F Vicini

Summary

Affiliation: William Beaumont Hospital
Country: USA

Publications

  1. doi request reprint Increasing accrual in cancer clinical trials with a focus on minority enrollment: The William Beaumont Hospital Community Clinical Oncology Program Experience
    Frank Vicini
    Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 117:4764-71. 2011
  2. doi request reprint Strategies for reducing cancer incidence and mortality in African American and Arab American and Chaldean communities in the Detroit metropolitan area
    Frank A Vicini
    Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Am J Clin Oncol 35:316-21. 2012
  3. doi request reprint Factors associated with optimal long-term cosmetic results in patients treated with accelerated partial breast irradiation using balloon-based brachytherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 83:512-8. 2012
  4. ncbi request reprint An interinstitutional and interspecialty comparison of treatment outcome data for patients with prostate carcinoma based on predefined prognostic categories and minimum follow-up
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 95:2126-35. 2002
  5. ncbi request reprint Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:1336-44. 2002
  6. ncbi request reprint Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy?
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 97:910-9. 2003
  7. ncbi request reprint First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity: results of the American Society of Breast Surgeons MammoSite breast brachytherapy trial
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Cancer 104:1138-48. 2005
  8. doi request reprint Differences in disease presentation, management techniques, treatment outcome, and toxicities in African-American women with early stage breast cancer treated with breast-conserving therapy
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 116:3485-92. 2010
  9. ncbi request reprint The role of high-dose rate brachytherapy in locally advanced prostate cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Semin Radiat Oncol 13:98-108. 2003
  10. ncbi request reprint Defining the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:722-30. 2004

Detail Information

Publications92

  1. doi request reprint Increasing accrual in cancer clinical trials with a focus on minority enrollment: The William Beaumont Hospital Community Clinical Oncology Program Experience
    Frank Vicini
    Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 117:4764-71. 2011
    ....
  2. doi request reprint Strategies for reducing cancer incidence and mortality in African American and Arab American and Chaldean communities in the Detroit metropolitan area
    Frank A Vicini
    Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Am J Clin Oncol 35:316-21. 2012
    ....
  3. doi request reprint Factors associated with optimal long-term cosmetic results in patients treated with accelerated partial breast irradiation using balloon-based brachytherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 83:512-8. 2012
    ..To evaluate factors associated with optimal cosmetic results at 72 months for early-stage breast cancer patients treated with Mammosite balloon-based accelerated partial breast irradiation (APBI)...
  4. ncbi request reprint An interinstitutional and interspecialty comparison of treatment outcome data for patients with prostate carcinoma based on predefined prognostic categories and minimum follow-up
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 95:2126-35. 2002
    ..The current study was conducted to compare and contrast outcomes with different forms of therapy for patients with prostate carcinoma who were treated at several institutions using predefined prognostic categories...
  5. ncbi request reprint Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:1336-44. 2002
    ..To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy...
  6. ncbi request reprint Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy?
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 97:910-9. 2003
    ....
  7. ncbi request reprint First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity: results of the American Society of Breast Surgeons MammoSite breast brachytherapy trial
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Cancer 104:1138-48. 2005
    ..Patient demographics, technical reproducibility, cosmesis, and early toxicity were evaluated...
  8. doi request reprint Differences in disease presentation, management techniques, treatment outcome, and toxicities in African-American women with early stage breast cancer treated with breast-conserving therapy
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 116:3485-92. 2010
    ..Data on patients who received breast-conserving therapy (BCT) for early stage breast cancer were examined to detect differences in disease presentation, management techniques, long-term treatment outcomes, and toxicities based on race...
  9. ncbi request reprint The role of high-dose rate brachytherapy in locally advanced prostate cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Semin Radiat Oncol 13:98-108. 2003
    ....
  10. ncbi request reprint Defining the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:722-30. 2004
    ..This pathologic analysis was conducted to help define the clinical target volume (CTV) for partial breast irradiation (PBI) by analyzing the amount and distance of residual disease found at reexcision after an initial lumpectomy...
