Jacob A Canick

Summary

Affiliation: Women and Infants' Hospital
Country: USA

Publications

  1. doi The impact of maternal plasma DNA fetal fraction on next generation sequencing tests for common fetal aneuploidies
    Jacob A Canick
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Alpert Medical School of Brown University, Providence, RI 02903, USA
    Prenat Diagn 33:667-74. 2013
  2. doi DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations
    Jacob A Canick
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA
    Prenat Diagn 32:730-4. 2012
  3. doi Prenatal screening for trisomy 21: recent advances and guidelines
    Jacob Canick
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA
    Clin Chem Lab Med 50:1003-8. 2012
  4. ncbi Urinary analyte screening: a noninvasive detection method for Down syndrome?
    J A Canick
    Dept of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown University School of Medicine, Providence, RI, USA
    Mol Med Today 5:68-73. 1999
  5. ncbi Prenatal screening for Down syndrome: current and future methods
    Jacob A Canick
    Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Clin Lab Med 23:395-411. 2003
  6. ncbi Prenatal screening for open neural tube defects
    Jacob A Canick
    Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, 101 Dudley Street, Providence, RI 02905 2401, USA
    Clin Lab Med 23:385-94, ix. 2003
  7. ncbi Second trimester serum markers
    Jacob A Canick
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Semin Perinatol 29:203-8. 2005
  8. ncbi First trimester screening for aneuploidy: serum biochemical markers
    J A Canick
    Women and Infants Hospital and the Department of Pathology and Laboratory Medicine, Brown University School of Medicine, Providence, RI 02905, USA
    Semin Perinatol 23:359-68. 1999
  9. pmc First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study
    Geralyn Lambert-Messerlian
    Warren Alpert Medical School of Brown University, Providence, RI, USA
    Am J Obstet Gynecol 199:62.e1-6. 2008
  10. pmc Variability in thyroid-stimulating hormone suppression by human chorionic [corrected] gonadotropin during early pregnancy
    James E Haddow
    The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Clin Endocrinol Metab 93:3341-7. 2008

