dysregulated fetal growth...
  15. ncbi Postmortem lung weight/body weight standards for term and preterm infants
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital and Brown University Medical School, Providence, Rhode Island 02905, USA
    Pediatr Pulmonol 40:445-8. 2005
    ..Correlation of LW/BW with age-matched reference values at postmortem examination represents an invaluable additional tool to evaluate lung growth, particularly in preterm infants...
  16. ncbi Hyperoxia-induced apoptosis and Fas/FasL expression in lung epithelial cells
    Monique E De Paepe
    Dept of Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Am J Physiol Lung Cell Mol Physiol 289:L647-59. 2005
    ..Elucidation of regulation of hyperoxia-induced lung apoptosis may lead to alternative therapeutic strategies for perinatal or adult pulmonary diseases characterized by dysregulated type II cell apoptosis...
  17. ncbi Renal tubular apoptosis in twin-to-twin transfusion syndrome
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
    Pediatr Dev Pathol 6:215-25. 2003
    ..We speculate that the risk for development of tubular apoptosis in TTTS depends on the severity and timing of the hemodynamic imbalance, whereby early mid-trimester fetuses may be more vulnerable...
  18. ncbi Postmortem validation of imaging-derived formulas for prediction of fetal lung volume
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA
    Fetal Diagn Ther 18:353-9. 2003
    ..To determine the validity of existing imaging-derived formulas for predicting the fetal lung volume (FLV)...
  19. ncbi Placental findings after laser ablation of communicating vessels in twin-to-twin transfusion syndrome
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Providence, RI 02905, USA
    Pediatr Dev Pathol 7:159-65. 2004
    ..Detailed analysis of laser-treated placentas and clinicopathological correlation may lead to a better understanding of the pathophysiology of TTTS and continued refinement of therapeutic approaches for this often lethal condition...
  20. pmc Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development
    Monique E De Paepe
    Women and Infants Hospital, Dept of Pathology, 101 Dudley St, Providence, RI 02905, USA
    Am J Pathol 173:42-56. 2008
    ....
  21. ncbi Fas/FasL-mediated apoptosis in perinatal murine lungs
    Monique E De Paepe
    Program of Fetal Medicine, Women and Infants Hospital, Providence, RI 02905, USA
    Am J Physiol Lung Cell Mol Physiol 287:L730-42. 2004
    ..The developmental time dependence of apoptosis-related events in the murine model should facilitate investigations of the regulation of perinatal pulmonary apoptotic gene expression...
  22. ncbi Vascular distribution patterns in monochorionic twin placentas
    M E De Paepe
    Department of Pathology, Women and Infants Hospital and Brown Medical School, 101 Dudley Street, Providence, RI 02905, United States
    Placenta 26:471-5. 2005
    ..These findings suggest that the magistral/mixed vascular distribution pattern may represent an important placental architectural feature contributing to the complex pathophysiology of TTTS...
  23. pmc Effects of Fas-ligand overexpression on alveolar type II cell growth kinetics in perinatal murine lungs
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, and Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA
    Pediatr Res 68:57-62. 2010
    ..In conclusion, these results, and our previous studies, suggest that FasL signaling has dual timing-dependent proapoptotic and proproliferative effects on postcanalicular type II cell kinetics...
  24. pmc The Fas system confers protection against alveolar disruption in hyperoxia-exposed newborn mice
    Quanfu Mao
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Am J Respir Cell Mol Biol 39:717-29. 2008
    ..The capacity of the Fas/FasL signaling pathway to mediate protective rather than destructive functions in hyperoxic newborn lungs highlights the versatility of this complex pathway...
  25. pmc Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice
    James A Fritzell
    Women and Infants Hospital, Dept of Pathology, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Cell Mol Biol 40:575-87. 2009
    ....
  26. ncbi Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein
    Lewis P Rubin
    Department of Pediatrics, Brown Medical School and Women and Infants Hospital, Providence, Rhode Island 02905 2499, USA
    Dev Dyn 230:278-89. 2004
    ....
  27. pmc Ex vivo expanded human cord blood-derived hematopoietic progenitor cells induce lung growth and alveolarization in injured newborn lungs
    Quanfu Mao
    Department of Pathology, Women and Infants Hospital, Providence, RI, USA
    Respir Res 14:37. 2013
    ....
  28. ncbi The histologic fetoplacental inflammatory response in fatal perinatal group B-streptococcus infection
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital and Brown Medical School, 101 Dudley Street, Providence, RI 02905, USA
    J Perinatol 24:441-5. 2004
    ..To determine the rate of histologic fetoplacental inflammation in fetuses and newborns with fatal perinatal Group B-Streptococcus (GBS) infection...
