Alvaro Martinez

Summary

Affiliation: William Beaumont Hospital
Country: USA

Publications

  1. ncbi Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
    Ching Yee O Wong
    Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA
    Radiat Oncol 2:18. 2007
  2. ncbi Interim report of image-guided conformal high-dose-rate brachytherapy for patients with unfavorable prostate cancer: the William Beaumont phase II dose-escalating trial
    A A Martinez
    Department ofRadiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 47:343-52. 2000
  3. ncbi No apparent benefit at 5 years from a course of neoadjuvant/concurrent androgen deprivation for patients with prostate cancer treated with a high total radiation dose
    Alvaro Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 170:2296-301. 2003
  4. ncbi Lack of benefit from a short course of androgen deprivation for unfavorable prostate cancer patients treated with an accelerated hypofractionated regime
    Alvaro A Martinez
    Department of Radiation Oncology and Urology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 62:1322-31. 2005
  5. ncbi High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Oncol 33:481-8. 2010
  6. ncbi Dose escalation using conformal high-dose-rate brachytherapy improves outcome in unfavorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:316-27. 2002
  7. ncbi Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer
    A A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 50:1226-34. 2001
  8. ncbi Phase II prospective study of the use of conformal high-dose-rate brachytherapy as monotherapy for the treatment of favorable stage prostate cancer: a feasibility report
    A A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 49:61-9. 2001
  9. ncbi Dose escalation improves cancer-related events at 10 years for intermediate- and high-risk prostate cancer patients treated with hypofractionated high-dose-rate boost and external beam radiotherapy
    Alvaro A Martinez
    Radiation Oncology Department, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Int J Radiat Oncol Biol Phys 79:363-70. 2011
  10. ncbi Differences in disease presentation, treatment outcomes, and toxicities in African American patients treated with radiation therapy for prostate cancer
    Chirag Shah
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Clin Oncol 35:566-71. 2012

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
    Ching Yee O Wong
    Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA
    Radiat Oncol 2:18. 2007
    ..To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy...
  2. ncbi Interim report of image-guided conformal high-dose-rate brachytherapy for patients with unfavorable prostate cancer: the William Beaumont phase II dose-escalating trial
    A A Martinez
    Department ofRadiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 47:343-52. 2000
    ..This interim report discusses treatment outcome and prognostic factors using this treatment approach...
  3. ncbi No apparent benefit at 5 years from a course of neoadjuvant/concurrent androgen deprivation for patients with prostate cancer treated with a high total radiation dose
    Alvaro Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 170:2296-301. 2003
    ....
  4. ncbi Lack of benefit from a short course of androgen deprivation for unfavorable prostate cancer patients treated with an accelerated hypofractionated regime
    Alvaro A Martinez
    Department of Radiation Oncology and Urology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 62:1322-31. 2005
    ....
  5. ncbi High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Oncol 33:481-8. 2010
    ..The 5-year experience at William Beaumont Hospital (WBH) and the California Endocurietherapy Center (CET) with accelerated-hypofractionated high-dose-rate (HDR) monotherapy in favorable prostate cancer is presented...
  6. ncbi Dose escalation using conformal high-dose-rate brachytherapy improves outcome in unfavorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:316-27. 2002
    ....
  7. ncbi Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer
    A A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 50:1226-34. 2001
    ..The potential dose escalation achievable with this ART process is quantified for both conformal radiotherapy (CRT) delivery and intensity-modulated radiotherapy (IMRT) delivery...
  8. ncbi Phase II prospective study of the use of conformal high-dose-rate brachytherapy as monotherapy for the treatment of favorable stage prostate cancer: a feasibility report
    A A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 49:61-9. 2001
    ....
  9. ncbi Dose escalation improves cancer-related events at 10 years for intermediate- and high-risk prostate cancer patients treated with hypofractionated high-dose-rate boost and external beam radiotherapy
    Alvaro A Martinez
    Radiation Oncology Department, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Int J Radiat Oncol Biol Phys 79:363-70. 2011
    ....
  10. ncbi Differences in disease presentation, treatment outcomes, and toxicities in African American patients treated with radiation therapy for prostate cancer
    Chirag Shah
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Am J Clin Oncol 35:566-71. 2012
    ..We analyzed differences in disease presentation, outcomes, and toxicities between African American (AA) and White (W) men treated with definitive radiation therapy for their prostate cancer...
