Lance D Wilson

Summary

Country: USA

Publications

  1. ncbi Tolerance develops to the sympathomimetic but not the local anesthetic effects of cocaine
    L D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Toxicol Clin Toxicol 38:719-27. 2000
  2. ncbi Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse
    L D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH, USA
    Acad Emerg Med 8:211-22. 2001
  3. ncbi Cocaethylene's effects on coronary artery blood flow and cardiac function in a canine model
    Lance D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Toxicol Clin Toxicol 40:535-46. 2002
  4. ncbi Electrophysiologic and hemodynamic effects of sodium bicarbonate in a canine model of severe cocaine intoxication
    Lance D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Toxicol Clin Toxicol 41:777-88. 2003
  5. pmc Ionic bases for electrical remodeling of the canine cardiac ventricle
    Darwin Jeyaraj
    The Heart and Vascular Research Center and Department of Biomedical Engineering, MetroHealth Campus, Case Western Reserve University, Cleveland, OH 44109, USA
    Am J Physiol Heart Circ Physiol 305:H410-9. 2013
  6. pmc Heart failure enhances susceptibility to arrhythmogenic cardiac alternans
    Lance D Wilson
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Heart Rhythm 6:251-9. 2009
  7. pmc Spontaneous calcium release in tissue from the failing canine heart
    Gregory S Hoeker
    Department of Biomedical Engineering, CaseWestern Reserve University, The Heart and Vascular Research Center, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Heart Circ Physiol 297:H1235-42. 2009
  8. doi Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia
    Tamer H Said
    The Heart and Vascular Research Center, Metro Health Campus, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    J Cardiovasc Pharmacol 60:165-71. 2012
  9. doi Cocaine and ethanol: combined effects on coronary artery blood flow and myocardial function in dogs
    Lance D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH, USA
    Acad Emerg Med 16:646-55. 2009
  10. pmc Enhanced dispersion of repolarization explains increased arrhythmogenesis in severe versus therapeutic hypothermia
    Joseph S Piktel
    The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH, USA
    Circ Arrhythm Electrophysiol 4:79-86. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Tolerance develops to the sympathomimetic but not the local anesthetic effects of cocaine
    L D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Toxicol Clin Toxicol 38:719-27. 2000
    ..The cardiovascular effects of cocaine are complex and include sympathomimetic as well as local anesthetic effects. The aim of the present study was to delineate cocaine toxicity in a model simulating cocaine binging patterns...
  2. ncbi Cocaine, ethanol, and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse
    L D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH, USA
    Acad Emerg Med 8:211-22. 2001
    ..The purpose of this study was to delineate the role of CE in the combined cardiotoxicity of cocaine and ethanol in a model simulating their abuse...
  3. ncbi Cocaethylene's effects on coronary artery blood flow and cardiac function in a canine model
    Lance D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Toxicol Clin Toxicol 40:535-46. 2002
    ..Though cocaine causes coronary vasoconstriction, cocaethylene's effects on coronaryflow are unknown. The aim of our study was to describe cocaethylene 's effects on coronary flow and cardiac function...
  4. ncbi Electrophysiologic and hemodynamic effects of sodium bicarbonate in a canine model of severe cocaine intoxication
    Lance D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Toxicol Clin Toxicol 41:777-88. 2003
    ..The hypothesis of this study was that NaHCO3 would correct cocaine-induced conduction abnormalities and resultant hemodynamic compromise in an animal model simulating severe cocaine intoxication...
  5. pmc Ionic bases for electrical remodeling of the canine cardiac ventricle
    Darwin Jeyaraj
    The Heart and Vascular Research Center and Department of Biomedical Engineering, MetroHealth Campus, Case Western Reserve University, Cleveland, OH 44109, USA
    Am J Physiol Heart Circ Physiol 305:H410-9. 2013
