David A Loeffler

Summary

Affiliation: William Beaumont Hospital
Country: USA

Publications

  1. pmc α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls
    Lynnae M Smith
    Department of Neurology Research, Beaumont Health System, Royal Oak, Michigan, USA
    PLoS ONE 7:e52285. 2012
  2. pmc Intravenous immunoglobulin and Alzheimer's disease: what now?
    David A Loeffler
    Department of Neurology Research, William Beaumont Hospital Research Institute, Beaumont Health System, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    J Neuroinflammation 10:70. 2013
  3. pmc Development of antihuman IgG antibodies and hematologic deficits but not clinical abnormalities in C57BL/6 mice after repeated administration of human intravenous immunoglobulin
    David A Loeffler
    Department of Neurology Research, William Beaumont Hospital, Royal Oak, Michigan, USA
    Comp Med 62:31-6. 2012
  4. pmc Plaque complement activation and cognitive loss in Alzheimer's disease
    David A Loeffler
    Neurology Research Laboratory, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 5:9. 2008
  5. ncbi request reprint Measurement by ELISA of complement factor 4 (C4) in the rat brain: necessity for removal of cerebrovascular proteins
    David A Loeffler
    Division of Neurology, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Neurochem Res 31:999-1002. 2006
  6. ncbi request reprint Comparison of PCR and culture for detection of Nocardia asteroides in brain specimens from experimentally infected BALB/c mice
    David A Loeffler
    William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    Microbiol Res 159:277-83. 2004
  7. ncbi request reprint Characterization of dopamine-depleting activity of Nocardia asteroides strain GUH-2 culture filtrate on PC12 cells
    David A Loeffler
    Department of Neurology, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Microb Pathog 37:73-85. 2004
  8. ncbi request reprint Early complement activation increases in the brain in some aged normal subjects
    David A Loeffler
    Division of Neurology, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    Neurobiol Aging 25:1001-7. 2004
  9. pmc ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
    Andrea C Klaver
    Department of Neurology Research, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 8:93. 2011
  10. doi request reprint Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity
    Lynnae M Smith
    Department of Neurology Research, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int Immunopharmacol 14:550-7. 2012