  11. ncbi A new model using number of needles and androgen deprivation to predict chronic urinary toxicity for high or low dose rate prostate brachytherapy
    Carlos Vargas
    William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 174:882-7. 2005
    ..However, grade 1 was lower for HDR. The impotence rate was decrease by half with HDR. Neoadjuvant hormonal therapy and 14 or greater needles were significantly associated with increased chronic urinary toxicity on multivariate analysis...
  12. ncbi Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: the combined experience of nine institutions in patients treated in 1994 and 1995
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 61:415-9. 2005
    ..To study the radiation dose-response as determined by Kaplan-Meier prostate-specific antigen (PSA) disease-free survival (PSA-DFS) estimates in patients with stage T1-T2 prostate cancer treated within a 2-year period (1994-1995)...
  13. ncbi Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1124-30. 2007
    ....
  14. ncbi Analysis of treatment efficacy, cosmesis, and toxicity using the MammoSite breast brachytherapy catheter to deliver accelerated partial-breast irradiation: the william beaumont hospital experience
    K Kenneth Chao
    Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 69:32-40. 2007
    ..Marlborough, MA) breast brachytherapy catheter to deliver accelerated partial-breast irradiation (APBI), for determining short-term treatment efficacy, cosmesis, and toxicity...
  15. ncbi Conformal high dose rate brachytherapy improves biochemical control and cause specific survival in patients with prostate cancer and poor prognostic factors
    Alvaro Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    J Urol 169:974-9; discussion 979-80. 2003
    ..Another important advantage is that the patient is not radioactive after the high dose rate implant...
  16. ncbi Predictors for chronic urinary toxicity after the treatment of prostate cancer with adaptive three-dimensional conformal radiotherapy: dose-volume analysis of a phase II dose-escalation study
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1100-9. 2007
    ..To identify factors predictive for chronic urinary toxicity secondary to high-dose adaptive three-dimensional conformal radiation...
  17. ncbi Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up
    J Vito Antonucci
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 74:447-52. 2009
    ..e., accelerated partial breast irradiation, [APBI]) in selected patients treated with breast-conserving therapy (BCT) and compare them with results of matched BCT patients who underwent whole-breast irradiation (WBI)...
  18. ncbi Phase I/II study evaluating early tolerance in breast cancer patients undergoing accelerated partial breast irradiation treated with the mammosite balloon breast brachytherapy catheter using a 2-day dose schedule
    Michelle Wallace
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 77:531-6. 2010
    ..Initial Phase I/II results using balloon brachytherapy to deliver accelerated partial breast irradiation (APBI) in 2 days in patients with early-stage breast cancer are presented...
  19. ncbi Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48703, USA
    Int J Radiat Oncol Biol Phys 62:1297-308. 2005
    ..To select the prescribed dose, different dose-volume histogram constraints may be used including the rectal wall V70. Patients experiencing acute rectal toxicity are more likely to experience chronic toxicity...
  20. ncbi Lack of benefit for the addition of androgen deprivation therapy to dose-escalated radiotherapy in the treatment of intermediate- and high-risk prostate cancer
    Daniel Krauss
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 80:1064-71. 2011
    ..Assessment of androgen deprivation therapy (ADT) benefits for prostate cancer treated with dose-escalated radiotherapy (RT)...
  21. ncbi High-dose-rate brachytherapy as monotherapy delivered in two fractions within one day for favorable/intermediate-risk prostate cancer: preliminary toxicity data
    Michel Ghilezan
    Department of Radiation Oncology, William Beaumont Hospital and Rose Cancer Institute, Royal Oak, Michigan 48073, USA
    Int J Radiat Oncol Biol Phys 83:927-32. 2012
    ..The dose was subsequently increased to 27 Gy (13.5 Gy × 2) delivered in 1 day. We report the acute and early chronic genitourinary and gastrointestinal toxicity...
  22. ncbi Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 68:341-6. 2007
    ..To determine the long-term efficacy and cosmetic results of accelerated partial breast irradiation (APBI) by reviewing our institution's experience...
  23. ncbi Year of treatment as independent predictor of relapse-free survival in patients with localized prostate cancer treated with definitive radiotherapy in the PSA era
    Patrick Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 63:795-9. 2005
    ..Accounting for these changes would facilitate the retrospective comparison of outcomes for patients treated in different periods...
