Rachel E Ellsworth

Summary

Affiliation: Windber Research Institute
Country: USA

Publications

  1. ncbi A gene expression signature that defines breast cancer metastases
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Clin Exp Metastasis 26:205-13. 2009
  2. ncbi Chromosomal alterations in pure nonneoplastic breast lesions: implications for breast cancer progression
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for Advancement of Military Medicine, Windber, PA, USA
    Ann Surg Oncol 17:1688-94. 2010
  3. ncbi Amplification of HER2 is a marker for global genomic instability
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M, Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA
    BMC Cancer 8:297. 2008
  4. ncbi Chromosomal alterations associated with the transition from in situ to invasive breast cancer
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jakcon Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 15:2519-25. 2008
  5. ncbi Genomic alterations associated with early stages of breast tumor metastasis
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 15:1989-95. 2008
  6. ncbi The Clinical Breast Care Project: an important resource in investigating environmental and genetic contributions to breast cancer in African American women
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA
    Cell Tissue Bank 9:109-20. 2008
  7. ncbi Molecular changes in primary breast tumors and the Nottingham Histologic Score
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA, 15963, USA
    Pathol Oncol Res 15:541-7. 2009
  8. ncbi Correlation of levels and patterns of genomic instability with histological grading of DCIS
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 14:3070-7. 2007
  9. ncbi Correlation of levels and patterns of genomic instability with histological grading of invasive breast tumors
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, PA, USA
    Breast Cancer Res Treat 107:259-65. 2008
  10. ncbi Timing of critical genetic changes in human breast disease
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 12:1054-60. 2005