  11. doi request reprint Limitations of the American Society of Therapeutic Radiology and Oncology Consensus Panel guidelines on the use of accelerated partial breast irradiation
    Frank Vicini
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 79:977-84. 2011
    ....
  12. ncbi request reprint High dose rate brachytherapy in the treatment of prostate cancer
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48072, USA
    World J Urol 21:220-8. 2003
    ....
  13. ncbi request reprint Limited-field radiation therapy in the management of early-stage breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    J Natl Cancer Inst 95:1205-10. 2003
    ..e., limited-field radiation therapy) in selected patients treated with breast-conserving therapy and compared them with results of matched breast-conserving therapy patients who underwent whole-breast radiation therapy...
  14. doi request reprint Five-year analysis of treatment efficacy and cosmesis by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 79:808-17. 2011
    ..To present 5-year data on treatment efficacy, cosmetic results, and toxicities for patients enrolled on the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial...
  15. pmc Initial efficacy results of RTOG 0319: three-dimensional conformal radiation therapy (3D-CRT) confined to the region of the lumpectomy cavity for stage I/ II breast carcinoma
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 77:1120-7. 2010
    ..Initial data on efficacy and toxicity are presented...
  16. ncbi request reprint Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1124-30. 2007
    ....
  17. doi request reprint Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI)
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48072, USA
    Cancer 112:758-66. 2008
    ..This report presents 3 years of data on treatment efficacy, cosmetic results, and toxicities for patients enrolled on the American Society of Breast Surgeons MammoSite (Cytyc, Bedford, Mass) Breast Brachytherapy Registry Trial...
  18. doi request reprint Molecular evidence demonstrating local treatment failure is the source of distant metastases in some patients treated for breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 71:689-94. 2008
    ..To examine the clonality relationships among initial invasive breast carcinoma (IBC), ipsilateral breast failure (IBF), and distant metastasis (DM) to determine the effect of local tumor recurrence on the development of DMs...
  19. ncbi request reprint Defining a dose-response relationship with radiotherapy for prostate cancer: is more really better?
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 51:1200-8. 2001
    ..Data were reviewed addressing the association between radiation therapy (RT) dose and treatment outcome for localized prostate cancer to help clarify the existence of a potential dose-response relationship...
  20. ncbi request reprint Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 68:341-6. 2007
    ..To determine the long-term efficacy and cosmetic results of accelerated partial breast irradiation (APBI) by reviewing our institution's experience...
  21. ncbi request reprint Breast brachytherapy: North American experience
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Semin Radiat Oncol 15:108-15. 2005
    ..We conclude that APBI brachytherapy programs that include all of these components have great potential to overcome many of the barriers that have prevented women from pursuing standard breast-conserving therapy...
  22. ncbi request reprint Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breast cancer treated with breast conserving therapy
    F Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Surg Oncol 70:33-40. 1999
    ....
  23. ncbi request reprint The role of androgen deprivation in the definitive management of clinically localized prostate cancer treated with radiation therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 43:707-13. 1999
    ..We performed a MEDLINE search of all available studies on this topic to determine if any conclusions could be reached on the efficacy of this treatment approach and the patients most suitable for its application...
  24. ncbi request reprint Pathologic and technical considerations in the treatment of ductal carcinoma in situ of the breast with lumpectomy and radiation therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Ann Oncol 10:883-90. 1999
    ..Multiple studies have attempted to identify factors associated with the development of local recurrences in these patients. Despite extensive reports examining this issue, no factor(s) has consistently been correlated with outcome...
  25. ncbi request reprint The importance of adequate follow-up in defining treatment success after external beam irradiation for prostate cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 45:553-61. 1999
    ....
  26. ncbi request reprint Dose-volume analysis for quality assurance of interstitial brachytherapy for breast cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 45:803-10. 1999
    ..Analyses performed in this fashion will be needed to ultimately assist in determining the efficacy of breast implants...
  27. ncbi request reprint Impact of young age on outcome in patients with ductal carcinoma-in-situ treated with breast-conserving therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 18:296-306. 2000
    ..We reviewed our institution's experience treating patients with ductal carcinoma-in-situ (DCIS) with breast-conserving therapy (BCT) to determine the impact of patient age on outcome...