  24. ncbi Geometric and dosimetric evaluations of an online image-guidance strategy for 3D-CRT of prostate cancer
    Qiuwen Wu
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 64:1596-609. 2006
    ..To evaluate an online image-guidance strategy for conformal treatment of prostate cancer and to estimate margin-reduction benefits...
  25. ncbi A dose-escalation trial with the adaptive radiotherapy process as a delivery system in localized prostate cancer: analysis of chronic toxicity
    Donald Brabbins
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073-6589, USA
    Int J Radiat Oncol Biol Phys 61:400-8. 2005
    ..Our data validate the rectal and bladder dose-volume constraints chosen for our three-dimensional conformal and IMRT prostrate radiotherapy planning...
  26. ncbi Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation
    Peter Y Chen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 76:991-7. 2010
    ..This prospective study examines the use of three-dimensional conformal external beam radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Four-year data on efficacy, cosmesis, and toxicity are presented...
  27. ncbi Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution
    Helen Pass
    Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 101:713-20. 2004
    ....
  28. ncbi Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 68:1375-80. 2007
    ..In the present analysis, we reviewed the acute and chronic toxicity of this IMRT approach compared with conventional wedge-based treatment...
  29. ncbi Computed tomography guided management of interfractional patient variation
    Di Yan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Semin Radiat Oncol 15:168-79. 2005
    ....
  30. ncbi Limited-field radiation therapy in the management of early-stage breast cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    J Natl Cancer Inst 95:1205-10. 2003
    ..e., limited-field radiation therapy) in selected patients treated with breast-conserving therapy and compared them with results of matched breast-conserving therapy patients who underwent whole-breast radiation therapy...
  31. ncbi Factors associated with local recurrence and cause-specific survival in patients with ductal carcinoma in situ of the breast treated with breast-conserving therapy or mastectomy
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Beaumont Cancer Institute, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:1514-21. 2005
    ..These results suggest that optimizing local therapy (surgery and radiation) is crucial to improve local control and CSS in patients treated with DCIS...
  32. ncbi Risk factors for regional nodal failure after breast-conserving therapy: regional nodal irradiation reduces rate of axillary failure in patients with four or more positive lymph nodes
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 56:658-70. 2003
    ..Inadequate axillary dissection was not only associated with increased regional failure, but also reduced survival...
  33. ncbi Online image-guided intensity-modulated radiotherapy for prostate cancer: How much improvement can we expect? A theoretical assessment of clinical benefits and potential dose escalation by improving precision and accuracy of radiation delivery
    Michel Ghilezan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 60:1602-10. 2004
    ....
  34. ncbi Prostate volume reduction with androgen deprivation therapy before interstitial brachytherapy
    Roger Kucway
    Department of Radiation Oncology, Research Institute, William Beaumont Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 4807306769, USA
    J Urol 167:2443-7. 2002
    ..CONCLUSIONS: Androgen deprivation therapy before brachytherapy is a method of downsizing the prostate to overcome anatomical limitations, including larger gland volume and pubic arch interference...
  35. ncbi Lack of benefit of pelvic radiation in prostate cancer patients with a high risk of positive pelvic lymph nodes treated with high-dose radiation
    Carlos Enrique Vargas
    Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:1474-82. 2005
    ..Pelvic radiation added to high prostate radiation doses did not show a clinical benefit for patients at a high risk of pelvic LN disease (>15%) selected using the Roach formula...
  36. ncbi The role of high-dose rate brachytherapy in locally advanced prostate cancer
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Semin Radiat Oncol 13:98-108. 2003
    ....
  37. ncbi Adaptive radiation therapy for prostate cancer
    Michel Ghilezan
    Department of Radiation Oncology, William Beaumont Hospitals and Research Institute, Royal Oak, MI 48073 6769, USA
    Semin Radiat Oncol 20:130-7. 2010
    ....
  38. ncbi Image guidance in external beam accelerated partial breast irradiation: comparison of surrogates for the lumpectomy cavity
    Yasmin Hasan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 70:619-25. 2008
    ..To compare localization of the lumpectomy cavity by using breast surface matching vs. clips for image-guided external beam accelerated partial breast irradiation...
  39. ncbi Comparison of planned versus actual dose delivered for external beam accelerated partial breast irradiation using cone-beam CT and deformable registration
    Yasmin Hasan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 80:1473-6. 2011
    ..To assess the adequacy of dose delivery to the clinical target volume (CTV) using external beam (EB) accelerated partial breast irradiation (APBI)...
