Amie J Dirks

Summary

Affiliation: Wingate University
Country: USA

Publications

  1. ncbi Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
    Amie J Dirks
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 36:27-39. 2004
  2. ncbi Caloric restriction in humans: potential pitfalls and health concerns
    Amie J Dirks
    Wingate University, School of Pharmacy, 316 N Main Street, Wingate, NC 28174, USA
    Mech Ageing Dev 127:1-7. 2006
  3. ncbi Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction
    Amie J Dirks
    Wingate University, School of Pharmacy, Wingate, NC 28174, USA
    J Nutr Biochem 17:501-8. 2006
  4. ncbi Statin-induced apoptosis and skeletal myopathy
    Amie J Dirks
    Wingate University School of Pharmacy, Wingate, North Carolina 28174, USA
    Am J Physiol Cell Physiol 291:C1208-12. 2006
  5. ncbi The role of apoptosis in age-related skeletal muscle atrophy
    Amie J Dirks
    School of Pharmacy, Wingate University, Wingate, North Carolina, USA
    Sports Med 35:473-83. 2005
  6. ncbi Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
    Amie J Dirks
    Wingate University, School of Pharmacy, 316 N. Main Street, Wingate, NC 28174, USA
    Ageing Res Rev 5:179-95. 2006
  7. ncbi Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio
    April C Childs
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Gainesville, Florida 32611, USA
    Cancer Res 62:4592-8. 2002
  8. ncbi Radiation-induced cyclooxygenase 2 up-regulation is dependent on redox status in prostate cancer cells
    Lingyun Li
    Department of Radiation Oncology, Stanford University, School of Medicine, Stanford, California, USA
    Radiat Res 160:617-21. 2003

Collaborators

Detail Information

Publications8

  1. ncbi Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
    Amie J Dirks
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 36:27-39. 2004
    ..Calorie restriction is able to lower the apoptotic potential in aged skeletal muscle by altering several key apoptotic proteins toward cellular survival, thereby reducing the potential for sarcopenia...
  2. ncbi Caloric restriction in humans: potential pitfalls and health concerns
    Amie J Dirks
    Wingate University, School of Pharmacy, 316 N Main Street, Wingate, NC 28174, USA
    Mech Ageing Dev 127:1-7. 2006
    ..These potential pitfalls and "side effects" are not clearly addressed in the literature and will be a focus of this review...
  3. ncbi Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction
    Amie J Dirks
    Wingate University, School of Pharmacy, Wingate, NC 28174, USA
    J Nutr Biochem 17:501-8. 2006
    ..The potential role of TNF-alpha in the progression of sarcopenia will be discussed, as well as the effects of life-long caloric restriction on TNF-alpha signaling...
  4. ncbi Statin-induced apoptosis and skeletal myopathy
    Amie J Dirks
    Wingate University School of Pharmacy, Wingate, North Carolina 28174, USA
    Am J Physiol Cell Physiol 291:C1208-12. 2006
    ..The mitochondrion is considered a regulatory center of apoptosis, and therefore its role in the induction of apoptosis will be discussed as well as the mechanism of statin-induced apoptosis and myopathy...
  5. ncbi The role of apoptosis in age-related skeletal muscle atrophy
    Amie J Dirks
    School of Pharmacy, Wingate University, Wingate, North Carolina, USA
    Sports Med 35:473-83. 2005
    ..Exercise training and caloric restriction are two interventions known to enhance skeletal muscle function. The effects of these interventions on apoptosis are discussed...
  6. ncbi Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
    Amie J Dirks
    Wingate University, School of Pharmacy, 316 N. Main Street, Wingate, NC 28174, USA
    Ageing Res Rev 5:179-95. 2006
    ..Evidence concerning these series of events leading to energy depletion and apoptosis are discussed...
  7. ncbi Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio
    April C Childs
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Gainesville, Florida 32611, USA
    Cancer Res 62:4592-8. 2002
    ..These findings demonstrate that doxorubicin induces oxidative stress and mitochondrial-mediated apoptosis, as well as adaptive responses by the mitochondria to protect cardiac myocytes in vivo...
  8. ncbi Radiation-induced cyclooxygenase 2 up-regulation is dependent on redox status in prostate cancer cells
    Lingyun Li
    Department of Radiation Oncology, Stanford University, School of Medicine, Stanford, California, USA
    Radiat Res 160:617-21. 2003
    ..Radiation-induced increases in ROS levels contribute to the adaptive response of PC-3 cells, resulting in elevated levels of COX2...