Collaborators

Detail Information

Publications32

  1. ncbi A gene expression signature that defines breast cancer metastases
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Clin Exp Metastasis 26:205-13. 2009
    ..These data improve our understanding of the biological processes involved in successful metastatis and provide new targets to arrest tumor cell dissemination and metastatic colonization...
  2. ncbi Chromosomal alterations in pure nonneoplastic breast lesions: implications for breast cancer progression
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for Advancement of Military Medicine, Windber, PA, USA
    Ann Surg Oncol 17:1688-94. 2010
    ..We assessed allelic imbalance (AI) in pure CCL or ADH specimens to characterize molecular changes in nonneoplastic breast lesions...
  3. ncbi Amplification of HER2 is a marker for global genomic instability
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M, Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA
    BMC Cancer 8:297. 2008
    ..To assess the broader genomic implications of structural changes at the HER2 locus, we investigated relationships between genomic instability and HER2 status in patients with invasive breast cancer...
  4. ncbi Chromosomal alterations associated with the transition from in situ to invasive breast cancer
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jakcon Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 15:2519-25. 2008
    ..Although the transition from in situ to invasive disease is critical to the development of breast cancer, molecular and biological changes responsible for this transition are not well characterized...
  5. ncbi Genomic alterations associated with early stages of breast tumor metastasis
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 15:1989-95. 2008
    ....
  6. ncbi The Clinical Breast Care Project: an important resource in investigating environmental and genetic contributions to breast cancer in African American women
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA
    Cell Tissue Bank 9:109-20. 2008
    ....
  7. ncbi Molecular changes in primary breast tumors and the Nottingham Histologic Score
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA, 15963, USA
    Pathol Oncol Res 15:541-7. 2009
    ....
  8. ncbi Correlation of levels and patterns of genomic instability with histological grading of DCIS
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 14:3070-7. 2007
    ..In this study, levels and patterns of allelic imbalance (AI) were examined in DCIS lesions to develop molecular models that can distinguish pathological classifications of DCIS...
  9. ncbi Correlation of levels and patterns of genomic instability with histological grading of invasive breast tumors
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, PA, USA
    Breast Cancer Res Treat 107:259-65. 2008
    ....
  10. ncbi Timing of critical genetic changes in human breast disease
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 12:1054-60. 2005
    ..This study examined allelic imbalance (AI) in tissue samples representing a continuum of breast cancer development to examine the evolution of genomic instability...
  11. ncbi Outer breast quadrants demonstrate increased levels of genomic instability
    Darrell L Ellsworth
    Windber Research Institute, 600 Somerset Avenue, Windber, PA 15963, USA
    Ann Surg Oncol 11:861-8. 2004
    ....
  12. ncbi The genomic heritage of lymph node metastases: implications for clinical management of patients with breast cancer
    Tyson E Becker
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Ann Surg Oncol 15:1056-63. 2008
    ..To improve outcomes and develop more effective treatment strategies for patients with breast cancer, it is important to understand the molecular mechanisms underlying metastasis...
  13. ncbi Allelic imbalance in primary breast carcinomas and metastatic tumors of the axillary lymph nodes
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA
    Mol Cancer Res 3:71-7. 2005
    ..In addition, patterns of AI were highly discordant between tumor types, suggesting that additional genetic alterations accumulated independently in the two cell populations...
  14. ncbi Genomic patterns of allelic imbalance in disease free tissue adjacent to primary breast carcinomas
    Darrell L Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA
    Breast Cancer Res Treat 88:131-9. 2004
    ..Our data indicate that genomic instability may be inherently greater in disease-free tissue close to developing tumors, which may have important implications for defining surgical margins and predicting recurrence...
  15. ncbi Genomic instability and the development of metastatic lymph node tumors
    Karen A Callaghan
    Clinical Breast Care Project, Walter Reed Army Medical Center, Washington, DC, USA
    Ann Surg Oncol 14:3125-32. 2007
    ..Here, we examined levels and patterns of allelic imbalance (AI) in metastatic lymph node (LN) tumors to identify molecular signals that promote the survival and growth of disseminated breast tumor cells...
  16. ncbi Identification of differentially expressed genes in breast tumors from African American compared with Caucasian women
    Lori A Field
    Windber Research Institute, Windber, Pennsylvania, USA
    Cancer 118:1334-44. 2012
    ..Although socioeconomic status may influence prognosis, biological factors are also likely to contribute to tumor behavior...
  17. ncbi Genomic instability in the breast microenvironment? A critical evaluation of the evidence
    Charvonne Holliday
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Expert Rev Mol Diagn 9:667-78. 2009
    ..In this perspective, we present evidence surrounding the debate and critically evaluate arguments, both pros and cons, over the presence or absence of genomic instability tumor-associated stroma...
  18. ncbi Laser microdissection for gene expression profiling
    Lori A Field
    Windber Research Institute, Windber, PA, USA
    Methods Mol Biol 755:17-45. 2011
    ..This chapter provides detailed descriptions of protocols used to generate micro-array data from high-quality frozen breast tissue specimens, as well as challenges associated with formalin-fixed paraffin-embedded specimens...
  19. ncbi High-throughput loss of heterozygosity mapping in 26 commonly deleted regions in breast cancer
    Rachel E Ellsworth
    Clinical Breast Care Project, Windber Research Institute, Windber, Pennsylvania 15963, USA
    Cancer Epidemiol Biomarkers Prev 12:915-9. 2003
    ..This panel can be used to quickly detect genomic patterns of loss in large numbers of breast tumor samples and may provide both clinical information and molecular information regarding the underlying tumor suppressor genes...
  20. ncbi Relationships between the ABO blood group SNP rs505922 and breast cancer phenotypes: a genotype-phenotype correlation study
    Seth Rummel
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, Windber, USA
    BMC Med Genet 13:41. 2012
    ....
  21. ncbi Differential gene expression in primary breast tumors associated with lymph node metastasis
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA 15963, USA
    Int J Breast Cancer 2011:142763. 2011
    ....
  22. ncbi Functional identity of genes detectable in expression profiling assays following globin mRNA reduction of peripheral blood samples
    Lori A Field
    Clinical Breast Care Project, Windber Research Institute, Windber, PA 15963, USA
    Clin Biochem 40:499-502. 2007
    ..This study investigated the biological significance of genes whose expression was unmasked by globin mRNA reduction in peripheral blood...
  23. ncbi Genomic instability in histologically normal breast tissues: implications for carcinogenesis
    Darrell L Ellsworth
    Cardiovascular Disease Research Program, Windber Research Institute, Windber, PA 15963, USA
    Lancet Oncol 5:753-8. 2004
    ..Understanding the functional importance of genomic instability in early carcinogenesis has important implications for improvement of diagnostic and treatment strategies...
  24. ncbi Environmental chemicals and breast cancer risk--a structural chemistry perspective
    Jamie Weyandt
    Clinical Breast Care Project, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Curr Med Chem 15:2680-701. 2008
    ....
  25. ncbi FH535 inhibited migration and growth of breast cancer cells
    Joji Iida
    Department of Cell Biology, Windber Research Institute, Windber, Pennsylvania, United States of America
    PLoS ONE 7:e44418. 2012
    ..These results suggest not only a mechanism for migration and invasion involving the canonical WNT-signaling pathways but also novel strategies for treating patients who develop TN breast cancer...
  26. ncbi Genomic (in)stability of the breast tumor microenvironment
    Seth Rummel
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, Windber, PA 15963, USA
    Mol Cancer Res 10:1526-31. 2012
    ..These data, therefore, support a model in which the tumor microenvironment is genetically stable...
  27. ncbi Effect of ASCO/CAP guidelines for determining ER status on molecular subtype
    Brenda Deyarmin
    Windber Research Institute, Windber, PA, USA
    Ann Surg Oncol 20:87-93. 2013
    ..Here, we determined how this cutoff relates to molecular subtype...
  28. ncbi Molecular alterations associated with breast cancer mortality
    Laura M Voeghtly
    Clinical Breast Care Project, Windber Research Institute, Windber, Pennsylvania, United States of America
    PLoS ONE 7:e46814. 2012
    ..Identification of molecular alterations associated with disease outcome may improve risk assessment and treatments for aggressive breast cancer...
  29. ncbi Impact of lifestyle factors on prognosis among breast cancer survivors in the USA
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, Windber, PA 15963, USA
    Expert Rev Pharmacoecon Outcomes Res 12:451-64. 2012
    ..4 million by 2015, it is important to develop effective treatment paradigms that overcome barriers to behavioral modification to improve clinical outcomes and survivorship in breast cancer patients...
  30. ncbi Genomic heterogeneity of breast tumor pathogenesis
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, 620 Seventh Street, Windber, PA, 15963, USA
    Clin Med Oncol 3:77-85. 2009
    ..Finally, we discuss the clinical implications associated with different pathways of development, including a new clinical test to assign grade and guide treatment options...
  31. ncbi Evaluation of BRCA1 mutations in an unselected patient population with triple-negative breast cancer
    Seth Rummel
    Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA
    Breast Cancer Res Treat 137:119-25. 2013
    ..3 % in those without. Thus, evaluation of additional risk factors in both patients younger and older than 60 years should improve the identification of TNBC patients benefiting from genetic testing of BRCA1...
  32. ncbi Breast cancer in the personal genomics era
    Rachel E Ellsworth
    Clinical Breast Care Project, Henry M Jackson Foundation for the Advancement of Military Medicine, Windber, PA, USA
    Curr Genomics 11:146-61. 2010
    ..Molecular genomics has the potential to revolutionize clinical practice and improve the lives of women with breast cancer...