  40. ncbi The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer
    Joost J Nuyttens
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Cancer Radiother 8:297-304. 2004
    ....
  41. ncbi Ten-year outcome including patterns of failure and toxicity for adjuvant whole abdominopelvic irradiation in high-risk and poor histologic feature patients with endometrial carcinoma
    Kimberly D Stewart
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:527-35. 2002
    ..The low long-term complication rate with high CSS rate makes WAPI the treatment of choice for these patients with significant comorbidities...
  42. ncbi Percentage of positive biopsy cores as predictor of clinical outcome in prostate cancer treated with radiotherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 168:1994-9. 2002
    ..Percent positive cores should be seriously considered as a primary factor in risk group stratification for prostate cancer...
  43. ncbi An interinstitutional and interspecialty comparison of treatment outcome data for patients with prostate carcinoma based on predefined prognostic categories and minimum follow-up
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Cancer 95:2126-35. 2002
    ..The current study was conducted to compare and contrast outcomes with different forms of therapy for patients with prostate carcinoma who were treated at several institutions using predefined prognostic categories...
  44. ncbi Differences in disease presentation, management techniques, treatment outcome, and toxicities in African-American women with early stage breast cancer treated with breast-conserving therapy
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 116:3485-92. 2010
    ..Data on patients who received breast-conserving therapy (BCT) for early stage breast cancer were examined to detect differences in disease presentation, management techniques, long-term treatment outcomes, and toxicities based on race...
  45. ncbi Treatment of prostate cancer with radiotherapy: should the entire seminal vesicles be included in the clinical target volume?
    Larry Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:686-97. 2002
    ....
  46. ncbi Clinical applications of volumetric modulated arc therapy
    Martha M Matuszak
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Int J Radiat Oncol Biol Phys 77:608-16. 2010
    ....
  47. ncbi Cone-beam-CT guided radiation therapy: A model for on-line application
    Mark Oldham
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Radiother Oncol 75:271-8. 2005
    ..As with all image guided treatment techniques the development of efficient procedures to utilize on-line data are of paramount importance...
  48. ncbi High dose rate brachytherapy in the treatment of prostate cancer
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48072, USA
    World J Urol 21:220-8. 2003
    ....
  49. ncbi Adaptive replanning strategies accounting for shrinkage in head and neck IMRT
    Qiuwen Wu
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 75:924-32. 2009
    ..The purposes of this study were (1) to evaluate the differences between planned and delivered dose, (2) to investigate margins required for anatomic changes, and (3) to find optimal replanning strategies...
  50. ncbi Limitations in the use of serum prostate specific antigen levels to monitor patients after treatment for prostate cancer
    Frank A Vicini
    Departments of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 173:1456-62. 2005
    ..We reviewed the literature to help clarify the benefits and/or hazards associated with monitoring serum prostate specific antigen (PSA) after treatment with surgery or radiation therapy (RT) for nonmetastatic prostate cancer...
  51. ncbi Partial breast irradiation in breast conserving therapy by way of intersitial brachytherapy
    Pamela R Benitez
    Department of Surgery, William Beaumont Hospital, 3577 W 13 Mile Rd, Suite No 201, Royal Oak, MI 48073, USA
    Am J Surg 188:355-64. 2004
    ....
  52. ncbi Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:1336-44. 2002
    ..To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy...
  53. ncbi PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysis
    Michael E Ray
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 64:1140-50. 2006
    ....
  54. ncbi The influence of percentage of preradiation needle biopsies with adenocarcinoma and total radiation dose on the pathologic response of unfavorable prostate adenocarcinoma
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Pathol 117:927-34. 2002
    ..Gleason score and gland volume did not contribute significantly to this relationship...
  55. ncbi Unification of a common biochemical failure definition for prostate cancer treated with brachytherapy or external beam radiotherapy with or without androgen deprivation
    Dwight L Fitch
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:1430-9. 2006
    ..In general, BF definitions have greater predictive capacity for clinical outcome with brachytherapy or neoadjuvant AD than EBRT alone, possibly because of less "noise" from production of background PSA...
  56. ncbi High-dose irradiation for prostate cancer via a high-dose-rate brachytherapy boost: results of a phase I to II study
    Carlos E Vargas
    Radiation Oncology Department, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 66:416-23. 2006
    ..Improved locoregional control with higher radiation doses alone can significantly decrease biochemical and clinical failures...