Collaborators

Detail Information

Publications23

  1. pmc α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls
    Lynnae M Smith
    Department of Neurology Research, Beaumont Health System, Royal Oak, Michigan, USA
    PLoS ONE 7:e52285. 2012
    ..Our findings are consistent with those previous studies which suggested that serum concentrations of α-synuclein and its antibodies are not significantly altered in PD...
  2. pmc Intravenous immunoglobulin and Alzheimer's disease: what now?
    David A Loeffler
    Department of Neurology Research, William Beaumont Hospital Research Institute, Beaumont Health System, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    J Neuroinflammation 10:70. 2013
    ..This review summarizes the recent AD IVIG trials and discusses the major issues relating to possible use of IVIG for treating AD, as well as the critical questions which remain. ..
  3. pmc Development of antihuman IgG antibodies and hematologic deficits but not clinical abnormalities in C57BL/6 mice after repeated administration of human intravenous immunoglobulin
    David A Loeffler
    Department of Neurology Research, William Beaumont Hospital, Royal Oak, Michigan, USA
    Comp Med 62:31-6. 2012
    ..These factors could cause the effects of IvIg preparations in mouse models of human disease to differ from their effects in the human disorders...
  4. pmc Plaque complement activation and cognitive loss in Alzheimer's disease
    David A Loeffler
    Neurology Research Laboratory, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 5:9. 2008
    ..Complement activation is increased in Alzheimer's disease (AD), but its significance is unclear. The objective of this study was to determine the relationship between complement activation and cognition during the development of AD...
  5. ncbi request reprint Measurement by ELISA of complement factor 4 (C4) in the rat brain: necessity for removal of cerebrovascular proteins
    David A Loeffler
    Division of Neurology, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Rd, Royal Oak, MI 48073, USA
    Neurochem Res 31:999-1002. 2006
    ..01 versus sham-perfused means). These results indicate that C4 in the rat brain can be measured quantitatively by ELISA provided that cerebrovascular proteins are removed by perfusion...
  6. ncbi request reprint Comparison of PCR and culture for detection of Nocardia asteroides in brain specimens from experimentally infected BALB/c mice
    David A Loeffler
    William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    Microbiol Res 159:277-83. 2004
    ..These findings suggest that PCR may be more sensitive than culture for the detection of low numbers of Nocardia in the brain...
  7. ncbi request reprint Characterization of dopamine-depleting activity of Nocardia asteroides strain GUH-2 culture filtrate on PC12 cells
    David A Loeffler
    Department of Neurology, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Microb Pathog 37:73-85. 2004
    ..These results suggest that a protease-resistant, low molecular mass substance secreted by N. asteroides may be responsible for its dopamine-depleting effects...
  8. ncbi request reprint Early complement activation increases in the brain in some aged normal subjects
    David A Loeffler
    Division of Neurology, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    Neurobiol Aging 25:1001-7. 2004
    ..Normal subject age was moderately associated with both C4d (r=0.49) and iC3b (r=0.53) concentrations in the hippocampus. Increased brain complement activation in some elderly individuals may promote the subsequent development of AD...
  9. pmc ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects
    Andrea C Klaver
    Department of Neurology Research, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA
    J Neuroinflammation 8:93. 2011
    ....
  10. doi request reprint Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity
    Lynnae M Smith
    Department of Neurology Research, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int Immunopharmacol 14:550-7. 2012
    ..007 vs. protective effects of normal human IgG). These findings suggest that although IVIG does not prevent α-synuclein aggregation, it still may reduce α-synuclein neurotoxicity through an unknown mechanism...
  11. doi request reprint Antibody concentrations to Abeta1-42 monomer and soluble oligomers in untreated and antibody-antigen-dissociated intravenous immunoglobulin preparations
    Andrea C Klaver
    Division of Neurology, Beaumont Research Institute, William Beaumont Hospital, Suite 507, Royal Oak, MI 48073, USA
    Int Immunopharmacol 10:115-9. 2010
    ....
  12. ncbi request reprint Nocardia asteroides culture filtrates cause dopamine depletion and cytotoxicity in PC12 cells
    Dianne M Camp
    Division of Neurology, William Beaumont Hospital Research Institute, Royal Oak, Michigan 48073, USA
    Neurochem Res 28:1359-67. 2003
    ..These findings suggest that the loss of nigrostriatal dopamine neurons and concomitant striatal dopamine depletion in Nocardia-infected mice may be due, at least in part, to the neurotoxicity of nocardial secretory products...
  13. ncbi request reprint Lack of evidence for Nocardia asteroides in brain specimens from Lewy body-containing disorders
    Lin Lu
    Department of Neurology, William Beaumont Hospital Research Institute, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Microb Pathog 39:205-11. 2005
    ..4%; one case each of PD, DLB, and Alzheimer's disease), and none of the specimens was positive for Nocardia by PCR or Gram staining. These findings do not support an association of Nocardia with Lewy body-containing disorders...
  14. doi request reprint Measurement of anti-Abeta1-42 antibodies in intravenous immunoglobulin with indirect ELISA: the problem of nonspecific binding
    Andrea C Klaver
    Department of Neurology Research, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Suite 507, Royal Oak, MI 48073, USA
    J Neurosci Methods 187:263-9. 2010
    ..This must be subtracted from total binding to accurately measure specific anti-Abeta antibody concentrations...
  15. doi request reprint Effects of external beam radiation on in vitro formation of Abeta1-42 fibrils and preformed fibrils
    Lynnae M Patrias
    Department of Neurology Research, William Beaumont Hospital Research Institute, Royal Oak, Michigan 48073, USA
    Radiat Res 175:375-81. 2011
    ..This treatment might still lower plaque counts indirectly, but any potential benefits would need to be weighed against its possible neurotoxic effects, which could induce further cognitive deficits...
  16. doi request reprint Specificity and sensitivity of the Abeta oligomer ELISA
    Andrea C Klaver
    Department of Neurology Research, William Beaumont Hospital Research Institute, 3811 West Thirteen Mile Road, Suite 507, Royal Oak, MI 48073, USA
    J Neurosci Methods 195:249-54. 2011
    ....
  17. doi request reprint Intravenous immunoglobulin products contain specific antibodies to recombinant human tau protein
    Lynnae M Smith
    Department of Neurology Research, Beaumont Research Institute, Beaumont Health System, 3811 West Thirteen Mile Road, Royal Oak, MI 48073, USA
    Int Immunopharmacol 16:424-8. 2013
    ..Further studies are indicated to determine if IVIG also contains antibodies to pathologic forms of tau...
  18. pmc Cellular immune response to intrastriatally implanted allogeneic bone marrow stromal cells in a rat model of Parkinson's disease
    Dianne M Camp
    Division of Neurology, William Beaumont Hospital Research Institute, Royal Oak, Michigan 48073, USA
    J Neuroinflammation 6:17. 2009
    ....
  19. doi request reprint Comparison of ELISA measurements of anti-Aβ concentrations and percentages of specific binding to Aβ between unfractionated intravenous immunoglobulin products and their purified anti-Aβ antibodies
    Andrea C Klaver
    Department of Neurology Research, Beaumont Health System, Royal Oak, MI, United States Electronic address
    Immunol Lett 154:7-11. 2013
    ..Polyvalent binding occurs even with purified anti-Aβ antibodies eluated from IVIG products, but it is less extensive than with unfractionated IVIG. ..
  20. ncbi request reprint In situ hybridization for detection of nocardial 16S rRNA: reactivity within intracellular inclusions in experimentally infected cynomolgus monkeys--and in Lewy body-containing human brain specimens
    Gail Chapman
    Department of Medical Microbiology and Immunology, University of California School of Medicine, Davis, CA 95616, USA
    Exp Neurol 184:715-25. 2003
    ..These results suggest a possible association between Nocardia and neurodegenerative disorders in which Lewy bodies are present...
  21. ncbi request reprint Soluble egg antigens from Schistosoma mansoni induce angiogenesis-related processes by up-regulating vascular endothelial growth factor in human endothelial cells
    David A Loeffler
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Infect Dis 185:1650-6. 2002
    ..These findings suggest that products secreted by schistosome eggs may promote angiogenesis within hepatic granulomas by up-regulating endothelial cell VEGF...