    ....
  6. pmc Heart failure enhances susceptibility to arrhythmogenic cardiac alternans
    Lance D Wilson
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Heart Rhythm 6:251-9. 2009
    ..However, previous studies have focused on alternans in normal rather than failing myocardium...
  7. pmc Spontaneous calcium release in tissue from the failing canine heart
    Gregory S Hoeker
    Department of Biomedical Engineering, CaseWestern Reserve University, The Heart and Vascular Research Center, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Heart Circ Physiol 297:H1235-42. 2009
    ..e., an SCR), but importantly, it is the rate of SCR rise rather than amplitude that was associated with TA...
  8. doi Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia
    Tamer H Said
    The Heart and Vascular Research Center, Metro Health Campus, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    J Cardiovasc Pharmacol 60:165-71. 2012
    ..In contrast to QT prolongation, augmentation of TDR was induced by proarrhythmic but not nonproarrhythmic drugs, suggesting TDR is a superior preclinical marker of proarrhythmic risk during drug development...
  9. doi Cocaine and ethanol: combined effects on coronary artery blood flow and myocardial function in dogs
    Lance D Wilson
    Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH, USA
    Acad Emerg Med 16:646-55. 2009
    ..The aim of this study was to investigate combined effects of cocaine and ethanol on myocardial blood flow, in relation to indices of myocardial function...
  10. pmc Enhanced dispersion of repolarization explains increased arrhythmogenesis in severe versus therapeutic hypothermia
    Joseph S Piktel
    The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH, USA
    Circ Arrhythm Electrophysiol 4:79-86. 2011
    ..In addition, we investigated whether the degree of hypothermia, the rate of temperature change, and cooling versus rewarming would alter hypothermia-induced arrhythmia substrates...
  11. ncbi Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling
    Darwin Jeyaraj
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Dr, Cleveland, OH 44109 1998, USA
    Circulation 115:3145-55. 2007
    ..Although T-wave memory is associated with altered expression of sarcolemmal ion channels, the biophysical mechanisms responsible for triggering remodeling of cardiac ion channels are unknown...
  12. pmc Mild hypothermia decreases arrhythmia susceptibility in a canine model of global myocardial ischemia*
    Joseph S Piktel
    The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Crit Care Med 40:2954-9. 2012
    ..We hypothesized that mild hypothermia induced prior to myocardial ischemia and reperfusion will have a beneficial effect on ischemia-related arrhythmia substrates...
  13. ncbi IKs blockade reduces dispersion of repolarization in heart failure
    Mehdi Pajouh
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Heart Rhythm 2:731-8. 2005
    ..We hypothesize that, in contrast to I(Kr) blockade, I(Ks) blockade will have little effect on midmyocardial cells and hence decrease dispersion of repolarization in heart failure...
  14. ncbi Mechanisms of arrythmogenic cardiac alternans
    Lance D Wilson
    The Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Hamman 330, Cleveland, OH 44109 1998, USA
    Europace 9:vi77-82. 2007
    ....
  15. ncbi Hematocrit and metabolic changes caused by varied resuscitation strategies in a canine model of hemorrhagic shock
    Yitzchak A Glick
    Department of Emergency Medicine, PHS, Mt Sinai Medical Center, Cleveland, OH, USA
    Am J Emerg Med 20:303-9. 2002
    ..Acute hemorrhage caused a rapid, moderate drop in Hct, which quickly stabilized. Larger decreases in Hct were caused by fluid resuscitation. Large-volume resuscitation had no advantage over small volume in this hemorrhagic shock model...
  16. ncbi Cellular alternans: a mechanism linking calcium cycling proteins to cardiac arrhythmogenesis
    Lance D Wilson
    MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Hamann 330, Cleveland, OH 44109 1998, USA
    Ann N Y Acad Sci 1080:216-34. 2006
    ..We propose that cellular calcium alternans may be an important mechanism linking mechanical dysfunction to cardiac arrhythmogenesis...