  57. ncbi Accelerated partial breast irradiation: a dosimetric comparison of three different techniques
    Daniel W Weed
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Brachytherapy 4:121-9. 2005
    ..Of the brachytherapy techniques, MammoSite appears to be superior in PTV coverage. When comparing MammoSite vs. 3D-CRT PTV coverage at 90% of the PD, the difference was not significantly different...
  58. ncbi Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era
    Deborah A Kuban
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Int J Radiat Oncol Biol Phys 57:915-28. 2003
    ..To report the long-term outcome for patients with Stage T1-T2 adenocarcinoma of the prostate definitively irradiated in the prostate-specific antigen (PSA) era...
  59. ncbi Matched-pair analysis of prostate cancer patients with a high risk of positive pelvic lymph nodes treated with and without pelvic RT and high-dose radiation using high dose rate brachytherapy
    Carlos E Vargas
    Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Am J Clin Oncol 29:451-7. 2006
    ..We performed a matched-pair analysis of patients treated at 2 institutions to assess the impact of pelvic radiotherapy (P-RT)...
  60. ncbi Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy?
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 97:910-9. 2003
    ....
  61. ncbi Failure definition-dependent differences in outcome following radiation for localized prostate cancer: can one size fit all?
    Deborah Kuban
    Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 61:409-14. 2005
    ..To compare long-term outcome using alternative failure definitions after external beam radiation for localized prostate cancer...
  62. ncbi Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue
    David J Brenner
    Center for Radiological Research, Department of Radiation Oncology, Columbia University, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 52:6-13. 2002
    ..A direct approach to the question of whether prostate tumors have an atypically high sensitivity to fractionation (low alpha/beta ratio), more typical of the surrounding late-responding normal tissue...
  63. ncbi Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT)
    Kathy L Baglan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 55:302-11. 2003
    ..However, more patients and additional studies will be needed to validate the accuracy of this margin, and longer follow-up will be needed to assess acute and chronic toxicity, tumor control, and cosmetic results...
  64. ncbi Nadir prostate-specific antigen within 12 months after radiotherapy predicts biochemical and distant failure
    Michael E Ray
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
    Urology 68:1257-62. 2006
    ..To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk...
  65. ncbi Phase II dose escalation study of image-guided adaptive radiotherapy for prostate cancer: use of dose-volume constraints to achieve rectal isotoxicity
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 63:141-9. 2005
    ..On the other hand, a larger PTV will increase the rectal wall dose and chronic rectal toxicity rates. PTV volume and dose constraints should be defined, considering their potential benefit...
  66. ncbi Changes in temporal patterns of local failure after breast-conserving therapy and their prognostic implications
    Daniel J Krauss
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 60:731-40. 2004
    ..E failures are, overall, less frequent than TR/MM but contribute increasingly to the IBTR rate after 5 years. Time to tumor recurrence is the most reliable predictor of prognosis after IBTR...
  67. ncbi Vaginal brachytherapy alone: an alternative to adjuvant whole pelvis radiation for early stage endometrial cancer
    Shruti Jolly
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Gynecol Oncol 97:887-92. 2005
    ....
  68. ncbi Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 56:704-15. 2003
    ..Breast cancer; Breath hold; Radiation therapy; Intensity modulated radiation therapy..
  69. ncbi The impact of age on long-term outcome in patients with endometrial cancer treated with postoperative radiation
    Shruti Jolly
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Gynecol Oncol 103:87-93. 2006
    ..The impact of treatment-related variables did not alter the age-related outcome...
  70. ncbi Potential survival advantage with early androgen deprivation for biochemical failure after external beam radiotherapy: the importance of accurately defining biochemical disease status
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 60:453-62. 2004
    ..after clinical failure (clinical failure), and the associated impact of various BF definitions...
  71. ncbi Dosimetric characteristics of the MammoSite RTS, a new breast brachytherapy applicator
    Gregory K Edmundson
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 52:1132-9. 2002
    ..This is the first published report on the dosimetric characteristics of this device...
  72. ncbi Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:107-18. 2002
    ..We performed a detailed pathologic review of posttreatment biopsy specimens in an attempt to clarify their relationship with clinical outcome and radiation dose...
  73. ncbi Improved biochemical outcome with adjuvant radiotherapy after radical prostatectomy for prostate cancer with poor pathologic features
    Carlos Vargas
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W. Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 61:714-24. 2005
    ..For patients with poor pathologic features (extracapsular extension, seminal vesicle invasion, positive margins), adjuvant RT improved the biochemical outcome independent of other prognostic factors...