Collaborators

Detail Information

Publications48

  1. doi The impact of maternal plasma DNA fetal fraction on next generation sequencing tests for common fetal aneuploidies
    Jacob A Canick
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Alpert Medical School of Brown University, Providence, RI 02903, USA
    Prenat Diagn 33:667-74. 2013
    ..By understanding these aspects of the role of fetal fraction in maternal plasma DNA testing for aneuploidy, we can better appreciate the power and the limitations of this impressive new methodology...
  2. doi DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations
    Jacob A Canick
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA
    Prenat Diagn 32:730-4. 2012
    ..If MPSS testing is offered clinically, it is important to know if these trisomies will also be identified in multiple pregnancies...
  3. doi Prenatal screening for trisomy 21: recent advances and guidelines
    Jacob Canick
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA
    Clin Chem Lab Med 50:1003-8. 2012
    ....
  4. ncbi Urinary analyte screening: a noninvasive detection method for Down syndrome?
    J A Canick
    Dept of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown University School of Medicine, Providence, RI, USA
    Mol Med Today 5:68-73. 1999
    ..However, recent results have been unusually variable. Although it has great potential, the true clinical value of maternal urine screening to detect Down syndrome still remains to be determined...
  5. ncbi Prenatal screening for Down syndrome: current and future methods
    Jacob A Canick
    Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Clin Lab Med 23:395-411. 2003
    ..In the next few years, that goal will probably be achieved...
  6. ncbi Prenatal screening for open neural tube defects
    Jacob A Canick
    Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, 101 Dudley Street, Providence, RI 02905 2401, USA
    Clin Lab Med 23:385-94, ix. 2003
    ..In this article, the use of AFP in prenatal screening for open neural tube defects is discussed in the context of the laboratory and the laboratory's interactions with the practicing obstetrician...
  7. ncbi Second trimester serum markers
    Jacob A Canick
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Semin Perinatol 29:203-8. 2005
    ....
  8. ncbi First trimester screening for aneuploidy: serum biochemical markers
    J A Canick
    Women and Infants Hospital and the Department of Pathology and Laboratory Medicine, Brown University School of Medicine, Providence, RI 02905, USA
    Semin Perinatol 23:359-68. 1999
    ..For this reason, first trimester screening with serum markers alone cannot be recommended except in cases in which second trimester screening cannot be done...
  9. pmc First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study
    Geralyn Lambert-Messerlian
    Warren Alpert Medical School of Brown University, Providence, RI, USA
    Am J Obstet Gynecol 199:62.e1-6. 2008
    ..The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies...
  10. pmc Variability in thyroid-stimulating hormone suppression by human chorionic [corrected] gonadotropin during early pregnancy
    James E Haddow
    The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Clin Endocrinol Metab 93:3341-7. 2008
    ..The objective of the study was to further explore relationships between human chorionic gonadotropin (hCG), TSH, and free T4 in pregnant women at 11 through 18 wk gestation...
  11. ncbi Comparison of serum markers in first-trimester down syndrome screening
    Jacob A Canick
    Women and Infants Hospital and Brown Medical School, Providence, Rhode Island, USA
    Obstet Gynecol 108:1192-9. 2006
    ....
  12. pmc DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study
    Glenn E Palomaki
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Genet Med 14:296-305. 2012
    ..To determine whether maternal plasma cell-free DNA sequencing can effectively identify trisomy 18 and 13...
  13. ncbi Stability of first- and second-trimester serum markers after storage and shipment
    Geralyn M Lambert-Messerlian
    Department of Pathology and Laboratory Medicine, Brown University and Women and Infants Hospital, Providence, Rhode Island 02903, USA
    Prenat Diagn 26:17-21. 2006
    ..The purpose of this study was to examine the levels of first- and second-trimester maternal serum markers used in Down syndrome screening in relation to the time between sample collection and arrival at the laboratory...
  14. doi DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study
    Glenn E Palomaki
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Genet Med 13:913-20. 2011
    ..Prenatal screening for Down syndrome has improved, but the number of resulting invasive diagnostic procedures remains problematic. Measurement of circulating cell-free DNA in maternal plasma might offer improvement...
  15. doi Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery
    James E Haddow
    Women and Infants Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Obstet Gynecol 116:58-62. 2010
    ..To further evaluate the relationship between thyroid antibodies and preterm births...
  16. doi Feasibility of using plasma rather than serum in first and second trimester multiple marker Down's syndrome screening
    Geralyn M Lambert-Messerlian
    Women and Infants Hospital, 70 Elm Street, 2nd Floor, Providence, RI 02903, USA
    J Med Screen 19:164-70. 2012
    ..To compare maternal plasma with serum for measuring markers currently used in first and second trimester screening for Down's syndrome...
  17. doi Four years' experience with an interlaboratory comparison program involving first-trimester markers of Down syndrome
    Glenn E Palomaki