  28. ncbi request reprint A phase I/II trial to evaluate three-dimensional conformal radiation therapy confined to the region of the lumpectomy cavity for Stage I/II breast carcinoma: initial report of feasibility and reproducibility of Radiation Therapy Oncology Group (RTOG) Stud
    Frank Vicini
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:1531-7. 2005
    ..Reproducibility, as measured by technical feasibility, was the primary end point with the goal of demonstrating whether the technique is widely applicable in a multicenter setting before a Phase III trial is undertaken...
  29. ncbi request reprint Accelerated treatment of breast cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 19:1993-2001. 2001
    ..The goals of the study were to determine whether treatment time can be reduced and whether elective treatment of the entire breast is necessary...
  30. ncbi request reprint Relationship between excision volume, margin status, and tumor size with the development of local recurrence in patients with ductal carcinoma-in-situ treated with breast-conserving therapy
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Surg Oncol 76:245-54. 2001
    ....
  31. ncbi request reprint Limitations in the use of serum prostate specific antigen levels to monitor patients after treatment for prostate cancer
    Frank A Vicini
    Departments of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 173:1456-62. 2005
    ..We reviewed the literature to help clarify the benefits and/or hazards associated with monitoring serum prostate specific antigen (PSA) after treatment with surgery or radiation therapy (RT) for nonmetastatic prostate cancer...
  32. ncbi request reprint The emerging role of brachytherapy in the management of patients with breast cancer
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Semin Radiat Oncol 12:31-9. 2002
    ..Although preliminary results with brachytherapy alone are encouraging, proper patient selection and optimal dosimetric guidelines must be employed in order to achieve success when used in this setting...
  33. doi request reprint Identifying differences between biochemical failure and cure: incidence rates and predictors
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 81:e369-75. 2011
    ..Patients treated with radiation therapy (RT) for prostate cancer were evaluated to estimate the length of time required to document biochemical cure (BC) after treatment and the variables associated with long-term treatment efficacy...
  34. ncbi request reprint Age at diagnosis and outcome for women with ductal carcinoma-in-situ of the breast: a critical review of the literature
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 20:2736-44. 2002
    ....
  35. ncbi request reprint Use of pathologic factors to assist in establishing adequacy of excision before radiotherapy in patients treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 60:86-94. 2004
    ..We reviewed our experience in patients with early-stage breast carcinoma treated with breast-conserving therapy (BCT) to identify pathologic factors useful in defining the adequacy of excision before radiotherapy (RT)...
  36. doi request reprint Six-year analysis of treatment-related toxicities in patients treated with accelerated partial breast irradiation on the American Society of Breast Surgeons MammoSite Breast Brachytherapy registry trial
    A J Khan
    Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 19:1477-83. 2012
    ..The American Society of Breast Surgeons (ASBrS) enrolled women in a registry trial to prospectively study patients treated with the MammoSite RTS device. This report presents 6-year data on treatment-related toxicities from the trial...
  37. ncbi request reprint Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast
    Lawrence J Solin
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer 103:1137-46. 2005
    ..The objective of the current study was to determine the long-term outcome after breast-conservation surgery followed by definitive breast irradiation for women with mammographically detected DCIS of the breast...
  38. ncbi request reprint Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer
    A A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 50:1226-34. 2001
    ..The potential dose escalation achievable with this ART process is quantified for both conformal radiotherapy (CRT) delivery and intensity-modulated radiotherapy (IMRT) delivery...
  39. ncbi request reprint Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT)
    Kathy L Baglan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 55:302-11. 2003
    ..We present a novel three-dimensional conformal radiation therapy (3D-CRT) technique to treat the lumpectomy cavity, plus a 1.5-cm margin, in patients with early-stage breast cancer and study its clinical feasibility...
  40. ncbi request reprint Risk factors for regional nodal failure after breast-conserving therapy: regional nodal irradiation reduces rate of axillary failure in patients with four or more positive lymph nodes
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 56:658-70. 2003
    ....