  74. ncbi Biochemical and clinical significance of the posttreatment prostate-specific antigen bounce for prostate cancer patients treated with external beam radiation therapy alone: a multiinstitutional pooled analysis
    Eric M Horwitz
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer 107:1496-502. 2006
    ....
  75. ncbi Practical application of biochemical failure definitions: what to do and when to do it
    Larry L Kestin
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:304-15. 2002
    ..We performed an extensive analysis of post-radiotherapy PSA measurements to determine the clinical significance of biochemical failure (BF) and the correlation of BF with clinical failure (CF) and cause-specific death (CSD)...
  76. ncbi Volumetric modulated arc therapy for delivery of hypofractionated stereotactic lung radiotherapy: A dosimetric and treatment efficiency analysis
    Samuel D McGrath
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Radiother Oncol 95:153-7. 2010
    ..We compared VMAT plans with 3D-CRT for hypofractionated lung radiotherapy...
  77. ncbi Clinical implications of defining the gross tumor volume with combination of CT and 18FDG-positron emission tomography in non-small-cell lung cancer
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 67:709-19. 2007
    ..To compare the planning target volume (PTV) definitions for computed tomography (CT) vs. positron emission tomography (PET) in non-small-cell lung cancer (NSCLC)...
  78. ncbi High dose rate brachytherapy as prostate cancer monotherapy reduces toxicity compared to low dose rate palladium seeds
    Inga S Grills
    Department of Radiation, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 171:1098-104. 2004
    ..It is an accepted, convenient, cost-effective method of prostate brachytherapy for patients with favorable risk prostate cancer...
  79. ncbi Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation
    Inga S Grills
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48072, USA
    Int J Radiat Oncol Biol Phys 57:875-90. 2003
    ....
  80. ncbi Cone-beam-CT guided radiation therapy: technical implementation
    Daniel Letourneau
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Radiother Oncol 75:279-86. 2005
    ..In preparation for clinical implementation, phantom and patient imaging studies were conducted to determine the irradiation parameters that would trade-off image quality, patient dose and scanning time...
  81. ncbi Improved outcome at 10 years for serous-papillary/clear cell or high-risk endometrial cancer patients treated by adjuvant high-dose whole abdomino-pelvic irradiation
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Gynecol Oncol 90:537-46. 2003
    ....
  82. ncbi PSA bounce after prostate brachytherapy with or without neoadjuvant androgen deprivation
    Samuel D McGrath
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Brachytherapy 9:137-44. 2010
    ..To assess the impact of PSA bounce (PB) on biochemical failure (BF) and clinical failure (CF) in brachytherapy patients treated with or without neoadjuvant androgen deprivation (AD)...
  83. ncbi Assessment of residual error for online cone-beam CT-guided treatment of prostate cancer patients
    Daniel Letourneau
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 62:1239-46. 2005
    ..Residual error pertains to the uncertainty in image registration, the limited mechanical accuracy, and the intrafraction motion during imaging and treatment...
  84. ncbi Long-term cosmetic results and toxicity after accelerated partial-breast irradiation: a method of radiation delivery by interstitial brachytherapy for the treatment of early-stage breast carcinoma
    Peter Y Chen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 106:991-9. 2006
    ..The objective of this study was to assess the cosmesis and toxicities in patients with early-stage breast carcinoma who received treatment with accelerated partial breast irradiation (APBI) using interstitial brachytherapy...
  85. ncbi Flat-panel cone-beam computed tomography for image-guided radiation therapy
    David A Jaffray
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:1337-49. 2002
    ..The performance of the imaging system is evaluated and the application to image-guided radiation therapy is discussed...
  86. ncbi The emerging role of brachytherapy in the management of patients with breast cancer
    Frank Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Semin Radiat Oncol 12:31-9. 2002
    ..Although preliminary results with brachytherapy alone are encouraging, proper patient selection and optimal dosimetric guidelines must be employed in order to achieve success when used in this setting...
  87. ncbi The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment
    Joost J Nuyttens
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 53:497-503. 2002
    ..5 cm. Other borders of the CTV were based on muscle, bone, or major blood vessels and were stable. CONCLUSION: Modification of the CTV to design a PTV can be unequal, with the largest change at the anterior border of the inferior pelvis...