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI02903, USA
    Arch Pathol Lab Med 134:1685-91. 2010
    ..Objectives.-To evaluate the first 4 years of the interlaboratory comparison program against stated goals, to identify areas of concern, and to create new initiatives as indicated...
  18. pmc Impact of adjusting for the reciprocal relationship between maternal weight and free thyroxine during early pregnancy
    James E Haddow
    Division of Medical Screening and Special Testing, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Thyroid 23:225-30. 2013
    ..5th centile were associated with a 17 lb higher weight (2.9 kg/m(2)) than in the overall study population. We explore this relationship further...
  19. doi Impact of smoking on maternal serum markers and prenatal screening in the first and second trimesters
    Jing Zhang
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Alpert Medical School of Brown University, Providence, RI 02903, USA
    Prenat Diagn 31:583-8. 2011
    ....
  20. ncbi Adjustment of serum markers in first trimester screening
    Geralyn Lambert-Messerlian
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, 70 Elm Street, Providence, RI 02903 USA
    J Med Screen 16:102-3. 2009
    ..First trimester total hCG levels were significantly increased in twins (median = 1.87 MoM), mildly increased in pregnancies achieved by in vitro fertilization (1.04 MoM) and decreased in smokers (0.80 MoM)...
  21. doi Early onset preeclampsia and second trimester serum markers
    Geralyn M Lambert-Messerlian
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA
    Prenat Diagn 29:1109-17. 2009
    ..To examine serum markers measured in the second trimester to identify women who subsequently develop preeclampsia...
  22. doi Thyroperoxidase and thyroglobulin antibodies in early pregnancy and placental abruption
    James E Haddow
    Division of Medical Screening and Special Testing, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Obstet Gynecol 117:287-92. 2011
    ..To estimate the relationship between thyroid antibodies and placental abruption...
  23. doi Quality assessment of routine nuchal translucency measurements: a North American laboratory perspective
    Glenn E Palomaki
    Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Genet Med 10:131-8. 2008
    ..To assess nuchal translucency measurements that were performed as part of routine prenatal screening for Down syndrome...
  24. ncbi Recent advances in maternal serum screening for Down syndrome
    Geralyn M Messerlian
    Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, RI 02903, USA
    Med Health R I 85:362-5. 2002
    ....
  25. doi Sequential first- and second-trimester TSH, free thyroxine, and thyroid antibody measurements in women with known hypothyroidism: a FaSTER trial study
    Monica R McClain
    Warren Alpert Medical School, Brown University, Providence, RI 02903, USA
    Am J Obstet Gynecol 199:129.e1-6. 2008
    ..The purpose of this study was to examine how closely hypothyroidism management in the general pregnancy population satisfies recently issued guidelines and to determine whether improvements are indicated...
  26. ncbi Concentrations of serum total activin A and inhibin A in preterm and term labor patients: a cross-sectional study
    Michael P Plevyak
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, USA
    J Soc Gynecol Investig 10:231-6. 2003
    ..To compare maternal serum levels of total activin A and inhibin A in preterm and term patients who are in labor or not in labor...
  27. ncbi Placenta growth factor levels in second-trimester maternal serum in Down syndrome pregnancy and in the prediction of preeclampsia
    Geralyn M Lambert-Messerlian
    Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    Prenat Diagn 24:876-80. 2004
    ....
  28. doi Adjustment of maternal serum alpha-fetoprotein levels in women with pregestational diabetes
    Nicole Sprawka
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI 02905, USA
    Prenat Diagn 31:282-5. 2011
    ..The aim of this study is to determine if MSAFP levels in pregnant women with diabetes managed on oral antidiabetic agents is lower than non-diabetic controls and require adjustment similar to those on insulin...
  29. doi Technical standards and guidelines: prenatal screening for Down syndrome that includes first-trimester biochemistry and/or ultrasound measurements
    Glenn E Palomaki
    From the 1Women and Infants Hospital and Albert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA
    Genet Med 11:669-81. 2009
    ..Laboratories can use their professional judgment to make modification or additions...
  30. ncbi The relationship between PTH and 25-hydroxy vitamin D early in pregnancy
    James E Haddow
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital Alpert Medical School of Brown University, Providence, RI, USA
    Clin Endocrinol (Oxf) 75:309-14. 2011
    ..Measure serum PTH and 25(OH)D in a cross-sectional sample of pregnant women at 11th through 13th weeks' gestation to examine vitamin D status and consider implications...
  31. ncbi Clinical application of inhibin a measurement: prenatal serum screening for Down syndrome
    Geralyn M Lambert-Messerlian
    Department of Pathology and Laboratory Medicine, Division of Prenatal and Special Testing, Women and Infants Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    Semin Reprod Med 22:235-42. 2004
    ..We also address the method used for inhibin A measurement, the biology of inhibin A in Down syndrome pregnancy, and the effects of covariates and other fetal abnormalities on inhibin A levels...
  32. ncbi A summary analysis of Down syndrome markers in the late first trimester
    Glenn E Palomaki
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown University, Providence, Rhode Island, USA