  41. ncbi request reprint The influence of percentage of preradiation needle biopsies with adenocarcinoma and total radiation dose on the pathologic response of unfavorable prostate adenocarcinoma
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 117:927-34. 2002
    ..Gleason score and gland volume did not contribute significantly to this relationship...
  42. ncbi request reprint Analysis of treatment efficacy, cosmesis, and toxicity using the MammoSite breast brachytherapy catheter to deliver accelerated partial-breast irradiation: the william beaumont hospital experience
    K Kenneth Chao
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 69:32-40. 2007
    ..Marlborough, MA) breast brachytherapy catheter to deliver accelerated partial-breast irradiation (APBI), for determining short-term treatment efficacy, cosmesis, and toxicity...
  43. ncbi request reprint Changes in temporal patterns of local failure after breast-conserving therapy and their prognostic implications
    Daniel J Krauss
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:731-40. 2004
    ..elsewhere [E]) and to compare these to rates of contralateral failure in women with Stages I/II breast cancer treated with conservative surgery (CS) and radiation therapy (RT)...
  44. ncbi request reprint Intraductal carcinoma of the breast: pathologic features associated with local recurrence in patients treated with breast-conserving therapy
    N S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Surg Pathol 24:1058-67. 2000
    ..These results suggest that the volume of DCIS in the specimen, and the volume of DCIS near the margin are associated with local recurrence. These features can be used to identify those patients with a higher chance of local recurrence...
  45. doi request reprint Local control, toxicity, and cosmesis in women younger than 50 enrolled onto the American Society of Breast Surgeons MammoSite Radiation Therapy System registry trial
    A J Khan
    Department of Radiation Oncology, Robert Wood Johnson University Hospital Cancer Institute of New Jersey, New Brunswick, USA
    Ann Surg Oncol 16:1612-8. 2009
    ..This report examines local recurrence (LR), toxicity, and cosmesis as a function of age in women enrolled onto the trial...
  46. ncbi request reprint Percentage of positive biopsy cores as predictor of clinical outcome in prostate cancer treated with radiotherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 168:1994-9. 2002
    ..We performed a complete pathology analysis of pretreatment biopsy specimens in an attempt to clarify their impact on clinical outcome following radiotherapy...
  47. ncbi request reprint Adaptive radiation therapy
    D Yan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Phys Med Biol 42:123-32. 1997
    ..In this process, field margin and treatment dose can be routinely customized to each individual patient to achieve a safe dose escalation...
  48. ncbi request reprint Accelerated partial breast irradiation: a dosimetric comparison of three different techniques
    Daniel W Weed
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Brachytherapy 4:121-9. 2005
    ....
  49. ncbi request reprint Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution
    Helen Pass
    Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 101:713-20. 2004
    ..The goals of the current study were to determine the frequency and use of optimal local and systemic therapy techniques and to evaluate the impact of these changes on treatment efficacy...
  50. ncbi request reprint The impact of lobular carcinoma in situ in association with invasive breast cancer on the rate of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy
    Shruti Jolly
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:365-71. 2006
    ..We examined the impact of the presence and extent of LCIS associated with invasive breast cancer on clinical outcome in BCT patients...
  51. ncbi request reprint Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 68:1375-80. 2007
    ..In the present analysis, we reviewed the acute and chronic toxicity of this IMRT approach compared with conventional wedge-based treatment...
  52. ncbi request reprint Conformal high dose rate brachytherapy improves biochemical control and cause specific survival in patients with prostate cancer and poor prognostic factors
    Alvaro Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    J Urol 169:974-9; discussion 979-80. 2003
    ..To achieve this outcome a brachytherapy boost was given. We report the results of the first high dose rate dose-escalation brachytherapy trial...
  53. ncbi request reprint Unification of a common biochemical failure definition for prostate cancer treated with brachytherapy or external beam radiotherapy with or without androgen deprivation
    Dwight L Fitch
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:1430-9. 2006
    ..We retrospectively analyzed our institution's experience treating localized prostate cancer in an attempt to determine a BF definition that could be applied for these various treatment modalities...