  88. ncbi Impact of breathing motion on whole breast radiotherapy: a dosimetric analysis using active breathing control
    Robert C Frazier
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 58:1041-7. 2004
    ..However, an appreciable portion of the internal mammary nodes are irradiated during normal inhalation, contributing to the uncertainty in the analysis of the efficacy of internal mammary nodal RT in breast treatment...
  89. ncbi Definitions of biochemical failure that best predict clinical failure in patients with prostate cancer treated with external beam radiation alone: a multi-institutional pooled analysis
    Eric M Horwitz
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Urol 173:797-802. 2005
    ..In this report we determined the sensitivity and specificity of several BF definitions using distant failure (DF) alone or clinical failure (CF), defined as local failure (LF) and/or DF...
  90. ncbi MRI-based volumetric assessment of cardiac anatomy and dose reduction via active breathing control during irradiation for left-sided breast cancer
    Daniel J Krauss
    Department of Radiation Oncology, William Beaumont Hospital, 3601 W. Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 61:1243-50. 2005
    ....
  91. ncbi Increasing external beam dose for T1-T2 prostate cancer: effect on risk groups
    Howard D Thames
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, and Department of Radiation Oncology, William Beaumont Hospital, Deroit, MI, USA
    Int J Radiat Oncol Biol Phys 65:975-81. 2006
    ....
  92. ncbi The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer
    Kathy L Baglan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 52:176-83. 2002
    ..CONCLUSIONS: A strong dose-volume relationship exists for the development of Grade 3+ acute small bowel toxicity in patients receiving concurrent 5-FU-based chemoradiotherapy for rectal carcinoma...
  93. ncbi The validity of surgical clips as a radiographic surrogate for the lumpectomy cavity in image-guided accelerated partial breast irradiation
    Daniel W Weed
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 60:484-92. 2004
    ..If the clips were used to guide accelerated partial breast irradiation, a planning target volume margin of the order of 5 mm could be used, significantly smaller than the 10-mm margin currently employed...
  94. ncbi Sorafenib and radiation: a promising combination in colorectal cancer
    Andrew W Suen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 78:213-20. 2010
    ..To examine the combination of radiation and the multikinase inhibitor sorafenib in human colorectal cancer cell lines and xenografts...
  95. ncbi Three-dimensional evaluation of intra- and interfraction immobilization of lung and chest wall using active breathing control: a reproducibility study with breast cancer patients
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 57:968-78. 2003
    ..Internal margins for suspended breathing can be extrapolated from these data for various anatomic regions within the lung and chest wall...
  96. ncbi An Internet-ready database for prospective randomized clinical trials of high-dose-rate brachytherapy for adenocarcinoma of the prostate
    Phillip M Devlin
    Department of Radiation Oncology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 53:104-15. 2002
    ..To demonstrate a new interactive Internet-ready database for prospective clinical trials in high-dose-rate (HDR) brachytherapy for prostate cancer...
  97. ncbi Longitudinal assessment of quality of life and audiometric test outcomes in vestibular schwannoma patients treated with gamma knife surgery
    Sean S Park
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Otol Neurotol 32:676-9. 2011
    ..To prospectively assess the quality of life (QOL) and hearing acuity in vestibular schwannoma (VS) patients after gamma knife surgery (GKS)...
  98. ncbi Clinicopathologic analysis of extracapsular extension in prostate cancer: should the clinical target volume be expanded posterolaterally to account for microscopic extension?
    K Kenneth Chao
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, and Department of Radiaiton Oncology, University of Florida, Jacksonville, USA
    Int J Radiat Oncol Biol Phys 65:999-1007. 2006
    ....
  99. ncbi Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells
    Yasmin Hasan
    William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 76:896-904. 2010
    ..However, the effect of these agents on evidence-based radiotherapy practice is poorly understood. The present study aimed to determine whether dietary supplements radiosensitized normal prostate or prostate cancer cell lines...
  100. ncbi Prostate gland motion assessed with cine-magnetic resonance imaging (cine-MRI)
    Michel J Ghilezan
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 62:406-17. 2005
    ..The determination of appropriate intrafraction margins in radiation therapy to accommodate the time-dependent uncertainty in positional targeting is a topic of ongoing investigations for the on-line image guidance model...
  101. ncbi Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation
    Vincent M Remouchamps
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 55:392-406. 2003
    ..IMRT improves dose homogeneity, slightly reduces the dose to the heart, and diminishes the number of MUs required...