K J Wilson

Summary

Country: USA

Publications

  1. ncbi request reprint Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors
    K J Wilson
    3 Dimensional Pharmaceuticals, Inc, Exton, PA 19341, USA
    Bioorg Med Chem Lett 11:915-8. 2001
  2. ncbi request reprint Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors
    N L Subasinghe
    3 Dimensional Pharmaceuticals Inc, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 11:1379-82. 2001

Collaborators

  • M Zhang
  • N L Subasinghe
  • R Soll
  • F Lewandowski
  • C Illig
  • R DesJarlais
  • C Crysler
  • T Randle
  • B Grasberger
  • D Maguire
  • C J Molloy
  • J Spurlino
  • C Manthey
  • M J Rudolph
  • Z Zhou
  • R Bone
  • C Sharp
  • I Deckman
  • D Green
  • J Hoffman

Detail Information

Publications2

  1. ncbi request reprint Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors
    K J Wilson
    3 Dimensional Pharmaceuticals, Inc, Exton, PA 19341, USA
    Bioorg Med Chem Lett 11:915-8. 2001
    ..Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities...
  2. ncbi request reprint Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors
    N L Subasinghe
    3 Dimensional Pharmaceuticals Inc, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 11:1379-82. 2001
    ..Further structure based elaboration of this residue resulted in a novel class of potent and selective inhibitors of uPA...