  54. doi request reprint Timing of Chemotherapy after MammoSite radiation therapy system breast brachytherapy: analysis of the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial
    Bruce G Haffty
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Int J Radiat Oncol Biol Phys 72:1441-8. 2008
    ..To evaluate cosmetic outcome and radiation recall in the American Society of Breast Surgeons registry trial, as a function of the interval between accelerated partial breast irradiation (APBI) and initiation of chemotherapy (CTX)...
  55. ncbi request reprint The use of molecular assays to establish definitively the clonality of ipsilateral breast tumor recurrences and patterns of in-breast failure in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 109:1264-72. 2007
    ....
  56. ncbi request reprint Improved biochemical outcome with adjuvant radiotherapy after radical prostatectomy for prostate cancer with poor pathologic features
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 61:714-24. 2005
    ..We performed a retrospective comparison of our institution's experience treating prostate cancer with RP vs. RP followed by adjuvant EBRT...
  57. ncbi request reprint Breast cancer: new radiation treatment options
    Douglas W Arthur
    Department of Radiation Oncology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia, USA
    Oncology (Williston Park) 18:1621-9; discussion 1629-30, 1636-38. 2004
    ..However, further clinical study remains important to thoroughly define the appropriate clinical setting, patient selection criteria, and limitations for each of these innovative treatment approaches...
  58. ncbi request reprint Impact of breathing motion on whole breast radiotherapy: a dosimetric analysis using active breathing control
    Robert C Frazier
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 58:1041-7. 2004
    ..The active breathing control (ABC) apparatus was used to quantify the effect of breathing motion on whole breast radiotherapy (RT) with standard wedges and intensity-modulated RT (IMRT)...
  59. ncbi request reprint Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Int J Radiat Oncol Biol Phys 57:1247-53. 2003
    ..We present our ongoing clinical experience utilizing 3D conformal radiation therapy (3D-CRT) to deliver partial-breast irradiation (PBI) in patients with early-stage breast cancer treated with breast-conserving therapy...
  60. ncbi request reprint Potential survival advantage with early androgen deprivation for biochemical failure after external beam radiotherapy: the importance of accurately defining biochemical disease status
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 60:453-62. 2004
    ..after clinical failure (clinical failure), and the associated impact of various BF definitions...
  61. ncbi request reprint Partial breast irradiation. Patient selection, guidelines for treatment, and current results
    Peter Y Chen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Front Radiat Ther Oncol 40:253-71. 2007
    ..Results of PBI show excellent control rates with mild toxicities; cosmetic outcomes are good to excellent in the vast majority of patients...
  62. ncbi request reprint Partial breast irradiation in breast conserving therapy by way of intersitial brachytherapy
    Pamela R Benitez
    Department of Surgery, William Beaumont Hospital, 3577 W 13 Mile Rd, Suite No 201, Royal Oak, MI 48073, USA
    Am J Surg 188:355-64. 2004
    ....
  63. ncbi request reprint Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 57:875-90. 2003
    ....
  64. ncbi request reprint MRI-based volumetric assessment of cardiac anatomy and dose reduction via active breathing control during irradiation for left-sided breast cancer
    Daniel J Krauss
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 61:1243-50. 2005
    ....
  65. ncbi request reprint Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 56:704-15. 2003
    ....
  66. ncbi request reprint Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:107-18. 2002
    ..We performed a detailed pathologic review of posttreatment biopsy specimens in an attempt to clarify their relationship with clinical outcome and radiation dose...
  67. ncbi request reprint Long-term cosmetic results and toxicity after accelerated partial-breast irradiation: a method of radiation delivery by interstitial brachytherapy for the treatment of early-stage breast carcinoma
    Peter Y Chen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 106:991-9. 2006
    ..The objective of this study was to assess the cosmesis and toxicities in patients with early-stage breast carcinoma who received treatment with accelerated partial breast irradiation (APBI) using interstitial brachytherapy...