    Adv Clin Chem 43:177-210. 2007
    ..When both free beta and DIA, or total hCG and DIA are combined with maternal age, NT and PAPP-A, weighted summary detection rates are 85% and 83%, respectively...
  33. ncbi Down syndrome and cell-free fetal DNA in archived maternal serum
    Thomas Lee
    Divison of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, RI, USA
    Am J Obstet Gynecol 187:1217-21. 2002
    ....
  34. doi Examination of the pregnancy-associated plasma protein-A assay on the Beckman Coulter Access(®) platform: suitability for use in first trimester Down's syndrome screening
    Geralyn Lambert-Messerlian
    Department of Pathology and Laboratory Medicine, Division of Medical Screening and Special Testing, Women and Infants Hospital, 70 Elm St, Suite 2, Providence, RI 02903, USA
    J Med Screen 17:109-13. 2010
    ..To explore the clinical validity of the new Access(®) pregnancy-associated plasma protein-A (PAPP-A) assay for Down's syndrome screening...
  35. ncbi Second-trimester maternal serum markers in twin pregnancy with complete mole: report of 2 cases
    Geralyn Lambert-Messerlian
    Department of Pathology and Laboratory Medicine, Women and Infants Hospital and Brown University, 70 Elm Street, 2nd Floor, Providence, RI 02903, USA
    Pediatr Dev Pathol 8:230-4. 2005
    ..Serum marker levels may be useful in diagnosis of CHMCF, prenatal counseling, and evaluation of risk for persistent trophoblastic disease...
  36. ncbi Mechanism of increased maternal serum total activin a and inhibin a in preeclampsia
    Helayne M Silver
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and Department of Pathology, Brown University, Providence, Rhode Island 02905, USA
    J Soc Gynecol Investig 9:308-12. 2002
    ..To determine whether increased levels of maternal serum total activin A and inhibin A in preeclampsia are related to total blood volume, urinary clearance, or placental production...
  37. ncbi Maternal serum cell-free fetal DNA levels are increased in cases of trisomy 13 but not trisomy 18
    Tuangsit Wataganara
    Department of Pediatrics, Obstetrics and Gynecology, Division of Genetics, Tufts New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Box 394, Boston, MA 02111, USA
    Hum Genet 112:204-8. 2003
    ..Fetal DNA may facilitate noninvasive screening for trisomy 13 provided that a gender-independent fetal DNA marker can be developed...
  38. ncbi Evaluation of cell-free fetal DNA as a second-trimester maternal serum marker of Down syndrome pregnancy
    Antonio Farina
    Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy 40138
    Clin Chem 49:239-42. 2003
    ..In this study we evaluated the potential performance of fetal DNA as a screening marker for Down syndrome...
  39. ncbi Total activin A in maternal blood as a marker of preterm delivery in low-risk asymptomatic patients
    Antonio Farina
    Division of Prenatal Medicine, University of Bologna, Bologna, Italy
    Prenat Diagn 26:277-81. 2006
    ..To retrospectively evaluate whether increased serum levels of total activin A (t-activin A) are found in women who subsequently experience preterm delivery (PTD)...
  40. ncbi Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkers
    Srinivasa R Nagalla
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Proteome Res 6:1245-57. 2007
    ..Further characterization and quantification of these markers in a larger cohort of subjects may provide the basis for new tests for improved DS screening...
  41. doi Current methods of prenatal screening for Down syndrome and other fetal abnormalities
    Devereux N Saller
    Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, VA 22908, USA
    Clin Obstet Gynecol 51:24-36. 2008
    ..These choices can be confusing both to both patients and providers. The following discussion is meant to outline the various options in prenatal screening, and their individual advantages and disadvantages...
  42. ncbi First-trimester or second-trimester screening, or both, for Down's syndrome
    Fergal D Malone
    Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 353:2001-11. 2005
    ..It is uncertain how best to screen pregnant women for the presence of fetal Down's syndrome: to perform first-trimester screening, to perform second-trimester screening, or to use strategies incorporating measurements in both trimesters...
  43. ncbi Apparently low maternal serum inhibin A levels in second-trimester screening
    Geralyn M Lambert-Messerlian
    Prenat Diagn 25:967-8. 2005
  44. ncbi Cell-free fetal DNA levels in pregnancies conceived by IVF
    Phillip D Pan
    Division of Genetics, Department of Pediatricsogy, Tufts New England Medical Center, 750 Washington Street, Box 394, Boston, MA 02111, USA
    Hum Reprod 20:3152-6. 2005
    ..Increased levels of cell-free fetal DNA (cffDNA) in maternal plasma have been correlated with increased HCG levels. Our aim was to determine whether cffDNA levels are elevated in IVF pregnancies compared with natural pregnancies...
  45. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005
    ....
  46. ncbi First-trimester septated cystic hygroma: prevalence, natural history, and pediatric outcome
    Fergal D Malone
    Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obstet Gynecol 106:288-94. 2005
    ..To estimate prevalence, natural history, and outcome of septated cystic hygroma in the first trimester in the general obstetric population, and to differentiate this finding from simple increased nuchal translucency...
  47. ncbi Effect of folic acid fortification on prevalence of neural tube defects in Rhode Island
    Geralyn Lambert-Messerlian
    J Med Screen 11:106-7. 2004
  48. doi Contingent screening for Down syndrome
    Nicholas J Wald
    Prenat Diagn 28:781; author reply 782. 2008