  29. ncbi Demonstration of placental vascular anatomy in monochorionic twin gestations
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
    Pediatr Dev Pathol 5:37-44. 2002
    ..Correlating the anastomotic patterns and location of the laser coagulation scars with post-ablation outcome will aid in the design of rational therapeutic methods for this often lethal condition...
  30. ncbi Intratwin arteriovenous fistula of the placenta in a case of twin-to-twin transfusion syndrome
    Michael Poch
    Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Am J Perinatol 22:3-6. 2005
    ..We speculate that the hemodynamic effects of the fistula may have contributed to the refractoriness of the TTTS to serial amniodrainages and laser ablation of communicating intertwin vessels...
  31. doi Effects of chemotherapy during pregnancy on the placenta
    Rosanna G Abellar
    Department of Pathology, Women and Infants Hospital, Providence, RI, USA
    Pediatr Dev Pathol 12:35-41. 2009
    ..However, without appropriate controls (untreated patients with equivalent malignancies), the specific effects of chemotherapy in this group are difficult to assess...
  32. doi Correlation between cord insertion type and chorionic villus vascularization of the co-twin in diamniotic-monochorionic twin pregnancies
    Sharon Chu
    Department of Pathology, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI 02905, USA
    Early Hum Dev 89:243-7. 2013
    ..Specifically, for twins with paracentral cords, chorionic plate vascularization is significantly greater when the co-twin has a velamentous, rather than paracentral cord insertion...
  33. ncbi Intrauterine infection with Klebsiella pneumoniae: report of a case and literature review
    Rozbeh Torabi
    Department of Pathology, Women and Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Pediatr Dev Pathol 11:152-5. 2008
    ..This represents, to our knowledge, the 1st reported case of fatal intrauterine Klebsiella pneumoniae infection fully supported by conclusive fetal and placental histopathological evidence...
  34. ncbi Monochorionic twins discordant for mosaic trisomy 14
    Mai He
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, Providence, Rhode Island Warren Alpert Medical School of Brown University, Providence, Rhode Island
    Am J Med Genet A 164:1227-33. 2014
    ..CMA with placental tissue from both sides demonstrated normal karyotype and confirmed monozygosity, highlighting the value of array based testing on diagnosing mosaicism and zygosity. © 2014 Wiley Periodicals, Inc. ..
  35. ncbi Second-trimester maternal serum markers in twin pregnancy with complete mole: report of 2 cases
    Geralyn Lambert-Messerlian
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Brown University, 70 Elm Street, 2nd Floor, Providence, RI 02903, USA
    Pediatr Dev Pathol 8:230-4. 2005
    ..Serum marker levels may be useful in diagnosis of CHMCF, prenatal counseling, and evaluation of risk for persistent trophoblastic disease...
  36. ncbi Expression of apoptosis-related genes after fetal tracheal occlusion in rabbits
    Monique E De Paepe
    Department of Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    J Pediatr Surg 39:1616-25. 2004
    ..The aim of this study was to determine the effect of fetal TO on the spatiotemporal expression of key apoptosis-related signaling molecules...
  37. doi Postmortem lung volume/body weight standards for term and preterm infants
    Monique E De Paepe
    Department of Pathology, Alpert Medical School of Brown University, Providence, Rhode Island Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island
    Pediatr Pulmonol 49:60-6. 2014
    ..In selected situations assessment of lung volume/BW may represent a useful complementary tool to LW/BW for postmortem evaluation of lung size...
  38. ncbi What--and why--the pediatric surgeon should know about twin-to-twin transfusion syndrome
    Francois I Luks
    Division of Pediatric Surgery, Brown Medical School, Providence, RI 02912, USA
    J Pediatr Surg 40:1063-9. 2005
    ..Pediatric surgeons, with their knowledge of fetal and congenital pathology, and their technical expertise with minimally invasive surgery, can be of great benefit to the patient and the medical team...
  39. pmc siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth
    Fusun Gundogan
    Department of Pathology, Women and Infants Hospital, Providence, RI, United States
    Pathol Res Pract 207:545-53. 2011
    ....
  40. pmc Galectin-3 plays an important role in protection against disseminated candidiasis
    Jennifer R Linden
    Graduate Program in Pathobiology, Brown University, Providence, RI 02905, USA
    Med Mycol 51:641-51. 2013
    ..These data indicate that galectin-3 plays an important role in a murine model of disseminated candidiasis and suggest a potential mechanism of neonatal susceptibility to these infections...
  41. ncbi Educational and occupational outcomes among survivors of childhood cancer during the transition to emerging adulthood
    Cynthia A Gerhardt
    Center for Biobehavioral Health, The Ohio State University, Columbus, Ohio, USA
    J Dev Behav Pediatr 28:448-55. 2007
    ..To examine educational and occupational outcomes among survivors of childhood cancer and peers during the transition from adolescence to emerging adulthood...