  68. ncbi request reprint Molecular clonality relationships in initial carcinomas, ipsilateral breast failures, and distant metastases in patients treated with breast-conserving therapy: evidence suggesting that some distant metastases are derived from ipsilateral breast failures
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 124:49-57. 2005
    ..The relationships of initial carcinomas, IBFs, and DMs are complex. DMs seem to be the direct result of IBFs in some cases. Some carcinomas seem to be composed of subclones with different and unrelated IBF and DM potential...
  69. ncbi request reprint Acute and subacute toxicity associated with concurrent adjuvant radiation therapy and paclitaxel in primary breast cancer therapy
    Youseff M Hanna
    Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Breast J 8:149-53. 2002
    ..Concurrent radiation and paclitaxel with these doses and schedule should be approached cautiously until further studies documenting its safety are completed...
  70. ncbi request reprint Practical application of biochemical failure definitions: what to do and when to do it
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:304-15. 2002
    ..We performed an extensive analysis of post-radiotherapy PSA measurements to determine the clinical significance of biochemical failure (BF) and the correlation of BF with clinical failure (CF) and cause-specific death (CSD)...
  71. ncbi request reprint Dosimetric characteristics of the MammoSite RTS, a new breast brachytherapy applicator
    Gregory K Edmundson
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 52:1132-9. 2002
    ..This is the first published report on the dosimetric characteristics of this device...
  72. ncbi request reprint Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48703, USA
    Int J Radiat Oncol Biol Phys 62:1297-308. 2005
    ..We analyzed our experience treating localized prostate cancer with image-guided off-line correction with adaptive high-dose radiotherapy (ART) in our Phase II dose escalation study to identify factors predictive of chronic rectal toxicity...
  73. ncbi request reprint Factors associated with local recurrence and cause-specific survival in patients with ductal carcinoma in situ of the breast treated with breast-conserving therapy or mastectomy
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Beaumont Cancer Institute, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:1514-21. 2005
    ....
  74. doi request reprint PSA bounce after prostate brachytherapy with or without neoadjuvant androgen deprivation
    Samuel D McGrath
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Brachytherapy 9:137-44. 2010
    ..To assess the impact of PSA bounce (PB) on biochemical failure (BF) and clinical failure (CF) in brachytherapy patients treated with or without neoadjuvant androgen deprivation (AD)...
  75. doi request reprint Optimal use of re-excision in patients diagnosed with early-stage breast cancer by excisional biopsy treated with breast-conserving therapy
    Jamie L Caughran
    Department of Surgery, William Beaumont Hospital, Royal Oak, MI, USA
    Ann Surg Oncol 16:3020-7. 2009
    ....
  76. ncbi request reprint Three-dimensional evaluation of intra- and interfraction immobilization of lung and chest wall using active breathing control: a reproducibility study with breast cancer patients
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 57:968-78. 2003
    ....
  77. ncbi request reprint Molecular clonality determination of ipsilateral recurrence of invasive breast carcinomas after breast-conserving therapy: comparison with clinical and biologic factors
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 123:679-89. 2005
    ..Molecular clonality assays may provide a reliable means of identifying patients who might benefit from systemic chemotherapy at the time of IBF...
  78. ncbi request reprint MammoSite radiation therapy system
    Oscar E Streeter
    Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Breast 12:491-6. 2003
    ..Trials for DCIS are being developed, as well as a comparison trial to standard external beam radiation as well as other forms of accelerated partial breast irradiation (APBI)...
  79. ncbi request reprint Overview of accelerated partial breast irradiation
    Todd A Swanson
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, 3601 West 13 Mile Road, Royal Oak, MI 48073, USA
    Curr Oncol Rep 10:54-60. 2008
    ..This review discusses data accumulated to date exploring the experience with all APBI modalities and presents future studies exploring this concept...
  80. ncbi request reprint Monomorphic epithelial proliferations: characterization and evidence suggesting they are the pool of partially transformed lesions from which some invasive carcinomas arise
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 128:1023-34. 2007
    ..Radiation therapy may reduce the IBF rate by eradicating these precursor lesions and preventing new carcinomas from emerging rather than eradicating microscopic residual disease...
  81. ncbi request reprint The validity of surgical clips as a radiographic surrogate for the lumpectomy cavity in image-guided accelerated partial breast irradiation
    Daniel W Weed
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 60:484-92. 2004
    ..We hypothesize that surgical clips placed in the biopsy cavity during lumpectomy can be used as radiographic markers to facilitate image-guided external beam accelerated partial breast irradiation...
  82. ncbi request reprint Assessing the benefit of radiation therapy after breast-conserving surgery for ductal carcinoma-in-situ
    James A Hayman
    Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 23:5171-7. 2005
    ..To assess women's preferences regarding the trade-off between the risks and benefits of treatment with radiation therapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma-in-situ (DCIS)...
  83. ncbi request reprint Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results
    Jennifer K Marshall
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Cancer 97:2142-9. 2003
    ....
  84. doi request reprint Five-year outcome of patients classified using the American Society for Radiation Oncology consensus statement guidelines for the application of accelerated partial breast irradiation: an analysis of patients treated on the American Society of Breast Surg
    Simona F Shaitelman
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, Michigan 48072, USA
    Cancer 116:4677-85. 2010
    ....
  85. ncbi request reprint A cost comparison analysis of partial versus whole-breast irradiation after breast-conserving surgery for early-stage breast cancer
    W Warren Suh
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 62:790-6. 2005
    ..To assess, if and for whom, there are cost savings associated with alternate breast radiotherapy (RT) techniques when compared with the conventional external beam-based whole-breast RT with a boost (WBRT-B)...
  86. ncbi request reprint Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 122:728-39. 2004
    ..Tubular carcinoma as a distinct morphologic entity should be restricted to neoplasms with 70% or more tubularity, pure grade 1 nuclei, and rare mitoses. Other definitions of tubular carcinoma do not guarantee the excellent prognosis...
  87. ncbi request reprint Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situ
    Lawrence J Solin
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Eur J Cancer 41:1715-23. 2005
    ..Close follow-up after initial breast conservation treatment with radiation is warranted for the early detection of potentially salvageable local and local-regional recurrences...
  88. ncbi request reprint Prostate gland motion assessed with cine-magnetic resonance imaging (cine-MRI)
    Michel J Ghilezan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 62:406-17. 2005
    ..To quantify prostate motion during a radiation therapy treatment using cine-magnetic resonance imaging (cine-MRI) for time frames comparable to that expected in an image-guided radiation therapy treatment session (20-30 min)...
  89. pmc Accelerated partial breast irradiation after conservative surgery for breast cancer
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg 239:338-51. 2004
    ..To critically review the theoretical and actual risks and benefits of accelerated partial breast irradiation (APBI) after breast-conserving surgery...
  90. ncbi request reprint Initial outcomes for patients treated on the American Society of Breast Surgeons MammoSite clinical trial for ductal carcinoma-in-situ of the breast
    Jacqueline S Jeruss
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann Surg Oncol 13:967-76. 2006
    ..We hypothesized that APBI delivered with the MammoSite device would be well tolerated and be associated with a good cosmetic outcome in patients with ductal carcinoma-in-situ (DCIS)...
  91. ncbi request reprint Multi-institutional experience using the MammoSite radiation therapy system in the treatment of early-stage breast cancer: 2-year results
    Laurie W Cuttino
    Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298 0058, USA
    Int J Radiat Oncol Biol Phys 71:107-14. 2008
    ..To present a retrospective multi-institutional experience of patients treated with the MammoSite radiation therapy system (RTS)...
  92. ncbi request reprint Integrating partial breast irradiation into surgical practice and clinical trials
    Regina M Fearmonti
    The University of Texas M D Anderson Cancer Center, Department of Surgical Oncology Unit 444, 1400 Holcombe Boulevard, FC 12 3000, Houston, TX 77030, USA
    Surg Clin North Am 87:485-98, x-xi. 2007
    ..This article describes evolving methods of APBI in comparison to WBI and in the setting of ongoing clinical trials...